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Protein

Glucose-6-phosphate isomerase

Gene

GGI.R1

Organism
Plasmodium falciparum
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (GGI.R1)
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (P41), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei380Proton donorBy similarity1
Active sitei411By similarity1
Active sitei540By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

SABIO-RKiP18240
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:GGI.R1
OrganismiPlasmodium falciparum
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805471 – 591Glucose-6-phosphate isomeraseAdd BLAST591

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP18240
SMRiP18240
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiKOG2446 Eukaryota
COG0166 LUCA

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P18240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMEITNLKS YKELVTLSAE EKTKDLKDYL NDKNRSESLI KKFKNFYMDL
60 70 80 90 100
SRQRYSEKTL NKLVEYAEEV ELKKKVEKTF MGEKVNMTEN RSVLHTALRI
110 120 130 140 150
PIEKINTHKI IIDNKNVLED VHGVLKKIEK YSDDIRNGVI KTCKNTKFKN
160 170 180 190 200
VICIGIGGSY LGTEFVYEAM KYYYYNMELN KNEKDQVNNF NNNYDQDNVF
210 220 230 240 250
NVRFLANVDP NDVNRAIQNL DQYDTLVIII SKTFTTAETM LNARSIKKWL
260 270 280 290 300
SLKIKDDENL SKHMVAVSTN LKLTDEFGIS RDNVFEFWDW VGGRFSVTSS
310 320 330 340 350
VGILPLSIAF GYKNMRNFLN GCHDMDEHFL HADLKENIPV LLALTSFYNS
360 370 380 390 400
HFFDYKNVAI LPYFQNLLKF SAHIQQLSME SNGKSVDRNN QPIHYNTCQV
410 420 430 440 450
YFGEPGTNGQ HSFYQLIHQG QVIPVELIGF KHSHFPIKFD KEVVSNHDEL
460 470 480 490 500
MTNFFAQADA LAIGKTYEQV KEENEKNKMS PELLTHKVFN GNRPSTLLLF
510 520 530 540 550
DELNFYTCGL LLSLYESRIV AEGFLLNINS FDQWGVELGK VLAKEVRNYF
560 570 580 590
NDTRNQKKSD NTYNFNESTK NFIKLLLVQI KKKKKINTNL K
Length:591
Mass (Da):68,766
Last modified:November 1, 1990 - v1
Checksum:i82EC175BD2835B21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05544 Genomic DNA Translation: AAA29610.1
PIRiA36567 NUZQF

Similar proteinsi

Entry informationi

Entry nameiG6PI_PLAFA
AccessioniPrimary (citable) accession number: P18240
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: January 31, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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