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P18238 (ADT3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP,ATP carrier protein 3
Alternative name(s):
ADP/ATP translocase 3
Adenine nucleotide translocator 3
Short name=ANT 3
Gene names
Name:AAC3
Ordered Locus Names:YBR085W
ORF Names:YBR0753
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Subunit structure

Homodimer.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.

Present with 1080 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307ADP,ATP carrier protein 3
PRO_0000090595

Regions

Transmembrane9 – 4335Helical; Name=1; By similarity
Transmembrane80 – 10425Helical; Name=2; By similarity
Transmembrane112 – 14635Helical; Name=3; By similarity
Transmembrane181 – 20828Helical; Name=4; By similarity
Transmembrane213 – 24735Helical; Name=5; By similarity
Transmembrane276 – 30126Helical; Name=6; By similarity
Repeat10 – 10394Solcar 1
Repeat114 – 20693Solcar 2
Repeat214 – 30087Solcar 3
Motif241 – 2466Substrate recognition By similarity

Sites

Binding site851Nucleotide By similarity

Secondary structure

................................... 307
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P18238 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: D0C1329FEC1B4DC8

FASTA30733,313
        10         20         30         40         50         60 
MSSDAKQQET NFAINFLMGG VSAAIAKTAA SPIERVKILI QNQDEMIKQG TLDKKYSGIV 

        70         80         90        100        110        120 
DCFKRTAKQE GLISFWRGNT ANVIRYFPTQ ALNFAFKDKI KLMFGFKKEE GYGKWFAGNL 

       130        140        150        160        170        180 
ASGGAAGALS LLFVYSLDFA RTRLAADAKS SKKGGARQFN GLTDVYKKTL KSDGIAGLYR 

       190        200        210        220        230        240 
GFMPSVVGIV VYRGLYFGMF DSLKPLVLTG SLDGSFLASF LLGWVVTTGA STCSYPLDTV 

       250        260        270        280        290        300 
RRRMMMTSGQ AVKYNGAIDC LKKIVASEGV GSLFKGCGAN ILRSVAGAGV ISMYDQLQMI 


LFGKKFK 

« Hide

References

« Hide 'large scale' references
[1]"A third ADP/ATP translocator gene in yeast."
Kolarov J., Kolarova N., Nelson N.
J. Biol. Chem. 265:12711-12716(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M34076 Genomic DNA. Translation: AAA97485.1.
Z35954 Genomic DNA. Translation: CAA85031.1.
BK006936 Genomic DNA. Translation: DAA07205.1.
PIRA36582.
RefSeqNP_009642.3. NM_001178433.3.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4C9JX-ray3.40A/B3-307[»]
4C9QX-ray3.20A/B3-307[»]
ProteinModelPortalP18238.
SMRP18238. Positions 3-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32790. 25 interactions.
DIPDIP-6289N.
IntActP18238. 10 interactions.
MINTMINT-688418.
STRING4932.YBR085W.

Protein family/group databases

TCDB2.A.29.1.9. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBP18238.
PaxDbP18238.
PeptideAtlasP18238.
PRIDEP18238.

Protocols and materials databases

DNASU852380.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBR085W; YBR085W; YBR085W.
GeneID852380.
KEGGsce:YBR085W.

Organism-specific databases

CYGDYBR085w.
SGDS000000289. AAC3.

Phylogenomic databases

eggNOGNOG238123.
GeneTreeENSGT00390000011543.
HOGENOMHOG000165727.
KOK05863.
OMACWRKIFK.
OrthoDBEOG7NCVDV.

Enzyme and pathway databases

BioCycYEAST:G3O-29052-MONOMER.

Gene expression databases

GenevestigatorP18238.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio971180.

Entry information

Entry nameADT3_YEAST
AccessionPrimary (citable) accession number: P18238
Secondary accession number(s): D6VQ85
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 11, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references