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Protein

37 kDa salivary gland allergen Aed a 2

Gene

D7

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thought to be involved in blood-feeding.1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
37 kDa salivary gland allergen Aed a 2
Alternative name(s):
Protein D7
Allergen: Aed a 2
Gene namesi
Name:D7
ORF Names:AAEL006424
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3540. Aed a 2.0101.
4. Aed a 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 32130437 kDa salivary gland allergen Aed a 2PRO_0000021059Add
BLAST

Expressioni

Tissue specificityi

Expressed in the distal-lateral and medial lobes of the adult female salivary gland.1 Publication

Structurei

Secondary structure

1
321
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 3815Combined sources
Helixi45 – 528Combined sources
Turni53 – 553Combined sources
Helixi63 – 7513Combined sources
Beta strandi78 – 803Combined sources
Turni81 – 844Combined sources
Helixi89 – 979Combined sources
Helixi99 – 1013Combined sources
Helixi104 – 11512Combined sources
Helixi124 – 13714Combined sources
Helixi139 – 1457Combined sources
Helixi150 – 16011Combined sources
Helixi161 – 1633Combined sources
Helixi171 – 1799Combined sources
Helixi187 – 1893Combined sources
Helixi190 – 1934Combined sources
Turni194 – 1963Combined sources
Helixi202 – 21413Combined sources
Helixi226 – 23510Combined sources
Helixi241 – 25212Combined sources
Helixi258 – 2603Combined sources
Helixi261 – 27111Combined sources
Helixi275 – 28915Combined sources
Turni292 – 2954Combined sources
Beta strandi296 – 2983Combined sources
Helixi304 – 31815Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DXLX-ray1.30A20-321[»]
3DY9X-ray1.70A20-321[»]
3DYEX-ray1.75A20-321[»]
3DZTX-ray1.80A20-321[»]
ProteinModelPortaliP18153.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18153.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000033906.
InParanoidiP18153.
OMAiTRCMEDN.
OrthoDBiEOG091G09SC.
PhylomeDBiP18153.

Family and domain databases

Gene3Di1.10.238.20. 2 hits.
InterProiIPR006170. PBP_GOBP.
[Graphical view]
PfamiPF01395. PBP_GOBP. 2 hits.
[Graphical view]
SMARTiSM00708. PhBP. 2 hits.
[Graphical view]
SUPFAMiSSF47565. SSF47565. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P18153-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLPLLLAIV TTFSVVASTG PFDPEEMLFT FTRCMEDNLE DGPNRLPMLA
60 70 80 90 100
KWKEWINEPV DSPATQCFGK CVLVRTGLYD PVAQKFDASV IQEQFKAYPS
110 120 130 140 150
LGEKSKVEAY ANAVQQLPST NNDCAAVFKA YDPVHKAHKD TSKNLFHGNK
160 170 180 190 200
ELTKGLYEKL GKDIRQKKQS YFEFCENKYY PAGSDKRQQL CKIRQYTVLD
210 220 230 240 250
DALFKEHTDC VMKGIRYITK NNELDAEEVK RDFMQVNKDT KALEKVLNDC
260 270 280 290 300
KSKEPSNAGE KSWHYYKCLV ESSVKDDFKE AFDYREVRSQ IYAFNLPKKQ
310 320
VYSKPAVQSQ VMEIDGKQCP Q
Length:321
Mass (Da):36,895
Last modified:July 22, 2008 - v2
Checksum:i9BAF0F0335B93070
GO
Isoform B (identifier: P18153-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-87: Missing.
     161-161: G → V
     162-226: Missing.

Show »
Length:242
Mass (Da):27,537
Checksum:i7D95CF83EC782D85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41P → L in AAA29347 (PubMed:2052024).Curated
Sequence conflicti10 – 101V → F in AAA29347 (PubMed:2052024).Curated
Sequence conflicti19 – 191T → M in AAA29347 (PubMed:2052024).Curated
Sequence conflicti19 – 191T → M in AAD01849 (PubMed:10436938).Curated
Sequence conflicti30 – 301T → I in AAA29347 (PubMed:2052024).Curated
Sequence conflicti30 – 301T → I in AAD01849 (PubMed:10436938).Curated
Sequence conflicti43 – 431P → A in AAA29347 (PubMed:2052024).Curated
Sequence conflicti43 – 431P → A in AAD01849 (PubMed:10436938).Curated
Sequence conflicti115 – 1151Q → K in AAA29347 (PubMed:2052024).Curated
Sequence conflicti115 – 1151Q → K in AAD01849 (PubMed:10436938).Curated
Sequence conflicti169 – 1691Q → K in AAA29348 (PubMed:2052024).Curated
Sequence conflicti192 – 1921K → Q in AAA29347 (PubMed:2052024).Curated
Sequence conflicti221 – 2266NNELDA → DNQLDV in AAA29347 (PubMed:2052024).Curated
Sequence conflicti234 – 2352MQ → KL in AAA29347 (PubMed:2052024).Curated
Sequence conflicti234 – 2352MQ → KL in AAA29348 (PubMed:2052024).Curated
Sequence conflicti234 – 2352MQ → KL in AAD01849 (PubMed:10436938).Curated
Sequence conflicti259 – 2591G → K in AAA29347 (PubMed:2052024).Curated
Sequence conflicti259 – 2591G → K in AAA29348 (PubMed:2052024).Curated
Sequence conflicti259 – 2591G → K in AAD01849 (PubMed:10436938).Curated
Sequence conflicti301 – 3011V → A in AAA29347 (PubMed:2052024).Curated
Sequence conflicti301 – 3011V → A in AAA29348 (PubMed:2052024).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei74 – 8714Missing in isoform B. 1 PublicationVSP_034863Add
BLAST
Alternative sequencei161 – 1611G → V in isoform B. 1 PublicationVSP_034864
Alternative sequencei162 – 22665Missing in isoform B. 1 PublicationVSP_034865Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33156 Genomic DNA. Translation: AAA29347.1.
M33157 mRNA. Translation: AAA29348.1.
EF173376 Genomic DNA. Translation: ABM68616.1.
CH477389 Genomic DNA. Translation: EAT41994.1.
AF027814 mRNA. Translation: AAD01849.1.
RefSeqiXP_001657779.1. XM_001657729.1. [P18153-1]
UniGeneiAae.5737.

Genome annotation databases

EnsemblMetazoaiAAEL006424-RA; AAEL006424-PA; AAEL006424. [P18153-1]
GeneIDi5567958.
KEGGiaag:AaeL_AAEL006424.
VectorBaseiAAEL006424-RA; AAEL006424-PA; AAEL006424.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33156 Genomic DNA. Translation: AAA29347.1.
M33157 mRNA. Translation: AAA29348.1.
EF173376 Genomic DNA. Translation: ABM68616.1.
CH477389 Genomic DNA. Translation: EAT41994.1.
AF027814 mRNA. Translation: AAD01849.1.
RefSeqiXP_001657779.1. XM_001657729.1. [P18153-1]
UniGeneiAae.5737.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DXLX-ray1.30A20-321[»]
3DY9X-ray1.70A20-321[»]
3DYEX-ray1.75A20-321[»]
3DZTX-ray1.80A20-321[»]
ProteinModelPortaliP18153.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3540. Aed a 2.0101.
4. Aed a 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAAEL006424-RA; AAEL006424-PA; AAEL006424. [P18153-1]
GeneIDi5567958.
KEGGiaag:AaeL_AAEL006424.
VectorBaseiAAEL006424-RA; AAEL006424-PA; AAEL006424.

Organism-specific databases

CTDi5567958.

Phylogenomic databases

HOGENOMiHOG000033906.
InParanoidiP18153.
OMAiTRCMEDN.
OrthoDBiEOG091G09SC.
PhylomeDBiP18153.

Miscellaneous databases

EvolutionaryTraceiP18153.

Family and domain databases

Gene3Di1.10.238.20. 2 hits.
InterProiIPR006170. PBP_GOBP.
[Graphical view]
PfamiPF01395. PBP_GOBP. 2 hits.
[Graphical view]
SMARTiSM00708. PhBP. 2 hits.
[Graphical view]
SUPFAMiSSF47565. SSF47565. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiALL2_AEDAE
AccessioniPrimary (citable) accession number: P18153
Secondary accession number(s): O96364, Q0IF92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 22, 2008
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.