UniProtKB - P18111 (CDX1_MOUSE)
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Protein
Homeobox protein CDX-1
Gene
Cdx1
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 154 – 213 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding transcription factor activity Source: UniProtKB
- RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
- RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
- transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
- transcription regulatory region DNA binding Source: UniProtKB
GO - Biological processi
- anterior/posterior axis specification Source: GO_Central
- anterior/posterior pattern specification Source: MGI
- bone morphogenesis Source: MGI
- cell differentiation Source: GO_Central
- pattern specification process Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of somitogenesis Source: UniProtKB
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein CDX-1Alternative name(s): Caudal-type homeobox protein 1 |
Gene namesi | Name:Cdx1 Synonyms:Cdx-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88360 Cdx1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048847 | 1 – 268 | Homeobox protein CDX-1Add BLAST | 268 |
Proteomic databases
PaxDbi | P18111 |
PeptideAtlasi | P18111 |
PRIDEi | P18111 |
PTM databases
PhosphoSitePlusi | P18111 |
Expressioni
Tissue specificityi
Intestinal epithelium.
Gene expression databases
Bgeei | ENSMUSG00000024619 |
CleanExi | MM_CDX1 |
Genevisiblei | P18111 MM |
Interactioni
Protein-protein interaction databases
BioGridi | 1986636 interactors. |
STRINGi | 10090.ENSMUSP00000025521 |
Structurei
3D structure databases
ProteinModelPortali | P18111 |
SMRi | P18111 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 144 – 149 | Poly-Gly | 6 | |
Compositional biasi | 217 – 221 | Poly-Gln | 5 |
Sequence similaritiesi
Belongs to the Caudal homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0848 Eukaryota ENOG4111W2J LUCA |
GeneTreei | ENSGT00910000143983 |
HOGENOMi | HOG000115975 |
HOVERGENi | HBG005302 |
InParanoidi | P18111 |
KOi | K09312 |
OMAi | EDWHSYG |
OrthoDBi | EOG091G0LXJ |
PhylomeDBi | P18111 |
TreeFami | TF351605 |
Family and domain databases
CDDi | cd00086 homeodomain, 1 hit |
InterProi | View protein in InterPro IPR006820 Caudal_activation_dom IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR000047 HTH_motif |
Pfami | View protein in Pfam PF04731 Caudal_act, 1 hit PF00046 Homeobox, 1 hit |
PRINTSi | PR00024 HOMEOBOX PR00031 HTHREPRESSR |
SMARTi | View protein in SMART SM00389 HOX, 1 hit |
SUPFAMi | SSF46689 SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P18111-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYVGYVLDKD SPVYPGPARP SSLGLGPPTY APPGPAPAPP QYPDFAGYTH
60 70 80 90 100
VEPAPAPPPT WAAPFPAPKD DWAAAYGPGP TASAASPAPL AFGPPPDFSP
110 120 130 140 150
VPAPPGPGPG ILAQSLGAPG APSSPGAPRR TPYEWMRRSV AAAGGGGSGK
160 170 180 190 200
TRTKDKYRVV YTDHQRLELE KEFHYSRYIT IRRKSELAAN LGLTERQVKI
210 220 230 240 250
WFQNRRAKER KVNKKKQQQQ QPLPPTQLPL PLDGTPTPSG PPLGSLCPTN
260
AGLLGTPSPV PVKEEFLP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | P → Q in AAH19986 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 146 | G → C in AAA37412 (PubMed:2905686).Curated | 1 | |
Sequence conflicti | 157 | Y → S in AAA37412 (PubMed:2905686).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37163 mRNA Translation: AAA37412.1 Sequence problems. M80463 Unassigned DNA Translation: AAA16447.1 Sequence problems. BC019986 mRNA Translation: AAH19986.1 |
CCDSi | CCDS29279.1 |
PIRi | A49303 |
RefSeqi | NP_034010.3, NM_009880.3 |
UniGenei | Mm.144448 |
Genome annotation databases
Ensembli | ENSMUST00000025521; ENSMUSP00000025521; ENSMUSG00000024619 |
GeneIDi | 12590 |
KEGGi | mmu:12590 |
UCSCi | uc008fbj.2 mouse |
Similar proteinsi
Entry informationi
Entry namei | CDX1_MOUSE | |
Accessioni | P18111Primary (citable) accession number: P18111 Secondary accession number(s): Q8VCF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1995 | |
Last modified: | March 28, 2018 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |