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Protein

ADP,ATP carrier protein 3

Gene

AAC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85NucleotideBy similarity1

GO - Molecular functioni

GO - Biological processi

  • anaerobic respiration Source: SGD
  • heme transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29052-MONOMER.
ReactomeiR-SCE-422356. Regulation of insulin secretion.

Protein family/group databases

TCDBi2.A.29.1.9. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 3
Alternative name(s):
ADP/ATP translocase 3
Adenine nucleotide translocator 3
Short name:
ANT 3
Gene namesi
Name:AAC3
Ordered Locus Names:YBR085W
ORF Names:YBR0753
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR085W.
SGDiS000000289. AAC3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 43Helical; Name=1By similarityAdd BLAST35
Transmembranei80 – 104Helical; Name=2By similarityAdd BLAST25
Transmembranei112 – 146Helical; Name=3By similarityAdd BLAST35
Transmembranei181 – 208Helical; Name=4By similarityAdd BLAST28
Transmembranei213 – 247Helical; Name=5By similarityAdd BLAST35
Transmembranei276 – 301Helical; Name=6By similarityAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000905951 – 307ADP,ATP carrier protein 3Add BLAST307

Proteomic databases

MaxQBiP18238.
PRIDEiP18238.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi32790. 27 interactors.
DIPiDIP-6289N.
IntActiP18238. 10 interactors.
MINTiMINT-688418.

Structurei

Secondary structure

1307
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 29Combined sources25
Helixi31 – 41Combined sources11
Helixi43 – 48Combined sources6
Helixi59 – 69Combined sources11
Helixi73 – 76Combined sources4
Helixi79 – 104Combined sources26
Turni108 – 110Combined sources3
Helixi112 – 146Combined sources35
Helixi162 – 172Combined sources11
Helixi175 – 178Combined sources4
Turni179 – 181Combined sources3
Helixi182 – 202Combined sources21
Helixi217 – 233Combined sources17
Helixi235 – 246Combined sources12
Turni247 – 249Combined sources3
Helixi257 – 268Combined sources12
Helixi270 – 274Combined sources5
Helixi277 – 301Combined sources25
Beta strandi302 – 304Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C9JX-ray3.40A/B3-307[»]
4C9QX-ray3.20A/B3-307[»]
ProteinModelPortaliP18238.
SMRiP18238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 103Solcar 1Add BLAST94
Repeati114 – 206Solcar 2Add BLAST93
Repeati214 – 300Solcar 3Add BLAST87

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi241 – 246Substrate recognitionBy similarity6

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
InParanoidiP18238.
KOiK05863.
OMAiGSSQREF.
OrthoDBiEOG092C3PSA.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDAKQQET NFAINFLMGG VSAAIAKTAA SPIERVKILI QNQDEMIKQG
60 70 80 90 100
TLDKKYSGIV DCFKRTAKQE GLISFWRGNT ANVIRYFPTQ ALNFAFKDKI
110 120 130 140 150
KLMFGFKKEE GYGKWFAGNL ASGGAAGALS LLFVYSLDFA RTRLAADAKS
160 170 180 190 200
SKKGGARQFN GLTDVYKKTL KSDGIAGLYR GFMPSVVGIV VYRGLYFGMF
210 220 230 240 250
DSLKPLVLTG SLDGSFLASF LLGWVVTTGA STCSYPLDTV RRRMMMTSGQ
260 270 280 290 300
AVKYNGAIDC LKKIVASEGV GSLFKGCGAN ILRSVAGAGV ISMYDQLQMI

LFGKKFK
Length:307
Mass (Da):33,313
Last modified:November 1, 1990 - v1
Checksum:iD0C1329FEC1B4DC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34076 Genomic DNA. Translation: AAA97485.1.
Z35954 Genomic DNA. Translation: CAA85031.1.
BK006936 Genomic DNA. Translation: DAA07205.1.
PIRiA36582.
RefSeqiNP_009642.3. NM_001178433.3.

Genome annotation databases

EnsemblFungiiYBR085W; YBR085W; YBR085W.
GeneIDi852380.
KEGGisce:YBR085W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34076 Genomic DNA. Translation: AAA97485.1.
Z35954 Genomic DNA. Translation: CAA85031.1.
BK006936 Genomic DNA. Translation: DAA07205.1.
PIRiA36582.
RefSeqiNP_009642.3. NM_001178433.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C9JX-ray3.40A/B3-307[»]
4C9QX-ray3.20A/B3-307[»]
ProteinModelPortaliP18238.
SMRiP18238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32790. 27 interactors.
DIPiDIP-6289N.
IntActiP18238. 10 interactors.
MINTiMINT-688418.

Protein family/group databases

TCDBi2.A.29.1.9. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBiP18238.
PRIDEiP18238.

Protocols and materials databases

DNASUi852380.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR085W; YBR085W; YBR085W.
GeneIDi852380.
KEGGisce:YBR085W.

Organism-specific databases

EuPathDBiFungiDB:YBR085W.
SGDiS000000289. AAC3.

Phylogenomic databases

GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
InParanoidiP18238.
KOiK05863.
OMAiGSSQREF.
OrthoDBiEOG092C3PSA.

Enzyme and pathway databases

BioCyciYEAST:G3O-29052-MONOMER.
ReactomeiR-SCE-422356. Regulation of insulin secretion.

Miscellaneous databases

PROiP18238.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADT3_YEAST
AccessioniPrimary (citable) accession number: P18238
Secondary accession number(s): D6VQ85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity
Present with 1080 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.