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Protein

CD48 antigen

Gene

Cd48

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

GO - Molecular functioni

GO - Biological processi

  • regulation of adaptive immune response Source: InterPro
  • signal transduction Source: MGI
  • T cell activation Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
CD48 antigen
Alternative name(s):
BCM1 surface antigen
BLAST-1
HM48-1
MRC OX-45 surface antigen
SLAM family member 2
Short name:
SLAMF2
Signaling lymphocytic activation molecule 2
sgp-60
CD_antigen: CD48
Gene namesi
Name:Cd48
Synonyms:Bcm-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88339 Cd48

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001488323 – 217CD48 antigenAdd BLAST195
PropeptideiPRO_0000014884218 – 240Removed in mature formAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi151 ↔ 193PROSITE-ProRule annotation
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi217GPI-anchor amidated serine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP18181
MaxQBiP18181
PaxDbiP18181
PeptideAtlasiP18181
PRIDEiP18181

PTM databases

PhosphoSitePlusiP18181
SwissPalmiP18181

Expressioni

Gene expression databases

BgeeiENSMUSG00000015355
CleanExiMM_CD48
ExpressionAtlasiP18181 baseline and differential
GenevisibleiP18181 MM

Interactioni

Subunit structurei

Interacts with CD2 (PubMed:1383383). Interacts with CD244 in a heterophilic manner (PubMed:17950006).2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064241

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 34Combined sources5
Beta strandi39 – 41Combined sources3
Beta strandi52 – 59Combined sources8
Beta strandi62 – 68Combined sources7
Beta strandi73 – 75Combined sources3
Turni79 – 83Combined sources5
Beta strandi84 – 86Combined sources3
Turni88 – 90Combined sources3
Beta strandi93 – 97Combined sources5
Helixi100 – 102Combined sources3
Beta strandi104 – 115Combined sources12
Beta strandi118 – 125Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PTTX-ray1.63A27-128[»]
2PTVX-ray1.66A27-128[»]
ProteinModelPortaliP18181
SMRiP18181
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18181

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 125Ig-like C2-type 1Add BLAST97
Domaini129 – 209Ig-like C2-type 2Add BLAST81

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J3RS Eukaryota
ENOG410ZR3T LUCA
GeneTreeiENSGT00510000049275
HOGENOMiHOG000111487
HOVERGENiHBG004490
InParanoidiP18181
KOiK06479
OMAiSSGVAWI
OrthoDBiEOG091G0K94
PhylomeDBiP18181
TreeFamiTF334964

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR033548 CD48
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PANTHERiPTHR12080:SF47 PTHR12080:SF47, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCFIKQGWCL VLELLLLPLG TGFQGHSIPD INATTGSNVT LKIHKDPLGP
60 70 80 90 100
YKRITWLHTK NQKILEYNYN STKTIFESEF KGRVYLEENN GALHISNVRK
110 120 130 140 150
EDKGTYYMRV LRETENELKI TLEVFDPVPK PSIEINKTEA STDSCHLRLS
160 170 180 190 200
CEVKDQHVDY TWYESSGPFP KKSPGYVLDL IVTPQNKSTF YTCQVSNPVS
210 220 230 240
SKNDTVYFTL PCDLARSSGV CWTATWLVVT TLIIHRILLT
Length:240
Mass (Da):27,383
Last modified:November 1, 1990 - v1
Checksum:iF3BF6987A9E9C71E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53526 mRNA Translation: CAA37604.1
X17501 mRNA Translation: CAA35542.1
AK007741 mRNA Translation: BAB25228.1
AK084984 mRNA Translation: BAC39328.1
AK151601 mRNA Translation: BAE30541.1
CCDSiCCDS15501.1
PIRiJL0143
RefSeqiNP_031675.1, NM_007649.4
UniGeneiMm.1738

Genome annotation databases

EnsembliENSMUST00000068584; ENSMUSP00000064241; ENSMUSG00000015355
GeneIDi12506
KEGGimmu:12506
UCSCiuc007doz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCD48_MOUSE
AccessioniPrimary (citable) accession number: P18181
Secondary accession number(s): Q545K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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