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P18106

- FPS_DROME

UniProt

P18106 - FPS_DROME

Protein

Tyrosine-protein kinase Fps85D

Gene

Fps85D

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 3 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1092 – 10921ATPPROSITE-ProRule annotation
    Active sitei1185 – 11851Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1069 – 10779ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    3. phospholipid binding Source: FlyBase
    4. protein tyrosine kinase activity Source: FlyBase

    GO - Biological processi

    1. actin filament bundle assembly Source: FlyBase
    2. axon guidance Source: FlyBase
    3. dorsal closure Source: FlyBase
    4. dorsal closure, amnioserosa morphology change Source: FlyBase
    5. dorsal closure, elongation of leading edge cells Source: FlyBase
    6. peptidyl-tyrosine phosphorylation Source: GOC
    7. protein phosphorylation Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein, Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 1994.
    SignaLinkiP18106.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase Fps85D (EC:2.7.10.2)
    Alternative name(s):
    dFer
    Gene namesi
    Name:Fps85D
    Synonyms:Fer, fps, HD-179
    ORF Names:CG8874
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0000723. Fps85D.

    Subcellular locationi

    Membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. adherens junction Source: FlyBase
    2. extrinsic component of membrane Source: FlyBase
    3. plasma membrane Source: FlyBase

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13251325Tyrosine-protein kinase Fps85DPRO_0000088095Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1213 – 12131Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP18106.

    Expressioni

    Tissue specificityi

    Expressed in many tissues during embryonic development, some expression is transient and absent from most of nervous system. Larvae exhibit graded expression in all imaginal disks and expression in neural tissues. Pupal expression is seen in muscles and varies during development. Expression in adults is strong in the retina and present in ovaries, no expression is present in adult brain.1 Publication

    Developmental stagei

    Isoforms B and D are expressed in identical patterns during all stages of development.1 Publication

    Gene expression databases

    BgeeiP18106.

    Interactioni

    Protein-protein interaction databases

    BioGridi66283. 5 interactions.
    IntActiP18106. 4 interactions.
    MINTiMINT-892362.

    Structurei

    3D structure databases

    ProteinModelPortaliP18106.
    SMRiP18106. Positions 1-306, 953-1320.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8282FCHPROSITE-ProRule annotationAdd
    BLAST
    Domaini960 – 105192SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1063 – 1318256Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.PROSITE-ProRule annotation
    Contains 1 FCH domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117264.
    InParanoidiP18106.
    KOiK08889.
    OMAiHIYADLE.
    OrthoDBiEOG708VXW.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR001060. FCH_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF00611. FCH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00055. FCH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50133. FCH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: P18106-4) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGFSSALQSR AAHEALIVRQ DAELRLMETM KRSIQMKAKC DKEYAISLTA     50
    VAQQGLKIDR ADEMQGSLIS KSWRSYMDEL DHQAKQFKFN AEQLEVVCDK 100
    LTHLSQDKRK ARKAYQEEHA KIAARLNHLT DEVVRKKSEY QKHLEGYKAL 150
    RTRFEENYIK APSRSGRKLD DVRDKYQKAC RKLHLTHNEY VLSITEAIEV 200
    EKDFRNVLLP GLLEHQQSVQ ESFILLWRNI LQEAAQYGDL TADKYKEIQK 250
    RIDTVIGSIN PTEEYGEFTE KYKTSPTTPL LFQFDETLIQ DIPGKLQSST 300
    LTVDNLTVDW LRNRLQELEG AVRDCQEKQM KMIEHVNGGS PVANGSIISN 350
    GSNTSNGIQS NKDSLCRQSK DLNALRCQEK QKQKLVDMIK CALNEVGCEE 400
    LPSGCDDDLT LEQNFIENGY NNEQQRSNST SSPGLGIMNE LMRRGGVLTL 450
    LRGRGRHFKR KSTPQPATPM TRSRQGRFNK LQPRSQSLGS LSVIRDGNGP 500
    SPARYEPITN HRLRQAASVH YLGEEIATSS TNPPDLTRLR RTQCSMLCLG 550
    EDEEPVVLAS PAPLTQLTAA VLTNTNNNHI YADLELDKKK DTSPSPECKG 600
    EQIQPKKEQI RIEINQTAPQ NSIDAHLDRI DELNRVLDDR LKRTLQPSDD 650
    VNAIESAEEN HIQTRKLAKD PDSQTKRSSS SSSECRSSKD TSHSKKRSLS 700
    FSQKSISNIF SNLKEFSKSP LVRMGKNHIL NEEQDAKRTQ PSQHHHSSGS 750
    DCPTNSSSSS SNNNNNNKNT SSNSNHSASQ STIITSTITT TITTTTTTTP 800
    SKENSRLKFK VPKIQKKSKA IRNTFRSKLL NFQLKRSKPC KQCTKRRRIH 850
    PSKSVFDFAK EFEVEQPAGS AADEQFCNCP PAGQKPVKPS VQISGHKDHP 900
    FESSSGELDE NSDRDIDNDE EEEDSASDDV LSMKDHCYCV PSLAASISLS 950
    TNRPLYEEEW FHGVLPREEV VRLLNNDGDF LVRETIRNEE SQIVLSVCWN 1000
    GHKHFIVQTT GEGNFRFEGP PFASIQELIM HQYHSELPVT VKSGAILRRP 1050
    VCRERWELSN DDVVLLERIG RGNFGDVYKA KLKSTKLDVA VKTCRMTLPD 1100
    EQKRKFLQEG RILKQYDHPN IVKLIGICVQ KQPIMIVMEL VLGGSLLTYL 1150
    RKNSNGLTTR QQMGMCRDAA AGMRYLESKN CIHRDLAARN CLVDLEHSVK 1200
    ISDFGMSREE EEYIVSDGMK QIPVKWTAPE ALNFGKYTSL CDVWSYGILM 1250
    WEIFSKGDTP YSGMTNSRAR ERIDTGYRMP TPKSTPEEMY RLMLQCWAAD 1300
    AESRPHFDEI YNVVDALILR LDNSH 1325

    Note: No experimental confirmation available.

    Length:1,325
    Mass (Da):150,263
    Last modified:March 1, 2004 - v3
    Checksum:i7DFC98D9B9776E78
    GO
    Isoform B (identifier: P18106-1) [UniParc]FASTAAdd to Basket

    Also known as: p92

    The sequence of this isoform differs from the canonical sequence as follows:
         426-946: Missing.

    Show »
    Length:804
    Mass (Da):92,439
    Checksum:i6666EA45BF6E5784
    GO
    Isoform C (identifier: P18106-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-329: Missing.
         426-946: Missing.

    Show »
    Length:475
    Mass (Da):54,200
    Checksum:i09EA965D56F33E62
    GO
    Isoform D (identifier: P18106-2) [UniParc]FASTAAdd to Basket

    Also known as: p45

    The sequence of this isoform differs from the canonical sequence as follows:
         1-932: Missing.

    Show »
    Length:393
    Mass (Da):45,192
    Checksum:iD222275E8240C0FF
    GO

    Sequence cautioni

    The sequence AAA93470.1 differs from that shown. Reason: Frameshift at positions 937, 941 and 944.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581I → T in CAA37036. (PubMed:1898762)Curated
    Sequence conflicti230 – 24819ILQEA…KYKEI → TCRRRPSMATSRPTSTRRF in CAA37036. (PubMed:1898762)CuratedAdd
    BLAST
    Sequence conflicti320 – 34122GAVRD…NGGSP → EPSGLPGEADEDDRACEWWL A in CAA37036. (PubMed:1898762)CuratedAdd
    BLAST
    Sequence conflicti364 – 3641S → D in CAA37036. (PubMed:1898762)Curated
    Sequence conflicti940 – 9401V → W(PubMed:9038371)Curated
    Sequence conflicti1050 – 10501P → T(PubMed:1898762)Curated
    Sequence conflicti1050 – 10501P → T(PubMed:9038371)Curated
    Sequence conflicti1161 – 11611Q → E(PubMed:1898762)Curated
    Sequence conflicti1161 – 11611Q → E(PubMed:9038371)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 932932Missing in isoform D. 1 PublicationVSP_004986Add
    BLAST
    Alternative sequencei1 – 329329Missing in isoform C. CuratedVSP_004987Add
    BLAST
    Alternative sequencei426 – 946521Missing in isoform B and isoform C. 2 PublicationsVSP_004988Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52844 mRNA. Translation: CAA37036.1.
    U50450 mRNA. Translation: AAA93470.1. Frameshift.
    AE014297 Genomic DNA. Translation: AAF54366.1.
    AE014297 Genomic DNA. Translation: AAF54367.3.
    AE014297 Genomic DNA. Translation: AAN13420.1.
    AE014297 Genomic DNA. Translation: AAN13421.1.
    BT003462 mRNA. Translation: AAO39465.1.
    AJ002916 Genomic DNA. Translation: CAA05751.1.
    PIRiA39670. OKFFPS.
    RefSeqiNP_524288.3. NM_079564.4. [P18106-4]
    NP_731341.1. NM_169274.2. [P18106-1]
    NP_731342.1. NM_169275.2. [P18106-3]
    NP_731343.1. NM_169276.2. [P18106-2]
    UniGeneiDm.8026.

    Genome annotation databases

    EnsemblMetazoaiFBtr0082052; FBpp0081530; FBgn0000723. [P18106-4]
    GeneIDi41118.
    KEGGidme:Dmel_CG8874.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52844 mRNA. Translation: CAA37036.1 .
    U50450 mRNA. Translation: AAA93470.1 . Frameshift.
    AE014297 Genomic DNA. Translation: AAF54366.1 .
    AE014297 Genomic DNA. Translation: AAF54367.3 .
    AE014297 Genomic DNA. Translation: AAN13420.1 .
    AE014297 Genomic DNA. Translation: AAN13421.1 .
    BT003462 mRNA. Translation: AAO39465.1 .
    AJ002916 Genomic DNA. Translation: CAA05751.1 .
    PIRi A39670. OKFFPS.
    RefSeqi NP_524288.3. NM_079564.4. [P18106-4 ]
    NP_731341.1. NM_169274.2. [P18106-1 ]
    NP_731342.1. NM_169275.2. [P18106-3 ]
    NP_731343.1. NM_169276.2. [P18106-2 ]
    UniGenei Dm.8026.

    3D structure databases

    ProteinModelPortali P18106.
    SMRi P18106. Positions 1-306, 953-1320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 66283. 5 interactions.
    IntActi P18106. 4 interactions.
    MINTi MINT-892362.

    Proteomic databases

    PaxDbi P18106.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0082052 ; FBpp0081530 ; FBgn0000723 . [P18106-4 ]
    GeneIDi 41118.
    KEGGi dme:Dmel_CG8874.

    Organism-specific databases

    CTDi 41118.
    FlyBasei FBgn0000723. Fps85D.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117264.
    InParanoidi P18106.
    KOi K08889.
    OMAi HIYADLE.
    OrthoDBi EOG708VXW.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 1994.
    SignaLinki P18106.

    Miscellaneous databases

    GenomeRNAii 41118.
    NextBioi 822270.
    PROi P18106.

    Gene expression databases

    Bgeei P18106.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR001060. FCH_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00611. FCH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00055. FCH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50133. FCH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A gene related to the proto-oncogene fps/fes is expressed at diverse times during the life cycle of Drosophila melanogaster."
      Katzen A.L., Montarras D., Jackson J., Paulson R.F., Kornberg T., Bishop J.M.
      Mol. Cell. Biol. 11:226-239(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Embryo and Head.
    2. "The DFer gene of Drosophila melanogaster encodes two membrane-associated proteins that can both transform vertebrate cells."
      Paulson R.F., Jackson J., Immergluck K., Bishop J.M.
      Oncogene 14:641-652(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND D), SUBCELLULAR LOCATION.
      Tissue: Embryo and Head.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Strain: Berkeley.
      Tissue: Head.
    6. "Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA."
      Oates A.C., Wollberg P., Achen M.G., Wilks A.F.
      Biochem. Biophys. Res. Commun. 249:660-667(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1191-1241.

    Entry informationi

    Entry nameiFPS_DROME
    AccessioniPrimary (citable) accession number: P18106
    Secondary accession number(s): Q27576
    , Q86P62, Q8INP1, Q8INP2, Q9TYI1, Q9VHE7, Q9VHE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 159 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3