Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA polymerase principal sigma factor HrdC

Gene

hrdC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi300 – 31920H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Sigma factor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase principal sigma factor HrdC
Gene namesi
Name:hrdC
Ordered Locus Names:SCO0895
ORF Names:SCM1.28c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339RNA polymerase principal sigma factor HrdCPRO_0000093993Add
BLAST

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.By similarity

Protein-protein interaction databases

STRINGi100226.SCO0895.

Structurei

3D structure databases

ProteinModelPortaliP18184.
SMRiP18184. Positions 97-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi130 – 14314Polymerase core bindingAdd
BLAST

Sequence similaritiesi

Belongs to the sigma-70 factor family.Curated

Phylogenomic databases

eggNOGiENOG4105DG1. Bacteria.
COG0568. LUCA.
HOGENOMiHOG000270273.
InParanoidiP18184.
KOiK03087.
OMAiCGISHER.
OrthoDBiPOG091H0012.
PhylomeDBiP18184.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18184-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTARTPTA RTRDDRRATT RTARLRTRIP EPDEEPDLLG QYLTQIGATP
60 70 80 90 100
LLTAEDEVRL ATRIEAGVRA REELETADTG EPAPTPRRRR TLEETVHDGQ
110 120 130 140 150
EAKDHMVRAN LRLVVSMAKR HAHRGLPLLD VIQEGNLGLI RAVEKFDHTK
160 170 180 190 200
GFKFSTYATW WIRQAIERGL ATHARTVRLP VHVVEQLQKL AKVERKLRAG
210 220 230 240 250
LDREPTTEEV AAESGIDVDK VVWLRRVGRD AVSLDTPVDE TGDTVVGDLI
260 270 280 290 300
PDTEVLRAPE VAEFQALAAE LREAVGTLAP RESLILSLRY GLHDGRPRTL
310 320 330
QQVAQHVGLT RERVRQLEKE SLAHLRAPEN RERLLDWAS
Length:339
Mass (Da):38,173
Last modified:November 1, 1990 - v1
Checksum:i36B875EF5B047489
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731H → HI no nucleotide entry (PubMed:3194753).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52981 Genomic DNA. Translation: CAA37173.1.
AL939107 Genomic DNA. Translation: CAB62686.1.
PIRiS17930.
RefSeqiNP_625194.1. NC_003888.3.
WP_003977963.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB62686; CAB62686; CAB62686.
GeneIDi1096318.
KEGGisco:SCO0895.
PATRICi23731330. VBIStrCoe124346_0887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52981 Genomic DNA. Translation: CAA37173.1.
AL939107 Genomic DNA. Translation: CAB62686.1.
PIRiS17930.
RefSeqiNP_625194.1. NC_003888.3.
WP_003977963.1. NC_003888.3.

3D structure databases

ProteinModelPortaliP18184.
SMRiP18184. Positions 97-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO0895.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB62686; CAB62686; CAB62686.
GeneIDi1096318.
KEGGisco:SCO0895.
PATRICi23731330. VBIStrCoe124346_0887.

Phylogenomic databases

eggNOGiENOG4105DG1. Bacteria.
COG0568. LUCA.
HOGENOMiHOG000270273.
InParanoidiP18184.
KOiK03087.
OMAiCGISHER.
OrthoDBiPOG091H0012.
PhylomeDBiP18184.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHRDC_STRCO
AccessioniPrimary (citable) accession number: P18184
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.