P18238 (ADT3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADP,ATP carrier protein 3

Alternative name(s):
ADP/ATP translocase 3
Adenine nucleotide translocator 3
Short name=ANT 3

Gene names

Name:	AAC3
Ordered Locus Names:	YBR085W
ORF Names:	YBR0753

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.
Subunit structure	Homodimer.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Miscellaneous	The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity. Present with 1080 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Belongs to the mitochondrial carrier family. Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anaerobic respiration Inferred from genetic interaction Ref.1. Source: SGD heme transport Inferred from mutant phenotype. Source: SGD transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	ADP,ATP carrier protein 3		PRO_0000090595
Regions
	Transmembrane	9 – 43	35	Helical; Name=1; By similarity
	Transmembrane	80 – 104	25	Helical; Name=2; By similarity
	Transmembrane	112 – 146	35	Helical; Name=3; By similarity
	Transmembrane	181 – 208	28	Helical; Name=4; By similarity
	Transmembrane	213 – 247	35	Helical; Name=5; By similarity
	Transmembrane	276 – 301	26	Helical; Name=6; By similarity
	Repeat	10 – 103	94	Solcar 1
	Repeat	114 – 206	93	Solcar 2
	Repeat	214 – 300	87	Solcar 3
	Motif	241 – 246	6	Substrate recognition By similarity
Sites
	Binding site	85	1	Nucleotide By similarity

Sequences

	Sequence		Length	Mass (Da)
	P18238 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: D0C1329FEC1B4DC8	FASTA	307	33,313
	10 20 30 40 50 60 MSSDAKQQET NFAINFLMGG VSAAIAKTAA SPIERVKILI QNQDEMIKQG TLDKKYSGIV 70 80 90 100 110 120 DCFKRTAKQE GLISFWRGNT ANVIRYFPTQ ALNFAFKDKI KLMFGFKKEE GYGKWFAGNL 130 140 150 160 170 180 ASGGAAGALS LLFVYSLDFA RTRLAADAKS SKKGGARQFN GLTDVYKKTL KSDGIAGLYR 190 200 210 220 230 240 GFMPSVVGIV VYRGLYFGMF DSLKPLVLTG SLDGSFLASF LLGWVVTTGA STCSYPLDTV 250 260 270 280 290 300 RRRMMMTSGQ AVKYNGAIDC LKKIVASEGV GSLFKGCGAN ILRSVAGAGV ISMYDQLQMI LFGKKFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A third ADP/ATP translocator gene in yeast." Kolarov J., Kolarova N., Nelson N. J. Biol. Chem. 265:12711-12716(1990) [PubMed: 2165073] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M34076 Genomic DNA. Translation: AAA97485.1. Z35954 Genomic DNA. Translation: CAA85031.1. BK006936 Genomic DNA. Translation: DAA07205.1.
PIR	A36582.
RefSeq	NP_009642.1. NM_001178433.1.
3D structure databases
ProteinModelPortal	P18238.
SMR	P18238. Positions 7-297.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6289N.
IntAct	P18238. 18 interactions.
MINT	MINT-688418.
STRING	P18238.
Proteomic databases
PeptideAtlas	P18238.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR085W; YBR085W; YBR085W.
GeneID	852380.
KEGG	sce:YBR085W.
NMPDR	fig|4932.3.peg.340.
Organism-specific databases
CYGD	YBR085w.
SGD	S000000289. AAC3.
Phylogenomic databases
eggNOG	fuNOG06875.
GeneTree	EFGT00050000002383.
HOGENOM	HBG610399.
OMA	YQHEGIN.
OrthoDB	EOG4RV613.
Gene expression databases
ArrayExpress	P18238.
Genevestigator	P18238.
GermOnline	YBR085W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002113. Aden_trnslctor. IPR002067. Mit_carrier. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Gene3D	G3DSA:1.50.40.10. G3DSA:1.50.40.10. 1 hit.
KO	K05863.
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00927. ADPTRNSLCASE. PR00926. MITOCARRIER.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	971180.

Entry information

Entry name

ADT3_YEAST

Accession

Primary (citable) accession number: P18238
Secondary accession number(s): D6VQ85

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	January 25, 2012
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program