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P18106

- FPS_DROME

UniProt

P18106 - FPS_DROME

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Protein
Tyrosine-protein kinase Fps85D
Gene
Fps85D, Fer, fps, HD-179, CG8874
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1092 – 10921ATP By similarity
Active sitei1185 – 11851Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1069 – 10779ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  3. phospholipid binding Source: FlyBase
  4. protein tyrosine kinase activity Source: FlyBase
Complete GO annotation...

GO - Biological processi

  1. actin filament bundle assembly Source: FlyBase
  2. axon guidance Source: FlyBase
  3. dorsal closure Source: FlyBase
  4. dorsal closure, amnioserosa morphology change Source: FlyBase
  5. dorsal closure, elongation of leading edge cells Source: FlyBase
  6. peptidyl-tyrosine phosphorylation Source: GOC
  7. protein phosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1994.
SignaLinkiP18106.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Fps85D (EC:2.7.10.2)
Alternative name(s):
dFer
Gene namesi
Name:Fps85D
Synonyms:Fer, fps, HD-179
ORF Names:CG8874
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000723. Fps85D.

Subcellular locationi

Membrane; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. adherens junction Source: FlyBase
  2. extrinsic component of membrane Source: FlyBase
  3. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13251325Tyrosine-protein kinase Fps85D
PRO_0000088095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1213 – 12131Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP18106.

Expressioni

Tissue specificityi

Expressed in many tissues during embryonic development, some expression is transient and absent from most of nervous system. Larvae exhibit graded expression in all imaginal disks and expression in neural tissues. Pupal expression is seen in muscles and varies during development. Expression in adults is strong in the retina and present in ovaries, no expression is present in adult brain.1 Publication

Developmental stagei

Isoforms B and D are expressed in identical patterns during all stages of development.1 Publication

Gene expression databases

BgeeiP18106.

Interactioni

Protein-protein interaction databases

BioGridi66283. 5 interactions.
IntActiP18106. 4 interactions.
MINTiMINT-892362.

Structurei

3D structure databases

ProteinModelPortaliP18106.
SMRiP18106. Positions 1-306, 953-1320.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282FCH
Add
BLAST
Domaini960 – 105192SH2
Add
BLAST
Domaini1063 – 1318256Protein kinase
Add
BLAST

Sequence similaritiesi

Contains 1 FCH domain.
Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00750000117264.
InParanoidiP18106.
KOiK08889.
OMAiHIYADLE.
OrthoDBiEOG708VXW.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P18106-4) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGFSSALQSR AAHEALIVRQ DAELRLMETM KRSIQMKAKC DKEYAISLTA     50
VAQQGLKIDR ADEMQGSLIS KSWRSYMDEL DHQAKQFKFN AEQLEVVCDK 100
LTHLSQDKRK ARKAYQEEHA KIAARLNHLT DEVVRKKSEY QKHLEGYKAL 150
RTRFEENYIK APSRSGRKLD DVRDKYQKAC RKLHLTHNEY VLSITEAIEV 200
EKDFRNVLLP GLLEHQQSVQ ESFILLWRNI LQEAAQYGDL TADKYKEIQK 250
RIDTVIGSIN PTEEYGEFTE KYKTSPTTPL LFQFDETLIQ DIPGKLQSST 300
LTVDNLTVDW LRNRLQELEG AVRDCQEKQM KMIEHVNGGS PVANGSIISN 350
GSNTSNGIQS NKDSLCRQSK DLNALRCQEK QKQKLVDMIK CALNEVGCEE 400
LPSGCDDDLT LEQNFIENGY NNEQQRSNST SSPGLGIMNE LMRRGGVLTL 450
LRGRGRHFKR KSTPQPATPM TRSRQGRFNK LQPRSQSLGS LSVIRDGNGP 500
SPARYEPITN HRLRQAASVH YLGEEIATSS TNPPDLTRLR RTQCSMLCLG 550
EDEEPVVLAS PAPLTQLTAA VLTNTNNNHI YADLELDKKK DTSPSPECKG 600
EQIQPKKEQI RIEINQTAPQ NSIDAHLDRI DELNRVLDDR LKRTLQPSDD 650
VNAIESAEEN HIQTRKLAKD PDSQTKRSSS SSSECRSSKD TSHSKKRSLS 700
FSQKSISNIF SNLKEFSKSP LVRMGKNHIL NEEQDAKRTQ PSQHHHSSGS 750
DCPTNSSSSS SNNNNNNKNT SSNSNHSASQ STIITSTITT TITTTTTTTP 800
SKENSRLKFK VPKIQKKSKA IRNTFRSKLL NFQLKRSKPC KQCTKRRRIH 850
PSKSVFDFAK EFEVEQPAGS AADEQFCNCP PAGQKPVKPS VQISGHKDHP 900
FESSSGELDE NSDRDIDNDE EEEDSASDDV LSMKDHCYCV PSLAASISLS 950
TNRPLYEEEW FHGVLPREEV VRLLNNDGDF LVRETIRNEE SQIVLSVCWN 1000
GHKHFIVQTT GEGNFRFEGP PFASIQELIM HQYHSELPVT VKSGAILRRP 1050
VCRERWELSN DDVVLLERIG RGNFGDVYKA KLKSTKLDVA VKTCRMTLPD 1100
EQKRKFLQEG RILKQYDHPN IVKLIGICVQ KQPIMIVMEL VLGGSLLTYL 1150
RKNSNGLTTR QQMGMCRDAA AGMRYLESKN CIHRDLAARN CLVDLEHSVK 1200
ISDFGMSREE EEYIVSDGMK QIPVKWTAPE ALNFGKYTSL CDVWSYGILM 1250
WEIFSKGDTP YSGMTNSRAR ERIDTGYRMP TPKSTPEEMY RLMLQCWAAD 1300
AESRPHFDEI YNVVDALILR LDNSH 1325

Note: No experimental confirmation available.

Length:1,325
Mass (Da):150,263
Last modified:March 1, 2004 - v3
Checksum:i7DFC98D9B9776E78
GO
Isoform B (identifier: P18106-1) [UniParc]FASTAAdd to Basket

Also known as: p92

The sequence of this isoform differs from the canonical sequence as follows:
     426-946: Missing.

Show »
Length:804
Mass (Da):92,439
Checksum:i6666EA45BF6E5784
GO
Isoform C (identifier: P18106-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.
     426-946: Missing.

Show »
Length:475
Mass (Da):54,200
Checksum:i09EA965D56F33E62
GO
Isoform D (identifier: P18106-2) [UniParc]FASTAAdd to Basket

Also known as: p45

The sequence of this isoform differs from the canonical sequence as follows:
     1-932: Missing.

Show »
Length:393
Mass (Da):45,192
Checksum:iD222275E8240C0FF
GO

Sequence cautioni

The sequence AAA93470.1 differs from that shown. Reason: Frameshift at positions 937, 941 and 944.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 932932Missing in isoform D.
VSP_004986Add
BLAST
Alternative sequencei1 – 329329Missing in isoform C.
VSP_004987Add
BLAST
Alternative sequencei426 – 946521Missing in isoform B and isoform C.
VSP_004988Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581I → T in CAA37036. 1 Publication
Sequence conflicti230 – 24819ILQEA…KYKEI → TCRRRPSMATSRPTSTRRF in CAA37036. 1 Publication
Add
BLAST
Sequence conflicti320 – 34122GAVRD…NGGSP → EPSGLPGEADEDDRACEWWL A in CAA37036. 1 Publication
Add
BLAST
Sequence conflicti364 – 3641S → D in CAA37036. 1 Publication
Sequence conflicti940 – 9401V → W1 Publication
Sequence conflicti1050 – 10501P → T1 Publication
Sequence conflicti1050 – 10501P → T1 Publication
Sequence conflicti1161 – 11611Q → E1 Publication
Sequence conflicti1161 – 11611Q → E1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52844 mRNA. Translation: CAA37036.1.
U50450 mRNA. Translation: AAA93470.1. Frameshift.
AE014297 Genomic DNA. Translation: AAF54366.1.
AE014297 Genomic DNA. Translation: AAF54367.3.
AE014297 Genomic DNA. Translation: AAN13420.1.
AE014297 Genomic DNA. Translation: AAN13421.1.
BT003462 mRNA. Translation: AAO39465.1.
AJ002916 Genomic DNA. Translation: CAA05751.1.
PIRiA39670. OKFFPS.
RefSeqiNP_524288.3. NM_079564.4. [P18106-4]
NP_731341.1. NM_169274.2. [P18106-1]
NP_731342.1. NM_169275.2. [P18106-3]
NP_731343.1. NM_169276.2. [P18106-2]
UniGeneiDm.8026.

Genome annotation databases

EnsemblMetazoaiFBtr0082052; FBpp0081530; FBgn0000723. [P18106-4]
GeneIDi41118.
KEGGidme:Dmel_CG8874.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52844 mRNA. Translation: CAA37036.1 .
U50450 mRNA. Translation: AAA93470.1 . Frameshift.
AE014297 Genomic DNA. Translation: AAF54366.1 .
AE014297 Genomic DNA. Translation: AAF54367.3 .
AE014297 Genomic DNA. Translation: AAN13420.1 .
AE014297 Genomic DNA. Translation: AAN13421.1 .
BT003462 mRNA. Translation: AAO39465.1 .
AJ002916 Genomic DNA. Translation: CAA05751.1 .
PIRi A39670. OKFFPS.
RefSeqi NP_524288.3. NM_079564.4. [P18106-4 ]
NP_731341.1. NM_169274.2. [P18106-1 ]
NP_731342.1. NM_169275.2. [P18106-3 ]
NP_731343.1. NM_169276.2. [P18106-2 ]
UniGenei Dm.8026.

3D structure databases

ProteinModelPortali P18106.
SMRi P18106. Positions 1-306, 953-1320.
ModBasei Search...

Protein-protein interaction databases

BioGridi 66283. 5 interactions.
IntActi P18106. 4 interactions.
MINTi MINT-892362.

Proteomic databases

PaxDbi P18106.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0082052 ; FBpp0081530 ; FBgn0000723 . [P18106-4 ]
GeneIDi 41118.
KEGGi dme:Dmel_CG8874.

Organism-specific databases

CTDi 41118.
FlyBasei FBgn0000723. Fps85D.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00750000117264.
InParanoidi P18106.
KOi K08889.
OMAi HIYADLE.
OrthoDBi EOG708VXW.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 1994.
SignaLinki P18106.

Miscellaneous databases

GenomeRNAii 41118.
NextBioi 822270.
PROi P18106.

Gene expression databases

Bgeei P18106.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A gene related to the proto-oncogene fps/fes is expressed at diverse times during the life cycle of Drosophila melanogaster."
    Katzen A.L., Montarras D., Jackson J., Paulson R.F., Kornberg T., Bishop J.M.
    Mol. Cell. Biol. 11:226-239(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryo and Head.
  2. "The DFer gene of Drosophila melanogaster encodes two membrane-associated proteins that can both transform vertebrate cells."
    Paulson R.F., Jackson J., Immergluck K., Bishop J.M.
    Oncogene 14:641-652(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND D), SUBCELLULAR LOCATION.
    Tissue: Embryo and Head.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley.
    Tissue: Head.
  6. "Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA."
    Oates A.C., Wollberg P., Achen M.G., Wilks A.F.
    Biochem. Biophys. Res. Commun. 249:660-667(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1191-1241.

Entry informationi

Entry nameiFPS_DROME
AccessioniPrimary (citable) accession number: P18106
Secondary accession number(s): Q27576
, Q86P62, Q8INP1, Q8INP2, Q9TYI1, Q9VHE7, Q9VHE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 1, 2004
Last modified: July 9, 2014
This is version 158 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi