P18267 (TRPE_BACPU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Bacillus pumilus (Bacillus mesentericus)

Taxonomic identifier

1408 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.
Sequence caution	The sequence AAB02272.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	Anthranilate synthase component 1		PRO_0000154077

Sequences

	Sequence		Length	Mass (Da)
	P18267 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 0E6B19904421CC5A	FASTA	513	58,091
	10 20 30 40 50 60 MNSQSNLTQF LKDSESYKTI PIVETITVDT LSPIQIVEKL KQDIVYLLES KDESSSWSRY 70 80 90 100 110 120 SFIGLHPFLT LHDDQNKYIA RDAAGQKLMQ KQELKELLDW MKEQYQIKTP DIDIPFTGGA 130 140 150 160 170 180 VGYLSYDLIP TLTSVRPHRS ASTIENAHIC LPTMIAFDHE TNHVHFIQYT QLTGHETEDE 190 200 210 220 230 240 KIRAYKEKQK QLEQMIHKLH SKVDMKELIL SGNMNEPPSF EHVTSTYEKA QFLKDVEKIK 250 260 270 280 290 300 EYIRAGDIFQ GVLSQRFDIP VSVSSFELYR VLRIVNPSPY MYFMKLKDRD LVGSSPERLI 310 320 330 340 350 360 HAKNGHLEIH PIAGTRKRGT TREEDAELAR ELLEDEKEKA EHYMLVDLAR NDVGRVAEYG 370 380 390 400 410 420 SVSVPTFTKV VNFSHVMHII SIVTGKLKRD THPVDALMSA FPAGTLTGAP KIRAMQLLNE 430 440 450 460 470 480 MEPEPRETYG GCIAYIGFDG NIDSCITIRT MSVKNHTASI QAGAGIVADS VPENEWEETC 490 500 510 NKAGALLKAI QLAEHIFSEK ESVQDESPTI SSC

References

[1]	"The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus." Rivas M.V., Jarvis E.D., Rudner R. Gene 87:71-78(1990) [PubMed: 2110100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: RUB502.
[2]	Erratum Rivas M.V., Jarvis E.D., Rudner R. Gene 94:141-143(1990) [PubMed: 2227447] [Abstract]
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M36468 Genomic DNA. Translation: AAB02272.1. Different initiation.
PIR	JH0098.
3D structure databases
ProteinModelPortal	P18267.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. TrpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_BACPU

Accession

Primary (citable) accession number: P18267

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	May 30, 2000
Last modified:	September 21, 2011
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program