Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L7

Gene

RPL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.

GO - Molecular functioni

  • DNA binding Source: MGI
  • mRNA binding Source: MGI
  • poly(A) RNA binding Source: UniProtKB
  • protein homodimerization activity Source: MGI
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147604-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7
Gene namesi
Name:RPL7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:10363. RPL7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: MGI
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6129.
OpenTargetsiENSG00000147604.
PharmGKBiPA34759.

Polymorphism and mutation databases

BioMutaiRPL7.
DMDMi133021.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001046331 – 24860S ribosomal protein L7Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources2 Publications1
Modified residuei17PhosphothreonineCombined sources1
Modified residuei124N6-acetyllysineCombined sources1
Modified residuei127N6-succinyllysineBy similarity1
Modified residuei139PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP18124.
MaxQBiP18124.
PaxDbiP18124.
PeptideAtlasiP18124.
PRIDEiP18124.
TopDownProteomicsiP18124.

2D gel databases

SWISS-2DPAGEP18124.

PTM databases

iPTMnetiP18124.
PhosphoSitePlusiP18124.
SwissPalmiP18124.

Expressioni

Gene expression databases

BgeeiENSG00000147604.
CleanExiHS_RPL7.
ExpressionAtlasiP18124. baseline and differential.
GenevisibleiP18124. HS.

Organism-specific databases

HPAiHPA058373.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
IPO5O004104EBI-350806,EBI-356424
NEDD8Q158432EBI-350806,EBI-716247

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi112049. 212 interactors.
IntActiP18124. 45 interactors.
MINTiMINT-1152474.
STRINGi9606.ENSP00000339795.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LF1-248[»]
4V6Xelectron microscopy5.00CF1-248[»]
5AJ0electron microscopy3.50AF1-248[»]
ProteinModelPortaliP18124.
SMRiP18124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 181Add BLAST12
Repeati19 – 302Add BLAST12
Repeati31 – 423Add BLAST12
Repeati43 – 544Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 544 X 12 AA tandem repeatsAdd BLAST48

Sequence similaritiesi

Belongs to the ribosomal protein L30P family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3184. Eukaryota.
COG1841. LUCA.
GeneTreeiENSGT00390000006213.
HOGENOMiHOG000170917.
HOVERGENiHBG003280.
InParanoidiP18124.
KOiK02937.
OMAiPYITYGE.
OrthoDBiEOG091G0IHS.
PhylomeDBiP18124.
TreeFamiTF300740.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiIPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
[Graphical view]
PfamiPF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
[Graphical view]
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGVEEKKKE VPAVPETLKK KRRNFAELKI KRLRKKFAQK MLRKARRKLI
60 70 80 90 100
YEKAKHYHKE YRQMYRTEIR MARMARKAGN FYVPAEPKLA FVIRIRGING
110 120 130 140 150
VSPKVRKVLQ LLRLRQIFNG TFVKLNKASI NMLRIVEPYI AWGYPNLKSV
160 170 180 190 200
NELIYKRGYG KINKKRIALT DNALIARSLG KYGIICMEDL IHEIYTVGKR
210 220 230 240
FKEANNFLWP FKLSSPRGGM KKKTTHFVEG GDAGNREDQI NRLIRRMN
Length:248
Mass (Da):29,226
Last modified:November 1, 1990 - v1
Checksum:i070EB4C904E6795A
GO

Sequence cautioni

The sequence CAA41026 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48K → E in CAG33054 (Ref. 4) Curated1
Sequence conflicti157R → L in CAA41026 (PubMed:8441630).Curated1
Sequence conflicti157R → L in CAA41027 (PubMed:8441630).Curated1
Sequence conflicti160G → A in CAA41026 (PubMed:8441630).Curated1
Sequence conflicti166R → Q in CAA41026 (PubMed:8441630).Curated1
Sequence conflicti173A → S in AAA03081 (PubMed:8360149).Curated1
Sequence conflicti192H → R in CAG33054 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57958 mRNA. Translation: CAA41026.1. Different initiation.
X57959 mRNA. Translation: CAA41027.1.
L16558 mRNA. Translation: AAA03081.1.
X52967 mRNA. Translation: CAA37139.1.
CR456773 mRNA. Translation: CAG33054.1.
AK291119 mRNA. Translation: BAF83808.1.
AK313365 mRNA. Translation: BAG36165.1.
BC006095 mRNA. Translation: AAH06095.1.
BC008850 mRNA. Translation: AAH08850.1.
BC009599 mRNA. Translation: AAH09599.1.
BC071671 mRNA. Translation: AAH71671.1.
BC071894 mRNA. Translation: AAH71894.1.
BC071895 mRNA. Translation: AAH71895.1.
BC087837 mRNA. Translation: AAH87837.1.
CCDSiCCDS6212.1.
PIRiS11709. R5HU7.
RefSeqiNP_000962.2. NM_000971.3.
UniGeneiHs.421257.
Hs.571841.

Genome annotation databases

EnsembliENST00000352983; ENSP00000339795; ENSG00000147604.
GeneIDi6129.
KEGGihsa:6129.
UCSCiuc003xzg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57958 mRNA. Translation: CAA41026.1. Different initiation.
X57959 mRNA. Translation: CAA41027.1.
L16558 mRNA. Translation: AAA03081.1.
X52967 mRNA. Translation: CAA37139.1.
CR456773 mRNA. Translation: CAG33054.1.
AK291119 mRNA. Translation: BAF83808.1.
AK313365 mRNA. Translation: BAG36165.1.
BC006095 mRNA. Translation: AAH06095.1.
BC008850 mRNA. Translation: AAH08850.1.
BC009599 mRNA. Translation: AAH09599.1.
BC071671 mRNA. Translation: AAH71671.1.
BC071894 mRNA. Translation: AAH71894.1.
BC071895 mRNA. Translation: AAH71895.1.
BC087837 mRNA. Translation: AAH87837.1.
CCDSiCCDS6212.1.
PIRiS11709. R5HU7.
RefSeqiNP_000962.2. NM_000971.3.
UniGeneiHs.421257.
Hs.571841.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LF1-248[»]
4V6Xelectron microscopy5.00CF1-248[»]
5AJ0electron microscopy3.50AF1-248[»]
ProteinModelPortaliP18124.
SMRiP18124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112049. 212 interactors.
IntActiP18124. 45 interactors.
MINTiMINT-1152474.
STRINGi9606.ENSP00000339795.

PTM databases

iPTMnetiP18124.
PhosphoSitePlusiP18124.
SwissPalmiP18124.

Polymorphism and mutation databases

BioMutaiRPL7.
DMDMi133021.

2D gel databases

SWISS-2DPAGEP18124.

Proteomic databases

EPDiP18124.
MaxQBiP18124.
PaxDbiP18124.
PeptideAtlasiP18124.
PRIDEiP18124.
TopDownProteomicsiP18124.

Protocols and materials databases

DNASUi6129.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352983; ENSP00000339795; ENSG00000147604.
GeneIDi6129.
KEGGihsa:6129.
UCSCiuc003xzg.4. human.

Organism-specific databases

CTDi6129.
DisGeNETi6129.
GeneCardsiRPL7.
H-InvDBHIX0058339.
HGNCiHGNC:10363. RPL7.
HPAiHPA058373.
MIMi604166. gene.
neXtProtiNX_P18124.
OpenTargetsiENSG00000147604.
PharmGKBiPA34759.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3184. Eukaryota.
COG1841. LUCA.
GeneTreeiENSGT00390000006213.
HOGENOMiHOG000170917.
HOVERGENiHBG003280.
InParanoidiP18124.
KOiK02937.
OMAiPYITYGE.
OrthoDBiEOG091G0IHS.
PhylomeDBiP18124.
TreeFamiTF300740.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147604-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL7. human.
GeneWikiiRPL7.
GenomeRNAii6129.
PROiP18124.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147604.
CleanExiHS_RPL7.
ExpressionAtlasiP18124. baseline and differential.
GenevisibleiP18124. HS.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiIPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
[Graphical view]
PfamiPF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
[Graphical view]
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL7_HUMAN
AccessioniPrimary (citable) accession number: P18124
Secondary accession number(s): A8K504
, Q15289, Q3KQU0, Q5I0X1, Q6IBM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 179 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.