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Protein

Protein tailless

Gene

tll

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi31 – 108Nuclear receptorPROSITE-ProRule annotationAdd BLAST78
Zinc fingeri34 – 54NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri70 – 96NR C4-typePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

  • DNA binding Source: FlyBase
  • nuclear receptor activity Source: FlyBase
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone receptor activity Source: InterPro
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • anterior/posterior axis specification Source: FlyBase
  • Bolwig's organ morphogenesis Source: FlyBase
  • cell fate commitment Source: FlyBase
  • cell fate specification Source: FlyBase
  • gastrulation Source: FlyBase
  • inter-male aggressive behavior Source: FlyBase
  • mushroom body development Source: FlyBase
  • neuroblast development Source: FlyBase
  • neuroblast division Source: FlyBase
  • optic lobe placode development Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • regulation of cell cycle Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • ring gland development Source: FlyBase
  • signal release Source: FlyBase
  • terminal region determination Source: FlyBase
  • torso signaling pathway Source: FlyBase
  • transcription, DNA-templated Source: FlyBase

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Receptor, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-383280. Nuclear Receptor transcription pathway.
SignaLinkiP18102.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tailless
Alternative name(s):
Nuclear receptor subfamily 2 group E member 2
Gene namesi
Name:tll
Synonyms:NR2E2
ORF Names:CG1378
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003720. tll.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535971 – 452Protein taillessAdd BLAST452

Proteomic databases

PaxDbiP18102.
PRIDEiP18102.

Expressioni

Tissue specificityi

Brain and peripheral nervous system.1 Publication

Developmental stagei

During stage 10 found in the anterior part of the visual system that later gives rise to the anterior lip of the optic lobe. At stage 12 also found in the posterior lip of the optic lobe. In third larval instar expressed in the optic lobe of the larval brain and in the eye antennal disk, both in antennal and eye portion.1 Publication

Gene expression databases

BgeeiFBgn0003720.
GenevisibleiP18102. DM.

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
sbbQ9N6932EBI-159966,EBI-3403504

Protein-protein interaction databases

BioGridi68506. 25 interactors.
DIPiDIP-19302N.
IntActiP18102. 4 interactors.
MINTiMINT-300240.
STRINGi7227.FBpp0085071.

Structurei

3D structure databases

ProteinModelPortaliP18102.
SMRiP18102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni244 – 389Ligand-bindingBy similarityAdd BLAST146

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi262 – 265Poly-Leu4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 54NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri70 – 96NR C4-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118948.
InParanoidiP18102.
KOiK08545.
OMAiFPGVPMP.
OrthoDBiEOG091G0AV3.
PhylomeDBiP18102.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR035500. NHR_like_dom_sf.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 3 hits.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P18102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSSEGSPDM MDQKYNSVRL SPAASSRILY HVPCKVCRDH SSGKHYGIYA
60 70 80 90 100
CDGCAGFFKR SIRRSRQYVC KSQKQGLCVV DKTHRNQCRA CRLRKCFEVG
110 120 130 140 150
MNKDAVQHER GPRNSTLRRH MAMYKDAMMG AGEMPQIPAE ILMNTAALTG
160 170 180 190 200
FPGVPMPMPG LPQRAGHHPA HMAAFQPPPS AAAVLDLSVP RVPHHPVHQG
210 220 230 240 250
HHGFFSPTAA YMNALATRAL PPTPPLMAAE HIKETAAEHL FKNVNWIKSV
260 270 280 290 300
RAFTELPMPD QLLLLEESWK EFFILAMAQY LMPMNFAQLL FVYESENANR
310 320 330 340 350
EIMGMVTREV HAFQEVLNQL CHLNIDSTEY ECLRAISLFR KSPPSASSTE
360 370 380 390 400
DLANSSILTG SGSPNSSASA ESRGLLESGK VAAMHNDARS ALHNYIQRTH
410 420 430 440 450
PSQPMRFQTL LGVVQLMHKV SSFTIEELFF RKTIGDITIV RLISDMYSQR

KI
Length:452
Mass (Da):50,549
Last modified:November 1, 1990 - v1
Checksum:iA4ABEFFDE993A37C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34639 mRNA. Translation: AAA28936.1.
AF019362 Genomic DNA. Translation: AAB71371.1.
AE014297 Genomic DNA. Translation: AAF57091.1.
BT022195 mRNA. Translation: AAY51589.1.
PIRiA35602.
RefSeqiNP_524596.1. NM_079857.4.
UniGeneiDm.1906.

Genome annotation databases

EnsemblMetazoaiFBtr0085709; FBpp0085071; FBgn0003720.
GeneIDi43656.
KEGGidme:Dmel_CG1378.
UCSCiCG1378-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiTLL_DROME
AccessioniPrimary (citable) accession number: P18102
Secondary accession number(s): Q4V6W1, Q9VA33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 22, 2017
This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families