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P18196

- MINC_ECOLI

UniProt

P18196 - MINC_ECOLI

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Protein

Septum site-determining protein MinC

Gene

minC

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.1 Publication

GO - Biological processi

  1. barrier septum assembly Source: UniProtKB-KW
  2. cell division Source: EcoliWiki
  3. cell morphogenesis Source: InterPro
  4. regulation of cell cycle Source: InterPro
  5. regulation of cell division Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyciEcoCyc:EG10596-MONOMER.
ECOL316407:JW1165-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Septum site-determining protein MinC
Gene namesi
Name:minC
Ordered Locus Names:b1176, JW1165
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10596. minC.

Pathology & Biotechi

Disruption phenotypei

In a minCDE operon disruption (minC-minD-minE), cells divide not only at midpoint but also at their poles, yielding small minicells and long rods. Loss of polar localization of several polar-localized proteins including GroEL-GroES, TnaA and YqjD.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Septum site-determining protein MinCPRO_0000189033Add
BLAST

Proteomic databases

PaxDbiP18196.
PRIDEiP18196.

Expressioni

Gene expression databases

GenevestigatoriP18196.

Interactioni

Subunit structurei

Interacts with MinD and FtsZ; homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
eutNP0AEJ83EBI-554060,EBI-8767793
manAP009463EBI-554060,EBI-554045
minDP0AEZ32EBI-554060,EBI-554545
yjjWP394092EBI-554060,EBI-9132384

Protein-protein interaction databases

DIPiDIP-10214N.
IntActiP18196. 32 interactions.
MINTiMINT-113907.
STRINGi511145.b1176.

Structurei

3D structure databases

ProteinModelPortaliP18196.
SMRiP18196. Positions 4-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MinC family.Curated

Phylogenomic databases

eggNOGiCOG0850.
HOGENOMiHOG000062060.
InParanoidiP18196.
KOiK03610.
OMAiRIYAPNC.
OrthoDBiEOG606588.
PhylomeDBiP18196.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
HAMAPiMF_00267. MinC.
InterProiIPR016098. CAP/MinC_C.
IPR013033. MinC.
IPR007874. MinC_N.
IPR005526. Septum_form_inhib_MinC_C.
[Graphical view]
PfamiPF03775. MinC_C. 1 hit.
PF05209. MinC_N. 1 hit.
[Graphical view]
SUPFAMiSSF63848. SSF63848. 1 hit.
TIGRFAMsiTIGR01222. minC. 1 hit.

Sequencei

Sequence statusi: Complete.

P18196-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNTPIELKG SSFTLSVVHL HEAEPKVIHQ ALEDKIAQAP AFLKHAPVVL
60 70 80 90 100
NVSALEDPVN WSAMHKAVSA TGLRVIGVSG CKDAQLKAEI EKMGLPILTE
110 120 130 140 150
GKEKAPRPAP TPQAPAQNTT PVTKTRLIDT PVRSGQRIYA PQCDLIVTSH
160 170 180 190 200
VSAGAELIAD GNIHVYGMMR GRALAGASGD RETQIFCTNL MAELVSIAGE
210 220 230
YWLSDQIPAE FYGKAARLQL VENALTVQPL N
Length:231
Mass (Da):24,776
Last modified:November 1, 1990 - v1
Checksum:iE4283A6AD850DAD0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101G → D in minC19; reduces affinity of MinC for FtsZ.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03153 Genomic DNA. Translation: AAB59061.1.
U00096 Genomic DNA. Translation: AAC74260.1.
AP009048 Genomic DNA. Translation: BAA36010.1.
PIRiA31877. CEECIC.
RefSeqiNP_415694.1. NC_000913.3.
YP_489443.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74260; AAC74260; b1176.
BAA36010; BAA36010; BAA36010.
GeneIDi12931104.
945744.
KEGGiecj:Y75_p1148.
eco:b1176.
PATRICi32117596. VBIEscCol129921_1220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03153 Genomic DNA. Translation: AAB59061.1 .
U00096 Genomic DNA. Translation: AAC74260.1 .
AP009048 Genomic DNA. Translation: BAA36010.1 .
PIRi A31877. CEECIC.
RefSeqi NP_415694.1. NC_000913.3.
YP_489443.1. NC_007779.1.

3D structure databases

ProteinModelPortali P18196.
SMRi P18196. Positions 4-101.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-10214N.
IntActi P18196. 32 interactions.
MINTi MINT-113907.
STRINGi 511145.b1176.

Proteomic databases

PaxDbi P18196.
PRIDEi P18196.

Protocols and materials databases

DNASUi 945744.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74260 ; AAC74260 ; b1176 .
BAA36010 ; BAA36010 ; BAA36010 .
GeneIDi 12931104.
945744.
KEGGi ecj:Y75_p1148.
eco:b1176.
PATRICi 32117596. VBIEscCol129921_1220.

Organism-specific databases

EchoBASEi EB0591.
EcoGenei EG10596. minC.

Phylogenomic databases

eggNOGi COG0850.
HOGENOMi HOG000062060.
InParanoidi P18196.
KOi K03610.
OMAi RIYAPNC.
OrthoDBi EOG606588.
PhylomeDBi P18196.

Enzyme and pathway databases

BioCyci EcoCyc:EG10596-MONOMER.
ECOL316407:JW1165-MONOMER.

Miscellaneous databases

PROi P18196.

Gene expression databases

Genevestigatori P18196.

Family and domain databases

Gene3Di 2.160.20.70. 1 hit.
HAMAPi MF_00267. MinC.
InterProi IPR016098. CAP/MinC_C.
IPR013033. MinC.
IPR007874. MinC_N.
IPR005526. Septum_form_inhib_MinC_C.
[Graphical view ]
Pfami PF03775. MinC_C. 1 hit.
PF05209. MinC_N. 1 hit.
[Graphical view ]
SUPFAMi SSF63848. SSF63848. 1 hit.
TIGRFAMsi TIGR01222. minC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli."
    de Boer P.A.J., Crossley R.E., Rothfield L.I.
    Cell 56:641-649(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The MinC component of the division site selection system in Escherichia coli interacts with FtsZ to prevent polymerization."
    Hu Z., Mukherjee A., Pichoff S., Lutkenhaus J.
    Proc. Natl. Acad. Sci. U.S.A. 96:14819-14824(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "Analysis of MinC reveals two independent domains involved in interaction with MinD and FtsZ."
    Hu Z., Lutkenhaus J.
    J. Bacteriol. 182:3965-3971(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. "Isolation and identification of new inner membrane-associated proteins that localize to cell poles in Escherichia coli."
    Li G., Young K.D.
    Mol. Microbiol. 84:276-295(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LOCATION AT CELL POLES, DISRUPTION PHENOTYPE.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiMINC_ECOLI
AccessioniPrimary (citable) accession number: P18196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3