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Protein

37 kDa salivary gland allergen Aed a 2

Gene

D7

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thought to be involved in blood-feeding.1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
37 kDa salivary gland allergen Aed a 2
Alternative name(s):
Protein D7
Allergen: Aed a 2
Gene namesi
Name:D7
ORF Names:AAEL006424
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3540. Aed a 2.0101.
4. Aed a 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002105918 – 32137 kDa salivary gland allergen Aed a 2Add BLAST304

Expressioni

Tissue specificityi

Expressed in the distal-lateral and medial lobes of the adult female salivary gland.1 Publication

Structurei

Secondary structure

1321
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 38Combined sources15
Helixi45 – 52Combined sources8
Turni53 – 55Combined sources3
Helixi63 – 75Combined sources13
Beta strandi78 – 80Combined sources3
Turni81 – 84Combined sources4
Helixi89 – 97Combined sources9
Helixi99 – 101Combined sources3
Helixi104 – 115Combined sources12
Helixi124 – 137Combined sources14
Helixi139 – 145Combined sources7
Helixi150 – 160Combined sources11
Helixi161 – 163Combined sources3
Helixi171 – 179Combined sources9
Helixi187 – 189Combined sources3
Helixi190 – 193Combined sources4
Turni194 – 196Combined sources3
Helixi202 – 214Combined sources13
Helixi226 – 235Combined sources10
Helixi241 – 252Combined sources12
Helixi258 – 260Combined sources3
Helixi261 – 271Combined sources11
Helixi275 – 289Combined sources15
Turni292 – 295Combined sources4
Beta strandi296 – 298Combined sources3
Helixi304 – 318Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DXLX-ray1.30A20-321[»]
3DY9X-ray1.70A20-321[»]
3DYEX-ray1.75A20-321[»]
3DZTX-ray1.80A20-321[»]
ProteinModelPortaliP18153.
SMRiP18153.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18153.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000033906.
InParanoidiP18153.
OMAiTRCMEDN.
OrthoDBiEOG091G09SC.
PhylomeDBiP18153.

Family and domain databases

Gene3Di1.10.238.20. 2 hits.
InterProiIPR006170. PBP_GOBP.
[Graphical view]
PfamiPF01395. PBP_GOBP. 2 hits.
[Graphical view]
SMARTiSM00708. PhBP. 2 hits.
[Graphical view]
SUPFAMiSSF47565. SSF47565. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P18153-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLPLLLAIV TTFSVVASTG PFDPEEMLFT FTRCMEDNLE DGPNRLPMLA
60 70 80 90 100
KWKEWINEPV DSPATQCFGK CVLVRTGLYD PVAQKFDASV IQEQFKAYPS
110 120 130 140 150
LGEKSKVEAY ANAVQQLPST NNDCAAVFKA YDPVHKAHKD TSKNLFHGNK
160 170 180 190 200
ELTKGLYEKL GKDIRQKKQS YFEFCENKYY PAGSDKRQQL CKIRQYTVLD
210 220 230 240 250
DALFKEHTDC VMKGIRYITK NNELDAEEVK RDFMQVNKDT KALEKVLNDC
260 270 280 290 300
KSKEPSNAGE KSWHYYKCLV ESSVKDDFKE AFDYREVRSQ IYAFNLPKKQ
310 320
VYSKPAVQSQ VMEIDGKQCP Q
Length:321
Mass (Da):36,895
Last modified:July 22, 2008 - v2
Checksum:i9BAF0F0335B93070
GO
Isoform B (identifier: P18153-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-87: Missing.
     161-161: G → V
     162-226: Missing.

Show »
Length:242
Mass (Da):27,537
Checksum:i7D95CF83EC782D85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4P → L in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti10V → F in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti19T → M in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti19T → M in AAD01849 (PubMed:10436938).Curated1
Sequence conflicti30T → I in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti30T → I in AAD01849 (PubMed:10436938).Curated1
Sequence conflicti43P → A in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti43P → A in AAD01849 (PubMed:10436938).Curated1
Sequence conflicti115Q → K in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti115Q → K in AAD01849 (PubMed:10436938).Curated1
Sequence conflicti169Q → K in AAA29348 (PubMed:2052024).Curated1
Sequence conflicti192K → Q in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti221 – 226NNELDA → DNQLDV in AAA29347 (PubMed:2052024).Curated6
Sequence conflicti234 – 235MQ → KL in AAA29347 (PubMed:2052024).Curated2
Sequence conflicti234 – 235MQ → KL in AAA29348 (PubMed:2052024).Curated2
Sequence conflicti234 – 235MQ → KL in AAD01849 (PubMed:10436938).Curated2
Sequence conflicti259G → K in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti259G → K in AAA29348 (PubMed:2052024).Curated1
Sequence conflicti259G → K in AAD01849 (PubMed:10436938).Curated1
Sequence conflicti301V → A in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti301V → A in AAA29348 (PubMed:2052024).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03486374 – 87Missing in isoform B. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_034864161G → V in isoform B. 1 Publication1
Alternative sequenceiVSP_034865162 – 226Missing in isoform B. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33156 Genomic DNA. Translation: AAA29347.1.
M33157 mRNA. Translation: AAA29348.1.
EF173376 Genomic DNA. Translation: ABM68616.1.
CH477389 Genomic DNA. Translation: EAT41994.1.
AF027814 mRNA. Translation: AAD01849.1.
RefSeqiXP_001657779.1. XM_001657729.1. [P18153-1]
UniGeneiAae.5737.

Genome annotation databases

EnsemblMetazoaiAAEL006424-RA; AAEL006424-PA; AAEL006424. [P18153-1]
GeneIDi5567958.
KEGGiaag:AaeL_AAEL006424.
VectorBaseiAAEL006424-RA; AAEL006424-PA; AAEL006424.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33156 Genomic DNA. Translation: AAA29347.1.
M33157 mRNA. Translation: AAA29348.1.
EF173376 Genomic DNA. Translation: ABM68616.1.
CH477389 Genomic DNA. Translation: EAT41994.1.
AF027814 mRNA. Translation: AAD01849.1.
RefSeqiXP_001657779.1. XM_001657729.1. [P18153-1]
UniGeneiAae.5737.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DXLX-ray1.30A20-321[»]
3DY9X-ray1.70A20-321[»]
3DYEX-ray1.75A20-321[»]
3DZTX-ray1.80A20-321[»]
ProteinModelPortaliP18153.
SMRiP18153.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3540. Aed a 2.0101.
4. Aed a 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAAEL006424-RA; AAEL006424-PA; AAEL006424. [P18153-1]
GeneIDi5567958.
KEGGiaag:AaeL_AAEL006424.
VectorBaseiAAEL006424-RA; AAEL006424-PA; AAEL006424.

Organism-specific databases

CTDi5567958.

Phylogenomic databases

HOGENOMiHOG000033906.
InParanoidiP18153.
OMAiTRCMEDN.
OrthoDBiEOG091G09SC.
PhylomeDBiP18153.

Miscellaneous databases

EvolutionaryTraceiP18153.

Family and domain databases

Gene3Di1.10.238.20. 2 hits.
InterProiIPR006170. PBP_GOBP.
[Graphical view]
PfamiPF01395. PBP_GOBP. 2 hits.
[Graphical view]
SMARTiSM00708. PhBP. 2 hits.
[Graphical view]
SUPFAMiSSF47565. SSF47565. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiALL2_AEDAE
AccessioniPrimary (citable) accession number: P18153
Secondary accession number(s): O96364, Q0IF92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.