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P18153 (ALL2_AEDAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
37 kDa salivary gland allergen Aed a 2
Alternative name(s):
Protein D7
Allergen=Aed a 2
Gene names
Name:D7
ORF Names:AAEL006424
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thought to be involved in blood-feeding. Ref.1

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed in the distal-lateral and medial lobes of the adult female salivary gland. Ref.1

Allergenic properties

Causes an allergic reaction in human.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DiseaseAllergen
   DomainSignal
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionodorant binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: P18153-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: P18153-2)

The sequence of this isoform differs from the canonical sequence as follows:
     74-87: Missing.
     161-161: G → V
     162-226: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 32130437 kDa salivary gland allergen Aed a 2
PRO_0000021059

Natural variations

Alternative sequence74 – 8714Missing in isoform B.
VSP_034863
Alternative sequence1611G → V in isoform B.
VSP_034864
Alternative sequence162 – 22665Missing in isoform B.
VSP_034865

Experimental info

Sequence conflict41P → L in AAA29347. Ref.1
Sequence conflict101V → F in AAA29347. Ref.1
Sequence conflict191T → M in AAA29347. Ref.1
Sequence conflict191T → M in AAD01849. Ref.4
Sequence conflict301T → I in AAA29347. Ref.1
Sequence conflict301T → I in AAD01849. Ref.4
Sequence conflict431P → A in AAA29347. Ref.1
Sequence conflict431P → A in AAD01849. Ref.4
Sequence conflict1151Q → K in AAA29347. Ref.1
Sequence conflict1151Q → K in AAD01849. Ref.4
Sequence conflict1691Q → K in AAA29348. Ref.1
Sequence conflict1921K → Q in AAA29347. Ref.1
Sequence conflict221 – 2266NNELDA → DNQLDV in AAA29347. Ref.1
Sequence conflict234 – 2352MQ → KL in AAA29347. Ref.1
Sequence conflict234 – 2352MQ → KL in AAA29348. Ref.1
Sequence conflict234 – 2352MQ → KL in AAD01849. Ref.4
Sequence conflict2591G → K in AAA29347. Ref.1
Sequence conflict2591G → K in AAA29348. Ref.1
Sequence conflict2591G → K in AAD01849. Ref.4
Sequence conflict3011V → A in AAA29347. Ref.1
Sequence conflict3011V → A in AAA29348. Ref.1

Secondary structure

1 ............................................. 321
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: 9BAF0F0335B93070

FASTA32136,895
        10         20         30         40         50         60 
MKLPLLLAIV TTFSVVASTG PFDPEEMLFT FTRCMEDNLE DGPNRLPMLA KWKEWINEPV 

        70         80         90        100        110        120 
DSPATQCFGK CVLVRTGLYD PVAQKFDASV IQEQFKAYPS LGEKSKVEAY ANAVQQLPST 

       130        140        150        160        170        180 
NNDCAAVFKA YDPVHKAHKD TSKNLFHGNK ELTKGLYEKL GKDIRQKKQS YFEFCENKYY 

       190        200        210        220        230        240 
PAGSDKRQQL CKIRQYTVLD DALFKEHTDC VMKGIRYITK NNELDAEEVK RDFMQVNKDT 

       250        260        270        280        290        300 
KALEKVLNDC KSKEPSNAGE KSWHYYKCLV ESSVKDDFKE AFDYREVRSQ IYAFNLPKKQ 

       310        320 
VYSKPAVQSQ VMEIDGKQCP Q

« Hide

Isoform B [UniParc].

Checksum: 7D95CF83EC782D85
Show »

FASTA24227,537

References

« Hide 'large scale' references
[1]"Isolation and characterization of the gene expressing the major salivary gland protein of the female mosquito, Aedes aegypti."
James A.A., Blackmer K., Marinotti O., Ghosn C.R., Racioppi J.V.
Mol. Biochem. Parasitol. 44:245-254(1991) [PubMed: 2052024] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM A), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: Rockefeller.
Tissue: Salivary gland.
[2]"Analysis of 14 BAC sequences from the Aedes aegypti genome: a benchmark for genome annotation and assembly."
Lobo N.F., Campbell K.S., Thaner D., Debruyn B., Koo H., Gelbart W.M., Loftus B.J., Severson D.W., Collins F.H.
Genome Biol. 8:R88.1-R88.12(2007) [PubMed: 17519023] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Liverpool.
[3]"Genome sequence of Aedes aegypti, a major arbovirus vector."
Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. expand/collapse author list , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
Science 316:1718-1723(2007) [PubMed: 17510324] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LVPib12.
[4]"Vertebrate exon trapping methods: implications for transcript mapping with mosquito DNA."
Brown S.E., Wood S.H., Knudson D.L.
Insect Biochem. Mol. Biol. 29:643-651(1999) [PubMed: 10436938] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-286 (ISOFORM B).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M33156 Genomic DNA. Translation: AAA29347.1.
M33157 mRNA. Translation: AAA29348.1.
EF173376 Genomic DNA. Translation: ABM68616.1.
CH477389 Genomic DNA. Translation: EAT41994.1.
AF027814 mRNA. Translation: AAD01849.1.
RefSeqXP_001657779.1. XM_001657729.1.
UniGeneAae.21977.
Aae.5737.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3DXLX-ray1.30A20-321[»]
3DY9X-ray1.70A20-321[»]
3DYEX-ray1.75A20-321[»]
3DZTX-ray1.80A20-321[»]
ProteinModelPortalP18153.
ModBaseSearch...

Protein family/group databases

Allergome3540. Aed a 2.0101.
4. Aed a 2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAAEL006424-RA; AAEL006424-PA; AAEL006424.
GeneID5567958.
KEGGaag:AaeL_AAEL006424.

Phylogenomic databases

GeneTreeEMGT00050000012178.
InParanoidP18153.
OMATRCMEDN.
OrthoDBEOG431ZFP.

Family and domain databases

InterProIPR006625. Insect_phero_odorant-bd.
IPR006170. PBP_GOBP.
IPR023316. PBP_GOBP_dom.
[Graphical view]
Gene3DG3DSA:1.10.238.20. PBP_GOBP. 2 hits.
PfamPF01395. PBP_GOBP. 2 hits.
[Graphical view]
SMARTSM00708. PhBP. 2 hits.
[Graphical view]
SUPFAMSSF47565. PBP_GOBP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALL2_AEDAE
AccessionPrimary (citable) accession number: P18153
Secondary accession number(s): O96364, Q0IF92
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 22, 2008
Last modified: January 25, 2012
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Allergens

Nomenclature of allergens and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents