Skip Header

Contribute Send feedback
Read comments (?) or add your own

P18130 (ADA1A_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-1A adrenergic receptor
Alternative name(s):
Alpha-1A adrenoreceptor
Short name=Alpha-1A adrenoceptor
Alpha-1C adrenergic receptor
Gene names
Name:ADRA1A
Synonyms:ADRA1C
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G11 proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes By similarity.

Subunit structure

Homo- and heterooligomer By similarity. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes By similarity.

Subcellular location

Nucleus membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity. Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 466466Alpha-1A adrenergic receptor
PRO_0000069060

Regions

Topological domain1 – 2727Extracellular By similarity
Transmembrane28 – 5124Helical; Name=1; By similarity
Topological domain52 – 6413Cytoplasmic By similarity
Transmembrane65 – 8824Helical; Name=2; By similarity
Topological domain89 – 9911Extracellular By similarity
Transmembrane100 – 12223Helical; Name=3; By similarity
Topological domain123 – 14321Cytoplasmic By similarity
Transmembrane144 – 16724Helical; Name=4; By similarity
Topological domain168 – 18114Extracellular By similarity
Transmembrane182 – 20524Helical; Name=5; By similarity
Topological domain206 – 27368Cytoplasmic By similarity
Transmembrane274 – 29724Helical; Name=6; By similarity
Topological domain298 – 3058Extracellular By similarity
Transmembrane306 – 32924Helical; Name=7; By similarity
Topological domain330 – 466137Cytoplasmic By similarity
Region334 – 34916Nuclear localization signal By similarity

Amino acid modifications

Modified residue2151Phosphoserine; by PKA Potential
Lipidation3451S-palmitoyl cysteine Potential
Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation131N-linked (GlcNAc...) Potential
Glycosylation221N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 176 By similarity

Sequences

Sequence LengthMass (Da)Tools
P18130 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 77635153B39E85EC

FASTA46651,466
        10         20         30         40         50         60 
MVFLSGNASD SSNCTHPPPP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 

        70         80         90        100        110        120 
THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN VWAAVDVLCC TASIMGLCII 

       130        140        150        160        170        180 
SIDRYIGVSY PLRYPTIVTQ KRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 

       190        200        210        220        230        240 
EPGYVLFSAL GSFYVPLTII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 

       250        260        270        280        290        300 
AQVGGSGVTS AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 

       310        320        330        340        350        360 
FRPSETVFKI AFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLRRKQ SSKHTLGYTL 

       370        380        390        400        410        420 
HAPSHVLEGQ HKDLVRIPVG SAETFYKISK TDGVCEWKIF SSLPRGSARM AVARDPSACT 

       430        440        450        460 
TARVRSKSFL QVCCCLGPST PSHGENHQIP TIKIHTISLS ENGEEV

« Hide

References

[1]"Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype."
Schwinn D.A., Lomasney J.W., Lorenz W., Szklut P.J., Fremeau R.T. Jr., Yang-Feng T.L., Caron M.G., Lefkowitz R.J., Cotecchia S.
J. Biol. Chem. 265:8183-8189(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The alpha 1C-adrenergic receptor: a new member in the alpha 1-adrenergic receptor family."
Schwinn D.A., Cotecchia S., Lorenz W., Caron M.G., Lefkowitz R.J.
Trans. Assoc. Am. Physicians 103:112-118(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J05426 mRNA. Translation: AAA30374.1.
IPIIPI00701074.
PIRA35375.
RefSeqNP_776923.1. NM_174498.2.
UniGeneBt.374.

3D structure databases

ProteinModelPortalP18130.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000042306.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP18130.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID282134.
KEGGbta:282134.

Organism-specific databases

CTD148.

Phylogenomic databases

eggNOGNOG293490.
HOVERGENHBG106962.
KOK04135.

Family and domain databases

InterProIPR001004. Adrene_rcpt_A1Cs.
IPR002233. Adrnrgc_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP18130.
ChEMBLCHEMBL4892.
NextBio20805969.

Entry information

Entry nameADA1A_BOVIN
AccessionPrimary (citable) accession number: P18130
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents