Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Septum site-determining protein MinC

Gene

minC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.1 Publication

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: EcoliWiki
  • cell morphogenesis Source: InterPro
  • regulation of cell division Source: EcoliWiki
  • regulation of division septum assembly Source: EcoCyc

Keywordsi

Biological processCell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyciEcoCyc:EG10596-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Septum site-determining protein MinC
Gene namesi
Name:minC
Ordered Locus Names:b1176, JW1165
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10596 minC

Subcellular locationi

GO - Cellular componenti

  • cell pole Source: EcoCyc
  • cytosol Source: EcoCyc

Pathology & Biotechi

Disruption phenotypei

In a minCDE operon disruption (minC-minD-minE), cells divide not only at midpoint but also at their poles, yielding small minicells and long rods. Loss of polar localization of several polar-localized proteins including GroEL-GroES, TnaA and YqjD.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001890331 – 231Septum site-determining protein MinCAdd BLAST231

Proteomic databases

PaxDbiP18196
PRIDEiP18196

Interactioni

Subunit structurei

Interacts with MinD and FtsZ; homodimer.

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4260098, 287 interactors
DIPiDIP-10214N
IntActiP18196, 32 interactors
MINTiP18196
STRINGi316385.ECDH10B_1229

Structurei

3D structure databases

ProteinModelPortaliP18196
SMRiP18196
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MinC family.Curated

Phylogenomic databases

eggNOGiENOG4105K7U Bacteria
COG0850 LUCA
HOGENOMiHOG000062060
InParanoidiP18196
KOiK03610
OMAiRRDPLWG
PhylomeDBiP18196

Family and domain databases

Gene3Di2.160.20.70, 1 hit
3.30.750.120, 1 hit
HAMAPiMF_00267 MinC, 1 hit
InterProiView protein in InterPro
IPR016098 CAP/MinC_C
IPR013033 MinC
IPR036145 MinC_C_sf
IPR007874 MinC_N
IPR038061 MinC_Proteobac_N_sf
IPR005526 Septum_form_inhib_MinC_C
PANTHERiPTHR34108 PTHR34108, 1 hit
PfamiView protein in Pfam
PF03775 MinC_C, 1 hit
PF05209 MinC_N, 1 hit
SUPFAMiSSF63848 SSF63848, 1 hit
TIGRFAMsiTIGR01222 minC, 1 hit

Sequencei

Sequence statusi: Complete.

P18196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTPIELKG SSFTLSVVHL HEAEPKVIHQ ALEDKIAQAP AFLKHAPVVL
60 70 80 90 100
NVSALEDPVN WSAMHKAVSA TGLRVIGVSG CKDAQLKAEI EKMGLPILTE
110 120 130 140 150
GKEKAPRPAP TPQAPAQNTT PVTKTRLIDT PVRSGQRIYA PQCDLIVTSH
160 170 180 190 200
VSAGAELIAD GNIHVYGMMR GRALAGASGD RETQIFCTNL MAELVSIAGE
210 220 230
YWLSDQIPAE FYGKAARLQL VENALTVQPL N
Length:231
Mass (Da):24,776
Last modified:November 1, 1990 - v1
Checksum:iE4283A6AD850DAD0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti10G → D in minC19; reduces affinity of MinC for FtsZ. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03153 Genomic DNA Translation: AAB59061.1
U00096 Genomic DNA Translation: AAC74260.1
AP009048 Genomic DNA Translation: BAA36010.1
PIRiA31877 CEECIC
RefSeqiNP_415694.1, NC_000913.3
WP_001301105.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74260; AAC74260; b1176
BAA36010; BAA36010; BAA36010
GeneIDi945744
KEGGiecj:JW1165
eco:b1176
PATRICifig|1411691.4.peg.1112

Entry informationi

Entry nameiMINC_ECOLI
AccessioniPrimary (citable) accession number: P18196
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 25, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health