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Protein

Glycerol uptake facilitator protein

Gene

glpF

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGlycerol metabolism, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU09280-MONOMER

Protein family/group databases

TCDBi1.A.8.2.1 the major intrinsic protein (mip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol uptake facilitator protein
Gene namesi
Name:glpF
Ordered Locus Names:BSU09280
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640771 – 274Glycerol uptake facilitator proteinAdd BLAST274

Proteomic databases

PaxDbiP18156
PRIDEiP18156

Expressioni

Inductioni

Requires glycerol 3-phosphate and the GlpP product; repressed by glucose.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100005123

Structurei

3D structure databases

ProteinModelPortaliP18156
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 66NPA 13
Motifi185 – 187NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580 LUCA
HOGENOMiHOG000288285
InParanoidiP18156
KOiK02440
OMAiQVVATMF
PhylomeDBiP18156

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR000425 MIP
IPR022357 MIP_CS
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequencei

Sequence statusi: Complete.

P18156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAFWGEVIG TMLLIIFGAG VCAGVNLKKS LSFQSGWIVV VFGWGLGVAM
60 70 80 90 100
AAYAVGGISG AHLNPALTIA LAFVGDFPWK EVPVYIAAQM IGAIIGAVII
110 120 130 140 150
YLHYLPHWKS TDDPAAKLGV FSTGPSIPHT FANVLSEVIG TFVLVLGILA
160 170 180 190 200
IGANQFTEGL NPLIVGFLIV AIGISLGGTT GYAINPARDL GPRIAHAFLP
210 220 230 240 250
IPGKGSSNWK YAWVPVVGPI LGGSFGGVFY NAAFKGHITS SFWIVSVILV
260 270
VVLLGLYVYT KSHSAKTLSN SKYI
Length:274
Mass (Da):28,735
Last modified:April 1, 1993 - v2
Checksum:i8624D0046A63075D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99611 Genomic DNA Translation: AAA22490.1
Y14079 Genomic DNA Translation: CAA74428.1
AL009126 Genomic DNA Translation: CAB12756.1
M34393 Genomic DNA Translation: AAA22485.1 Sequence problems.
PIRiC47700
RefSeqiNP_388809.1, NC_000964.3
WP_003233386.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB12756; CAB12756; BSU09280
GeneIDi939266
KEGGibsu:BSU09280
PATRICifig|224308.179.peg.1001

Similar proteinsi

Entry informationi

Entry nameiGLPF_BACSU
AccessioniPrimary (citable) accession number: P18156
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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