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P18238

- ADT3_YEAST

UniProt

P18238 - ADT3_YEAST

Protein

ADP,ATP carrier protein 3

Gene

AAC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851NucleotideBy similarity

    GO - Molecular functioni

    1. ATP:ADP antiporter activity Source: SGD

    GO - Biological processi

    1. ADP transport Source: GOC
    2. anaerobic respiration Source: SGD
    3. ATP transport Source: GOC
    4. heme transport Source: SGD
    5. transmembrane transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29052-MONOMER.

    Protein family/group databases

    TCDBi2.A.29.1.9. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP,ATP carrier protein 3
    Alternative name(s):
    ADP/ATP translocase 3
    Adenine nucleotide translocator 3
    Short name:
    ANT 3
    Gene namesi
    Name:AAC3
    Ordered Locus Names:YBR085W
    ORF Names:YBR0753
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR085w.
    SGDiS000000289. AAC3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307ADP,ATP carrier protein 3PRO_0000090595Add
    BLAST

    Proteomic databases

    MaxQBiP18238.
    PaxDbiP18238.
    PeptideAtlasiP18238.
    PRIDEiP18238.

    Expressioni

    Gene expression databases

    GenevestigatoriP18238.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    BioGridi32790. 25 interactions.
    DIPiDIP-6289N.
    IntActiP18238. 10 interactions.
    MINTiMINT-688418.
    STRINGi4932.YBR085W.

    Structurei

    Secondary structure

    1
    307
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 2925
    Helixi31 – 4111
    Helixi43 – 486
    Helixi59 – 6911
    Helixi73 – 764
    Helixi79 – 10426
    Turni108 – 1103
    Helixi112 – 14635
    Helixi162 – 17211
    Helixi175 – 1784
    Turni179 – 1813
    Helixi182 – 20221
    Helixi217 – 23317
    Helixi235 – 24612
    Turni247 – 2493
    Helixi257 – 26812
    Helixi270 – 2745
    Helixi277 – 30125
    Beta strandi302 – 3043

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4C9JX-ray3.40A/B3-307[»]
    4C9QX-ray3.20A/B3-307[»]
    ProteinModelPortaliP18238.
    SMRiP18238. Positions 3-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 4335Helical; Name=1By similarityAdd
    BLAST
    Transmembranei80 – 10425Helical; Name=2By similarityAdd
    BLAST
    Transmembranei112 – 14635Helical; Name=3By similarityAdd
    BLAST
    Transmembranei181 – 20828Helical; Name=4By similarityAdd
    BLAST
    Transmembranei213 – 24735Helical; Name=5By similarityAdd
    BLAST
    Transmembranei276 – 30126Helical; Name=6By similarityAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati10 – 10394Solcar 1Add
    BLAST
    Repeati114 – 20693Solcar 2Add
    BLAST
    Repeati214 – 30087Solcar 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi241 – 2466Substrate recognitionBy similarity

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238123.
    GeneTreeiENSGT00390000011543.
    HOGENOMiHOG000165727.
    KOiK05863.
    OMAiCWRKIFK.
    OrthoDBiEOG7NCVDV.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18238-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDAKQQET NFAINFLMGG VSAAIAKTAA SPIERVKILI QNQDEMIKQG    50
    TLDKKYSGIV DCFKRTAKQE GLISFWRGNT ANVIRYFPTQ ALNFAFKDKI 100
    KLMFGFKKEE GYGKWFAGNL ASGGAAGALS LLFVYSLDFA RTRLAADAKS 150
    SKKGGARQFN GLTDVYKKTL KSDGIAGLYR GFMPSVVGIV VYRGLYFGMF 200
    DSLKPLVLTG SLDGSFLASF LLGWVVTTGA STCSYPLDTV RRRMMMTSGQ 250
    AVKYNGAIDC LKKIVASEGV GSLFKGCGAN ILRSVAGAGV ISMYDQLQMI 300
    LFGKKFK 307
    Length:307
    Mass (Da):33,313
    Last modified:November 1, 1990 - v1
    Checksum:iD0C1329FEC1B4DC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34076 Genomic DNA. Translation: AAA97485.1.
    Z35954 Genomic DNA. Translation: CAA85031.1.
    BK006936 Genomic DNA. Translation: DAA07205.1.
    PIRiA36582.
    RefSeqiNP_009642.3. NM_001178433.3.

    Genome annotation databases

    EnsemblFungiiYBR085W; YBR085W; YBR085W.
    GeneIDi852380.
    KEGGisce:YBR085W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34076 Genomic DNA. Translation: AAA97485.1 .
    Z35954 Genomic DNA. Translation: CAA85031.1 .
    BK006936 Genomic DNA. Translation: DAA07205.1 .
    PIRi A36582.
    RefSeqi NP_009642.3. NM_001178433.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4C9J X-ray 3.40 A/B 3-307 [» ]
    4C9Q X-ray 3.20 A/B 3-307 [» ]
    ProteinModelPortali P18238.
    SMRi P18238. Positions 3-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32790. 25 interactions.
    DIPi DIP-6289N.
    IntActi P18238. 10 interactions.
    MINTi MINT-688418.
    STRINGi 4932.YBR085W.

    Protein family/group databases

    TCDBi 2.A.29.1.9. the mitochondrial carrier (mc) family.

    Proteomic databases

    MaxQBi P18238.
    PaxDbi P18238.
    PeptideAtlasi P18238.
    PRIDEi P18238.

    Protocols and materials databases

    DNASUi 852380.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR085W ; YBR085W ; YBR085W .
    GeneIDi 852380.
    KEGGi sce:YBR085W.

    Organism-specific databases

    CYGDi YBR085w.
    SGDi S000000289. AAC3.

    Phylogenomic databases

    eggNOGi NOG238123.
    GeneTreei ENSGT00390000011543.
    HOGENOMi HOG000165727.
    KOi K05863.
    OMAi CWRKIFK.
    OrthoDBi EOG7NCVDV.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29052-MONOMER.

    Miscellaneous databases

    NextBioi 971180.

    Gene expression databases

    Genevestigatori P18238.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A third ADP/ATP translocator gene in yeast."
      Kolarov J., Kolarova N., Nelson N.
      J. Biol. Chem. 265:12711-12716(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiADT3_YEAST
    AccessioniPrimary (citable) accession number: P18238
    Secondary accession number(s): D6VQ85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.By similarity
    Present with 1080 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3