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P18146

- EGR1_HUMAN

UniProt

P18146 - EGR1_HUMAN

Protein

Early growth response protein 1

Gene

EGR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri338 – 36225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. double-stranded DNA binding Source: Ensembl
    3. histone acetyltransferase binding Source: BHF-UCL
    4. metal ion binding Source: UniProtKB-KW
    5. protein binding Source: UniProtKB
    6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    7. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    8. sequence-specific DNA binding Source: UniProtKB
    9. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    10. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. BMP signaling pathway Source: Ensembl
    2. cellular response to antibiotic Source: Ensembl
    3. cellular response to cAMP Source: RefGenome
    4. cellular response to drug Source: Ensembl
    5. cellular response to follicle-stimulating hormone stimulus Source: Ensembl
    6. cellular response to gamma radiation Source: Ensembl
    7. cellular response to gonadotropin stimulus Source: RefGenome
    8. cellular response to growth factor stimulus Source: Ensembl
    9. cellular response to heparin Source: UniProtKB
    10. cellular response to hyperoxia Source: Ensembl
    11. cellular response to hypoxia Source: Ensembl
    12. cellular response to insulin stimulus Source: Ensembl
    13. cellular response to isoquinoline alkaloid Source: Ensembl
    14. cellular response to mechanical stimulus Source: Ensembl
    15. cellular response to mycophenolic acid Source: UniProtKB
    16. cellular response to steroid hormone stimulus Source: Ensembl
    17. circadian rhythm Source: Ensembl
    18. cytokine-mediated signaling pathway Source: Reactome
    19. glomerular mesangial cell proliferation Source: UniProtKB
    20. interleukin-1-mediated signaling pathway Source: BHF-UCL
    21. learning or memory Source: Ensembl
    22. long-term synaptic potentiation Source: Ensembl
    23. negative regulation of apoptotic process Source: RefGenome
    24. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    25. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    26. oligodendrocyte differentiation Source: Ensembl
    27. positive regulation of glomerular metanephric mesangial cell proliferation Source: UniProtKB
    28. positive regulation of neuron apoptotic process Source: Ensembl
    29. positive regulation of transcription, DNA-templated Source: UniProtKB
    30. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    31. regulation of long-term neuronal synaptic plasticity Source: RefGenome
    32. regulation of protein sumoylation Source: BHF-UCL
    33. response to amphetamine Source: Ensembl
    34. response to carbon monoxide Source: Ensembl
    35. response to cocaine Source: Ensembl
    36. response to electrical stimulus Source: Ensembl
    37. response to ethanol Source: Ensembl
    38. response to glucose Source: Ensembl
    39. response to norepinephrine Source: Ensembl
    40. response to nutrient levels Source: Ensembl
    41. skeletal muscle cell differentiation Source: RefGenome
    42. T cell differentiation Source: Ensembl
    43. transcription from RNA polymerase II promoter Source: BHF-UCL
    44. type I interferon signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_25162. Interferon alpha/beta signaling.
    SignaLinkiP18146.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Early growth response protein 1
    Short name:
    EGR-1
    Alternative name(s):
    AT225
    Nerve growth factor-induced protein A
    Short name:
    NGFI-A
    Transcription factor ETR103
    Transcription factor Zif268
    Zinc finger protein 225
    Zinc finger protein Krox-24
    Gene namesi
    Name:EGR1
    Synonyms:KROX24, ZNF225
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:3238. EGR1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleoplasm Source: Reactome
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27673.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Early growth response protein 1PRO_0000047109Add
    BLAST

    Proteomic databases

    PaxDbiP18146.
    PRIDEiP18146.

    PTM databases

    PhosphoSiteiP18146.

    Expressioni

    Inductioni

    By growth factors.

    Gene expression databases

    ArrayExpressiP18146.
    BgeeiP18146.
    CleanExiHS_EGR1.
    HS_ZNF225.
    GenevestigatoriP18146.

    Organism-specific databases

    HPAiCAB019427.
    HPA029938.

    Interactioni

    Subunit structurei

    Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDKN2AQ8N7264EBI-2834611,EBI-625922
    CTNNB1P352227EBI-2834611,EBI-491549

    Protein-protein interaction databases

    BioGridi108278. 23 interactions.
    IntActiP18146. 13 interactions.
    MINTiMINT-234136.
    STRINGi9606.ENSP00000239938.

    Structurei

    3D structure databases

    ProteinModelPortaliP18146.
    SMRiP18146. Positions 336-444.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi57 – 8428Gly/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri338 – 36225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000036856.
    HOVERGENiHBG003909.
    InParanoidiP18146.
    KOiK09203.
    OMAiAVTNSFS.
    OrthoDBiEOG7Z69C7.
    PhylomeDBiP18146.
    TreeFamiTF318980.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR021839. DUF3432.
    IPR021849. DUF3446.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF11914. DUF3432. 2 hits.
    PF11928. DUF3446. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18146-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG    50
    AAGAPEGSGS NSSSSSSGGG GGGGGGSNSS SSSSTFNPQA DTGEQPYEHL 100
    TAESFPDISL NNEKVLVETS YPSQTTRLPP ITYTGRFSLE PAPNSGNTLW 150
    PEPLFSLVSG LVSMTNPPAS SSSAPSPAAS SASASQSPPL SCAVPSNDSS 200
    PIYSAAPTFP TPNTDIFPEP QSQAFPGSAG TALQYPPPAY PAAKGGFQVP 250
    MIPDYLFPQQ QGDLGLGTPD QKPFQGLESR TQQPSLTPLS TIKAFATQSG 300
    SQDLKALNTS YQSQLIKPSR MRKYPNRPSK TPPHERPYAC PVESCDRRFS 350
    RSDELTRHIR IHTGQKPFQC RICMRNFSRS DHLTTHIRTH TGEKPFACDI 400
    CGRKFARSDE RKRHTKIHLR QKDKKADKSV VASSATSSLS SYPSPVATSY 450
    PSPVTTSYPS PATTSYPSPV PTSFSSPGSS TYPSPVHSGF PSPSVATTYS 500
    SVPPAFPAQV SSFPSSAVTN SFSASTGLSD MTATFSPRTI EIC 543
    Length:543
    Mass (Da):57,507
    Last modified:November 1, 1990 - v1
    Checksum:i768CE670D9743E4E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281T → I.
    Corresponds to variant rs13181973 [ dbSNP | Ensembl ].
    VAR_052712
    Natural varianti144 – 1441N → K.
    Corresponds to variant rs28365166 [ dbSNP | Ensembl ].
    VAR_029330
    Natural varianti145 – 1451S → R.
    Corresponds to variant rs28365164 [ dbSNP | Ensembl ].
    VAR_029331
    Natural varianti219 – 2191E → D.
    Corresponds to variant rs28365165 [ dbSNP | Ensembl ].
    VAR_029332

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52541 mRNA. Translation: CAA36777.1.
    M62829 mRNA. Translation: AAA35815.1.
    M80583 mRNA. No translation available.
    BC073983 mRNA. Translation: AAH73983.1.
    CCDSiCCDS4206.1.
    PIRiA41211.
    RefSeqiNP_001955.1. NM_001964.2.
    UniGeneiHs.326035.
    Hs.708393.

    Genome annotation databases

    EnsembliENST00000239938; ENSP00000239938; ENSG00000120738.
    GeneIDi1958.
    KEGGihsa:1958.
    UCSCiuc003ldb.1. human.

    Polymorphism databases

    DMDMi119242.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52541 mRNA. Translation: CAA36777.1 .
    M62829 mRNA. Translation: AAA35815.1 .
    M80583 mRNA. No translation available.
    BC073983 mRNA. Translation: AAH73983.1 .
    CCDSi CCDS4206.1.
    PIRi A41211.
    RefSeqi NP_001955.1. NM_001964.2.
    UniGenei Hs.326035.
    Hs.708393.

    3D structure databases

    ProteinModelPortali P18146.
    SMRi P18146. Positions 336-444.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108278. 23 interactions.
    IntActi P18146. 13 interactions.
    MINTi MINT-234136.
    STRINGi 9606.ENSP00000239938.

    PTM databases

    PhosphoSitei P18146.

    Polymorphism databases

    DMDMi 119242.

    Proteomic databases

    PaxDbi P18146.
    PRIDEi P18146.

    Protocols and materials databases

    DNASUi 1958.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000239938 ; ENSP00000239938 ; ENSG00000120738 .
    GeneIDi 1958.
    KEGGi hsa:1958.
    UCSCi uc003ldb.1. human.

    Organism-specific databases

    CTDi 1958.
    GeneCardsi GC05P137801.
    HGNCi HGNC:3238. EGR1.
    HPAi CAB019427.
    HPA029938.
    MIMi 128990. gene.
    neXtProti NX_P18146.
    PharmGKBi PA27673.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000036856.
    HOVERGENi HBG003909.
    InParanoidi P18146.
    KOi K09203.
    OMAi AVTNSFS.
    OrthoDBi EOG7Z69C7.
    PhylomeDBi P18146.
    TreeFami TF318980.

    Enzyme and pathway databases

    Reactomei REACT_25162. Interferon alpha/beta signaling.
    SignaLinki P18146.

    Miscellaneous databases

    ChiTaRSi EGR1. human.
    GeneWikii EGR1.
    GenomeRNAii 1958.
    NextBioi 7943.
    PROi P18146.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18146.
    Bgeei P18146.
    CleanExi HS_EGR1.
    HS_ZNF225.
    Genevestigatori P18146.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR021839. DUF3432.
    IPR021849. DUF3446.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF11914. DUF3432. 2 hits.
    PF11928. DUF3446. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence of the human cellular early growth response gene Egr-1."
      Suggs S.V., Katzowitz J.L., Tsai-Morris C.-H., Sukhatme V.P.
      Nucleic Acids Res. 18:4283-4283(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Foreskin.
    2. "A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation."
      Shimizu N., Ohta M., Fujiwara C., Sagara J., Mochizuki N., Oda T., Utiyama H.
      J. Biochem. 111:272-277(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells."
      Wright J.J., Gunter K.C., Mitsuya H., Irving S.G., Kelly K., Siebenlist U.
      Science 248:588-591(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PNS.
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    6. "Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b."
      Hu C.T., Chang T.Y., Cheng C.C., Liu C.S., Wu J.R., Li M.C., Wu W.S.
      FEBS J. 277:1202-1218(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNAI1 AND SP1.

    Entry informationi

    Entry nameiEGR1_HUMAN
    AccessioniPrimary (citable) accession number: P18146
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 146 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3