Reviewed,
UniProtKB/Swiss-Prot P18242 (CATD_MOUSE)
Last modified
October 13, 2009.
Version 97.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cathepsin D EC=3.4.23.5 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 410 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Acid protease active in intracellular protein breakdown. |
| Catalytic activity | Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. |
| Subunit structure | Consists of a light chain and a heavy chain By similarity. |
| Subcellular location | Lysosome. Melanosome By similarity. |
| Sequence similarities | Belongs to the peptidase A1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome |
| Domain | Signal |
| Molecular function | Aspartyl protease Hydrolase Protease |
| PTM | Disulfide bond Glycoprotein Zymogen |
| Gene Ontology (GO) | |
| Biological process | autophagic vacuole formation Inferred from mutant phenotype. Source: MGI proteolysisInferred by curator. Source: MGI |
| Cellular component | lysosome Inferred from direct assay. Source: MGI melanosomeInferred from electronic annotation. Source: UniProtKB-SubCell mitochondrionInferred from direct assay. Source: MGI |
| Molecular function | aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Potential | ||||||||
| Propeptide | 21 – 64 | 44 | Activation peptide Potential | PRO_0000025953 | |||||||
| Chain | 65 – 410 | 346 | Cathepsin D | PRO_0000025954 | |||||||
Sites | |||||||||||
| Active site | 97 | 1 | By similarity | ||||||||
| Active site | 293 | 1 | By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 134 | 1 | N-linked (GlcNAc...) By similarity | ||||||||
| Glycosylation | 261 | 1 | N-linked (GlcNAc...) (high mannose) Ref.5 | ||||||||
| Disulfide bond | 91 ↔ 160 | By similarity | |||||||||
| Disulfide bond | 110 ↔ 117 | By similarity | |||||||||
| Disulfide bond | 284 ↔ 288 | By similarity | |||||||||
| Disulfide bond | 327 ↔ 364 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Nucleotide sequence of a cDNA encoding mouse cathepsin D." Diedrich J.F., Staskus K.A., Retzel E.F., Haase A.T. Nucleic Acids Res. 18:7184-7184(1990) [PubMed: 2263503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Brain. |
| [2] | "Molecular cloning of mouse cathepsin D." Grusby M.J., Mitchell S.C., Glimcher L.H. Nucleic Acids Res. 18:4008-4008(1990) [PubMed: 2374732] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization." Hetman M., Perschl A., Saftig P., von Figura K., Peters C. DNA Cell Biol. 13:419-427(1994) [PubMed: 8011168] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6J. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain and Mammary gland. |
| [5] | "High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis." Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K., Nishimura S. Mol. Cell. Proteomics 4:1977-1989(2005) [PubMed: 16170054] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261, MASS SPECTROMETRY. Tissue: Epidermis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X53337 mRNA. Translation: CAA37423.1. X52886 mRNA. Translation: CAA37067.1. X68378 X68383 Genomic DNA. Translation: CAA48453.1. BC054758 mRNA. Translation: AAH54758.1. BC057931 mRNA. Translation: AAH57931.1. | |
| IPI | IPI00111013. |
| PIR | KHMSD. I48278. |
| RefSeq | NP_034113.1. |
| UniGene | Mm.231395 Mm.392048 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1LYB based on UniProtKB P07339. |
| SMR | P18242. Positions 169-407. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P18242. 1 interaction. |
| STRING | P18242. |
Protein family/group databases | |
| MEROPS | A01.009. |
Proteomic databases | |
| PRIDE | P18242. |
Genome annotation databases | |
| Ensembl | ENSMUST00000008035; ENSMUSP00000008035; ENSMUSG00000007891; Mus musculus. [Genome view] ENSMUST00000066401; ENSMUSP00000063904; ENSMUSG00000007891; Mus musculus. [Genome view] |
| GeneID | 13033. |
| KEGG | mmu:13033. |
| UCSC | uc009kmv.1. mouse. |
Organism-specific databases | |
| CTD | 13033. |
| MGI | MGI:88562. Ctsd. |
Phylogenomic databases | |
| HOVERGEN | P18242. |
Enzyme and pathway databases | |
| BRENDA | 3.4.23.5. 244. |
Gene expression databases | |
| ArrayExpress | P18242. |
| Bgee | P18242. |
| CleanEx | MM_CTSD. |
| Genevestigator | P18242. |
| GermOnline | ENSMUSG00000007891. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001461. Peptidase_A1. IPR001969. Peptidase_aspartic_AS. IPR009007. Peptidase_aspartic_catalytic. IPR012848. Propep_A1. [Graphical view] |
| Gene3D | G3DSA:2.40.70.10. Pept_Aspartc_cat. 2 hits. |
| PANTHER | PTHR13683. Peptidase_A1. 1 hit. |
| Pfam | PF07966. A1_Propeptide. 1 hit. PF00026. Asp. 1 hit. [Graphical view] |
| PRINTS | PR00792. PEPSIN. |
| PROSITE | PS00141. ASP_PROTEASE. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 282908. |
| SOURCE | Search... |
Entry information
| Entry name | CATD_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P18242 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


