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Protein

Involucrin

Gene

IVL

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Involucrin
Gene namesi
Name:IVL
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm

  • Note: Constituent of the scaffolding of the cornified envelope.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597411 – 347InvolucrinAdd BLAST347

Post-translational modificationi

Substrate of transglutaminase. Specific glutamines or lysines are cross-linked to keratins, desmoplakin and to inter involucrin molecules.

Proteomic databases

PaxDbiP18175.
PRIDEiP18175.

Expressioni

Tissue specificityi

Keratinocytes of epidermis and other stratified squamous epithelia.

Interactioni

Subunit structurei

Directly or indirectly cross-linked to cornifelin (CNFN).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007032.

Family & Domainsi

Sequence similaritiesi

Belongs to the involucrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JDU1. Eukaryota.
ENOG410Z08K. LUCA.
HOGENOMiHOG000172481.
HOVERGENiHBG006166.
InParanoidiP18175.

Family and domain databases

InterProiIPR009733. Involucrin2.
IPR019743. Involucrin_CS.
IPR019571. Involucrin_N.
[Graphical view]
PfamiPF06994. Involucrin2. 6 hits.
PF10583. Involucrin_N. 1 hit.
[Graphical view]
PROSITEiPS00795. INVOLUCRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQYTLPVT LPPALSQEPL KPVSPPADTQ QEQVKQATPL PAPCQKMLSE
60 70 80 90 100
LPVEVPLEDA EKHTTLVKGV PEQECEPQPQ EPQQQELHVE QQQQQQESQV
110 120 130 140 150
QELHVDQQQQ QQESQEQELH VDQQQQQQES QEQELHVDQQ QQQESQVQEL
160 170 180 190 200
HVGHHQQQQE SQEQELHVDH HQQQQESQEQ ELHVDQQQQQ QESQEQELHV
210 220 230 240 250
DQQQQQQESQ EQELHVDHHQ QQQESQVQEL HVDHQQQQQE SQEQELHVDQ
260 270 280 290 300
HQQQQESQEQ ELHVDQQQQE LQVQEVQQQQ QQQQEQQEDH QKAEHLEQEE
310 320 330 340
AQREQQLKGQ LEQEKKGVYQ HLDQELTKRD EHLEKKGEHC WSSRRSL
Length:347
Mass (Da):41,408
Last modified:November 1, 1990 - v1
Checksum:i3DE579871CF1C829
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34441 Genomic DNA. Translation: AAA31058.1.
PIRiI46592.
RefSeqiNP_999613.1. NM_214448.1.
UniGeneiSsc.101821.
Ssc.42788.

Genome annotation databases

GeneIDi407242.
KEGGissc:407242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34441 Genomic DNA. Translation: AAA31058.1.
PIRiI46592.
RefSeqiNP_999613.1. NM_214448.1.
UniGeneiSsc.101821.
Ssc.42788.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007032.

Proteomic databases

PaxDbiP18175.
PRIDEiP18175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi407242.
KEGGissc:407242.

Organism-specific databases

CTDi3713.

Phylogenomic databases

eggNOGiENOG410JDU1. Eukaryota.
ENOG410Z08K. LUCA.
HOGENOMiHOG000172481.
HOVERGENiHBG006166.
InParanoidiP18175.

Family and domain databases

InterProiIPR009733. Involucrin2.
IPR019743. Involucrin_CS.
IPR019571. Involucrin_N.
[Graphical view]
PfamiPF06994. Involucrin2. 6 hits.
PF10583. Involucrin_N. 1 hit.
[Graphical view]
PROSITEiPS00795. INVOLUCRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINVO_PIG
AccessioniPrimary (citable) accession number: P18175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.