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P18196

- MINC_ECOLI

UniProt

P18196 - MINC_ECOLI

Protein

Septum site-determining protein MinC

Gene

minC

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. barrier septum assembly Source: UniProtKB-KW
    2. cell division Source: EcoliWiki
    3. cell morphogenesis Source: InterPro
    4. regulation of cell cycle Source: InterPro
    5. regulation of cell division Source: EcoliWiki

    Keywords - Biological processi

    Cell cycle, Cell division, Septation

    Enzyme and pathway databases

    BioCyciEcoCyc:EG10596-MONOMER.
    ECOL316407:JW1165-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Septum site-determining protein MinC
    Gene namesi
    Name:minC
    Ordered Locus Names:b1176, JW1165
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG10596. minC.

    Pathology & Biotechi

    Disruption phenotypei

    In a minCDE operon disruption (minC-minD-minE), cells divide not only at midpoint but also at their poles, yielding small minicells and long rods. Loss of polar localization of several polar-localized proteins including GroEL-GroES, TnaA and YqjD.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 231231Septum site-determining protein MinCPRO_0000189033Add
    BLAST

    Proteomic databases

    PaxDbiP18196.
    PRIDEiP18196.

    Expressioni

    Gene expression databases

    GenevestigatoriP18196.

    Interactioni

    Subunit structurei

    Interacts with MinD and FtsZ; homodimer.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    eutNP0AEJ83EBI-554060,EBI-8767793
    manAP009463EBI-554060,EBI-554045
    minDP0AEZ32EBI-554060,EBI-554545
    yjjWP394092EBI-554060,EBI-9132384

    Protein-protein interaction databases

    DIPiDIP-10214N.
    IntActiP18196. 32 interactions.
    MINTiMINT-113907.
    STRINGi511145.b1176.

    Structurei

    3D structure databases

    ProteinModelPortaliP18196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MinC family.Curated

    Phylogenomic databases

    eggNOGiCOG0850.
    HOGENOMiHOG000062060.
    KOiK03610.
    OMAiRIYAPNC.
    OrthoDBiEOG606588.
    PhylomeDBiP18196.

    Family and domain databases

    Gene3Di2.160.20.70. 1 hit.
    HAMAPiMF_00267. MinC.
    InterProiIPR016098. CAP/MinC_C.
    IPR013033. MinC.
    IPR007874. MinC_N.
    IPR005526. Septum_form_inhib_MinC_C.
    [Graphical view]
    PfamiPF03775. MinC_C. 1 hit.
    PF05209. MinC_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF63848. SSF63848. 1 hit.
    TIGRFAMsiTIGR01222. minC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P18196-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNTPIELKG SSFTLSVVHL HEAEPKVIHQ ALEDKIAQAP AFLKHAPVVL    50
    NVSALEDPVN WSAMHKAVSA TGLRVIGVSG CKDAQLKAEI EKMGLPILTE 100
    GKEKAPRPAP TPQAPAQNTT PVTKTRLIDT PVRSGQRIYA PQCDLIVTSH 150
    VSAGAELIAD GNIHVYGMMR GRALAGASGD RETQIFCTNL MAELVSIAGE 200
    YWLSDQIPAE FYGKAARLQL VENALTVQPL N 231
    Length:231
    Mass (Da):24,776
    Last modified:November 1, 1990 - v1
    Checksum:iE4283A6AD850DAD0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101G → D in minC19; reduces affinity of MinC for FtsZ.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03153 Genomic DNA. Translation: AAB59061.1.
    U00096 Genomic DNA. Translation: AAC74260.1.
    AP009048 Genomic DNA. Translation: BAA36010.1.
    PIRiA31877. CEECIC.
    RefSeqiNP_415694.1. NC_000913.3.
    YP_489443.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC74260; AAC74260; b1176.
    BAA36010; BAA36010; BAA36010.
    GeneIDi12931104.
    945744.
    KEGGiecj:Y75_p1148.
    eco:b1176.
    PATRICi32117596. VBIEscCol129921_1220.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03153 Genomic DNA. Translation: AAB59061.1 .
    U00096 Genomic DNA. Translation: AAC74260.1 .
    AP009048 Genomic DNA. Translation: BAA36010.1 .
    PIRi A31877. CEECIC.
    RefSeqi NP_415694.1. NC_000913.3.
    YP_489443.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P18196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-10214N.
    IntActi P18196. 32 interactions.
    MINTi MINT-113907.
    STRINGi 511145.b1176.

    Proteomic databases

    PaxDbi P18196.
    PRIDEi P18196.

    Protocols and materials databases

    DNASUi 945744.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC74260 ; AAC74260 ; b1176 .
    BAA36010 ; BAA36010 ; BAA36010 .
    GeneIDi 12931104.
    945744.
    KEGGi ecj:Y75_p1148.
    eco:b1176.
    PATRICi 32117596. VBIEscCol129921_1220.

    Organism-specific databases

    EchoBASEi EB0591.
    EcoGenei EG10596. minC.

    Phylogenomic databases

    eggNOGi COG0850.
    HOGENOMi HOG000062060.
    KOi K03610.
    OMAi RIYAPNC.
    OrthoDBi EOG606588.
    PhylomeDBi P18196.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG10596-MONOMER.
    ECOL316407:JW1165-MONOMER.

    Miscellaneous databases

    PROi P18196.

    Gene expression databases

    Genevestigatori P18196.

    Family and domain databases

    Gene3Di 2.160.20.70. 1 hit.
    HAMAPi MF_00267. MinC.
    InterProi IPR016098. CAP/MinC_C.
    IPR013033. MinC.
    IPR007874. MinC_N.
    IPR005526. Septum_form_inhib_MinC_C.
    [Graphical view ]
    Pfami PF03775. MinC_C. 1 hit.
    PF05209. MinC_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63848. SSF63848. 1 hit.
    TIGRFAMsi TIGR01222. minC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli."
      de Boer P.A.J., Crossley R.E., Rothfield L.I.
      Cell 56:641-649(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "The MinC component of the division site selection system in Escherichia coli interacts with FtsZ to prevent polymerization."
      Hu Z., Mukherjee A., Pichoff S., Lutkenhaus J.
      Proc. Natl. Acad. Sci. U.S.A. 96:14819-14824(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    6. "Analysis of MinC reveals two independent domains involved in interaction with MinD and FtsZ."
      Hu Z., Lutkenhaus J.
      J. Bacteriol. 182:3965-3971(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    7. "Isolation and identification of new inner membrane-associated proteins that localize to cell poles in Escherichia coli."
      Li G., Young K.D.
      Mol. Microbiol. 84:276-295(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN LOCATION AT CELL POLES, DISRUPTION PHENOTYPE.
      Strain: K12 / MG1655 / ATCC 47076.

    Entry informationi

    Entry nameiMINC_ECOLI
    AccessioniPrimary (citable) accession number: P18196
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3