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Protein

60S ribosomal protein L7

Gene

RPL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit (PubMed:12962325). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.1 Publication

GO - Molecular functioni

  • DNA binding Source: MGI
  • mRNA binding Source: MGI
  • protein homodimerization activity Source: MGI
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • cytoplasmic translation Source: GO_Central
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • ribosomal large subunit biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: ProtInc
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7
Alternative name(s):
Large ribosomal subunit protein uL301 Publication
Gene namesi
Name:RPL7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147604.13
HGNCiHGNC:10363 RPL7
MIMi604166 gene
neXtProtiNX_P18124

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6129
OpenTargetsiENSG00000147604
PharmGKBiPA34759

Polymorphism and mutation databases

BioMutaiRPL7
DMDMi133021

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001046331 – 24860S ribosomal protein L7Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources2 Publications1
Modified residuei17PhosphothreonineCombined sources1
Modified residuei124N6-acetyllysineCombined sources1
Modified residuei127N6-succinyllysineBy similarity1
Modified residuei139PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP18124
MaxQBiP18124
PaxDbiP18124
PeptideAtlasiP18124
PRIDEiP18124
TopDownProteomicsiP18124

2D gel databases

SWISS-2DPAGEP18124

PTM databases

iPTMnetiP18124
PhosphoSitePlusiP18124
SwissPalmiP18124

Expressioni

Gene expression databases

BgeeiENSG00000147604
CleanExiHS_RPL7
ExpressionAtlasiP18124 baseline and differential
GenevisibleiP18124 HS

Organism-specific databases

HPAiHPA058373

Interactioni

Subunit structurei

Component of the large ribosomal subunit (Probable). Homodimer. Interacts with DHX33 (PubMed:26100019).1 Publication1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi112049, 230 interactors
CORUMiP18124
IntActiP18124, 48 interactors
MINTiP18124
STRINGi9606.ENSP00000339795

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LF1-248[»]
4V6Xelectron microscopy5.00CF1-248[»]
5AJ0electron microscopy3.50AF1-248[»]
5LKSelectron microscopy3.60LF1-248[»]
5T2Celectron microscopy3.60m1-248[»]
6EK0electron microscopy2.90LF1-248[»]
ProteinModelPortaliP18124
SMRiP18124
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 181Add BLAST12
Repeati19 – 302Add BLAST12
Repeati31 – 423Add BLAST12
Repeati43 – 544Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 544 X 12 AA tandem repeatsAdd BLAST48

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3184 Eukaryota
COG1841 LUCA
GeneTreeiENSGT00390000006213
HOGENOMiHOG000170917
HOVERGENiHBG003280
InParanoidiP18124
KOiK02937
OMAiPTGGWRT
OrthoDBiEOG091G0IHS
PhylomeDBiP18124
TreeFamiTF300740

Family and domain databases

CDDicd01657 Ribosomal_L7_archeal_euk, 1 hit
Gene3Di1.10.15.30, 1 hit
3.30.1390.20, 2 hits
InterProiView protein in InterPro
IPR036919 L30_ferredoxin-like_sf
IPR023106 Ribosomal_L30_central_dom_arc
IPR018038 Ribosomal_L30_CS
IPR016082 Ribosomal_L30_ferredoxin-like
IPR012988 Ribosomal_L30_N
IPR005998 Ribosomal_L7_euk
IPR035808 Ribosomal_L7_euk_arc
PfamiView protein in Pfam
PF00327 Ribosomal_L30, 1 hit
PF08079 Ribosomal_L30_N, 1 hit
SUPFAMiSSF55129 SSF55129, 1 hit
TIGRFAMsiTIGR01310 uL30_euk, 1 hit
PROSITEiView protein in PROSITE
PS00634 RIBOSOMAL_L30, 1 hit

Sequencei

Sequence statusi: Complete.

P18124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGVEEKKKE VPAVPETLKK KRRNFAELKI KRLRKKFAQK MLRKARRKLI
60 70 80 90 100
YEKAKHYHKE YRQMYRTEIR MARMARKAGN FYVPAEPKLA FVIRIRGING
110 120 130 140 150
VSPKVRKVLQ LLRLRQIFNG TFVKLNKASI NMLRIVEPYI AWGYPNLKSV
160 170 180 190 200
NELIYKRGYG KINKKRIALT DNALIARSLG KYGIICMEDL IHEIYTVGKR
210 220 230 240
FKEANNFLWP FKLSSPRGGM KKKTTHFVEG GDAGNREDQI NRLIRRMN
Length:248
Mass (Da):29,226
Last modified:November 1, 1990 - v1
Checksum:i070EB4C904E6795A
GO

Sequence cautioni

The sequence CAA41026 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48K → E in CAG33054 (Ref. 4) Curated1
Sequence conflicti157R → L in CAA41026 (PubMed:8441630).Curated1
Sequence conflicti157R → L in CAA41027 (PubMed:8441630).Curated1
Sequence conflicti160G → A in CAA41026 (PubMed:8441630).Curated1
Sequence conflicti166R → Q in CAA41026 (PubMed:8441630).Curated1
Sequence conflicti173A → S in AAA03081 (PubMed:8360149).Curated1
Sequence conflicti192H → R in CAG33054 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57958 mRNA Translation: CAA41026.1 Different initiation.
X57959 mRNA Translation: CAA41027.1
L16558 mRNA Translation: AAA03081.1
X52967 mRNA Translation: CAA37139.1
CR456773 mRNA Translation: CAG33054.1
AK291119 mRNA Translation: BAF83808.1
AK313365 mRNA Translation: BAG36165.1
BC006095 mRNA Translation: AAH06095.1
BC008850 mRNA Translation: AAH08850.1
BC009599 mRNA Translation: AAH09599.1
BC071671 mRNA Translation: AAH71671.1
BC071894 mRNA Translation: AAH71894.1
BC071895 mRNA Translation: AAH71895.1
BC087837 mRNA Translation: AAH87837.1
CCDSiCCDS6212.1
PIRiS11709 R5HU7
RefSeqiNP_000962.2, NM_000971.3
UniGeneiHs.421257
Hs.571841

Genome annotation databases

EnsembliENST00000352983; ENSP00000339795; ENSG00000147604
GeneIDi6129
KEGGihsa:6129
UCSCiuc003xzg.4 human

Similar proteinsi

Entry informationi

Entry nameiRL7_HUMAN
AccessioniPrimary (citable) accession number: P18124
Secondary accession number(s): A8K504
, Q15289, Q3KQU0, Q5I0X1, Q6IBM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 195 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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