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Protein

Alpha-lactalbumin

Gene

LALBA

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi96 – 10712PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Keywords - Biological processi

Lactose biosynthesis

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-SSC-5653890. Lactose synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-lactalbumin
Alternative name(s):
Lactose synthase B protein
Gene namesi
Name:LALBA
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 141122Alpha-lactalbuminPRO_0000018447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 138PROSITE-ProRule annotation
Disulfide bondi47 ↔ 129PROSITE-ProRule annotation
Disulfide bondi80 ↔ 95PROSITE-ProRule annotation
Disulfide bondi91 ↔ 109PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP18137.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

GenevisibleiP18137. SS.

Interactioni

Subunit structurei

Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024183.

Structurei

3D structure databases

ProteinModelPortaliP18137.
SMRiP18137. Positions 20-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX41. Eukaryota.
ENOG410ZQK6. LUCA.
GeneTreeiENSGT00550000074398.
HOVERGENiHBG052297.
InParanoidiP18137.
KOiK00704.
OMAiLAHKPLC.
OrthoDBiEOG7BW0M5.
TreeFamiTF324882.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000545. Lactalbumin.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00136. LACTALBUMIN.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSFVSLLVV GILFPAIQAK QFTKCELSQV LKDMDGYGDI TLPEWICTIF
60 70 80 90 100
HISGYDTKTI VHDNGSTEYG LFQINNKLWC RDNQIQSKNI CGISCDKFLD
110 120 130 140
DDLTDDMMCA KKILDNEGID YWLAHKALCS EKLDQWLCEK M
Length:141
Mass (Da):16,174
Last modified:May 1, 1992 - v2
Checksum:iC1524571466A0D27
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 632HD → SN AA sequence (PubMed:2222864).Curated
Sequence conflicti107 – 1071M → D AA sequence (PubMed:2222864).Curated
Sequence conflicti141 – 1411M → L AA sequence (PubMed:2222864).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80520 mRNA. Translation: AAA31060.1.
PIRiJH0264. LAPG.
RefSeqiNP_999525.1. NM_214360.1.
UniGeneiSsc.13765.

Genome annotation databases

EnsembliENSSSCT00000025257; ENSSSCP00000024183; ENSSSCG00000024573.
GeneIDi397647.
KEGGissc:397647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80520 mRNA. Translation: AAA31060.1.
PIRiJH0264. LAPG.
RefSeqiNP_999525.1. NM_214360.1.
UniGeneiSsc.13765.

3D structure databases

ProteinModelPortaliP18137.
SMRiP18137. Positions 20-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024183.

Proteomic databases

PaxDbiP18137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000025257; ENSSSCP00000024183; ENSSSCG00000024573.
GeneIDi397647.
KEGGissc:397647.

Organism-specific databases

CTDi3906.

Phylogenomic databases

eggNOGiENOG410IX41. Eukaryota.
ENOG410ZQK6. LUCA.
GeneTreeiENSGT00550000074398.
HOVERGENiHBG052297.
InParanoidiP18137.
KOiK00704.
OMAiLAHKPLC.
OrthoDBiEOG7BW0M5.
TreeFamiTF324882.

Enzyme and pathway databases

ReactomeiR-SSC-5653890. Lactose synthesis.

Gene expression databases

GenevisibleiP18137. SS.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000545. Lactalbumin.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00136. LACTALBUMIN.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The sequence of a porcine cDNA encoding alpha-lactalbumin."
    Das Gupta N.A., Alexander L.J., Beattie C.W.
    Gene 110:265-266(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The complete primary structure of alpha-lactalbumin isolated from pig (Sus scrofa) milk."
    Godovac-Zimmermann J., Conti A., Napolitano L.
    Biol. Chem. Hoppe-Seyler 371:649-653(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-141.

Entry informationi

Entry nameiLALBA_PIG
AccessioniPrimary (citable) accession number: P18137
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: May 1, 1992
Last modified: November 11, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The pig alpha-lactalbumin shows complete loss of both lysozyme functional residues.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.