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P18240 (G6PI_PLAFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:GGI.R1
OrganismPlasmodium falciparum
Taxonomic identifier5833 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subunit structure

Homodimer.

Subcellular location

Cytoplasm HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180547

Sites

Active site3801Proton donor By similarity
Active site4111 By similarity
Active site5401 By similarity

Sequences

Sequence LengthMass (Da)Tools
P18240 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 82EC175BD2835B21

FASTA59168,766
        10         20         30         40         50         60 
MNMEITNLKS YKELVTLSAE EKTKDLKDYL NDKNRSESLI KKFKNFYMDL SRQRYSEKTL 

        70         80         90        100        110        120 
NKLVEYAEEV ELKKKVEKTF MGEKVNMTEN RSVLHTALRI PIEKINTHKI IIDNKNVLED 

       130        140        150        160        170        180 
VHGVLKKIEK YSDDIRNGVI KTCKNTKFKN VICIGIGGSY LGTEFVYEAM KYYYYNMELN 

       190        200        210        220        230        240 
KNEKDQVNNF NNNYDQDNVF NVRFLANVDP NDVNRAIQNL DQYDTLVIII SKTFTTAETM 

       250        260        270        280        290        300 
LNARSIKKWL SLKIKDDENL SKHMVAVSTN LKLTDEFGIS RDNVFEFWDW VGGRFSVTSS 

       310        320        330        340        350        360 
VGILPLSIAF GYKNMRNFLN GCHDMDEHFL HADLKENIPV LLALTSFYNS HFFDYKNVAI 

       370        380        390        400        410        420 
LPYFQNLLKF SAHIQQLSME SNGKSVDRNN QPIHYNTCQV YFGEPGTNGQ HSFYQLIHQG 

       430        440        450        460        470        480 
QVIPVELIGF KHSHFPIKFD KEVVSNHDEL MTNFFAQADA LAIGKTYEQV KEENEKNKMS 

       490        500        510        520        530        540 
PELLTHKVFN GNRPSTLLLF DELNFYTCGL LLSLYESRIV AEGFLLNINS FDQWGVELGK 

       550        560        570        580        590 
VLAKEVRNYF NDTRNQKKSD NTYNFNESTK NFIKLLLVQI KKKKKINTNL K 

« Hide

References

[1]"Cloning metabolic pathway genes by complementation in Escherichia coli. Isolation and expression of Plasmodium falciparum glucose phosphate isomerase."
Kaslow D.C., Hill S.
J. Biol. Chem. 265:12337-12341(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J05544 Genomic DNA. Translation: AAA29610.1.
PIRNUZQF. A36567.

3D structure databases

ProteinModelPortalP18240.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0166.

Enzyme and pathway databases

SABIO-RKP18240.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_PLAFA
AccessionPrimary (citable) accession number: P18240
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways