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Protein

RNA polymerase principal sigma factor HrdC

Gene

hrdC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi300 – 319H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Sigma factor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase principal sigma factor HrdC
Gene namesi
Name:hrdC
Ordered Locus Names:SCO0895
ORF Names:SCM1.28c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000939931 – 339RNA polymerase principal sigma factor HrdCAdd BLAST339

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.By similarity

Protein-protein interaction databases

STRINGi100226.SCO0895

Structurei

3D structure databases

ProteinModelPortaliP18184
SMRiP18184
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 143Polymerase core bindingAdd BLAST14

Sequence similaritiesi

Belongs to the sigma-70 factor family.Curated

Phylogenomic databases

eggNOGiENOG4105DG1 Bacteria
COG0568 LUCA
HOGENOMiHOG000270273
InParanoidiP18184
KOiK03087
OMAiRFGRQPN
OrthoDBiPOG091H0012
PhylomeDBiP18184

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR009042 RNA_pol_sigma70_r1_2
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00140 Sigma70_r1_2, 1 hit
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit
PS00716 SIGMA70_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18184-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTARTPTA RTRDDRRATT RTARLRTRIP EPDEEPDLLG QYLTQIGATP
60 70 80 90 100
LLTAEDEVRL ATRIEAGVRA REELETADTG EPAPTPRRRR TLEETVHDGQ
110 120 130 140 150
EAKDHMVRAN LRLVVSMAKR HAHRGLPLLD VIQEGNLGLI RAVEKFDHTK
160 170 180 190 200
GFKFSTYATW WIRQAIERGL ATHARTVRLP VHVVEQLQKL AKVERKLRAG
210 220 230 240 250
LDREPTTEEV AAESGIDVDK VVWLRRVGRD AVSLDTPVDE TGDTVVGDLI
260 270 280 290 300
PDTEVLRAPE VAEFQALAAE LREAVGTLAP RESLILSLRY GLHDGRPRTL
310 320 330
QQVAQHVGLT RERVRQLEKE SLAHLRAPEN RERLLDWAS
Length:339
Mass (Da):38,173
Last modified:November 1, 1990 - v1
Checksum:i36B875EF5B047489
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173H → HI no nucleotide entry (PubMed:3194753).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52981 Genomic DNA Translation: CAA37173.1
AL939107 Genomic DNA Translation: CAB62686.1
PIRiS17930
RefSeqiNP_625194.1, NC_003888.3
WP_003977963.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB62686; CAB62686; CAB62686
GeneIDi1096318
29658422
KEGGisco:SCO0895
PATRICifig|100226.15.peg.887

Similar proteinsi

Entry informationi

Entry nameiHRDC_STRCO
AccessioniPrimary (citable) accession number: P18184
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health