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Protein

Thyroid hormone receptor beta-B

Gene

thrb-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor for triiodothyronine (T3).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi60 – 13475Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri60 – 8021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri98 – 12225NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta-B
Short name:
TRbetaB
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2-B
Gene namesi
Name:thrb-b
Synonyms:nr1a2-b, thrb2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252616. thrb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Thyroid hormone receptor beta-BPRO_0000053459Add
BLAST

Proteomic databases

PRIDEiP18119.

Expressioni

Developmental stagei

Expression peaks at the climax of metamorphosis.1 Publication

Inductioni

By thyroid hormone.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP18119.
SMRiP18119. Positions 57-145, 164-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5959ModulatingAdd
BLAST
Regioni135 – 414280Ligand-bindingAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri60 – 8021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri98 – 12225NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG005606.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform Beta-B2 (identifier: P18119-1) [UniParc]FASTAAdd to basket
Also known as: BetaB-II

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSSMSVRLF TASAAQRKKI QEGDCCVVLA GKTQGRFILI GAVARVSGYI
60 70 80 90 100
PSYLDKDELC VVCGDKATGY HYRCITCEGC KGFFRRTIQK NLHPSYSCKY
110 120 130 140 150
EGKCVIDKVT RNQCQECRFK KCKTVGMATD LVLDDSKRLA KRKLIEENRE
160 170 180 190 200
KRRKDEIQKS IVQRPEPTQE EWELIQVVTE AHVATNAQGS HWKQKRKFLP
210 220 230 240 250
EDIGQAPIVN APEGGKVDLE AFSQFTKIIT PAITRVVDFA KKLPMFCELP
260 270 280 290 300
CEDQIILLKG CCMEIMSLRA AVRYDPESET LTLNGEMAVT RGQLKNGGLG
310 320 330 340 350
VVSDAIFDLG VSLSSFSLDD TEVALLQAVL LMSSDRPGLS SVERIEKCQE
360 370 380 390 400
GFLLAFEHYI NYRKHNIAHF WPKLLMKVTD LRMIGACHAS RFLHMKVECP
410
TELFPPLFLE VFED
Length:414
Mass (Da):46,706
Last modified:November 1, 1990 - v1
Checksum:iF136F8380B2494BE
GO
Isoform Beta-B1 (identifier: P18119-2) [UniParc]FASTAAdd to basket
Also known as: BetaB-I

The sequence of this isoform differs from the canonical sequence as follows:
     7-46: Missing.

Show »
Length:374
Mass (Da):42,449
Checksum:iB78D9A9A450029A3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei7 – 4640Missing in isoform Beta-B1. 1 PublicationVSP_003628Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35362 mRNA. Translation: AAA49658.1.
M35361 mRNA. Translation: AAA49657.1.
PIRiD36067.
RefSeqiNP_001081250.1. NM_001087781.1. [P18119-1]
UniGeneiXl.57134.

Genome annotation databases

GeneIDi397734.
KEGGixla:397734.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35362 mRNA. Translation: AAA49658.1.
M35361 mRNA. Translation: AAA49657.1.
PIRiD36067.
RefSeqiNP_001081250.1. NM_001087781.1. [P18119-1]
UniGeneiXl.57134.

3D structure databases

ProteinModelPortaliP18119.
SMRiP18119. Positions 57-145, 164-413.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP18119.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397734.
KEGGixla:397734.

Organism-specific databases

CTDi397734.
XenbaseiXB-GENE-6252616. thrb.

Phylogenomic databases

HOVERGENiHBG005606.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHBB_XENLA
AccessioniPrimary (citable) accession number: P18119
Secondary accession number(s): P18118
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.