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P18240

- G6PI_PLAFA

UniProt

P18240 - G6PI_PLAFA

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Protein

Glucose-6-phosphate isomerase

Gene

GGI.R1

Organism
Plasmodium falciparum
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei380 – 3801Proton donorBy similarity
Active sitei411 – 4111By similarity
Active sitei540 – 5401By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

SABIO-RKP18240.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:GGI.R1
OrganismiPlasmodium falciparum
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Glucose-6-phosphate isomerasePRO_0000180547Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP18240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18240-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNMEITNLKS YKELVTLSAE EKTKDLKDYL NDKNRSESLI KKFKNFYMDL
60 70 80 90 100
SRQRYSEKTL NKLVEYAEEV ELKKKVEKTF MGEKVNMTEN RSVLHTALRI
110 120 130 140 150
PIEKINTHKI IIDNKNVLED VHGVLKKIEK YSDDIRNGVI KTCKNTKFKN
160 170 180 190 200
VICIGIGGSY LGTEFVYEAM KYYYYNMELN KNEKDQVNNF NNNYDQDNVF
210 220 230 240 250
NVRFLANVDP NDVNRAIQNL DQYDTLVIII SKTFTTAETM LNARSIKKWL
260 270 280 290 300
SLKIKDDENL SKHMVAVSTN LKLTDEFGIS RDNVFEFWDW VGGRFSVTSS
310 320 330 340 350
VGILPLSIAF GYKNMRNFLN GCHDMDEHFL HADLKENIPV LLALTSFYNS
360 370 380 390 400
HFFDYKNVAI LPYFQNLLKF SAHIQQLSME SNGKSVDRNN QPIHYNTCQV
410 420 430 440 450
YFGEPGTNGQ HSFYQLIHQG QVIPVELIGF KHSHFPIKFD KEVVSNHDEL
460 470 480 490 500
MTNFFAQADA LAIGKTYEQV KEENEKNKMS PELLTHKVFN GNRPSTLLLF
510 520 530 540 550
DELNFYTCGL LLSLYESRIV AEGFLLNINS FDQWGVELGK VLAKEVRNYF
560 570 580 590
NDTRNQKKSD NTYNFNESTK NFIKLLLVQI KKKKKINTNL K
Length:591
Mass (Da):68,766
Last modified:November 1, 1990 - v1
Checksum:i82EC175BD2835B21
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05544 Genomic DNA. Translation: AAA29610.1.
PIRiA36567. NUZQF.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05544 Genomic DNA. Translation: AAA29610.1 .
PIRi A36567. NUZQF.

3D structure databases

ProteinModelPortali P18240.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0166.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
SABIO-RK P18240.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning metabolic pathway genes by complementation in Escherichia coli. Isolation and expression of Plasmodium falciparum glucose phosphate isomerase."
    Kaslow D.C., Hill S.
    J. Biol. Chem. 265:12337-12341(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiG6PI_PLAFA
AccessioniPrimary (citable) accession number: P18240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3