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Protein

Catalase isozyme 1

Gene

CAT1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65PROSITE-ProRule annotation1
Active sitei138PROSITE-ProRule annotation1
Metal bindingi348Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • catalase activity Source: AgBase
  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cold acclimation Source: AgBase
  • hydrogen peroxide catabolic process Source: UniProtKB-KW
  • protein heterotetramerization Source: AgBase
  • protein homotetramerization Source: AgBase
  • response to abscisic acid Source: AgBase
  • response to auxin Source: AgBase
  • response to oxidative stress Source: AgBase
  • response to reactive oxygen species Source: AgBase
  • response to xenobiotic stimulus Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei6437. ZmKat1.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase isozyme 1 (EC:1.11.1.6)
Gene namesi
Name:CAT1
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi13855.

Subcellular locationi

GO - Cellular componenti

  • peroxisome Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849461 – 492Catalase isozyme 1Add BLAST492

Proteomic databases

PaxDbiP18122.
PRIDEiP18122.

Expressioni

Tissue specificityi

Scutella, milky endosperm of immature kernels, leaves and epicotyls.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi4577.GRMZM2G088212_P01.

Structurei

3D structure databases

ProteinModelPortaliP18122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiKOG0047. Eukaryota.
COG0753. LUCA.
HOGENOMiHOG000087852.
KOiK03781.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18122-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPYKHRPSS GSNSSFWTTN SGAPVWNNNS ALTVGQRGPI LLEDYHLIEK
60 70 80 90 100
LAQFDRERIP ERVVHARGAS AKGFFEVTHD VSHLTCADFL RAPGVQTPVI
110 120 130 140 150
VRFSTVVHER GSPETLRDPR GFAVKFYTRE GNFDLVGNNM PVFFIRDGMK
160 170 180 190 200
FPDMVHAFKP NPKTNLQENW RIVDFFSHHP ESLHMFTFLF DDVGIPLNYR
210 220 230 240 250
HMEGFGVNTY SLINRDGKPH LVKFHWKPTC GVKCLLDNEA VTVGGTCHSH
260 270 280 290 300
ATKDLYDSIA AGNYPEWKLY IQTIDLDHED KFDFDPLDVT KTWPEDIIPL
310 320 330 340 350
QPVGRMVLNK NVDNFFAENE QIAFCPAISV PAIHYSDDKL LQTRIFSYAD
360 370 380 390 400
TQRHRLGPNY LMLPVNAPKC AHHNNHHDGF MNFMHRDEEV NYFPSRFDPA
410 420 430 440 450
RHAEKVPIPP RVLTRCREKC IIQKENNFKQ AGERYRSFDP ARQDRFIQRW
460 470 480 490
VDALTHPRVT HEHRTIWISY WSQCDAALGQ KLPSRLNLKP SM
Length:492
Mass (Da):56,877
Last modified:November 1, 1990 - v1
Checksum:iCE10C93BEC1D9529
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti332A → G in CAA31056 (PubMed:2461221).Curated1
Sequence conflicti332A → G in CAA42720 (PubMed:2461221).Curated1
Sequence conflicti415R → G in CAA31056 (PubMed:2461221).Curated1
Sequence conflicti415R → G in CAA42720 (PubMed:2461221).Curated1
Sequence conflicti456H → D in CAA31056 (PubMed:2461221).Curated1
Sequence conflicti456H → D in CAA42720 (PubMed:2461221).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti157A → V in strain: cv. W64A. 1
Natural varianti211S → T in strain: cv. W64A. 1
Natural varianti329S → I in strain: cv. W64A. 1
Natural varianti483P → A in strain: cv. W64A. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12538 mRNA. Translation: CAA31056.1.
X60135 Genomic DNA. Translation: CAA42720.1.
PIRiS48124.
RefSeqiNP_001105415.1. NM_001111945.1.
UniGeneiZm.160908.

Genome annotation databases

GeneIDi542369.
KEGGizma:542369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12538 mRNA. Translation: CAA31056.1.
X60135 Genomic DNA. Translation: CAA42720.1.
PIRiS48124.
RefSeqiNP_001105415.1. NM_001111945.1.
UniGeneiZm.160908.

3D structure databases

ProteinModelPortaliP18122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM2G088212_P01.

Protein family/group databases

PeroxiBasei6437. ZmKat1.

Proteomic databases

PaxDbiP18122.
PRIDEiP18122.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi542369.
KEGGizma:542369.

Organism-specific databases

MaizeGDBi13855.

Phylogenomic databases

eggNOGiKOG0047. Eukaryota.
COG0753. LUCA.
HOGENOMiHOG000087852.
KOiK03781.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATA1_MAIZE
AccessioniPrimary (citable) accession number: P18122
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 5, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.