P18111 (CDX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein CDX-1

Alternative name(s):
Caudal-type homeobox protein 1

Gene names

Name:	Cdx1
Synonyms:	Cdx-1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Could play a role in the terminal differentiation of the intestine.
Subcellular location	Nucleus.
Tissue specificity	Intestinal epithelium.
Sequence similarities	Belongs to the Caudal homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from mutant phenotype PubMed 11784046PubMed 7585967. Source: MGI bone morphogenesis Inferred from mutant phenotype PubMed 11784046. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 7585967. Source: MGI
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA polymerase II distal enhancer sequence-specific DNA binding Inferred from electronic annotation. Source: Ensembl RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from electronic annotation. Source: Ensembl
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Homeobox protein CDX-1		PRO_0000048847
Regions
	DNA binding	154 – 213	60	Homeobox
	Compositional bias	144 – 149	6	Poly-Gly
	Compositional bias	217 – 221	5	Poly-Gln
Experimental info
	Sequence conflict	15	1	P → Q in AAH19986. Ref.3
	Sequence conflict	146	1	G → C in AAA37412. Ref.2
	Sequence conflict	157	1	Y → S in AAA37412. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P18111 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 85F45B2A3E12B2AE	FASTA	268	28,436
	10 20 30 40 50 60 MYVGYVLDKD SPVYPGPARP SSLGLGPPTY APPGPAPAPP QYPDFAGYTH VEPAPAPPPT 70 80 90 100 110 120 WAAPFPAPKD DWAAAYGPGP TASAASPAPL AFGPPPDFSP VPAPPGPGPG ILAQSLGAPG 130 140 150 160 170 180 APSSPGAPRR TPYEWMRRSV AAAGGGGSGK TRTKDKYRVV YTDHQRLELE KEFHYSRYIT 190 200 210 220 230 240 IRRKSELAAN LGLTERQVKI WFQNRRAKER KVNKKKQQQQ QPLPPTQLPL PLDGTPTPSG 250 260 PPLGSLCPTN AGLLGTPSPV PVKEEFLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the murine homeobox gene Cdx-1. Regulation of expression in intestinal epithelial cells." Hu Y., Kazenwadel J., James R. J. Biol. Chem. 268:27214-27225(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine." Duprey P., Chowdhury K., Dressler G.R., Balling R., Simon D., Guenet J.-L., Gruss P. Genes Dev. 2:1647-1654(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Embryonic intestine.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M37163 mRNA. Translation: AAA37412.1. Sequence problems. M80463 Unassigned DNA. Translation: AAA16447.1. Sequence problems. BC019986 mRNA. Translation: AAH19986.1.
IPI	IPI00109616.
PIR	A49303.
RefSeq	NP_034010.3. NM_009880.3.
UniGene	Mm.144448.
3D structure databases
ProteinModelPortal	P18111.
SMR	P18111. Positions 158-213.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000025521.
PTM databases
PhosphoSite	P18111.
Proteomic databases
PRIDE	P18111.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025521; ENSMUSP00000025521; ENSMUSG00000024619.
GeneID	12590.
KEGG	mmu:12590.
UCSC	uc008fbj.2. mouse.
Organism-specific databases
CTD	1044.
MGI	MGI:88360. Cdx1.
Phylogenomic databases
eggNOG	NOG291290.
GeneTree	ENSGT00530000063388.
HOGENOM	HOG000115975.
HOVERGEN	HBG005302.
InParanoid	P18111.
KO	K09312.
OMA	YSHVEPG.
OrthoDB	EOG71P2BK.
Gene expression databases
Bgee	P18111.
CleanEx	MM_CDX1.
Genevestigator	P18111.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR006820. Caudal_activation_dom. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR020479. Homeobox_metazoa. IPR009057. Homeodomain-like. IPR000047. HTH_motif. [Graphical view]
Pfam	PF04731. Caudal_act. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. SSF46689. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	281734.
PRO	P18111.
SOURCE	Search...

Entry information

Entry name

CDX1_MOUSE

Accession

Primary (citable) accession number: P18111
Secondary accession number(s): Q8VCF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1995
Last modified:	November 13, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program