P18175 (INVO_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Involucrin

Gene names

Name:

IVL

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Subunit structure	Directly or indirectly cross-linked to cornifelin (CNFN) By similarity.
Subcellular location	Cytoplasm. Note: Constituent of the scaffolding of the cornified envelope.
Tissue specificity	Keratinocytes of epidermis and other stratified squamous epithelia.
Post-translational modification	Substrate of transglutaminase. Specific glutamines or lysines are cross-linked to keratins, desmoplakin and to inter involucrin molecules.
Sequence similarities	Belongs to the involucrin family.

Ontologies

Keywords
Biological process	Keratinization
Cellular component	Cytoplasm
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	keratinization Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cornified envelope Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Involucrin		PRO_0000159741

Sequences

	Sequence		Length	Mass (Da)
	P18175 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 3DE579871CF1C829	FASTA	347	41,408
	10 20 30 40 50 60 MSQQYTLPVT LPPALSQEPL KPVSPPADTQ QEQVKQATPL PAPCQKMLSE LPVEVPLEDA 70 80 90 100 110 120 EKHTTLVKGV PEQECEPQPQ EPQQQELHVE QQQQQQESQV QELHVDQQQQ QQESQEQELH 130 140 150 160 170 180 VDQQQQQQES QEQELHVDQQ QQQESQVQEL HVGHHQQQQE SQEQELHVDH HQQQQESQEQ 190 200 210 220 230 240 ELHVDQQQQQ QESQEQELHV DQQQQQQESQ EQELHVDHHQ QQQESQVQEL HVDHQQQQQE 250 260 270 280 290 300 SQEQELHVDQ HQQQQESQEQ ELHVDQQQQE LQVQEVQQQQ QQQQEQQEDH QKAEHLEQEE 310 320 330 340 AQREQQLKGQ LEQEKKGVYQ HLDQELTKRD EHLEKKGEHC WSSRRSL

References

[1]	"The involucrin genes of pig and dog: comparison of their segments of repeats with those of prosimians and higher primates." Tseng H., Green H. Mol. Biol. Evol. 7:293-302(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M34441 Genomic DNA. Translation: AAA31058.1.
PIR	I46592.
RefSeq	NP_999613.1. NM_214448.1.
UniGene	Ssc.42788.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	407242.
KEGG	ssc:407242.
Organism-specific databases
CTD	3713.
Phylogenomic databases
eggNOG	NOG80441.
HOGENOM	HOG000172481.
HOVERGEN	HBG006166.
Family and domain databases
InterPro	IPR002360. Involucrin. IPR009733. Involucrin2. IPR019743. Involucrin_CS. IPR019571. Involucrin_N. [Graphical view]
PANTHER	PTHR13905. PTHR13905. 1 hit.
Pfam	PF06994. Involucrin2. 9 hits. PF10583. Involucrin_N. 1 hit. [Graphical view]
PROSITE	PS00795. INVOLUCRIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

INVO_PIG

Accession

Primary (citable) accession number: P18175

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program