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Protein

Thyroid hormone receptor beta

Gene

Thrb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei282Thyroid hormoneBy similarity1
Binding sitei320Thyroid hormoneBy similarity1
Binding sitei331Thyroid hormone; via amide nitrogenBy similarity1
Binding sitei435Thyroid hormoneBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi107 – 181Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri145 – 169NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • double-stranded DNA binding Source: RGD
  • nuclear receptor activity Source: RGD
  • protein homodimerization activity Source: RGD
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone receptor activity Source: InterPro
  • thyroid hormone binding Source: UniProtKB
  • thyroid hormone receptor activity Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • embryonic organ development Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of chondrocyte differentiation Source: RGD
  • positive regulation of ossification Source: RGD
  • regulation of cholesterol metabolic process Source: RGD
  • regulation of lipid metabolic process Source: RGD
  • regulation of triglyceride metabolic process Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
c-erbA-2
c-erbA-beta
Gene namesi
Name:Thrb
Synonyms:Erba2, Nr1a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi3858 Thrb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3917

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534501 – 461Thyroid hormone receptor betaAdd BLAST461

Proteomic databases

PRIDEiP18113

PTM databases

PhosphoSitePlusiP18113

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRA (By similarity). Interacts with the coactivators NCOA1/SRC1, NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner (By similarity). Interacts with the corepressor NCOR1 in absence of ligand. Interacts with C1D (By similarity). Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements (By similarity). Interacts with PRMT2 and THRSP (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

DIPiDIP-61264N
IntActiP18113, 1 interactor

Chemistry databases

BindingDBiP18113

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni108 – 110Combined sources3
Beta strandi116 – 122Combined sources7
Helixi125 – 136Combined sources12
Helixi140 – 142Combined sources3
Turni155 – 159Combined sources5
Helixi162 – 171Combined sources10
Helixi176 – 178Combined sources3
Helixi182 – 202Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M9EX-ray2.41A/B/E/F104-206[»]
ProteinModelPortaliP18113
SMRiP18113
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18113

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 461NR LBDPROSITE-ProRule annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 106ModulatingAdd BLAST106
Regioni244 – 461Interaction with NR2F6By similarityAdd BLAST218

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri145 – 169NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000010313
HOVERGENiHBG005606
InParanoidiP18113
PhylomeDBiP18113

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta-1 (identifier: P18113-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPNSMTENR LPAWDKQKPH PDRGQDWKLV GMSEACLHRK SHVERRGALK
60 70 80 90 100
NEQTSSHLIQ ATWASSIFHL DPDDVNDQSV SSAQTFQTEE KKCKGYIPSY
110 120 130 140 150
LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKSLH PSYSCKYEGK
160 170 180 190 200
CIIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR
210 220 230 240 250
REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI
260 270 280 290 300
GQAPIVNAPE GGQVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED
310 320 330 340 350
QIILLKGCCM EIMSLRAAVR YDPDSETLTL NGEMAVTRGQ LKNGGLGVVS
360 370 380 390 400
DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL
410 420 430 440 450
LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL
460
FPPLFLEVFE D
Length:461
Mass (Da):52,656
Last modified:October 1, 1994 - v2
Checksum:i16705C200E02995B
GO
Isoform Beta-2 (identifier: P18113-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MTPNSMTENR...QTFQTEEKKC → MNYCVPEVHE...QVRSPPHSHK

Show »
Length:475
Mass (Da):54,013
Checksum:iAA86694C55019718
GO

Sequence cautioni

The sequence AAA40916 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA42200 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 10NR → KC in AAA60743 (PubMed:2899322).Curated2
Sequence conflicti263Q → K in AAA60743 (PubMed:2899322).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0310791 – 93MTPNS…EEKKC → MNYCVPEVHEVCPAAGSNRY MQVTDYLAYLEDSPAYSGCD VQAVPGSSIYLEQAWTLNQP YTCSYPGNLFKSKDSDLDMA LSQYSQPAHLPEEKPFPQVR SPPHSHK in isoform Beta-2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03933 mRNA Translation: AAA40916.1 Different initiation.
J03819 mRNA Translation: AAA60743.1
M25071 mRNA Translation: AAA42200.1 Different initiation.
PIRiA31820
A41355
UniGeneiRn.230446
Rn.34019

Genome annotation databases

UCSCiRGD:3858 rat [P18113-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiTHB_RAT
AccessioniPrimary (citable) accession number: P18113
Secondary accession number(s): P37826
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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