P18241 (TBB1_BRUPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Tubulin beta-1 chain Alternative name(s): Beta-1-tubulin
Organism	Brugia pahangi (Filarial nematode worm)
Taxonomic identifier	6280 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Nematoda › Chromadorea › Spirurida › Filarioidea › Onchocercidae › Brugia

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
Subunit structure	Dimer of alpha and beta chains.
Subcellular location	Cytoplasm › cytoskeleton.
Sequence similarities	Belongs to the tubulin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Ligand	GTP-binding Nucleotide-binding
Gene Ontology (GO)
Biological process	microtubule-based movement Inferred from electronic annotation. Source: InterPro protein polymerization Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Tubulin beta-1 chain		PRO_0000048284
Regions
	Nucleotide binding	140 – 146	7	GTP Potential

Sequences

	Sequence		Length	Mass (Da)
	P18241 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 65BB5BB9384A8735	FASTA	448	50,191
	10 20 30 40 50 60 MREIVHVQAG QCGNQIGAKF WEVISDEHGV QPDGTYKGDS DLQIERINVY YNEANGGKYV 70 80 90 100 110 120 PRAVLVDLEP GTMDSIRGGE FGQLFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDNVLDVI 130 140 150 160 170 180 RKEAEGCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMSSFSVV PSPKVSDVVL 190 200 210 220 230 240 EPYNATLSVH QLVENTDETF CIDNEALYDI CFRTLKLANP TYGDLNHLVS VTMSGVTTCL 250 260 270 280 290 300 RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLSARDAAA YRALNVAELT QQMFDAKNMM 310 320 330 340 350 360 AACDPRHGRY LTVAAMFRGR MSMREVDEQM MQVQNKNSSY FVEWIPNNVK TAVCDIPPRG 370 380 390 400 410 420 LKMSATFIGN TTAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS 430 440 EYQQYQDATA DEEGDLQEGE SEYIEQEE

References

[1]	"Characterization of a beta-tubulin gene and a beta-tubulin gene products of Brugia pahangi." Guenette S., Prichard R.K., Klein R.D., Matlashewski G. Mol. Biochem. Parasitol. 44:153-164(1991) [PubMed: 2052017] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Localization and immunogenicity of tubulin in the filarial nematodes Brugia malayi and B. pahangi." Helm R., Selkirk M.E., Bradley J.E., Burns R.G., Hamilton A.J., Croft S., Maizels R.M. Parasite Immunol. 11:479-502(1989) [PubMed: 2685715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 409-448.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M36380 Genomic DNA. Translation: AAA27865.1.
PIR	A60645.
3D structure databases
ProteinModelPortal	P18241.
SMR	P18241. Positions 1-427.
ModBase	Search...
Proteomic databases
PRIDE	P18241.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR013838. Beta-tubulin_BS. IPR002453. Beta_tubulin. IPR008280. Tub_FtsZ_C. IPR000217. Tubulin. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR023123. Tubulin_C. IPR017975. Tubulin_CS. IPR003008. Tubulin_FtsZ_GTPase. [Graphical view]
Gene3D	G3DSA:3.30.1330.20. Tubulin/FtsZ_2-layer-sand-dom. 1 hit. G3DSA:1.10.287.600. Tubulin_C. 1 hit. G3DSA:3.40.50.1440. Tubulin_FtsZ. 1 hit.
PANTHER	PTHR11588. Tubulin. 1 hit.
Pfam	PF00091. Tubulin. 1 hit. PF03953. Tubulin_C. 1 hit. [Graphical view]
PRINTS	PR01163. BETATUBULIN. PR01161. TUBULIN.
SMART	SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit. [Graphical view]
SUPFAM	SSF55307. Tub_FtsZ_C. 1 hit. SSF52490. Tubulin_FtsZ. 1 hit.
PROSITE	PS00227. TUBULIN. 1 hit. PS00228. TUBULIN_B_AUTOREG. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00518. Albendazole.

Entry information

Entry name

TBB1_BRUPA

Accession

Primary (citable) accession number: P18241

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	March 8, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)