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Protein

RNA polymerase principal sigma factor HrdD

Gene

hrdD

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi294 – 313H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Sigma factor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase principal sigma factor HrdD
Gene namesi
Name:hrdD
Ordered Locus Names:SCO3202
ORF Names:SCE22.19c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000939941 – 332RNA polymerase principal sigma factor HrdDAdd BLAST332

Proteomic databases

PRIDEiP18249

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.By similarity

Protein-protein interaction databases

STRINGi100226.SCO3202

Structurei

3D structure databases

ProteinModelPortaliP18249
SMRiP18249
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi124 – 137Polymerase core bindingAdd BLAST14

Sequence similaritiesi

Belongs to the sigma-70 factor family.Curated

Phylogenomic databases

eggNOGiENOG4105I8R Bacteria
COG0568 LUCA
HOGENOMiHOG000270273
InParanoidiP18249
OMAiRRVQREF
OrthoDBiPOG091H0012
PhylomeDBiP18249

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR009042 RNA_pol_sigma70_r1_2
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00140 Sigma70_r1_2, 1 hit
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit
PS00716 SIGMA70_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRAVARRK SAAGETSGSA TSVRANGGEL ADRDLVGMYL DEIARTPLLD
60 70 80 90 100
AAKEVELSQT IEAGVFARQV LEGYEETGAD ATREELQALI DESERAKDVF
110 120 130 140 150
IRSNLRLVVA VARRYPRSGL PLLDLIQEGN AGLVRAVEKF DYRKGFKFST
160 170 180 190 200
YATWWIRQAI TRSIADQSRT IRLPVHLVEE LGRIRRVQRE FNREHGREPE
210 220 230 240 250
PAEIAAELGS TPERVTDVLD WARDPVSLNM SVDDEGETQF GDLLEDTSAV
260 270 280 290 300
SPEQSVLTLL RSEELDDLIG RLDPRTASII KMRYGIDDGR ERTLTEVGKE
310 320 330
HGLTRERIRQ IEKHALLELK KLARDTGFEA AA
Length:332
Mass (Da):37,155
Last modified:October 18, 2001 - v2
Checksum:iBEAC010BBC0C442B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148F → I no nucleotide entry (PubMed:3194753).Curated1
Sequence conflicti167Q → H no nucleotide entry (PubMed:3194753).Curated1
Sequence conflicti216T → H in CAA37174 (PubMed:1944221).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52982 Genomic DNA Translation: CAA37174.1
AL939115 Genomic DNA Translation: CAB90986.1
PIRiD40116
S17931 S11714
RefSeqiNP_627416.1, NC_003888.3
WP_003975615.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB90986; CAB90986; CAB90986
GeneIDi1098636
KEGGisco:SCO3202
PATRICifig|100226.15.peg.3262

Similar proteinsi

Entry informationi

Entry nameiHRDD_STRCO
AccessioniPrimary (citable) accession number: P18249
Secondary accession number(s): Q9KYU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 18, 2001
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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