P18268 (TRPC_BACPU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:

trpC

Organism

Bacillus pumilus (Bacillus mesentericus)

Taxonomic identifier

1408 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	68 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›68	›68	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_0000154212
Experimental info
	Non-terminal residue	68	1

Sequences

	Sequence		Length	Mass (Da)
	P18268 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: DFDDBEFC80E7BDE4	FASTA	68	7,688
	10 20 30 40 50 60 MLNQIIARKK EHIQTLQLPV DGHFERRSFK EALMNPHRSI GLIAEVKKAS PSKGIIQPNF DPLQTAKA

References

[1]	"The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus." Rivas M.V., Jarvis E.D., Rudner R. Gene 87:71-78(1990) [PubMed: 2110100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: RUB502.
[2]	Erratum Rivas M.V., Jarvis E.D., Rudner R. Gene 94:141-143(1990) [PubMed: 2227447] [Abstract]

Cross-references

Sequence databases
EMBL GenBank DDBJ	M36468 Genomic DNA. Translation: AAB02274.1.
PIR	JH0100.
3D structure databases
ProteinModelPortal	P18268.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACPU

Accession

Primary (citable) accession number: P18268

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	October 19, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program