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Protein

C-type natriuretic peptide

Gene

NPPC

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Molecular functioni

  1. receptor binding Source: AgBase

GO - Biological processi

  1. cGMP biosynthetic process Source: UniProtKB
  2. growth plate cartilage chondrocyte differentiation Source: UniProtKB
  3. growth plate cartilage chondrocyte proliferation Source: UniProtKB
  4. negative regulation of meiotic cell cycle Source: Ensembl
  5. negative regulation of oocyte maturation Source: Ensembl
  6. ossification Source: UniProtKB-KW
  7. post-embryonic development Source: Ensembl
  8. receptor guanylyl cyclase signaling pathway Source: UniProtKB
  9. regulation of blood vessel size Source: UniProtKB-KW
  10. regulation of cAMP metabolic process Source: Ensembl
  11. regulation of cGMP metabolic process Source: Ensembl
  12. regulation of multicellular organism growth Source: Ensembl
  13. single organism reproductive process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Keywords - Biological processi

Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
C-type natriuretic peptide
Cleaved into the following 3 chains:
Gene namesi
Name:NPPC
Synonyms:CNP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 73501 PublicationPRO_0000001561Add
BLAST
Peptidei74 – 12653CNP-53PRO_0000001562Add
BLAST
Peptidei98 – 12629CNP-29By similarityPRO_0000001563Add
BLAST
Peptidei105 – 12622CNP-22PRO_0000001564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi110 ↔ 126

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Miscellaneous databases

PMAP-CutDBP18104.

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000015492.
HOVERGENiHBG004229.
InParanoidiP18104.
KOiK12336.
OMAiTPPGEEV.
OrthoDBiEOG79CZ1S.
TreeFamiTF106305.

Family and domain databases

InterProiIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPGEEV AEPQAAGGGQ
60 70 80 90 100
KKGDKTPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG
110 120
GNKKGLSKGC FGLKLDRIGS MSGLGC
Length:126
Mass (Da):13,243
Last modified:August 1, 1991 - v2
Checksum:iE2474B2D4AABF4DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64758 Genomic DNA. Translation: AAA31018.1.
PIRiA36155.
RefSeqiNP_001008482.1. NM_001008482.1.
XP_005672336.1. XM_005672279.1.
XP_005672337.1. XM_005672280.1.
UniGeneiSsc.23867.

Genome annotation databases

EnsembliENSSSCT00000028969; ENSSSCP00000022217; ENSSSCG00000026852.
GeneIDi493772.
KEGGissc:493772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64758 Genomic DNA. Translation: AAA31018.1.
PIRiA36155.
RefSeqiNP_001008482.1. NM_001008482.1.
XP_005672336.1. XM_005672279.1.
XP_005672337.1. XM_005672280.1.
UniGeneiSsc.23867.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000028969; ENSSSCP00000022217; ENSSSCG00000026852.
GeneIDi493772.
KEGGissc:493772.

Organism-specific databases

CTDi4880.

Phylogenomic databases

GeneTreeiENSGT00390000015492.
HOVERGENiHBG004229.
InParanoidiP18104.
KOiK12336.
OMAiTPPGEEV.
OrthoDBiEOG79CZ1S.
TreeFamiTF106305.

Miscellaneous databases

PMAP-CutDBP18104.

Family and domain databases

InterProiIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "N-terminally extended form of C-type natriuretic peptide (CNP-53) identified in porcine brain."
    Minamino N., Kangawa K., Matsuo H.
    Biochem. Biophys. Res. Commun. 170:973-979(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 74-126.
    Tissue: Brain.
  3. "C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain."
    Sudoh T., Minamino N., Kangawa K., Matsuo H.
    Biochem. Biophys. Res. Commun. 168:863-870(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 105-126.
    Tissue: Brain.

Entry informationi

Entry nameiANFC_PIG
AccessioniPrimary (citable) accession number: P18104
Secondary accession number(s): P21806
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 1, 1991
Last modified: April 1, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.