Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P18239

- ADT2_YEAST

UniProt

P18239 - ADT2_YEAST

Protein

ADP,ATP carrier protein 2

Gene

PET9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (01 Oct 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei96 – 961NucleotideBy similarity

    GO - Molecular functioni

    1. ATP:ADP antiporter activity Source: SGD

    GO - Biological processi

    1. ADP transport Source: SGD
    2. aerobic respiration Source: SGD
    3. anaerobic respiration Source: SGD
    4. apoptotic process Source: SGD
    5. ATP transport Source: SGD
    6. heme transport Source: SGD
    7. mitochondrial transport Source: SGD
    8. transmembrane transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28933-MONOMER.

    Protein family/group databases

    TCDBi2.A.29.1.7. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP,ATP carrier protein 2
    Alternative name(s):
    ADP/ATP translocase 2
    Adenine nucleotide translocator 2
    Short name:
    ANT 2
    Petite colonies protein 9
    Gene namesi
    Name:PET9
    Synonyms:AAC2
    Ordered Locus Names:YBL030C
    ORF Names:YBL0421
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBL030c.
    SGDiS000000126. PET9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: SGD
    3. mitochondrion Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318ADP,ATP carrier protein 2PRO_0000090594Add
    BLAST

    Proteomic databases

    MaxQBiP18239.
    PaxDbiP18239.
    PeptideAtlasiP18239.
    PRIDEiP18239.

    Expressioni

    Gene expression databases

    GenevestigatoriP18239.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    BioGridi32667. 125 interactions.
    DIPiDIP-2917N.
    IntActiP18239. 42 interactions.
    MINTiMINT-1360850.
    STRINGi4932.YBL030C.

    Structurei

    Secondary structure

    1
    318
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi25 – 5228
    Helixi54 – 596
    Helixi70 – 8112
    Helixi84 – 874
    Helixi90 – 956
    Helixi97 – 11519
    Helixi119 – 1213
    Helixi123 – 15634
    Helixi173 – 18311
    Turni187 – 1893
    Helixi193 – 21321
    Helixi229 – 24416
    Helixi246 – 25712
    Turni258 – 2603
    Helixi268 – 27912
    Helixi281 – 2855
    Helixi288 – 30821
    Beta strandi313 – 3153

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4C9GX-ray2.49A1-318[»]
    4C9HX-ray3.20A/B1-318[»]
    ProteinModelPortaliP18239.
    SMRiP18239. Positions 21-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 5435Helical; Name=1By similarityAdd
    BLAST
    Transmembranei91 – 11525Helical; Name=2By similarityAdd
    BLAST
    Transmembranei123 – 15735Helical; Name=3By similarityAdd
    BLAST
    Transmembranei192 – 21928Helical; Name=4By similarityAdd
    BLAST
    Transmembranei224 – 25835Helical; Name=5By similarityAdd
    BLAST
    Transmembranei287 – 31226Helical; Name=6By similarityAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati21 – 11494Solcar 1Add
    BLAST
    Repeati125 – 21793Solcar 2Add
    BLAST
    Repeati225 – 31187Solcar 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi252 – 2576Substrate recognitionBy similarity

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238123.
    GeneTreeiENSGT00390000011543.
    HOGENOMiHOG000165727.
    KOiK05863.
    OMAiSSYSAMN.
    OrthoDBiEOG7NCVDV.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18239-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSNAQVKTP LPPAPAPKKE SNFLIDFLMG GVSAAVAKTA ASPIERVKLL    50
    IQNQDEMLKQ GTLDRKYAGI LDCFKRTATQ EGVISFWRGN TANVIRYFPT 100
    QALNFAFKDK IKAMFGFKKE EGYAKWFAGN LASGGAAGAL SLLFVYSLDY 150
    ARTRLAADSK SSKKGGARQF NGLIDVYKKT LKSDGVAGLY RGFLPSVVGI 200
    VVYRGLYFGM YDSLKPLLLT GSLEGSFLAS FLLGWVVTTG ASTCSYPLDT 250
    VRRRMMMTSG QAVKYDGAFD CLRKIVAAEG VGSLFKGCGA NILRGVAGAG 300
    VISMYDQLQM ILFGKKFK 318
    Length:318
    Mass (Da):34,426
    Last modified:October 1, 1994 - v2
    Checksum:iA9805DC33D9E24AC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581L → I in AAA97484. (PubMed:2165073)Curated
    Sequence conflicti65 – 651R → K in AAA97484. (PubMed:2165073)Curated
    Sequence conflicti68 – 681A → S in AAA97484. (PubMed:2165073)Curated
    Sequence conflicti71 – 711L → V in AAA97484. (PubMed:2165073)Curated
    Sequence conflicti79 – 791T → K in AAA97484. (PubMed:2165073)Curated
    Sequence conflicti83 – 831V → L in AAA97484. (PubMed:2165073)Curated
    Sequence conflicti113 – 1131A → L in AAA97484. (PubMed:2165073)Curated
    Sequence conflicti124 – 1241A → G in AAA97484. (PubMed:2165073)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77291 Genomic DNA. Translation: CAA54501.1.
    J04021 Genomic DNA. Translation: AAA34381.1.
    M34075 Genomic DNA. Translation: AAA97484.1.
    X74427 Genomic DNA. Translation: CAA52446.1.
    Z35791 Genomic DNA. Translation: CAA84850.1.
    BK006936 Genomic DNA. Translation: DAA07089.1.
    PIRiA31978.
    RefSeqiNP_009523.1. NM_001178270.1.

    Genome annotation databases

    EnsemblFungiiYBL030C; YBL030C; YBL030C.
    GeneIDi852250.
    KEGGisce:YBL030C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77291 Genomic DNA. Translation: CAA54501.1 .
    J04021 Genomic DNA. Translation: AAA34381.1 .
    M34075 Genomic DNA. Translation: AAA97484.1 .
    X74427 Genomic DNA. Translation: CAA52446.1 .
    Z35791 Genomic DNA. Translation: CAA84850.1 .
    BK006936 Genomic DNA. Translation: DAA07089.1 .
    PIRi A31978.
    RefSeqi NP_009523.1. NM_001178270.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4C9G X-ray 2.49 A 1-318 [» ]
    4C9H X-ray 3.20 A/B 1-318 [» ]
    ProteinModelPortali P18239.
    SMRi P18239. Positions 21-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32667. 125 interactions.
    DIPi DIP-2917N.
    IntActi P18239. 42 interactions.
    MINTi MINT-1360850.
    STRINGi 4932.YBL030C.

    Protein family/group databases

    TCDBi 2.A.29.1.7. the mitochondrial carrier (mc) family.

    Proteomic databases

    MaxQBi P18239.
    PaxDbi P18239.
    PeptideAtlasi P18239.
    PRIDEi P18239.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBL030C ; YBL030C ; YBL030C .
    GeneIDi 852250.
    KEGGi sce:YBL030C.

    Organism-specific databases

    CYGDi YBL030c.
    SGDi S000000126. PET9.

    Phylogenomic databases

    eggNOGi NOG238123.
    GeneTreei ENSGT00390000011543.
    HOGENOMi HOG000165727.
    KOi K05863.
    OMAi SSYSAMN.
    OrthoDBi EOG7NCVDV.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28933-MONOMER.

    Miscellaneous databases

    NextBioi 970820.

    Gene expression databases

    Genevestigatori P18239.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Separate genes encode functionally equivalent ADP/ATP carrier proteins in Saccharomyces cerevisiae. Isolation and analysis of AAC2."
      Lawson J.E., Douglas M.G.
      J. Biol. Chem. 263:14812-14818(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "A third ADP/ATP translocator gene in yeast."
      Kolarov J., Kolarova N., Nelson N.
      J. Biol. Chem. 265:12711-12716(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Trezeguet V., le Saux A., Lauquin G.
      Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Analysis of a 17.4 kb DNA segment of yeast chromosome II encompassing the ribosomal protein L19 as well as proteins with homologies to components of the hnRNP and snRNP complexes and to the human proliferation-associated p120 antigen."
      van Dyck L., Jonniaux J.-L., Barreiros T.D.M., Kleine K., Goffeau A.
      Yeast 10:1663-1673(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    7. "Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential."
      Nelson D.R., Lawson J.E., Klingenberg M., Douglas M.G.
      J. Mol. Biol. 230:1159-1170(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS.
    8. "Function-based mapping of the yeast mitochondrial ADP/ATP translocator by selection for second site revertants."
      Nelson D.R., Douglas M.G.
      J. Mol. Biol. 230:1171-1182(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS, TOPOLOGY.
    9. "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
      Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
      Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.

    Entry informationi

    Entry nameiADT2_YEAST
    AccessioniPrimary (citable) accession number: P18239
    Secondary accession number(s): D6VPW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.By similarity

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3