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Protein

Glucose dehydrogenase [FAD, quinone]

Gene

Gld

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Essential for cuticular modification during development.

Catalytic activityi

D-glucose + a quinone = D-glucono-1,5-lactone + a quinol.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei544 – 5441Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 9530FADCuratedAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cuticle development Source: FlyBase
  • glucose metabolic process Source: FlyBase
  • pupal chitin-based cuticle development Source: FlyBase
  • sensory perception of pain Source: FlyBase
  • sperm storage Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose dehydrogenase [FAD, quinone] (EC:1.1.5.9)
Cleaved into the following chain:
Gene namesi
Name:Gld
ORF Names:CG1152
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0001112. Gld.

Subcellular locationi

  • Secreted

  • Note: Secreted as part of the seminal fluid transferred to females.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242Add
BLAST
Chaini43 – 625583Glucose dehydrogenase [FAD, quinone]PRO_0000012334Add
BLAST
Chaini43 – 612570Glucose dehydrogenase [FAD, quinone] short proteinPRO_0000012335Add
BLAST

Proteomic databases

PaxDbiP18173.

Expressioni

Gene expression databases

BgeeiFBgn0001112.
ExpressionAtlasiP18173. differential.
GenevisibleiP18173. DM.

Interactioni

Protein-protein interaction databases

BioGridi66070. 3 interactions.
IntActiP18173. 1 interaction.
MINTiMINT-1002609.
STRINGi7227.FBpp0081114.

Structurei

3D structure databases

ProteinModelPortaliP18173.
SMRiP18173. Positions 64-608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1238. Eukaryota.
COG2303. LUCA.
HOGENOMiHOG000219185.
InParanoidiP18173.
KOiK00108.
OrthoDBiEOG091G05AE.
PhylomeDBiP18173.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASASACDC LVGVPTGPTL ASTCGGSAFM LFMGLLEVFI RSQCDLEDPC
60 70 80 90 100
GRASSRFRSE PDYEYDFIVI GGGSAGSVVA SRLSEVPQWK VLLIEAGGDE
110 120 130 140 150
PVGAQIPSMF LNFIGSDIDY RYNTEPEPMA CLSSMEQRCY WPRGKVLGGT
160 170 180 190 200
SVLNGMMYVR GNREDYDDWA ADGNPGWAYN DVLPFFKKSE DNLDLDEVGT
210 220 230 240 250
EYHAKGGLLP VGKFPYNPPL SYAILKAGEE LGFSVHDLNG QNSTGFMIAQ
260 270 280 290 300
MTARNGIRYS SARAFLRPAR MRNNLHILLN TTATKILIHP HTKNVLGVEV
310 320 330 340 350
SDQFGSTRKI LVKKEVVLSA GAVNSPHILL LSGVGPKDEL QQVNVRTVHN
360 370 380 390 400
LPGVGKNLHN HVTYFTNFFI DDADTAPLNW ATAMEYLLFR DGLMSGTGIS
410 420 430 440 450
DVTAKLATRY ADSPERPDLQ LYFGGYLASC ARTGQVGELL SNNSRSIQIF
460 470 480 490 500
PAVLNPRSRG FIGLRSADPL EPPRIVANYL THEQDVKTLV EGIKFVIRLS
510 520 530 540 550
QTTPLKQYGM RLDKTVVKGC EAHAFGSDAY WECAVRQNTG PENHQAGSCK
560 570 580 590 600
MGPSHDPMAV VNHELRVHGI RGLRVMDTSI MPKVSSGNTH APAVMIAEKG
610 620
AYLLKRAWGA KVURVDATWT LHRVI
Length:625
Mass (Da):68,434
Last modified:February 26, 2008 - v3
Checksum:i02664FC3ABEEEDFC
GO

Sequence cautioni

The sequence AAA28571 differs from that shown. Reason: Erroneous termination at position 613. Translated as Sec.Curated
The sequence AAF54038 differs from that shown. Reason: Erroneous termination at position 613. Translated as Sec.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti484 – 4841Q → R in AAA28571 (PubMed:2108306).Curated

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei613 – 6131SelenocysteineCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29298 Genomic DNA. Translation: AAA28571.1. Sequence problems.
AE014297 Genomic DNA. Translation: AAF54038.1. Sequence problems.
X13582 Genomic DNA. Translation: CAA31918.1.
PIRiA39019.
RefSeqiNP_477503.1. NM_058155.5.

Genome annotation databases

GeneIDi40875.
KEGGidme:Dmel_CG1152.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29298 Genomic DNA. Translation: AAA28571.1. Sequence problems.
AE014297 Genomic DNA. Translation: AAF54038.1. Sequence problems.
X13582 Genomic DNA. Translation: CAA31918.1.
PIRiA39019.
RefSeqiNP_477503.1. NM_058155.5.

3D structure databases

ProteinModelPortaliP18173.
SMRiP18173. Positions 64-608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66070. 3 interactions.
IntActiP18173. 1 interaction.
MINTiMINT-1002609.
STRINGi7227.FBpp0081114.

Proteomic databases

PaxDbiP18173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi40875.
KEGGidme:Dmel_CG1152.

Organism-specific databases

CTDi40875.
FlyBaseiFBgn0001112. Gld.

Phylogenomic databases

eggNOGiKOG1238. Eukaryota.
COG2303. LUCA.
HOGENOMiHOG000219185.
InParanoidiP18173.
KOiK00108.
OrthoDBiEOG091G05AE.
PhylomeDBiP18173.

Miscellaneous databases

GenomeRNAii40875.
PROiP18173.

Gene expression databases

BgeeiFBgn0001112.
ExpressionAtlasiP18173. differential.
GenevisibleiP18173. DM.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHGL_DROME
AccessioniPrimary (citable) accession number: P18173
Secondary accession number(s): Q9VI87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.