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Protein

Kinesin-like protein Nod

Gene

nod

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the distributive chromosome segregation of non-exchange chromosomes during meiosis. May be a microtubule motor required to hold distributively "paired" chromosomes at the metaphase plate until anaphase.

Miscellaneous

The nod(DTW) mutation is a cold-sensitive recessive lethal mutation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi87 – 94ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
  • microtubule motor activity Source: UniProtKB
  • microtubule plus-end binding Source: FlyBase

GO - Biological processi

  • distributive segregation Source: FlyBase
  • establishment of meiotic spindle orientation Source: FlyBase
  • female meiotic nuclear division Source: FlyBase
  • meiotic chromosome segregation Source: UniProtKB
  • microtubule-based movement Source: FlyBase
  • positive regulation of microtubule polymerization Source: FlyBase
  • spindle assembly involved in female meiosis I Source: FlyBase

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein Nod
Gene namesi
Name:nod
Synonyms:NODA
ORF Names:CG1763
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0002948 nod

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254261 – 666Kinesin-like protein NodAdd BLAST666

Proteomic databases

PaxDbiP18105
PRIDEiP18105

Expressioni

Tissue specificityi

In adult female, found in meiotically active ovaries.

Developmental stagei

Embryonic, larval, and pupal stages. Only expressed in female adults.

Gene expression databases

BgeeiFBgn0002948
ExpressionAtlasiP18105 baseline and differential
GenevisibleiP18105 DM

Interactioni

GO - Molecular functioni

  • microtubule plus-end binding Source: FlyBase

Protein-protein interaction databases

BioGridi58516, 6 interactors
DIPiDIP-22708N
IntActiP18105, 1 interactor
STRINGi7227.FBpp0073363

Structurei

Secondary structure

1666
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 15Combined sources9
Beta strandi29 – 31Combined sources3
Beta strandi34 – 36Combined sources3
Beta strandi38 – 43Combined sources6
Beta strandi46 – 49Combined sources4
Beta strandi51 – 54Combined sources4
Helixi60 – 67Combined sources8
Helixi69 – 77Combined sources9
Beta strandi81 – 88Combined sources8
Helixi93 – 97Combined sources5
Helixi102 – 104Combined sources3
Helixi107 – 109Combined sources3
Helixi112 – 126Combined sources15
Beta strandi127 – 130Combined sources4
Beta strandi136 – 147Combined sources12
Beta strandi149 – 151Combined sources3
Turni165 – 167Combined sources3
Beta strandi172 – 176Combined sources5
Helixi177 – 189Combined sources13
Beta strandi205 – 214Combined sources10
Beta strandi219 – 226Combined sources8
Helixi252 – 264Combined sources13
Helixi272 – 274Combined sources3
Helixi276 – 280Combined sources5
Turni281 – 284Combined sources4
Beta strandi290 – 297Combined sources8
Helixi301 – 303Combined sources3
Helixi304 – 318Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DC4X-ray1.90A1-318[»]
3DCBX-ray2.50A1-318[»]
3DCOelectron microscopy1.90N1-318[»]
3PXNX-ray2.60A1-322[»]
ProteinModelPortaliP18105
SMRiP18105
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18105

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 320Kinesin motorPROSITE-ProRule annotationAdd BLAST313

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili639 – 666Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0244 Eukaryota
COG5059 LUCA
HOGENOMiHOG000244977
InParanoidiP18105
OMAiQRTRSEM
OrthoDBiEOG091G021T
PhylomeDBiP18105

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR010994 RuvA_2-like
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF47781 SSF47781, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGAKLSAVR IAVREAPYRQ FLGRREPSVV QFPPWSDGKS LIVDQNEFHF
60 70 80 90 100
DHAFPATISQ DEMYQALILP LVDKLLEGFQ CTALAYGQTG TGKSYSMGMT
110 120 130 140 150
PPGEILPEHL GILPRALGDI FERVTARQEN NKDAIQVYAS FIEIYNEKPF
160 170 180 190 200
DLLGSTPHMP MVAARCQRCT CLPLHSQADL HHILELGTRN RRVRPTNMNS
210 220 230 240 250
NSSRSHAIVT IHVKSKTHHS RMNIVDLAGS EGVRRTGHEG VARQEGVNIN
260 270 280 290 300
LGLLSINKVV MSMAAGHTVI PYRDSVLTTV LQASLTAQSY LTFLACISPH
310 320 330 340 350
QCDLSETLST LRFGTSAKKL RLNPMQVARQ KQSLAARTTH VFRQALCTST
360 370 380 390 400
AIKSNAANHN SIVVPKSKYS TTKPLSAVLH RTRSELGMTP KAKKRARELL
410 420 430 440 450
ELEETTLELS SIHIQDSSLS LLGFHSDSDK DRHLMPPPTG QEPRQASSQN
460 470 480 490 500
STLMGIVEET EPKESSKVQQ SMVAPTVPTT VRCQLFNTTI SPISLRASSS
510 520 530 540 550
QRELSGIQPM EETVVASPQQ PCLRRSVRLA SSMRSQNYGA IPKVMNLRRS
560 570 580 590 600
TRLAGIREHA TSVVVKNETD AIPHLRSTVQ KKRTRNVKPA PKAWMANNTK
610 620 630 640 650
CFLDLLNNGN VKQLQEIPGI GPKSAFSLAL HRSRLGCFEN LFQVKSLPIW
660
SGNKWERFCQ INCLDT
Length:666
Mass (Da):73,908
Last modified:November 1, 1990 - v1
Checksum:iE3DEF72C08973FC2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti94S → N in allele NOD(DTW). 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36195 Genomic DNA Translation: AAA28653.1
M94188 Genomic DNA Translation: AAC14452.1
AE014298 Genomic DNA Translation: AAF48064.2
AY050238 mRNA Translation: AAK84937.1
PIRiA36026
RefSeqiNP_001285129.1, NM_001298200.1
NP_511125.2, NM_078570.3
UniGeneiDm.139

Genome annotation databases

EnsemblMetazoaiFBtr0073516; FBpp0073363; FBgn0002948
FBtr0340297; FBpp0309258; FBgn0002948
GeneIDi32107
KEGGidme:Dmel_CG1763

Similar proteinsi

Entry informationi

Entry nameiNOD_DROME
AccessioniPrimary (citable) accession number: P18105
Secondary accession number(s): Q9VYW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health