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Protein

RNA polymerase principal sigma factor HrdD

Gene

hrdD

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi294 – 31320H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Sigma factor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase principal sigma factor HrdD
Gene namesi
Name:hrdD
Ordered Locus Names:SCO3202
ORF Names:SCE22.19c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332RNA polymerase principal sigma factor HrdDPRO_0000093994Add
BLAST

Proteomic databases

PRIDEiP18249.

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.By similarity

Protein-protein interaction databases

STRINGi100226.SCO3202.

Structurei

3D structure databases

ProteinModelPortaliP18249.
SMRiP18249. Positions 92-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi124 – 13714Polymerase core bindingAdd
BLAST

Sequence similaritiesi

Belongs to the sigma-70 factor family.Curated

Phylogenomic databases

eggNOGiENOG4105I8R. Bacteria.
COG0568. LUCA.
HOGENOMiHOG000270273.
InParanoidiP18249.
OMAiSPEQSVM.
OrthoDBiPOG091H0012.
PhylomeDBiP18249.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRAVARRK SAAGETSGSA TSVRANGGEL ADRDLVGMYL DEIARTPLLD
60 70 80 90 100
AAKEVELSQT IEAGVFARQV LEGYEETGAD ATREELQALI DESERAKDVF
110 120 130 140 150
IRSNLRLVVA VARRYPRSGL PLLDLIQEGN AGLVRAVEKF DYRKGFKFST
160 170 180 190 200
YATWWIRQAI TRSIADQSRT IRLPVHLVEE LGRIRRVQRE FNREHGREPE
210 220 230 240 250
PAEIAAELGS TPERVTDVLD WARDPVSLNM SVDDEGETQF GDLLEDTSAV
260 270 280 290 300
SPEQSVLTLL RSEELDDLIG RLDPRTASII KMRYGIDDGR ERTLTEVGKE
310 320 330
HGLTRERIRQ IEKHALLELK KLARDTGFEA AA
Length:332
Mass (Da):37,155
Last modified:October 18, 2001 - v2
Checksum:iBEAC010BBC0C442B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1481F → I no nucleotide entry (PubMed:3194753).Curated
Sequence conflicti167 – 1671Q → H no nucleotide entry (PubMed:3194753).Curated
Sequence conflicti216 – 2161T → H in CAA37174 (PubMed:1944221).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52982 Genomic DNA. Translation: CAA37174.1.
AL939115 Genomic DNA. Translation: CAB90986.1.
PIRiD40116.
S17931. S11714.
RefSeqiNP_627416.1. NC_003888.3.
WP_003975615.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB90986; CAB90986; CAB90986.
GeneIDi1098636.
KEGGisco:SCO3202.
PATRICi23736146. VBIStrCoe124346_3262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52982 Genomic DNA. Translation: CAA37174.1.
AL939115 Genomic DNA. Translation: CAB90986.1.
PIRiD40116.
S17931. S11714.
RefSeqiNP_627416.1. NC_003888.3.
WP_003975615.1. NC_003888.3.

3D structure databases

ProteinModelPortaliP18249.
SMRiP18249. Positions 92-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO3202.

Proteomic databases

PRIDEiP18249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB90986; CAB90986; CAB90986.
GeneIDi1098636.
KEGGisco:SCO3202.
PATRICi23736146. VBIStrCoe124346_3262.

Phylogenomic databases

eggNOGiENOG4105I8R. Bacteria.
COG0568. LUCA.
HOGENOMiHOG000270273.
InParanoidiP18249.
OMAiSPEQSVM.
OrthoDBiPOG091H0012.
PhylomeDBiP18249.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHRDD_STRCO
AccessioniPrimary (citable) accession number: P18249
Secondary accession number(s): Q9KYU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 18, 2001
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.