P18093 (REV_HV2BE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Rev

Alternative name(s):
Regulator of expression of viral proteins

Gene names

Name:

rev

Organism

Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) [Reference proteome]

Taxonomic identifier

11714 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group › Human immunodeficiency virus 2 › HIV-2 subtype A

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs By similarity.
Subunit structure	Homomultimer; when bound to the RRE. Multimeric assembly is essential for activity By similarity.
Subcellular location	Host nucleus › host nucleolus. Host cytoplasm. Note: The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm By similarity.
Domain	The RNA-binding motif binds to the RRE, a stem-and-loop structure present in incompletely spliced viral pre-mRNAs. This region also contains the NLS which mediates nuclear localization. These overlapping functions prevent Rev bound to RRE from undesirable return to the nucleus. When Rev binds the RRE, the NLS becomes masked while the NES remains accessible By similarity.
Miscellaneous	This isolate is from a German AIDS patient (with predominantly neurological complications) who was probably infected in Mali.

Ontologies

Keywords
Biological process	Transport mRNA transport
Cellular component	Host cytoplasm Host nucleus
Disease	AIDS
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	Protein Rev		PRO_0000085282
Regions
	Region	16 – 24	9	Homomultimerization By similarity
	Motif	35 – 49	15	Nuclear localization signal and RNA-binding (RRE) By similarity
	Motif	71 – 82	12	Nuclear export signal and binding to XPO1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P18093 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 8CC3B08D9536D3F1	FASTA	103	11,792
	10 20 30 40 50 60 MSERADEEGL QGKLRLLRLL HQTNPYPQGP GTASQRRNRR RRRRRQWLRL VALANKLCAV 70 80 90 100 PDPPTDSPLD RAIQHLQRLT IQELPDPPTD LPESNSNQGL AET

References

[1]

"A novel proviral clone of HIV-2: biological and phylogenetic relationship to other primate immunodeficiency viruses." Kirchhoff F., Jentsch K., Bachmann B., Stuke A., Laloux C., Lueke W., Stahl-Henning C., Schneider J., Nieselt K., Eigen M., Hunsmann G. Virology 177:305-311(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M30502 Genomic DNA. Translation: AAB00742.1.
RefSeq	NP_056843.1. NC_001722.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1724716.
Family and domain databases
InterPro	IPR000625. REV_protein. [Graphical view]
Pfam	PF00424. REV. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

REV_HV2BE

Accession

Primary (citable) accession number: P18093

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program