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P18239

- ADT2_YEAST

UniProt

P18239 - ADT2_YEAST

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Protein

ADP,ATP carrier protein 2

Gene

PET9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961NucleotideBy similarity

GO - Molecular functioni

  1. ATP:ADP antiporter activity Source: SGD

GO - Biological processi

  1. ADP transport Source: SGD
  2. aerobic respiration Source: SGD
  3. anaerobic respiration Source: SGD
  4. apoptotic process Source: SGD
  5. ATP transport Source: SGD
  6. heme transport Source: SGD
  7. mitochondrial transport Source: SGD
  8. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28933-MONOMER.
ReactomeiREACT_189277. Regulation of insulin secretion.

Protein family/group databases

TCDBi2.A.29.1.7. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 2
Alternative name(s):
ADP/ATP translocase 2
Adenine nucleotide translocator 2
Short name:
ANT 2
Petite colonies protein 9
Gene namesi
Name:PET9
Synonyms:AAC2
Ordered Locus Names:YBL030C
ORF Names:YBL0421
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBL030c.
SGDiS000000126. PET9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 5435Helical; Name=1By similarityAdd
BLAST
Transmembranei91 – 11525Helical; Name=2By similarityAdd
BLAST
Transmembranei123 – 15735Helical; Name=3By similarityAdd
BLAST
Transmembranei192 – 21928Helical; Name=4By similarityAdd
BLAST
Transmembranei224 – 25835Helical; Name=5By similarityAdd
BLAST
Transmembranei287 – 31226Helical; Name=6By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: SGD
  3. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318ADP,ATP carrier protein 2PRO_0000090594Add
BLAST

Proteomic databases

MaxQBiP18239.
PaxDbiP18239.
PeptideAtlasiP18239.
PRIDEiP18239.

Expressioni

Gene expression databases

GenevestigatoriP18239.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi32667. 127 interactions.
DIPiDIP-2917N.
IntActiP18239. 42 interactions.
MINTiMINT-1360850.
STRINGi4932.YBL030C.

Structurei

Secondary structure

1
318
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi25 – 5228Combined sources
Helixi54 – 596Combined sources
Helixi70 – 8112Combined sources
Helixi84 – 874Combined sources
Helixi90 – 956Combined sources
Helixi97 – 11519Combined sources
Helixi119 – 1213Combined sources
Helixi123 – 15634Combined sources
Helixi173 – 18311Combined sources
Turni187 – 1893Combined sources
Helixi193 – 21321Combined sources
Helixi229 – 24416Combined sources
Helixi246 – 25712Combined sources
Turni258 – 2603Combined sources
Helixi268 – 27912Combined sources
Helixi281 – 2855Combined sources
Helixi288 – 30821Combined sources
Beta strandi313 – 3153Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C9GX-ray2.49A1-318[»]
4C9HX-ray3.20A/B1-318[»]
ProteinModelPortaliP18239.
SMRiP18239. Positions 21-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 11494Solcar 1Add
BLAST
Repeati125 – 21793Solcar 2Add
BLAST
Repeati225 – 31187Solcar 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi252 – 2576Substrate recognitionBy similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238123.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
InParanoidiP18239.
KOiK05863.
OMAiSSYSAMN.
OrthoDBiEOG7NCVDV.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18239-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSNAQVKTP LPPAPAPKKE SNFLIDFLMG GVSAAVAKTA ASPIERVKLL
60 70 80 90 100
IQNQDEMLKQ GTLDRKYAGI LDCFKRTATQ EGVISFWRGN TANVIRYFPT
110 120 130 140 150
QALNFAFKDK IKAMFGFKKE EGYAKWFAGN LASGGAAGAL SLLFVYSLDY
160 170 180 190 200
ARTRLAADSK SSKKGGARQF NGLIDVYKKT LKSDGVAGLY RGFLPSVVGI
210 220 230 240 250
VVYRGLYFGM YDSLKPLLLT GSLEGSFLAS FLLGWVVTTG ASTCSYPLDT
260 270 280 290 300
VRRRMMMTSG QAVKYDGAFD CLRKIVAAEG VGSLFKGCGA NILRGVAGAG
310
VISMYDQLQM ILFGKKFK
Length:318
Mass (Da):34,426
Last modified:October 1, 1994 - v2
Checksum:iA9805DC33D9E24AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581L → I in AAA97484. (PubMed:2165073)Curated
Sequence conflicti65 – 651R → K in AAA97484. (PubMed:2165073)Curated
Sequence conflicti68 – 681A → S in AAA97484. (PubMed:2165073)Curated
Sequence conflicti71 – 711L → V in AAA97484. (PubMed:2165073)Curated
Sequence conflicti79 – 791T → K in AAA97484. (PubMed:2165073)Curated
Sequence conflicti83 – 831V → L in AAA97484. (PubMed:2165073)Curated
Sequence conflicti113 – 1131A → L in AAA97484. (PubMed:2165073)Curated
Sequence conflicti124 – 1241A → G in AAA97484. (PubMed:2165073)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77291 Genomic DNA. Translation: CAA54501.1.
J04021 Genomic DNA. Translation: AAA34381.1.
M34075 Genomic DNA. Translation: AAA97484.1.
X74427 Genomic DNA. Translation: CAA52446.1.
Z35791 Genomic DNA. Translation: CAA84850.1.
BK006936 Genomic DNA. Translation: DAA07089.1.
PIRiA31978.
RefSeqiNP_009523.1. NM_001178270.1.

Genome annotation databases

EnsemblFungiiYBL030C; YBL030C; YBL030C.
GeneIDi852250.
KEGGisce:YBL030C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77291 Genomic DNA. Translation: CAA54501.1 .
J04021 Genomic DNA. Translation: AAA34381.1 .
M34075 Genomic DNA. Translation: AAA97484.1 .
X74427 Genomic DNA. Translation: CAA52446.1 .
Z35791 Genomic DNA. Translation: CAA84850.1 .
BK006936 Genomic DNA. Translation: DAA07089.1 .
PIRi A31978.
RefSeqi NP_009523.1. NM_001178270.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4C9G X-ray 2.49 A 1-318 [» ]
4C9H X-ray 3.20 A/B 1-318 [» ]
ProteinModelPortali P18239.
SMRi P18239. Positions 21-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32667. 127 interactions.
DIPi DIP-2917N.
IntActi P18239. 42 interactions.
MINTi MINT-1360850.
STRINGi 4932.YBL030C.

Protein family/group databases

TCDBi 2.A.29.1.7. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBi P18239.
PaxDbi P18239.
PeptideAtlasi P18239.
PRIDEi P18239.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBL030C ; YBL030C ; YBL030C .
GeneIDi 852250.
KEGGi sce:YBL030C.

Organism-specific databases

CYGDi YBL030c.
SGDi S000000126. PET9.

Phylogenomic databases

eggNOGi NOG238123.
GeneTreei ENSGT00390000011543.
HOGENOMi HOG000165727.
InParanoidi P18239.
KOi K05863.
OMAi SSYSAMN.
OrthoDBi EOG7NCVDV.

Enzyme and pathway databases

BioCyci YEAST:G3O-28933-MONOMER.
Reactomei REACT_189277. Regulation of insulin secretion.

Miscellaneous databases

NextBioi 970820.

Gene expression databases

Genevestigatori P18239.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Separate genes encode functionally equivalent ADP/ATP carrier proteins in Saccharomyces cerevisiae. Isolation and analysis of AAC2."
    Lawson J.E., Douglas M.G.
    J. Biol. Chem. 263:14812-14818(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A third ADP/ATP translocator gene in yeast."
    Kolarov J., Kolarova N., Nelson N.
    J. Biol. Chem. 265:12711-12716(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Trezeguet V., le Saux A., Lauquin G.
    Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Analysis of a 17.4 kb DNA segment of yeast chromosome II encompassing the ribosomal protein L19 as well as proteins with homologies to components of the hnRNP and snRNP complexes and to the human proliferation-associated p120 antigen."
    van Dyck L., Jonniaux J.-L., Barreiros T.D.M., Kleine K., Goffeau A.
    Yeast 10:1663-1673(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. "Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential."
    Nelson D.R., Lawson J.E., Klingenberg M., Douglas M.G.
    J. Mol. Biol. 230:1159-1170(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS.
  8. "Function-based mapping of the yeast mitochondrial ADP/ATP translocator by selection for second site revertants."
    Nelson D.R., Douglas M.G.
    J. Mol. Biol. 230:1171-1182(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS, TOPOLOGY.
  9. "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
    Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
    Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.

Entry informationi

Entry nameiADT2_YEAST
AccessioniPrimary (citable) accession number: P18239
Secondary accession number(s): D6VPW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 1, 1994
Last modified: November 26, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3