Reviewed, UniProtKB/Swiss-Prot P18268 (TRPC_BACPU)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:

trpC

Organism

Bacillus pumilus (Bacillus mesentericus)

Taxonomic identifier

1408 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	68 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›68	›68	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_0000154212
Experimental info
	Non-terminal residue	68	1

Sequences

	Sequence		Length	Mass (Da)
	P18268-1 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: DFDDBEFC80E7BDE4	FASTA	68	7,688
	10 20 30 40 50 60 MLNQIIARKK EHIQTLQLPV DGHFERRSFK EALMNPHRSI GLIAEVKKAS PSKGIIQPNF DPLQTAKA

References

[1]	"The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus." Rivas M.V., Jarvis E.D., Rudner R. Gene 87:71-78(1990) [PubMed: 2110100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: RUB502.
[2]	Erratum Rivas M.V., Jarvis E.D., Rudner R. Gene 94:141-143(1990) [PubMed: 2227447] [Abstract]

Cross-references

Sequence databases
EMBLGenBankDDBJ	M36468 Genomic DNA. Translation: AAB02274.1.
PIR	JH0100.
3D structure databases
HSSP	HSSP built from PDB template 1JCM based on UniProtKB P00909.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.1.1.48. 1189.
Family and domain databases
HAMAP	MF_00134. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GPS_central. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
ProDom	PD001511. IGPS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACPU

Accession

Primary (citable) accession number: P18268

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	March 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)