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P18111 (CDX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein CDX-1
Alternative name(s):
Caudal-type homeobox protein 1
Gene names
Name:Cdx1
Synonyms:Cdx-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could play a role in the terminal differentiation of the intestine.

Subcellular location

Nucleus.

Tissue specificity

Intestinal epithelium.

Sequence similarities

Belongs to the Caudal homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Homeobox protein CDX-1
PRO_0000048847

Regions

DNA binding154 – 21360Homeobox
Compositional bias144 – 1496Poly-Gly
Compositional bias217 – 2215Poly-Gln

Experimental info

Sequence conflict151P → Q in AAH19986. Ref.3
Sequence conflict1461G → C in AAA37412. Ref.2
Sequence conflict1571Y → S in AAA37412. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P18111 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 85F45B2A3E12B2AE

FASTA26828,436
        10         20         30         40         50         60 
MYVGYVLDKD SPVYPGPARP SSLGLGPPTY APPGPAPAPP QYPDFAGYTH VEPAPAPPPT 

        70         80         90        100        110        120 
WAAPFPAPKD DWAAAYGPGP TASAASPAPL AFGPPPDFSP VPAPPGPGPG ILAQSLGAPG 

       130        140        150        160        170        180 
APSSPGAPRR TPYEWMRRSV AAAGGGGSGK TRTKDKYRVV YTDHQRLELE KEFHYSRYIT 

       190        200        210        220        230        240 
IRRKSELAAN LGLTERQVKI WFQNRRAKER KVNKKKQQQQ QPLPPTQLPL PLDGTPTPSG 

       250        260 
PPLGSLCPTN AGLLGTPSPV PVKEEFLP 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of the murine homeobox gene Cdx-1. Regulation of expression in intestinal epithelial cells."
Hu Y., Kazenwadel J., James R.
J. Biol. Chem. 268:27214-27225(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine."
Duprey P., Chowdhury K., Dressler G.R., Balling R., Simon D., Guenet J.-L., Gruss P.
Genes Dev. 2:1647-1654(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Embryonic intestine.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M37163 mRNA. Translation: AAA37412.1. Sequence problems.
M80463 Unassigned DNA. Translation: AAA16447.1. Sequence problems.
BC019986 mRNA. Translation: AAH19986.1.
PIRA49303.
RefSeqNP_034010.3. NM_009880.3.
UniGeneMm.144448.

3D structure databases

ProteinModelPortalP18111.
SMRP18111. Positions 158-213.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198663. 6 interactions.
STRING10090.ENSMUSP00000025521.

PTM databases

PhosphoSiteP18111.

Proteomic databases

PRIDEP18111.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025521; ENSMUSP00000025521; ENSMUSG00000024619.
GeneID12590.
KEGGmmu:12590.
UCSCuc008fbj.2. mouse.

Organism-specific databases

CTD1044.
MGIMGI:88360. Cdx1.

Phylogenomic databases

eggNOGNOG291290.
GeneTreeENSGT00530000063388.
HOGENOMHOG000115975.
HOVERGENHBG005302.
InParanoidP18111.
KOK09312.
OMAYSHVEPG.
OrthoDBEOG71P2BK.
PhylomeDBP18111.
TreeFamTF351605.

Gene expression databases

BgeeP18111.
CleanExMM_CDX1.
GenevestigatorP18111.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281734.
PROP18111.
SOURCESearch...

Entry information

Entry nameCDX1_MOUSE
AccessionPrimary (citable) accession number: P18111
Secondary accession number(s): Q8VCF7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot