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P18111

- CDX1_MOUSE

UniProt

P18111 - CDX1_MOUSE

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Protein

Homeobox protein CDX-1

Gene

Cdx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Could play a role in the terminal differentiation of the intestine.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi154 – 21360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. bone morphogenesis Source: MGI
  3. pattern specification process Source: MGI
  4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-1
Alternative name(s):
Caudal-type homeobox protein 1
Gene namesi
Name:Cdx1
Synonyms:Cdx-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:88360. Cdx1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Homeobox protein CDX-1PRO_0000048847Add
BLAST

Proteomic databases

PRIDEiP18111.

PTM databases

PhosphoSiteiP18111.

Expressioni

Tissue specificityi

Intestinal epithelium.

Gene expression databases

BgeeiP18111.
CleanExiMM_CDX1.
GenevestigatoriP18111.

Interactioni

Protein-protein interaction databases

BioGridi198663. 6 interactions.
STRINGi10090.ENSMUSP00000025521.

Structurei

3D structure databases

ProteinModelPortaliP18111.
SMRiP18111. Positions 158-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi144 – 1496Poly-Gly
Compositional biasi217 – 2215Poly-Gln

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG291290.
GeneTreeiENSGT00530000063388.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiP18111.
KOiK09312.
OMAiYSHVEPG.
OrthoDBiEOG71P2BK.
PhylomeDBiP18111.
TreeFamiTF351605.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18111-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYVGYVLDKD SPVYPGPARP SSLGLGPPTY APPGPAPAPP QYPDFAGYTH
60 70 80 90 100
VEPAPAPPPT WAAPFPAPKD DWAAAYGPGP TASAASPAPL AFGPPPDFSP
110 120 130 140 150
VPAPPGPGPG ILAQSLGAPG APSSPGAPRR TPYEWMRRSV AAAGGGGSGK
160 170 180 190 200
TRTKDKYRVV YTDHQRLELE KEFHYSRYIT IRRKSELAAN LGLTERQVKI
210 220 230 240 250
WFQNRRAKER KVNKKKQQQQ QPLPPTQLPL PLDGTPTPSG PPLGSLCPTN
260
AGLLGTPSPV PVKEEFLP
Length:268
Mass (Da):28,436
Last modified:November 1, 1995 - v2
Checksum:i85F45B2A3E12B2AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151P → Q in AAH19986. (PubMed:15489334)Curated
Sequence conflicti146 – 1461G → C in AAA37412. (PubMed:2905686)Curated
Sequence conflicti157 – 1571Y → S in AAA37412. (PubMed:2905686)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37163 mRNA. Translation: AAA37412.1. Sequence problems.
M80463 Unassigned DNA. Translation: AAA16447.1. Sequence problems.
BC019986 mRNA. Translation: AAH19986.1.
CCDSiCCDS29279.1.
PIRiA49303.
RefSeqiNP_034010.3. NM_009880.3.
UniGeneiMm.144448.

Genome annotation databases

EnsembliENSMUST00000025521; ENSMUSP00000025521; ENSMUSG00000024619.
GeneIDi12590.
KEGGimmu:12590.
UCSCiuc008fbj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37163 mRNA. Translation: AAA37412.1 . Sequence problems.
M80463 Unassigned DNA. Translation: AAA16447.1 . Sequence problems.
BC019986 mRNA. Translation: AAH19986.1 .
CCDSi CCDS29279.1.
PIRi A49303.
RefSeqi NP_034010.3. NM_009880.3.
UniGenei Mm.144448.

3D structure databases

ProteinModelPortali P18111.
SMRi P18111. Positions 158-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198663. 6 interactions.
STRINGi 10090.ENSMUSP00000025521.

PTM databases

PhosphoSitei P18111.

Proteomic databases

PRIDEi P18111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025521 ; ENSMUSP00000025521 ; ENSMUSG00000024619 .
GeneIDi 12590.
KEGGi mmu:12590.
UCSCi uc008fbj.2. mouse.

Organism-specific databases

CTDi 1044.
MGIi MGI:88360. Cdx1.

Phylogenomic databases

eggNOGi NOG291290.
GeneTreei ENSGT00530000063388.
HOGENOMi HOG000115975.
HOVERGENi HBG005302.
InParanoidi P18111.
KOi K09312.
OMAi YSHVEPG.
OrthoDBi EOG71P2BK.
PhylomeDBi P18111.
TreeFami TF351605.

Miscellaneous databases

NextBioi 281734.
PROi P18111.
SOURCEi Search...

Gene expression databases

Bgeei P18111.
CleanExi MM_CDX1.
Genevestigatori P18111.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the murine homeobox gene Cdx-1. Regulation of expression in intestinal epithelial cells."
    Hu Y., Kazenwadel J., James R.
    J. Biol. Chem. 268:27214-27225(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine."
    Duprey P., Chowdhury K., Dressler G.R., Balling R., Simon D., Guenet J.-L., Gruss P.
    Genes Dev. 2:1647-1654(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Embryonic intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiCDX1_MOUSE
AccessioniPrimary (citable) accession number: P18111
Secondary accession number(s): Q8VCF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3