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Protein

CD48 antigen

Gene

Cd48

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

GO - Molecular functioni

GO - Biological processi

  • mast cell activation Source: Ensembl
  • regulation of adaptive immune response Source: InterPro
  • signal transduction Source: MGI
  • T cell activation Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
CD48 antigen
Alternative name(s):
BCM1 surface antigen
BLAST-1
HM48-1
MRC OX-45 surface antigen
SLAM family member 2
Short name:
SLAMF2
Signaling lymphocytic activation molecule 2
sgp-60
CD_antigen: CD48
Gene namesi
Name:Cd48
Synonyms:Bcm-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88339. Cd48.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001488323 – 217CD48 antigenAdd BLAST195
PropeptideiPRO_0000014884218 – 240Removed in mature formAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi151 ↔ 193PROSITE-ProRule annotation
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Lipidationi217GPI-anchor amidated serine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP18181.
MaxQBiP18181.
PaxDbiP18181.
PeptideAtlasiP18181.
PRIDEiP18181.

PTM databases

PhosphoSitePlusiP18181.
SwissPalmiP18181.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015355.
CleanExiMM_CD48.
ExpressionAtlasiP18181. baseline and differential.
GenevisibleiP18181. MM.

Interactioni

Subunit structurei

Interacts with CD244 in a heterophilic manner.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064241.

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 34Combined sources5
Beta strandi39 – 41Combined sources3
Beta strandi52 – 59Combined sources8
Beta strandi62 – 68Combined sources7
Beta strandi73 – 75Combined sources3
Turni79 – 83Combined sources5
Beta strandi84 – 86Combined sources3
Turni88 – 90Combined sources3
Beta strandi93 – 97Combined sources5
Helixi100 – 102Combined sources3
Beta strandi104 – 115Combined sources12
Beta strandi118 – 125Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PTTX-ray1.63A27-128[»]
2PTVX-ray1.66A27-128[»]
ProteinModelPortaliP18181.
SMRiP18181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18181.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 125Ig-like C2-type 1Add BLAST97
Domaini129 – 209Ig-like C2-type 2Add BLAST81

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J3RS. Eukaryota.
ENOG410ZR3T. LUCA.
GeneTreeiENSGT00510000049275.
HOGENOMiHOG000111487.
HOVERGENiHBG004490.
InParanoidiP18181.
KOiK06479.
OMAiSSGVAWI.
OrthoDBiEOG091G0K94.
PhylomeDBiP18181.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR033548. CD48.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PANTHERiPTHR12080:SF47. PTHR12080:SF47. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCFIKQGWCL VLELLLLPLG TGFQGHSIPD INATTGSNVT LKIHKDPLGP
60 70 80 90 100
YKRITWLHTK NQKILEYNYN STKTIFESEF KGRVYLEENN GALHISNVRK
110 120 130 140 150
EDKGTYYMRV LRETENELKI TLEVFDPVPK PSIEINKTEA STDSCHLRLS
160 170 180 190 200
CEVKDQHVDY TWYESSGPFP KKSPGYVLDL IVTPQNKSTF YTCQVSNPVS
210 220 230 240
SKNDTVYFTL PCDLARSSGV CWTATWLVVT TLIIHRILLT
Length:240
Mass (Da):27,383
Last modified:November 1, 1990 - v1
Checksum:iF3BF6987A9E9C71E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53526 mRNA. Translation: CAA37604.1.
X17501 mRNA. Translation: CAA35542.1.
AK007741 mRNA. Translation: BAB25228.1.
AK084984 mRNA. Translation: BAC39328.1.
AK151601 mRNA. Translation: BAE30541.1.
CCDSiCCDS15501.1.
PIRiJL0143.
RefSeqiNP_031675.1. NM_007649.4.
UniGeneiMm.1738.

Genome annotation databases

EnsembliENSMUST00000068584; ENSMUSP00000064241; ENSMUSG00000015355.
GeneIDi12506.
KEGGimmu:12506.
UCSCiuc007doz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53526 mRNA. Translation: CAA37604.1.
X17501 mRNA. Translation: CAA35542.1.
AK007741 mRNA. Translation: BAB25228.1.
AK084984 mRNA. Translation: BAC39328.1.
AK151601 mRNA. Translation: BAE30541.1.
CCDSiCCDS15501.1.
PIRiJL0143.
RefSeqiNP_031675.1. NM_007649.4.
UniGeneiMm.1738.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PTTX-ray1.63A27-128[»]
2PTVX-ray1.66A27-128[»]
ProteinModelPortaliP18181.
SMRiP18181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064241.

PTM databases

PhosphoSitePlusiP18181.
SwissPalmiP18181.

Proteomic databases

EPDiP18181.
MaxQBiP18181.
PaxDbiP18181.
PeptideAtlasiP18181.
PRIDEiP18181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068584; ENSMUSP00000064241; ENSMUSG00000015355.
GeneIDi12506.
KEGGimmu:12506.
UCSCiuc007doz.1. mouse.

Organism-specific databases

CTDi962.
MGIiMGI:88339. Cd48.

Phylogenomic databases

eggNOGiENOG410J3RS. Eukaryota.
ENOG410ZR3T. LUCA.
GeneTreeiENSGT00510000049275.
HOGENOMiHOG000111487.
HOVERGENiHBG004490.
InParanoidiP18181.
KOiK06479.
OMAiSSGVAWI.
OrthoDBiEOG091G0K94.
PhylomeDBiP18181.
TreeFamiTF334964.

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

EvolutionaryTraceiP18181.
PROiP18181.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015355.
CleanExiMM_CD48.
ExpressionAtlasiP18181. baseline and differential.
GenevisibleiP18181. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR033548. CD48.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PANTHERiPTHR12080:SF47. PTHR12080:SF47. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD48_MOUSE
AccessioniPrimary (citable) accession number: P18181
Secondary accession number(s): Q545K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.