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P18242

- CATD_MOUSE

UniProt

P18242 - CATD_MOUSE

Protein

Cathepsin D

Gene

Ctsd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Acid protease active in intracellular protein breakdown.

    Catalytic activityi

    Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971PROSITE-ProRule annotation
    Active sitei293 – 2931PROSITE-ProRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: MGI
    2. peptidase activity Source: MGI

    GO - Biological processi

    1. autophagic vacuole assembly Source: MGI
    2. proteolysis Source: MGI

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_199055. Collagen degradation.

    Protein family/group databases

    MEROPSiA01.009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin D (EC:3.4.23.5)
    Gene namesi
    Name:Ctsd
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:88562. Ctsd.

    Subcellular locationi

    Lysosome. Melanosome By similarity. Secretedextracellular space By similarity

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular space Source: UniProtKB-SubCell
    3. lysosome Source: MGI
    4. melanosome Source: UniProtKB-SubCell
    5. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Lysosome, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 6444Activation peptideSequence AnalysisPRO_0000025953Add
    BLAST
    Chaini65 – 410346Cathepsin DPRO_0000025954Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi91 ↔ 160By similarity
    Disulfide bondi110 ↔ 117By similarity
    Glycosylationi134 – 1341N-linked (GlcNAc...)By similarity
    Glycosylationi261 – 2611N-linked (GlcNAc...) (high mannose)1 Publication
    Disulfide bondi284 ↔ 288By similarity
    Disulfide bondi327 ↔ 364By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiP18242.
    PaxDbiP18242.
    PRIDEiP18242.

    PTM databases

    PhosphoSiteiP18242.

    Expressioni

    Gene expression databases

    ArrayExpressiP18242.
    BgeeiP18242.
    CleanExiMM_CTSD.
    GenevestigatoriP18242.

    Interactioni

    Subunit structurei

    Consists of a light chain and a heavy chain.By similarity

    Protein-protein interaction databases

    IntActiP18242. 10 interactions.
    MINTiMINT-4089919.

    Structurei

    3D structure databases

    ProteinModelPortaliP18242.
    SMRiP18242. Positions 21-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG248684.
    HOGENOMiHOG000197681.
    HOVERGENiHBG000482.
    KOiK01379.
    OMAiNIACLMH.
    TreeFamiTF314990.

    Family and domain databases

    Gene3Di2.40.70.10. 2 hits.
    InterProiIPR001461. Aspartic_peptidase.
    IPR001969. Aspartic_peptidase_AS.
    IPR012848. Aspartic_peptidase_N.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view]
    PANTHERiPTHR13683. PTHR13683. 1 hit.
    PfamiPF07966. A1_Propeptide. 1 hit.
    PF00026. Asp. 1 hit.
    [Graphical view]
    PRINTSiPR00792. PEPSIN.
    SUPFAMiSSF50630. SSF50630. 1 hit.
    PROSITEiPS00141. ASP_PROTEASE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18242-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTPGVLLLI LGLLASSSFA IIRIPLRKFT SIRRTMTEVG GSVEDLILKG    50
    PITKYSMQSS PKTTEPVSEL LKNYLDAQYY GDIGIGTPPQ CFTVVFDTGS 100
    SNLWVPSIHC KILDIACWVH HKYNSDKSST YVKNGTSFDI HYGSGSLSGY 150
    LSQDTVSVPC KSDQSKARGI KVEKQIFGEA TKQPGIVFVA AKFDGILGMG 200
    YPHISVNNVL PVFDNLMQQK LVDKNIFSFY LNRDPEGQPG GELMLGGTDS 250
    KYYHGELSYL NVTRKAYWQV HMDQLEVGNE LTLCKGGCEA IVDTGTSLLV 300
    GPVEEVKELQ KAIGAVPLIQ GEYMIPCEKV SSLPTVYLKL GGKNYELHPD 350
    KYILKVSQGG KTICLSGFMG MDIPPPSGPL WILGDVFIGS YYTVFDRDNN 400
    RVGFANAVVL 410
    Length:410
    Mass (Da):44,954
    Last modified:November 1, 1990 - v1
    Checksum:iDC4928EC46928BF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53337 mRNA. Translation: CAA37423.1.
    X52886 mRNA. Translation: CAA37067.1.
    X68378
    , X68379, X68380, X68381, X68382, X68383 Genomic DNA. Translation: CAA48453.1.
    BC054758 mRNA. Translation: AAH54758.1.
    BC057931 mRNA. Translation: AAH57931.1.
    CCDSiCCDS22029.1.
    PIRiI48278. KHMSD.
    RefSeqiNP_034113.1. NM_009983.2.
    UniGeneiMm.231395.

    Genome annotation databases

    EnsembliENSMUST00000151120; ENSMUSP00000121203; ENSMUSG00000007891.
    GeneIDi13033.
    KEGGimmu:13033.
    UCSCiuc009kmv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53337 mRNA. Translation: CAA37423.1 .
    X52886 mRNA. Translation: CAA37067.1 .
    X68378
    , X68379 , X68380 , X68381 , X68382 , X68383 Genomic DNA. Translation: CAA48453.1 .
    BC054758 mRNA. Translation: AAH54758.1 .
    BC057931 mRNA. Translation: AAH57931.1 .
    CCDSi CCDS22029.1.
    PIRi I48278. KHMSD.
    RefSeqi NP_034113.1. NM_009983.2.
    UniGenei Mm.231395.

    3D structure databases

    ProteinModelPortali P18242.
    SMRi P18242. Positions 21-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P18242. 10 interactions.
    MINTi MINT-4089919.

    Protein family/group databases

    MEROPSi A01.009.

    PTM databases

    PhosphoSitei P18242.

    Proteomic databases

    MaxQBi P18242.
    PaxDbi P18242.
    PRIDEi P18242.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000151120 ; ENSMUSP00000121203 ; ENSMUSG00000007891 .
    GeneIDi 13033.
    KEGGi mmu:13033.
    UCSCi uc009kmv.1. mouse.

    Organism-specific databases

    CTDi 1509.
    MGIi MGI:88562. Ctsd.

    Phylogenomic databases

    eggNOGi NOG248684.
    HOGENOMi HOG000197681.
    HOVERGENi HBG000482.
    KOi K01379.
    OMAi NIACLMH.
    TreeFami TF314990.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_199055. Collagen degradation.

    Miscellaneous databases

    ChiTaRSi CTSD. mouse.
    NextBioi 282908.
    PROi P18242.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18242.
    Bgeei P18242.
    CleanExi MM_CTSD.
    Genevestigatori P18242.

    Family and domain databases

    Gene3Di 2.40.70.10. 2 hits.
    InterProi IPR001461. Aspartic_peptidase.
    IPR001969. Aspartic_peptidase_AS.
    IPR012848. Aspartic_peptidase_N.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view ]
    PANTHERi PTHR13683. PTHR13683. 1 hit.
    Pfami PF07966. A1_Propeptide. 1 hit.
    PF00026. Asp. 1 hit.
    [Graphical view ]
    PRINTSi PR00792. PEPSIN.
    SUPFAMi SSF50630. SSF50630. 1 hit.
    PROSITEi PS00141. ASP_PROTEASE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a cDNA encoding mouse cathepsin D."
      Diedrich J.F., Staskus K.A., Retzel E.F., Haase A.T.
      Nucleic Acids Res. 18:7184-7184(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization."
      Hetman M., Perschl A., Saftig P., von Figura K., Peters C.
      DNA Cell Biol. 13:419-427(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain and Mammary gland.
    5. "High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis."
      Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K., Nishimura S.
      Mol. Cell. Proteomics 4:1977-1989(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261.
      Tissue: Epidermis.

    Entry informationi

    Entry nameiCATD_MOUSE
    AccessioniPrimary (citable) accession number: P18242
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3