Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Insulin-like growth factor I

Gene

IGF1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-GGA-114608. Platelet degranulation.
R-GGA-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-GGA-2428928. IRS-related events triggered by IGF1R.
R-GGA-2428933. SHC-related events triggered by IGF1R.
R-GGA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-GGA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor I
Short name:
IGF-I
Alternative name(s):
Somatomedin
Gene namesi
Name:IGF1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 481 PublicationPRO_0000015690
Signal peptidei1 – ?
Chaini49 – 11870Insulin-like growth factor IPRO_0000015691Add
BLAST
Propeptidei119 – 15335E peptidePRO_0000015692Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 96By similarity
Disulfide bondi66 ↔ 109By similarity
Disulfide bondi95 ↔ 100By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP18254.
PRIDEiP18254.

Expressioni

Gene expression databases

ExpressionAtlasiP18254. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020787.

Structurei

3D structure databases

ProteinModelPortaliP18254.
SMRiP18254. Positions 49-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 7729BAdd
BLAST
Regioni78 – 8912CAdd
BLAST
Regioni90 – 11021AAdd
BLAST
Regioni111 – 1188D

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP18254.
KOiK05459.
OMAiHTVSYIH.
OrthoDBiEOG7TF7CG.
PhylomeDBiP18254.
TreeFamiTF332820.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKINSLSTQ LVKCCFCDFL KVKMHTVSYI HFFYLGLCLL TLTSSAAAGP
60 70 80 90 100
ETLCGAELVD ALQFVCGDRG FYFSKPTGYG SSSRRLHHKG IVDECCFQSC
110 120 130 140 150
DLRRLEMYCA PIKPPKSARS VRAQRHTDMP KAQKEVHLKN TSRGNTGNRN

YRM
Length:153
Mass (Da):17,267
Last modified:November 1, 1990 - v1
Checksum:iAAE13FDED13EE2F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32791 mRNA. Translation: AAA48828.1.
M74176 Genomic DNA. Translation: AAA48829.1.
PIRiA41399.
RefSeqiNP_001004384.1. NM_001004384.2.
UniGeneiGga.850.

Genome annotation databases

EnsembliENSGALT00000020816; ENSGALP00000020787; ENSGALG00000012755.
GeneIDi418090.
KEGGigga:418090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32791 mRNA. Translation: AAA48828.1.
M74176 Genomic DNA. Translation: AAA48829.1.
PIRiA41399.
RefSeqiNP_001004384.1. NM_001004384.2.
UniGeneiGga.850.

3D structure databases

ProteinModelPortaliP18254.
SMRiP18254. Positions 49-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020787.

Proteomic databases

PaxDbiP18254.
PRIDEiP18254.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000020816; ENSGALP00000020787; ENSGALG00000012755.
GeneIDi418090.
KEGGigga:418090.

Organism-specific databases

CTDi3479.

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP18254.
KOiK05459.
OMAiHTVSYIH.
OrthoDBiEOG7TF7CG.
PhylomeDBiP18254.
TreeFamiTF332820.

Enzyme and pathway databases

ReactomeiR-GGA-114608. Platelet degranulation.
R-GGA-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-GGA-2428928. IRS-related events triggered by IGF1R.
R-GGA-2428933. SHC-related events triggered by IGF1R.
R-GGA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-GGA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Miscellaneous databases

NextBioi20821300.
PROiP18254.

Gene expression databases

ExpressionAtlasiP18254. baseline and differential.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and expression of a chicken insulin-like growth factor I precursor."
    Kajimoto Y., Rotwein P.
    Mol. Endocrinol. 3:1907-1913(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of the chicken insulin-like growth factor I gene reveals conserved promoter elements."
    Rotwein P., Kajimoto Y.
    J. Biol. Chem. 266:9724-9731(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
  3. "Chicken insulin-like growth factor-I: amino acid sequence, radioimmunoassay, and plasma levels between strains and during growth."
    Ballard F.J., Johnson R.J., Owens P.C., Francis G.L., Upton F.M., McMurtry J.P., Wallace J.C.
    Gen. Comp. Endocrinol. 79:459-468(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 49-118.

Entry informationi

Entry nameiIGF1_CHICK
AccessioniPrimary (citable) accession number: P18254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.