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P18104

- ANFC_PIG

UniProt

P18104 - ANFC_PIG

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Protein
C-type natriuretic peptide
Gene
NPPC, CNP
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 By similarity.

GO - Molecular functioni

  1. receptor binding Source: AgBase

GO - Biological processi

  1. cGMP biosynthetic process Source: UniProtKB
  2. growth plate cartilage chondrocyte differentiation Source: UniProtKB
  3. growth plate cartilage chondrocyte proliferation Source: UniProtKB
  4. ossification Source: UniProtKB-KW
  5. post-embryonic development Source: Ensembl
  6. receptor guanylyl cyclase signaling pathway Source: UniProtKB
  7. regulation of blood vessel size Source: UniProtKB-KW
  8. regulation of multicellular organism growth Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Keywords - Biological processi

Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
C-type natriuretic peptide
Cleaved into the following 3 chains:
Gene namesi
Name:NPPC
Synonyms:CNP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 15

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Propeptidei24 – 7350
PRO_0000001561Add
BLAST
Peptidei74 – 12653CNP-531 Publication
PRO_0000001562Add
BLAST
Peptidei98 – 12629CNP-29 By similarity
PRO_0000001563Add
BLAST
Peptidei105 – 12622CNP-221 Publication
PRO_0000001564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi110 ↔ 126

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Miscellaneous databases

PMAP-CutDBP18104.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000015492.
HOVERGENiHBG004229.
KOiK12336.
OMAiHKMDRIG.
OrthoDBiEOG79CZ1S.
TreeFamiTF106305.

Family and domain databases

InterProiIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18104-1 [UniParc]FASTAAdd to Basket

« Hide

MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPGEEV AEPQAAGGGQ    50
KKGDKTPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG 100
GNKKGLSKGC FGLKLDRIGS MSGLGC 126
Length:126
Mass (Da):13,243
Last modified:August 1, 1991 - v2
Checksum:iE2474B2D4AABF4DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64758 Genomic DNA. Translation: AAA31018.1.
PIRiA36155.
RefSeqiNP_001008482.1. NM_001008482.1.
XP_005672336.1. XM_005672279.1.
XP_005672337.1. XM_005672280.1.
UniGeneiSsc.23867.

Genome annotation databases

EnsembliENSSSCT00000028969; ENSSSCP00000022217; ENSSSCG00000026852.
GeneIDi493772.
KEGGissc:493772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64758 Genomic DNA. Translation: AAA31018.1 .
PIRi A36155.
RefSeqi NP_001008482.1. NM_001008482.1.
XP_005672336.1. XM_005672279.1.
XP_005672337.1. XM_005672280.1.
UniGenei Ssc.23867.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000028969 ; ENSSSCP00000022217 ; ENSSSCG00000026852 .
GeneIDi 493772.
KEGGi ssc:493772.

Organism-specific databases

CTDi 4880.

Phylogenomic databases

GeneTreei ENSGT00390000015492.
HOVERGENi HBG004229.
KOi K12336.
OMAi HKMDRIG.
OrthoDBi EOG79CZ1S.
TreeFami TF106305.

Miscellaneous databases

PMAP-CutDB P18104.

Family and domain databases

InterProi IPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
[Graphical view ]
Pfami PF00212. ANP. 1 hit.
[Graphical view ]
PRINTSi PR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTi SM00183. NAT_PEP. 1 hit.
[Graphical view ]
PROSITEi PS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "N-terminally extended form of C-type natriuretic peptide (CNP-53) identified in porcine brain."
    Minamino N., Kangawa K., Matsuo H.
    Biochem. Biophys. Res. Commun. 170:973-979(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 74-126.
    Tissue: Brain.
  3. "C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain."
    Sudoh T., Minamino N., Kangawa K., Matsuo H.
    Biochem. Biophys. Res. Commun. 168:863-870(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 105-126.
    Tissue: Brain.

Entry informationi

Entry nameiANFC_PIG
AccessioniPrimary (citable) accession number: P18104
Secondary accession number(s): P21806
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 1, 1991
Last modified: February 19, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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