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Protein

Homeobox protein CDX-1

Gene

Cdx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi154 – 213HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior axis specification Source: GO_Central
  • anterior/posterior pattern specification Source: MGI
  • bone morphogenesis Source: MGI
  • cell differentiation Source: GO_Central
  • pattern specification process Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of somitogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-1
Alternative name(s):
Caudal-type homeobox protein 1
Gene namesi
Name:Cdx1
Synonyms:Cdx-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:88360. Cdx1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488471 – 268Homeobox protein CDX-1Add BLAST268

Proteomic databases

PaxDbiP18111.
PeptideAtlasiP18111.
PRIDEiP18111.

PTM databases

PhosphoSitePlusiP18111.

Expressioni

Tissue specificityi

Intestinal epithelium.

Gene expression databases

BgeeiENSMUSG00000024619.
CleanExiMM_CDX1.
GenevisibleiP18111. MM.

Interactioni

Protein-protein interaction databases

BioGridi198663. 6 interactors.
STRINGi10090.ENSMUSP00000025521.

Structurei

3D structure databases

ProteinModelPortaliP18111.
SMRiP18111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 149Poly-Gly6
Compositional biasi217 – 221Poly-Gln5

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0848. Eukaryota.
ENOG4111W2J. LUCA.
GeneTreeiENSGT00530000063388.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiP18111.
KOiK09312.
OMAiTQRRTPY.
OrthoDBiEOG091G0LXJ.
PhylomeDBiP18111.
TreeFamiTF351605.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVGYVLDKD SPVYPGPARP SSLGLGPPTY APPGPAPAPP QYPDFAGYTH
60 70 80 90 100
VEPAPAPPPT WAAPFPAPKD DWAAAYGPGP TASAASPAPL AFGPPPDFSP
110 120 130 140 150
VPAPPGPGPG ILAQSLGAPG APSSPGAPRR TPYEWMRRSV AAAGGGGSGK
160 170 180 190 200
TRTKDKYRVV YTDHQRLELE KEFHYSRYIT IRRKSELAAN LGLTERQVKI
210 220 230 240 250
WFQNRRAKER KVNKKKQQQQ QPLPPTQLPL PLDGTPTPSG PPLGSLCPTN
260
AGLLGTPSPV PVKEEFLP
Length:268
Mass (Da):28,436
Last modified:November 1, 1995 - v2
Checksum:i85F45B2A3E12B2AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15P → Q in AAH19986 (PubMed:15489334).Curated1
Sequence conflicti146G → C in AAA37412 (PubMed:2905686).Curated1
Sequence conflicti157Y → S in AAA37412 (PubMed:2905686).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37163 mRNA. Translation: AAA37412.1. Sequence problems.
M80463 Unassigned DNA. Translation: AAA16447.1. Sequence problems.
BC019986 mRNA. Translation: AAH19986.1.
CCDSiCCDS29279.1.
PIRiA49303.
RefSeqiNP_034010.3. NM_009880.3.
UniGeneiMm.144448.

Genome annotation databases

EnsembliENSMUST00000025521; ENSMUSP00000025521; ENSMUSG00000024619.
GeneIDi12590.
KEGGimmu:12590.
UCSCiuc008fbj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37163 mRNA. Translation: AAA37412.1. Sequence problems.
M80463 Unassigned DNA. Translation: AAA16447.1. Sequence problems.
BC019986 mRNA. Translation: AAH19986.1.
CCDSiCCDS29279.1.
PIRiA49303.
RefSeqiNP_034010.3. NM_009880.3.
UniGeneiMm.144448.

3D structure databases

ProteinModelPortaliP18111.
SMRiP18111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198663. 6 interactors.
STRINGi10090.ENSMUSP00000025521.

PTM databases

PhosphoSitePlusiP18111.

Proteomic databases

PaxDbiP18111.
PeptideAtlasiP18111.
PRIDEiP18111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025521; ENSMUSP00000025521; ENSMUSG00000024619.
GeneIDi12590.
KEGGimmu:12590.
UCSCiuc008fbj.2. mouse.

Organism-specific databases

CTDi1044.
MGIiMGI:88360. Cdx1.

Phylogenomic databases

eggNOGiKOG0848. Eukaryota.
ENOG4111W2J. LUCA.
GeneTreeiENSGT00530000063388.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiP18111.
KOiK09312.
OMAiTQRRTPY.
OrthoDBiEOG091G0LXJ.
PhylomeDBiP18111.
TreeFamiTF351605.

Miscellaneous databases

PROiP18111.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024619.
CleanExiMM_CDX1.
GenevisibleiP18111. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDX1_MOUSE
AccessioniPrimary (citable) accession number: P18111
Secondary accession number(s): Q8VCF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.