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P18113

- THB_RAT

UniProt

P18113 - THB_RAT

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Protein
Thyroid hormone receptor beta
Gene
Thrb, Erba2, Nr1a2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei282 – 2821Thyroid hormone By similarity
Binding sitei320 – 3201Thyroid hormone By similarity
Binding sitei331 – 3311Thyroid hormone; via amide nitrogen By similarity
Binding sitei435 – 4351Thyroid hormone By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi107 – 18175Nuclear receptor
Add
BLAST
Zinc fingeri107 – 12721NR C4-type
Add
BLAST
Zinc fingeri145 – 16925NR C4-type
Add
BLAST

GO - Molecular functioni

  1. double-stranded DNA binding Source: RGD
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RGD
  3. protein homodimerization activity Source: RGD
  4. sequence-specific DNA binding Source: InterPro
  5. steroid hormone receptor activity Source: InterPro
  6. thyroid hormone binding Source: UniProtKB
  7. thyroid hormone receptor activity Source: RGD
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. embryonic organ development Source: RGD
  2. intracellular receptor signaling pathway Source: GOC
  3. positive regulation of cell proliferation Source: RGD
  4. positive regulation of chondrocyte differentiation Source: RGD
  5. positive regulation of ossification Source: RGD
  6. regulation of cholesterol metabolic process Source: RGD
  7. regulation of lipid metabolic process Source: RGD
  8. regulation of triglyceride metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
c-erbA-2
c-erbA-beta
Gene namesi
Name:Thrb
Synonyms:Erba2, Nr1a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3858. Thrb.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Thyroid hormone receptor beta
PRO_0000053450Add
BLAST

Proteomic databases

PaxDbiP18113.
PRIDEiP18113.

PTM databases

PhosphoSiteiP18113.

Expressioni

Gene expression databases

GenevestigatoriP18113.

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRA By similarity. Interacts with the coactivators NCOA1/SRC1, NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner By similarity. Interacts with the corepressor NCOR1 in absence of ligand. Interacts with C1D By similarity. Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements By similarity. Interacts with PRMT2 and THRSP By similarity.1 Publication

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni108 – 1103
Beta strandi116 – 1227
Helixi125 – 13612
Helixi140 – 1423
Turni155 – 1595
Helixi162 – 17110
Helixi176 – 1783
Helixi182 – 20221

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3M9EX-ray2.41A/B/E/F104-206[»]
ProteinModelPortaliP18113.
SMRiP18113. Positions 104-192, 211-460.

Miscellaneous databases

EvolutionaryTraceiP18113.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 106106Modulating
Add
BLAST
Regioni244 – 461218Interaction with NR2F6 By similarity
Add
BLAST
Regioni244 – 461218Ligand-binding
Add
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG272726.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
InParanoidiP37826.
PhylomeDBiP18113.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Beta-1 (identifier: P18113-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTPNSMTENR LPAWDKQKPH PDRGQDWKLV GMSEACLHRK SHVERRGALK    50
NEQTSSHLIQ ATWASSIFHL DPDDVNDQSV SSAQTFQTEE KKCKGYIPSY 100
LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKSLH PSYSCKYEGK 150
CIIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR 200
REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI 250
GQAPIVNAPE GGQVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED 300
QIILLKGCCM EIMSLRAAVR YDPDSETLTL NGEMAVTRGQ LKNGGLGVVS 350
DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL 400
LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL 450
FPPLFLEVFE D 461
Length:461
Mass (Da):52,656
Last modified:October 1, 1994 - v2
Checksum:i16705C200E02995B
GO
Isoform Beta-2 (identifier: P18113-2) [UniParc] [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MTPNSMTENR...QTFQTEEKKC → MNYCVPEVHE...QVRSPPHSHK

Show »
Length:475
Mass (Da):54,013
Checksum:iAA86694C55019718
GO

Sequence cautioni

The sequence AAA40916.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAA42200.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9393MTPNS…EEKKC → MNYCVPEVHEVCPAAGSNRY MQVTDYLAYLEDSPAYSGCD VQAVPGSSIYLEQAWTLNQP YTCSYPGNLFKSKDSDLDMA LSQYSQPAHLPEEKPFPQVR SPPHSHK in isoform Beta-2.
VSP_031079Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 102NR → KC in AAA60743. 1 Publication
Sequence conflicti263 – 2631Q → K in AAA60743. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03933 mRNA. Translation: AAA40916.1. Different initiation.
J03819 mRNA. Translation: AAA60743.1.
M25071 mRNA. Translation: AAA42200.1. Different initiation.
PIRiA31820.
A41355.
UniGeneiRn.34019.

Genome annotation databases

UCSCiRGD:3858. rat. [P18113-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03933 mRNA. Translation: AAA40916.1 . Different initiation.
J03819 mRNA. Translation: AAA60743.1 .
M25071 mRNA. Translation: AAA42200.1 . Different initiation.
PIRi A31820.
A41355.
UniGenei Rn.34019.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3M9E X-ray 2.41 A/B/E/F 104-206 [» ]
ProteinModelPortali P18113.
SMRi P18113. Positions 104-192, 211-460.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P18113.
ChEMBLi CHEMBL3917.
GuidetoPHARMACOLOGYi 589.

PTM databases

PhosphoSitei P18113.

Proteomic databases

PaxDbi P18113.
PRIDEi P18113.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3858. rat. [P18113-1 ]

Organism-specific databases

RGDi 3858. Thrb.

Phylogenomic databases

eggNOGi NOG272726.
HOGENOMi HOG000010313.
HOVERGENi HBG005606.
InParanoidi P37826.
PhylomeDBi P18113.

Miscellaneous databases

EvolutionaryTracei P18113.
PROi P18113.

Gene expression databases

Genevestigatori P18113.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors."
    Murray M.B., Zilz N.D., McCreary N.L., Macdonald M.J., Towle H.C.
    J. Biol. Chem. 263:12770-12777(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-1).
    Tissue: Liver.
  2. "Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor."
    Koenig R.J., Warne R.L., Brent G.A., Harney J.W., Larsen P.R., Moore D.D.
    Proc. Natl. Acad. Sci. U.S.A. 85:5031-5035(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-1).
    Tissue: Pituitary.
  3. "Identification of a thyroid hormone receptor that is pituitary-specific."
    Hodin R.A., Lazar M.A., Wintman B.I., Darling D.S., Koenig R.J., Larsen P.R., Moore D.D., Chin W.W.
    Science 244:76-78(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-121 (ISOFORM BETA-2).
    Tissue: Pituitary.
  4. "Structure of a thyroid hormone receptor DNA-binding domain homodimer bound to an inverted palindrome DNA response element."
    Chen Y., Young M.A.
    Mol. Endocrinol. 24:1650-1664(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 104-206, SUBUNIT.

Entry informationi

Entry nameiTHB_RAT
AccessioniPrimary (citable) accession number: P18113
Secondary accession number(s): P37826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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