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P18104 (ANFC_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-type natriuretic peptide

Cleaved into the following 3 chains:

  1. CNP-22
  2. CNP-29
  3. CNP-53
Gene names
Name:NPPC
Synonyms:CNP
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length126 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the natriuretic peptide family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 7350
PRO_0000001561
Peptide74 – 12653CNP-53 Ref.2
PRO_0000001562
Peptide98 – 12629CNP-29 By similarity
PRO_0000001563
Peptide105 – 12622CNP-22 Ref.3
PRO_0000001564

Amino acid modifications

Disulfide bond110 ↔ 126

Sequences

Sequence LengthMass (Da)Tools
P18104 [UniParc].

Last modified August 1, 1991. Version 2.
Checksum: E2474B2D4AABF4DD

FASTA12613,243
        10         20         30         40         50         60 
MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPGEEV AEPQAAGGGQ KKGDKTPGGG 

        70         80         90        100        110        120 
GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG GNKKGLSKGC FGLKLDRIGS 


MSGLGC 

« Hide

References

[1]"Gene and precursor structure of porcine C-type natriuretic peptide."
Tawaragi Y., Fuchimura K., Nakazato H., Tanaka S., Minamino N., Kangawa K., Matsuo H.
Biochem. Biophys. Res. Commun. 172:627-632(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"N-terminally extended form of C-type natriuretic peptide (CNP-53) identified in porcine brain."
Minamino N., Kangawa K., Matsuo H.
Biochem. Biophys. Res. Commun. 170:973-979(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 74-126.
Tissue: Brain.
[3]"C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain."
Sudoh T., Minamino N., Kangawa K., Matsuo H.
Biochem. Biophys. Res. Commun. 168:863-870(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 105-126.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64758 Genomic DNA. Translation: AAA31018.1.
PIRA36155.
RefSeqNP_001008482.1. NM_001008482.1.
XP_005672336.1. XM_005672279.1.
XP_005672337.1. XM_005672280.1.
UniGeneSsc.23867.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000028969; ENSSSCP00000022217; ENSSSCG00000026852.
GeneID493772.
KEGGssc:493772.

Organism-specific databases

CTD4880.

Phylogenomic databases

GeneTreeENSGT00390000015492.
HOVERGENHBG004229.
KOK12336.
OMAHKMDRIG.
OrthoDBEOG79CZ1S.
TreeFamTF106305.

Family and domain databases

InterProIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
[Graphical view]
PfamPF00212. ANP. 1 hit.
[Graphical view]
PRINTSPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PMAP-CutDBP18104.

Entry information

Entry nameANFC_PIG
AccessionPrimary (citable) accession number: P18104
Secondary accession number(s): P21806
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 1, 1991
Last modified: February 19, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families