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Protein

CD48 antigen

Gene

Cd48

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

GO - Molecular functioni

GO - Biological processi

  • mast cell activation Source: Ensembl
  • signal transduction Source: MGI
  • T cell activation Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
CD48 antigen
Alternative name(s):
BCM1 surface antigen
BLAST-1
HM48-1
MRC OX-45 surface antigen
SLAM family member 2
Short name:
SLAMF2
Signaling lymphocytic activation molecule 2
sgp-60
CD_antigen: CD48
Gene namesi
Name:Cd48
Synonyms:Bcm-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88339. Cd48.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 217195CD48 antigenPRO_0000014883Add
BLAST
Propeptidei218 – 24023Removed in mature formPRO_0000014884Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence analysis
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi151 ↔ 193PROSITE-ProRule annotation
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence analysis
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence analysis
Lipidationi217 – 2171GPI-anchor amidated serine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP18181.
MaxQBiP18181.
PaxDbiP18181.
PRIDEiP18181.

PTM databases

PhosphoSiteiP18181.
SwissPalmiP18181.

Expressioni

Gene expression databases

BgeeiP18181.
CleanExiMM_CD48.
ExpressionAtlasiP18181. baseline and differential.
GenevisibleiP18181. MM.

Interactioni

Subunit structurei

Interacts with CD244 in a heterophilic manner.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064241.

Structurei

Secondary structure

1
240
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 345Combined sources
Beta strandi39 – 413Combined sources
Beta strandi52 – 598Combined sources
Beta strandi62 – 687Combined sources
Beta strandi73 – 753Combined sources
Turni79 – 835Combined sources
Beta strandi84 – 863Combined sources
Turni88 – 903Combined sources
Beta strandi93 – 975Combined sources
Helixi100 – 1023Combined sources
Beta strandi104 – 11512Combined sources
Beta strandi118 – 1258Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PTTX-ray1.63A27-128[»]
2PTVX-ray1.66A27-128[»]
ProteinModelPortaliP18181.
SMRiP18181. Positions 23-153.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18181.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 12597Ig-like C2-type 1Add
BLAST
Domaini129 – 20981Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J3RS. Eukaryota.
ENOG410ZR3T. LUCA.
GeneTreeiENSGT00510000049275.
HOGENOMiHOG000111487.
HOVERGENiHBG004490.
InParanoidiP18181.
KOiK06479.
OMAiAWIATWL.
PhylomeDBiP18181.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCFIKQGWCL VLELLLLPLG TGFQGHSIPD INATTGSNVT LKIHKDPLGP
60 70 80 90 100
YKRITWLHTK NQKILEYNYN STKTIFESEF KGRVYLEENN GALHISNVRK
110 120 130 140 150
EDKGTYYMRV LRETENELKI TLEVFDPVPK PSIEINKTEA STDSCHLRLS
160 170 180 190 200
CEVKDQHVDY TWYESSGPFP KKSPGYVLDL IVTPQNKSTF YTCQVSNPVS
210 220 230 240
SKNDTVYFTL PCDLARSSGV CWTATWLVVT TLIIHRILLT
Length:240
Mass (Da):27,383
Last modified:November 1, 1990 - v1
Checksum:iF3BF6987A9E9C71E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53526 mRNA. Translation: CAA37604.1.
X17501 mRNA. Translation: CAA35542.1.
AK007741 mRNA. Translation: BAB25228.1.
AK084984 mRNA. Translation: BAC39328.1.
AK151601 mRNA. Translation: BAE30541.1.
CCDSiCCDS15501.1.
PIRiJL0143.
RefSeqiNP_031675.1. NM_007649.4.
UniGeneiMm.1738.

Genome annotation databases

EnsembliENSMUST00000068584; ENSMUSP00000064241; ENSMUSG00000015355.
GeneIDi12506.
KEGGimmu:12506.
UCSCiuc007doz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53526 mRNA. Translation: CAA37604.1.
X17501 mRNA. Translation: CAA35542.1.
AK007741 mRNA. Translation: BAB25228.1.
AK084984 mRNA. Translation: BAC39328.1.
AK151601 mRNA. Translation: BAE30541.1.
CCDSiCCDS15501.1.
PIRiJL0143.
RefSeqiNP_031675.1. NM_007649.4.
UniGeneiMm.1738.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PTTX-ray1.63A27-128[»]
2PTVX-ray1.66A27-128[»]
ProteinModelPortaliP18181.
SMRiP18181. Positions 23-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064241.

PTM databases

PhosphoSiteiP18181.
SwissPalmiP18181.

Proteomic databases

EPDiP18181.
MaxQBiP18181.
PaxDbiP18181.
PRIDEiP18181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068584; ENSMUSP00000064241; ENSMUSG00000015355.
GeneIDi12506.
KEGGimmu:12506.
UCSCiuc007doz.1. mouse.

Organism-specific databases

CTDi962.
MGIiMGI:88339. Cd48.

Phylogenomic databases

eggNOGiENOG410J3RS. Eukaryota.
ENOG410ZR3T. LUCA.
GeneTreeiENSGT00510000049275.
HOGENOMiHOG000111487.
HOVERGENiHBG004490.
InParanoidiP18181.
KOiK06479.
OMAiAWIATWL.
PhylomeDBiP18181.
TreeFamiTF334964.

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

EvolutionaryTraceiP18181.
NextBioi281474.
PROiP18181.
SOURCEiSearch...

Gene expression databases

BgeeiP18181.
CleanExiMM_CD48.
ExpressionAtlasiP18181. baseline and differential.
GenevisibleiP18181. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3."
    Wong Y.W., Williams A.F., Kingsmore S.F., Seldin M.F.
    J. Exp. Med. 171:2115-2130(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GPI-ANCHOR AT SER-217.
    Strain: BALB/cJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Lung and Pancreas.
  3. "Identification, by protein sequencing and gene transfection, of sgp-60 as the murine homologue of CD48."
    Cabrero J.G., Freeman G.J., Lane W.S., Reiser H.
    Proc. Natl. Acad. Sci. U.S.A. 90:3418-3422(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 74-80.
  4. "CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation."
    Kato K., Koyanagi M., Okada H., Takanahi T., Wong Y.W., Williams A.F., Okumura K., Yagita H.
    J. Exp. Med. 176:1241-1249(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-40.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.
  6. "Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family."
    Velikovsky C.A., Deng L., Chlewicki L.K., Fernandez M.M., Kumar V., Mariuzza R.A.
    Immunity 27:572-584(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 27-128 ALONE AND IN COMPLEX WITH CD244.

Entry informationi

Entry nameiCD48_MOUSE
AccessioniPrimary (citable) accession number: P18181
Secondary accession number(s): Q545K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 11, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.