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P18242 (CATD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cathepsin D

EC=3.4.23.5
Gene names
Name:Ctsd
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acid protease active in intracellular protein breakdown.

Catalytic activity

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.

Subunit structure

Consists of a light chain and a heavy chain By similarity.

Subcellular location

Lysosome. Melanosome By similarity. Secretedextracellular space By similarity.

Sequence similarities

Belongs to the peptidase A1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 6444Activation peptide Potential
PRO_0000025953
Chain65 – 410346Cathepsin D
PRO_0000025954

Sites

Active site971 By similarity
Active site2931 By similarity

Amino acid modifications

Glycosylation1341N-linked (GlcNAc...) By similarity
Glycosylation2611N-linked (GlcNAc...) (high mannose) Ref.5
Disulfide bond91 ↔ 160 By similarity
Disulfide bond110 ↔ 117 By similarity
Disulfide bond284 ↔ 288 By similarity
Disulfide bond327 ↔ 364 By similarity

Sequences

Sequence LengthMass (Da)Tools
P18242 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: DC4928EC46928BF0

FASTA41044,954
        10         20         30         40         50         60 
MKTPGVLLLI LGLLASSSFA IIRIPLRKFT SIRRTMTEVG GSVEDLILKG PITKYSMQSS 

        70         80         90        100        110        120 
PKTTEPVSEL LKNYLDAQYY GDIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KILDIACWVH 

       130        140        150        160        170        180 
HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC KSDQSKARGI KVEKQIFGEA 

       190        200        210        220        230        240 
TKQPGIVFVA AKFDGILGMG YPHISVNNVL PVFDNLMQQK LVDKNIFSFY LNRDPEGQPG 

       250        260        270        280        290        300 
GELMLGGTDS KYYHGELSYL NVTRKAYWQV HMDQLEVGNE LTLCKGGCEA IVDTGTSLLV 

       310        320        330        340        350        360 
GPVEEVKELQ KAIGAVPLIQ GEYMIPCEKV SSLPTVYLKL GGKNYELHPD KYILKVSQGG 

       370        380        390        400        410 
KTICLSGFMG MDIPPPSGPL WILGDVFIGS YYTVFDRDNN RVGFANAVVL 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of a cDNA encoding mouse cathepsin D."
Diedrich J.F., Staskus K.A., Retzel E.F., Haase A.T.
Nucleic Acids Res. 18:7184-7184(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Brain.
[2]"Molecular cloning of mouse cathepsin D."
Grusby M.J., Mitchell S.C., Glimcher L.H.
Nucleic Acids Res. 18:4008-4008(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization."
Hetman M., Perschl A., Saftig P., von Figura K., Peters C.
DNA Cell Biol. 13:419-427(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain and Mammary gland.
[5]"High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis."
Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K., Nishimura S.
Mol. Cell. Proteomics 4:1977-1989(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261.
Tissue: Epidermis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53337 mRNA. Translation: CAA37423.1.
X52886 mRNA. Translation: CAA37067.1.
X68378 expand/collapse EMBL AC list , X68379, X68380, X68381, X68382, X68383 Genomic DNA. Translation: CAA48453.1.
BC054758 mRNA. Translation: AAH54758.1.
BC057931 mRNA. Translation: AAH57931.1.
PIRKHMSD. I48278.
RefSeqNP_034113.1. NM_009983.2.
UniGeneMm.231395.

3D structure databases

ProteinModelPortalP18242.
SMRP18242. Positions 21-408.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP18242. 5 interactions.
MINTMINT-4089919.

Protein family/group databases

MEROPSA01.009.

PTM databases

PhosphoSiteP18242.

Proteomic databases

PaxDbP18242.
PRIDEP18242.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000151120; ENSMUSP00000121203; ENSMUSG00000007891.
GeneID13033.
KEGGmmu:13033.
UCSCuc009kmv.1. mouse.

Organism-specific databases

CTD1509.
MGIMGI:88562. Ctsd.

Phylogenomic databases

eggNOGNOG248684.
HOGENOMHOG000197681.
HOVERGENHBG000482.
KOK01379.
OMAGEYMISC.
TreeFamTF314990.

Gene expression databases

ArrayExpressP18242.
BgeeP18242.
CleanExMM_CTSD.
GenevestigatorP18242.

Family and domain databases

Gene3D2.40.70.10. 2 hits.
InterProIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERPTHR13683. PTHR13683. 1 hit.
PfamPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSPR00792. PEPSIN.
SUPFAMSSF50630. SSF50630. 1 hit.
PROSITEPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCTSD. mouse.
NextBio282908.
PROP18242.
SOURCESearch...

Entry information

Entry nameCATD_MOUSE
AccessionPrimary (citable) accession number: P18242
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot