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P18111

- CDX1_MOUSE

UniProt

P18111 - CDX1_MOUSE

Protein

Homeobox protein CDX-1

Gene

Cdx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Could play a role in the terminal differentiation of the intestine.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi154 – 21360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. bone morphogenesis Source: MGI
    3. pattern specification process Source: MGI
    4. positive regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein CDX-1
    Alternative name(s):
    Caudal-type homeobox protein 1
    Gene namesi
    Name:Cdx1
    Synonyms:Cdx-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:88360. Cdx1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Homeobox protein CDX-1PRO_0000048847Add
    BLAST

    Proteomic databases

    PRIDEiP18111.

    PTM databases

    PhosphoSiteiP18111.

    Expressioni

    Tissue specificityi

    Intestinal epithelium.

    Gene expression databases

    BgeeiP18111.
    CleanExiMM_CDX1.
    GenevestigatoriP18111.

    Interactioni

    Protein-protein interaction databases

    BioGridi198663. 6 interactions.
    STRINGi10090.ENSMUSP00000025521.

    Structurei

    3D structure databases

    ProteinModelPortaliP18111.
    SMRiP18111. Positions 158-213.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi144 – 1496Poly-Gly
    Compositional biasi217 – 2215Poly-Gln

    Sequence similaritiesi

    Belongs to the Caudal homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG291290.
    GeneTreeiENSGT00530000063388.
    HOGENOMiHOG000115975.
    HOVERGENiHBG005302.
    InParanoidiP18111.
    KOiK09312.
    OMAiYSHVEPG.
    OrthoDBiEOG71P2BK.
    PhylomeDBiP18111.
    TreeFamiTF351605.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR006820. Caudal_activation_dom.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF04731. Caudal_act. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18111-1 [UniParc]FASTAAdd to Basket

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    MYVGYVLDKD SPVYPGPARP SSLGLGPPTY APPGPAPAPP QYPDFAGYTH    50
    VEPAPAPPPT WAAPFPAPKD DWAAAYGPGP TASAASPAPL AFGPPPDFSP 100
    VPAPPGPGPG ILAQSLGAPG APSSPGAPRR TPYEWMRRSV AAAGGGGSGK 150
    TRTKDKYRVV YTDHQRLELE KEFHYSRYIT IRRKSELAAN LGLTERQVKI 200
    WFQNRRAKER KVNKKKQQQQ QPLPPTQLPL PLDGTPTPSG PPLGSLCPTN 250
    AGLLGTPSPV PVKEEFLP 268
    Length:268
    Mass (Da):28,436
    Last modified:November 1, 1995 - v2
    Checksum:i85F45B2A3E12B2AE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151P → Q in AAH19986. (PubMed:15489334)Curated
    Sequence conflicti146 – 1461G → C in AAA37412. (PubMed:2905686)Curated
    Sequence conflicti157 – 1571Y → S in AAA37412. (PubMed:2905686)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37163 mRNA. Translation: AAA37412.1. Sequence problems.
    M80463 Unassigned DNA. Translation: AAA16447.1. Sequence problems.
    BC019986 mRNA. Translation: AAH19986.1.
    CCDSiCCDS29279.1.
    PIRiA49303.
    RefSeqiNP_034010.3. NM_009880.3.
    UniGeneiMm.144448.

    Genome annotation databases

    EnsembliENSMUST00000025521; ENSMUSP00000025521; ENSMUSG00000024619.
    GeneIDi12590.
    KEGGimmu:12590.
    UCSCiuc008fbj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37163 mRNA. Translation: AAA37412.1 . Sequence problems.
    M80463 Unassigned DNA. Translation: AAA16447.1 . Sequence problems.
    BC019986 mRNA. Translation: AAH19986.1 .
    CCDSi CCDS29279.1.
    PIRi A49303.
    RefSeqi NP_034010.3. NM_009880.3.
    UniGenei Mm.144448.

    3D structure databases

    ProteinModelPortali P18111.
    SMRi P18111. Positions 158-213.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198663. 6 interactions.
    STRINGi 10090.ENSMUSP00000025521.

    PTM databases

    PhosphoSitei P18111.

    Proteomic databases

    PRIDEi P18111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025521 ; ENSMUSP00000025521 ; ENSMUSG00000024619 .
    GeneIDi 12590.
    KEGGi mmu:12590.
    UCSCi uc008fbj.2. mouse.

    Organism-specific databases

    CTDi 1044.
    MGIi MGI:88360. Cdx1.

    Phylogenomic databases

    eggNOGi NOG291290.
    GeneTreei ENSGT00530000063388.
    HOGENOMi HOG000115975.
    HOVERGENi HBG005302.
    InParanoidi P18111.
    KOi K09312.
    OMAi YSHVEPG.
    OrthoDBi EOG71P2BK.
    PhylomeDBi P18111.
    TreeFami TF351605.

    Miscellaneous databases

    NextBioi 281734.
    PROi P18111.
    SOURCEi Search...

    Gene expression databases

    Bgeei P18111.
    CleanExi MM_CDX1.
    Genevestigatori P18111.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR006820. Caudal_activation_dom.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF04731. Caudal_act. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the murine homeobox gene Cdx-1. Regulation of expression in intestinal epithelial cells."
      Hu Y., Kazenwadel J., James R.
      J. Biol. Chem. 268:27214-27225(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine."
      Duprey P., Chowdhury K., Dressler G.R., Balling R., Simon D., Guenet J.-L., Gruss P.
      Genes Dev. 2:1647-1654(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Embryonic intestine.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiCDX1_MOUSE
    AccessioniPrimary (citable) accession number: P18111
    Secondary accession number(s): Q8VCF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3