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Protein

RNA polymerase principal sigma factor HrdA

Gene

hrdA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi357 – 376H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Sigma factor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase principal sigma factor HrdA
Gene namesi
Name:hrdA
Ordered Locus Names:SCO2465
ORF Names:SC7A8.04c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000939901 – 396RNA polymerase principal sigma factor HrdAAdd BLAST396

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core (By similarity). Interacts with RNA polymerase-binding protein RbpA.By similarity1 Publication

Protein-protein interaction databases

STRINGi100226.SCO2465

Structurei

3D structure databases

ProteinModelPortaliP18182
SMRiP18182
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi187 – 200Polymerase core bindingAdd BLAST14

Sequence similaritiesi

Belongs to the sigma-70 factor family.Curated

Phylogenomic databases

eggNOGiENOG4105DG1 Bacteria
COG0568 LUCA
HOGENOMiHOG000270273
InParanoidiP18182
KOiK03086
OMAiITNRESQ
OrthoDBiPOG091H0012
PhylomeDBiP18182

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR009042 RNA_pol_sigma70_r1_2
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00140 Sigma70_r1_2, 1 hit
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit
PS00716 SIGMA70_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGGQRRASR LRPPTYRRRP PPAASILEVA PVQTQTLTQT DTAAGGAEPD
60 70 80 90 100
AERGVLLAMP AQPGAGAALP HPGAPVDVPE HPEPPPPTRT ESGGPSSDLF
110 120 130 140 150
RQYLREIGRI PLLSAAEEVD LARRVEAGLF AEEKLRCSPG LDDRLALDLD
160 170 180 190 200
RLVVLGRLAK RRLIEANLRL VVSVAKRYVG RGLTMLDLVQ EGNLGLIRAV
210 220 230 240 250
EKFDYARGYK FSTYATWWIR QAMSRALADQ ARTIRVPVHV VELINRVVRV
260 270 280 290 300
QRRMLQERGC EPTPQEVAAH LDLAPERVGE VLRLAQEPVS LHAPVGEEDD
310 320 330 340 350
VALGDLIEDG DAASPVESAA FLLLRQHLEA VLSTLGERER KVVQLRYGLA
360 370 380 390
DGRPRTLEEI GRLFGVTRER IRQIESKTLS KLRDHAYADQ LRGYLD
Length:396
Mass (Da):43,837
Last modified:October 18, 2001 - v2
Checksum:iEB711BA589E58FCA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211F → I no nucleotide entry (PubMed:3194753).Curated1
Sequence conflicti364F → G in CAA37172 (PubMed:1944221).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52980 Genomic DNA Translation: CAA37172.1
AL939112 Genomic DNA Translation: CAB69753.1
PIRiS17929
RefSeqiNP_626707.1, NC_003888.3
WP_003976339.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB69753; CAB69753; CAB69753
GeneIDi1097899
KEGGisco:SCO2465
PATRICifig|100226.15.peg.2506

Similar proteinsi

Entry informationi

Entry nameiHRDA_STRCO
AccessioniPrimary (citable) accession number: P18182
Secondary accession number(s): Q9L2F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 18, 2001
Last modified: May 23, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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