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P18104

- ANFC_PIG

UniProt

P18104 - ANFC_PIG

Protein

C-type natriuretic peptide

Gene

NPPC

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 By similarity.By similarity

    GO - Molecular functioni

    1. receptor binding Source: AgBase

    GO - Biological processi

    1. cGMP biosynthetic process Source: UniProtKB
    2. growth plate cartilage chondrocyte differentiation Source: UniProtKB
    3. growth plate cartilage chondrocyte proliferation Source: UniProtKB
    4. ossification Source: UniProtKB-KW
    5. post-embryonic development Source: Ensembl
    6. receptor guanylyl cyclase signaling pathway Source: UniProtKB
    7. regulation of blood vessel size Source: UniProtKB-KW
    8. regulation of multicellular organism growth Source: Ensembl

    Keywords - Molecular functioni

    Hormone, Vasoactive

    Keywords - Biological processi

    Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-type natriuretic peptide
    Cleaved into the following 3 chains:
    Gene namesi
    Name:NPPC
    Synonyms:CNP
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 15

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 73501 PublicationPRO_0000001561Add
    BLAST
    Peptidei74 – 12653CNP-53PRO_0000001562Add
    BLAST
    Peptidei98 – 12629CNP-29By similarityPRO_0000001563Add
    BLAST
    Peptidei105 – 12622CNP-22PRO_0000001564Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi110 ↔ 126

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Miscellaneous databases

    PMAP-CutDBP18104.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the natriuretic peptide family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00390000015492.
    HOVERGENiHBG004229.
    KOiK12336.
    OMAiHKMDRIG.
    OrthoDBiEOG79CZ1S.
    TreeFamiTF106305.

    Family and domain databases

    InterProiIPR002406. C_natriurtcpep.
    IPR000663. Natr_peptide.
    [Graphical view]
    PfamiPF00212. ANP. 1 hit.
    [Graphical view]
    PRINTSiPR00713. CNATPEPTIDE.
    PR00710. NATPEPTIDES.
    SMARTiSM00183. NAT_PEP. 1 hit.
    [Graphical view]
    PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18104-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPGEEV AEPQAAGGGQ    50
    KKGDKTPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG 100
    GNKKGLSKGC FGLKLDRIGS MSGLGC 126
    Length:126
    Mass (Da):13,243
    Last modified:August 1, 1991 - v2
    Checksum:iE2474B2D4AABF4DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64758 Genomic DNA. Translation: AAA31018.1.
    PIRiA36155.
    RefSeqiNP_001008482.1. NM_001008482.1.
    XP_005672336.1. XM_005672279.1.
    XP_005672337.1. XM_005672280.1.
    UniGeneiSsc.23867.

    Genome annotation databases

    EnsembliENSSSCT00000028969; ENSSSCP00000022217; ENSSSCG00000026852.
    GeneIDi493772.
    KEGGissc:493772.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64758 Genomic DNA. Translation: AAA31018.1 .
    PIRi A36155.
    RefSeqi NP_001008482.1. NM_001008482.1.
    XP_005672336.1. XM_005672279.1.
    XP_005672337.1. XM_005672280.1.
    UniGenei Ssc.23867.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000028969 ; ENSSSCP00000022217 ; ENSSSCG00000026852 .
    GeneIDi 493772.
    KEGGi ssc:493772.

    Organism-specific databases

    CTDi 4880.

    Phylogenomic databases

    GeneTreei ENSGT00390000015492.
    HOVERGENi HBG004229.
    KOi K12336.
    OMAi HKMDRIG.
    OrthoDBi EOG79CZ1S.
    TreeFami TF106305.

    Miscellaneous databases

    PMAP-CutDB P18104.

    Family and domain databases

    InterProi IPR002406. C_natriurtcpep.
    IPR000663. Natr_peptide.
    [Graphical view ]
    Pfami PF00212. ANP. 1 hit.
    [Graphical view ]
    PRINTSi PR00713. CNATPEPTIDE.
    PR00710. NATPEPTIDES.
    SMARTi SM00183. NAT_PEP. 1 hit.
    [Graphical view ]
    PROSITEi PS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "N-terminally extended form of C-type natriuretic peptide (CNP-53) identified in porcine brain."
      Minamino N., Kangawa K., Matsuo H.
      Biochem. Biophys. Res. Commun. 170:973-979(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 74-126.
      Tissue: Brain.
    3. "C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain."
      Sudoh T., Minamino N., Kangawa K., Matsuo H.
      Biochem. Biophys. Res. Commun. 168:863-870(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 105-126.
      Tissue: Brain.

    Entry informationi

    Entry nameiANFC_PIG
    AccessioniPrimary (citable) accession number: P18104
    Secondary accession number(s): P21806
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3