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P18158

- GLPD_BACSU

UniProt

P18158 - GLPD_BACSU

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Protein

Aerobic glycerol-3-phosphate dehydrogenase

Gene

glpD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FAD.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 5229FADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: InterPro
  2. glycerol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciBSUB:BSU09300-MONOMER.
UniPathwayiUPA00618; UER00674.

Names & Taxonomyi

Protein namesi
Recommended name:
Aerobic glycerol-3-phosphate dehydrogenase (EC:1.1.5.3)
Gene namesi
Name:glpD
Ordered Locus Names:BSU09300
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU09300. [Micado]

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Aerobic glycerol-3-phosphate dehydrogenasePRO_0000126097Add
BLAST

Proteomic databases

PaxDbiP18158.

Expressioni

Inductioni

Requires glycerol 3-phosphate and the GlpP product; repressed by glucose.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU09300.

Structurei

3D structure databases

ProteinModelPortaliP18158.
SMRiP18158. Positions 6-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0578.
HOGENOMiHOG000004812.
InParanoidiP18158.
KOiK00111.
OrthoDBiEOG651SR7.
PhylomeDBiP18158.

Family and domain databases

InterProiIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18158-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMNHQFSSLE RDRMLTDMTK KTYDLFIIGG GITGAGTALD AASRGMKVAL
60 70 80 90 100
SEMQDFAAGT SSRSTKLVHG GLRYLKQFEV KMVAEVGKER AIVYENGPHV
110 120 130 140 150
TTPEWMLLPF HKGGTFGSFT TSIGLRVYDF LAGVKKSERR SMLSAKETLQ
160 170 180 190 200
KEPLVKKDGL KGGGYYVEYR TDDARLTIEV MKEAVKFGAE PVNYSKVKEL
210 220 230 240 250
LYEKGKAVGV LIEDVLTKKE YKVYAKKIVN ATGPWVDQLR EKDHSKNGKH
260 270 280 290 300
LQHTKGIHLV FDQSVFPLKQ AVYFDTPDGR MVFAIPREGK TYVGTTDTVY
310 320 330 340 350
KEALEHPRMT TEDRDYVIKS INYMFPELNI TANDIESSWA GLRPLIHEEG
360 370 380 390 400
KDPSEISRKD EIWTSDSGLI TIAGGKLTGY RKMAEHIVDL VRDRLKEEGE
410 420 430 440 450
KDFGPCKTKN MPISGGHVGG SKNLMSFVTA KTKEGIAAGL SEKDAKQLAI
460 470 480 490 500
RYGSNVDRVF DRVEALKDEA AKRNIPVHIL AEAEYSIEEE MTATPADFFV
510 520 530 540 550
RRTGRLFFDI NWVRTYKDAV IDFMSERFQW DEQAKNKHTE NLNKLLHDAV

VPLEQ
Length:555
Mass (Da):62,568
Last modified:June 16, 2009 - v2
Checksum:iA4181ACBC7E7F87A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti385 – 3862EH → DD in AAA22487. (PubMed:2127799)Curated
Sequence conflicti385 – 3862EH → DD in CAA74430. (PubMed:9579061)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34393 Genomic DNA. Translation: AAA22487.1.
Y14079 Genomic DNA. Translation: CAA74430.1.
AL009126 Genomic DNA. Translation: CAB12758.2.
PIRiC45868.
RefSeqiNP_388811.2. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB12758; CAB12758; BSU09300.
GeneIDi936250.
KEGGibsu:BSU09300.
PATRICi18973556. VBIBacSub10457_0972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34393 Genomic DNA. Translation: AAA22487.1 .
Y14079 Genomic DNA. Translation: CAA74430.1 .
AL009126 Genomic DNA. Translation: CAB12758.2 .
PIRi C45868.
RefSeqi NP_388811.2. NC_000964.3.

3D structure databases

ProteinModelPortali P18158.
SMRi P18158. Positions 6-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU09300.

Proteomic databases

PaxDbi P18158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB12758 ; CAB12758 ; BSU09300 .
GeneIDi 936250.
KEGGi bsu:BSU09300.
PATRICi 18973556. VBIBacSub10457_0972.

Organism-specific databases

GenoListi BSU09300. [Micado ]

Phylogenomic databases

eggNOGi COG0578.
HOGENOMi HOG000004812.
InParanoidi P18158.
KOi K00111.
OrthoDBi EOG651SR7.
PhylomeDBi P18158.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00674 .
BioCyci BSUB:BSU09300-MONOMER.

Family and domain databases

InterProi IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view ]
Pfami PF01266. DAO. 1 hit.
[Graphical view ]
PRINTSi PR01001. FADG3PDH.
PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Glycerol catabolism in Bacillus subtilis: nucleotide sequence of the genes encoding glycerol kinase (glpK) and glycerol-3-phosphate dehydrogenase (glpD)."
    Holmberg C., Beijer L., Rutberg B., Rutberg L.
    J. Gen. Microbiol. 136:2367-2375(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus subtilis chromosome contains several dysfunctional genes, the glyB marker, many genes encoding transporter proteins, and the ubiquitous hit gene."
    Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H., Venema G., Bron S.
    Microbiology 144:859-875(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 385-386.
  5. "Expression of the gene encoding glycerol-3-phosphate dehydrogenase (glpD) in Bacillus subtilis is controlled by antitermination."
    Holmberg C., Rutberg B.
    Mol. Microbiol. 5:2891-2900(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTIONAL REGULATION.

Entry informationi

Entry nameiGLPD_BACSU
AccessioniPrimary (citable) accession number: P18158
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3