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P18134 (HPRT_VIBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypoxanthine phosphoribosyltransferase

Short name=HPRT
EC=2.4.2.8
Gene names
Name:hpt
OrganismVibrio harveyi (Beneckea harveyi)
Taxonomic identifier669 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine By similarity.

Catalytic activity

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactor

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

Subunit structure

Homotetramer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 176176Hypoxanthine phosphoribosyltransferase
PRO_0000139637

Regions

Nucleotide binding98 – 10710IMP By similarity
Nucleotide binding157 – 1582IMP By similarity

Sites

Active site1021Proton acceptor By similarity
Metal binding1581Magnesium By similarity
Binding site1301IMP By similarity
Binding site1521IMP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P18134 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 2027D73A9CAAAACE

FASTA17619,963
        10         20         30         40         50         60 
MKHTVEVMIS EQEVQERIRE LGKQITERYQ GSEDLVMVGL LRGSFVFMAD LARAIELTHQ 

        70         80         90        100        110        120 
VDFMTASSYG NTMESSRDVR ILKDLDDDIK GKDVLIVEDI IDTGNTLNKI REILSLREPK 

       130        140        150        160        170 
SIAICTLLDK PSRREVEVPV DYVGFAIPDE FVVGVGIDYA QKYRDLPFIG KVVPQE 

« Hide

References

[1]"Nucleotide sequence of a gene, hpt, for hypoxanthine phosphoribosyltransferase from Vibrio harveyi."
Showalter R.E., Silverman M.R.
Nucleic Acids Res. 18:4621-4621(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53382 Genomic DNA. Translation: CAA37462.1.
PIRS10993.

3D structure databases

ProteinModelPortalP18134.
SMRP18134. Positions 1-173.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP18134.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-3881-MONOMER.
UniPathwayUPA00591; UER00648.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
InterProIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01203. HGPRTase. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPRT_VIBHA
AccessionPrimary (citable) accession number: P18134
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways