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P18238

- ADT3_YEAST

UniProt

P18238 - ADT3_YEAST

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Protein
ADP,ATP carrier protein 3
Gene
AAC3, YBR085W, YBR0753
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Nucleotide By similarity

GO - Molecular functioni

  1. ATP:ADP antiporter activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. ADP transport Source: GOC
  2. ATP transport Source: GOC
  3. anaerobic respiration Source: SGD
  4. heme transport Source: SGD
  5. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29052-MONOMER.

Protein family/group databases

TCDBi2.A.29.1.9. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 3
Alternative name(s):
ADP/ATP translocase 3
Adenine nucleotide translocator 3
Short name:
ANT 3
Gene namesi
Name:AAC3
Ordered Locus Names:YBR085W
ORF Names:YBR0753
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR085w.
SGDiS000000289. AAC3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 4335Helical; Name=1; By similarity
Add
BLAST
Transmembranei80 – 10425Helical; Name=2; By similarity
Add
BLAST
Transmembranei112 – 14635Helical; Name=3; By similarity
Add
BLAST
Transmembranei181 – 20828Helical; Name=4; By similarity
Add
BLAST
Transmembranei213 – 24735Helical; Name=5; By similarity
Add
BLAST
Transmembranei276 – 30126Helical; Name=6; By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307ADP,ATP carrier protein 3
PRO_0000090595Add
BLAST

Proteomic databases

MaxQBiP18238.
PaxDbiP18238.
PeptideAtlasiP18238.
PRIDEiP18238.

Expressioni

Gene expression databases

GenevestigatoriP18238.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi32790. 25 interactions.
DIPiDIP-6289N.
IntActiP18238. 10 interactions.
MINTiMINT-688418.
STRINGi4932.YBR085W.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2925
Helixi31 – 4111
Helixi43 – 486
Helixi59 – 6911
Helixi73 – 764
Helixi79 – 10426
Turni108 – 1103
Helixi112 – 14635
Helixi162 – 17211
Helixi175 – 1784
Turni179 – 1813
Helixi182 – 20221
Helixi217 – 23317
Helixi235 – 24612
Turni247 – 2493
Helixi257 – 26812
Helixi270 – 2745
Helixi277 – 30125
Beta strandi302 – 3043

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C9JX-ray3.40A/B3-307[»]
4C9QX-ray3.20A/B3-307[»]
ProteinModelPortaliP18238.
SMRiP18238. Positions 3-306.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati10 – 10394Solcar 1
Add
BLAST
Repeati114 – 20693Solcar 2
Add
BLAST
Repeati214 – 30087Solcar 3
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi241 – 2466Substrate recognition By similarity

Sequence similaritiesi

Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238123.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
KOiK05863.
OMAiCWRKIFK.
OrthoDBiEOG7NCVDV.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18238-1 [UniParc]FASTAAdd to Basket

« Hide

MSSDAKQQET NFAINFLMGG VSAAIAKTAA SPIERVKILI QNQDEMIKQG    50
TLDKKYSGIV DCFKRTAKQE GLISFWRGNT ANVIRYFPTQ ALNFAFKDKI 100
KLMFGFKKEE GYGKWFAGNL ASGGAAGALS LLFVYSLDFA RTRLAADAKS 150
SKKGGARQFN GLTDVYKKTL KSDGIAGLYR GFMPSVVGIV VYRGLYFGMF 200
DSLKPLVLTG SLDGSFLASF LLGWVVTTGA STCSYPLDTV RRRMMMTSGQ 250
AVKYNGAIDC LKKIVASEGV GSLFKGCGAN ILRSVAGAGV ISMYDQLQMI 300
LFGKKFK 307
Length:307
Mass (Da):33,313
Last modified:November 1, 1990 - v1
Checksum:iD0C1329FEC1B4DC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34076 Genomic DNA. Translation: AAA97485.1.
Z35954 Genomic DNA. Translation: CAA85031.1.
BK006936 Genomic DNA. Translation: DAA07205.1.
PIRiA36582.
RefSeqiNP_009642.3. NM_001178433.3.

Genome annotation databases

EnsemblFungiiYBR085W; YBR085W; YBR085W.
GeneIDi852380.
KEGGisce:YBR085W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34076 Genomic DNA. Translation: AAA97485.1 .
Z35954 Genomic DNA. Translation: CAA85031.1 .
BK006936 Genomic DNA. Translation: DAA07205.1 .
PIRi A36582.
RefSeqi NP_009642.3. NM_001178433.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4C9J X-ray 3.40 A/B 3-307 [» ]
4C9Q X-ray 3.20 A/B 3-307 [» ]
ProteinModelPortali P18238.
SMRi P18238. Positions 3-306.
ModBasei Search...

Protein-protein interaction databases

BioGridi 32790. 25 interactions.
DIPi DIP-6289N.
IntActi P18238. 10 interactions.
MINTi MINT-688418.
STRINGi 4932.YBR085W.

Protein family/group databases

TCDBi 2.A.29.1.9. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBi P18238.
PaxDbi P18238.
PeptideAtlasi P18238.
PRIDEi P18238.

Protocols and materials databases

DNASUi 852380.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR085W ; YBR085W ; YBR085W .
GeneIDi 852380.
KEGGi sce:YBR085W.

Organism-specific databases

CYGDi YBR085w.
SGDi S000000289. AAC3.

Phylogenomic databases

eggNOGi NOG238123.
GeneTreei ENSGT00390000011543.
HOGENOMi HOG000165727.
KOi K05863.
OMAi CWRKIFK.
OrthoDBi EOG7NCVDV.

Enzyme and pathway databases

BioCyci YEAST:G3O-29052-MONOMER.

Miscellaneous databases

NextBioi 971180.

Gene expression databases

Genevestigatori P18238.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A third ADP/ATP translocator gene in yeast."
    Kolarov J., Kolarova N., Nelson N.
    J. Biol. Chem. 265:12711-12716(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADT3_YEAST
AccessioniPrimary (citable) accession number: P18238
Secondary accession number(s): D6VQ85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 11, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.
Present with 1080 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

Similar proteinsi