Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP,ATP carrier protein 2

Gene

PET9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96NucleotideBy similarity1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: SGD

GO - Biological processi

  • ADP transport Source: SGD
  • aerobic respiration Source: SGD
  • anaerobic respiration Source: SGD
  • apoptotic process Source: SGD
  • ATP transport Source: SGD
  • heme transport Source: SGD
  • mitochondrial transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28933-MONOMER.
ReactomeiR-SCE-422356. Regulation of insulin secretion.

Protein family/group databases

TCDBi2.A.29.1.7. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 2
Alternative name(s):
ADP/ATP translocase 2
Adenine nucleotide translocator 2
Short name:
ANT 2
Petite colonies protein 9
Gene namesi
Name:PET9
Synonyms:AAC2
Ordered Locus Names:YBL030C
ORF Names:YBL0421
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL030C.
SGDiS000000126. PET9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 54Helical; Name=1By similarityAdd BLAST35
Transmembranei91 – 115Helical; Name=2By similarityAdd BLAST25
Transmembranei123 – 157Helical; Name=3By similarityAdd BLAST35
Transmembranei192 – 219Helical; Name=4By similarityAdd BLAST28
Transmembranei224 – 258Helical; Name=5By similarityAdd BLAST35
Transmembranei287 – 312Helical; Name=6By similarityAdd BLAST26

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000905941 – 318ADP,ATP carrier protein 2Add BLAST318

Proteomic databases

MaxQBiP18239.
PRIDEiP18239.

PTM databases

iPTMnetiP18239.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi32667. 132 interactors.
DIPiDIP-2917N.
IntActiP18239. 44 interactors.
MINTiMINT-1360850.

Structurei

Secondary structure

1318
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 52Combined sources28
Helixi54 – 59Combined sources6
Helixi70 – 81Combined sources12
Helixi84 – 87Combined sources4
Helixi90 – 95Combined sources6
Helixi97 – 115Combined sources19
Helixi119 – 121Combined sources3
Helixi123 – 156Combined sources34
Helixi173 – 183Combined sources11
Turni187 – 189Combined sources3
Helixi193 – 213Combined sources21
Helixi229 – 244Combined sources16
Helixi246 – 257Combined sources12
Turni258 – 260Combined sources3
Helixi268 – 279Combined sources12
Helixi281 – 285Combined sources5
Helixi288 – 308Combined sources21
Beta strandi313 – 315Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C9GX-ray2.49A1-318[»]
4C9HX-ray3.20A/B1-318[»]
ProteinModelPortaliP18239.
SMRiP18239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 114Solcar 1Add BLAST94
Repeati125 – 217Solcar 2Add BLAST93
Repeati225 – 311Solcar 3Add BLAST87

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi252 – 257Substrate recognitionBy similarity6

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
InParanoidiP18239.
KOiK05863.
OMAiECFKRTA.
OrthoDBiEOG092C3PSA.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNAQVKTP LPPAPAPKKE SNFLIDFLMG GVSAAVAKTA ASPIERVKLL
60 70 80 90 100
IQNQDEMLKQ GTLDRKYAGI LDCFKRTATQ EGVISFWRGN TANVIRYFPT
110 120 130 140 150
QALNFAFKDK IKAMFGFKKE EGYAKWFAGN LASGGAAGAL SLLFVYSLDY
160 170 180 190 200
ARTRLAADSK SSKKGGARQF NGLIDVYKKT LKSDGVAGLY RGFLPSVVGI
210 220 230 240 250
VVYRGLYFGM YDSLKPLLLT GSLEGSFLAS FLLGWVVTTG ASTCSYPLDT
260 270 280 290 300
VRRRMMMTSG QAVKYDGAFD CLRKIVAAEG VGSLFKGCGA NILRGVAGAG
310
VISMYDQLQM ILFGKKFK
Length:318
Mass (Da):34,426
Last modified:October 1, 1994 - v2
Checksum:iA9805DC33D9E24AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58L → I in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti65R → K in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti68A → S in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti71L → V in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti79T → K in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti83V → L in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti113A → L in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti124A → G in AAA97484 (PubMed:2165073).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77291 Genomic DNA. Translation: CAA54501.1.
J04021 Genomic DNA. Translation: AAA34381.1.
M34075 Genomic DNA. Translation: AAA97484.1.
X74427 Genomic DNA. Translation: CAA52446.1.
Z35791 Genomic DNA. Translation: CAA84850.1.
BK006936 Genomic DNA. Translation: DAA07089.1.
PIRiA31978.
RefSeqiNP_009523.1. NM_001178270.1.

Genome annotation databases

EnsemblFungiiYBL030C; YBL030C; YBL030C.
GeneIDi852250.
KEGGisce:YBL030C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77291 Genomic DNA. Translation: CAA54501.1.
J04021 Genomic DNA. Translation: AAA34381.1.
M34075 Genomic DNA. Translation: AAA97484.1.
X74427 Genomic DNA. Translation: CAA52446.1.
Z35791 Genomic DNA. Translation: CAA84850.1.
BK006936 Genomic DNA. Translation: DAA07089.1.
PIRiA31978.
RefSeqiNP_009523.1. NM_001178270.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C9GX-ray2.49A1-318[»]
4C9HX-ray3.20A/B1-318[»]
ProteinModelPortaliP18239.
SMRiP18239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32667. 132 interactors.
DIPiDIP-2917N.
IntActiP18239. 44 interactors.
MINTiMINT-1360850.

Protein family/group databases

TCDBi2.A.29.1.7. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiP18239.

Proteomic databases

MaxQBiP18239.
PRIDEiP18239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL030C; YBL030C; YBL030C.
GeneIDi852250.
KEGGisce:YBL030C.

Organism-specific databases

EuPathDBiFungiDB:YBL030C.
SGDiS000000126. PET9.

Phylogenomic databases

GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
InParanoidiP18239.
KOiK05863.
OMAiECFKRTA.
OrthoDBiEOG092C3PSA.

Enzyme and pathway databases

BioCyciYEAST:G3O-28933-MONOMER.
ReactomeiR-SCE-422356. Regulation of insulin secretion.

Miscellaneous databases

PROiP18239.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADT2_YEAST
AccessioniPrimary (citable) accession number: P18239
Secondary accession number(s): D6VPW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.