P18093 (REV_HV2BE) Reviewed, UniProtKB/Swiss-Prot
Last modified April 3, 2013. Version 64. History...
Names and origin
|Protein names||Recommended name:|
Regulator of expression of viral proteins
|Organism||Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) [Reference proteome]|
|Taxonomic identifier||11714 [NCBI]|
|Taxonomic lineage||Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group ›|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
|Sequence length||103 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs By similarity.
Homomultimer; when bound to the RRE. Multimeric assembly is essential for activity By similarity.
The RNA-binding motif binds to the RRE, a stem-and-loop structure present in incompletely spliced viral pre-mRNAs. This region also contains the NLS which mediates nuclear localization. These overlapping functions prevent Rev bound to RRE from undesirable return to the nucleus. When Rev binds the RRE, the NLS becomes masked while the NES remains accessible By similarity.
This isolate is from a German AIDS patient (with predominantly neurological complications) who was probably infected in Mali.
|Cellular component||Host cytoplasm|
|Technical term||Complete proteome|
|Gene Ontology (GO)|
Inferred from electronic annotation. Source: UniProtKB-KW
|Cellular_component||host cell cytoplasm|
Inferred from electronic annotation. Source: UniProtKB-SubCellhost cell nucleolus
Inferred from electronic annotation. Source: UniProtKB-SubCell
Inferred from electronic annotation. Source: UniProtKB-KWsequence-specific DNA binding transcription factor activity
Inferred from electronic annotation. Source: InterPro
|Complete GO annotation...|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 103||103||Protein Rev||PRO_0000085282|
|Region||16 – 24||9||Homomultimerization By similarity|
|Motif||35 – 49||15||Nuclear localization signal and RNA-binding (RRE) By similarity|
|Motif||71 – 82||12||Nuclear export signal and binding to XPO1 By similarity|
|||"A novel proviral clone of HIV-2: biological and phylogenetic relationship to other primate immunodeficiency viruses."|
Kirchhoff F., Jentsch K., Bachmann B., Stuke A., Laloux C., Lueke W., Stahl-Henning C., Schneider J., Nieselt K., Eigen M., Hunsmann G.
Virology 177:305-311(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
|M30502 Genomic DNA. Translation: AAB00742.1.|
|RefSeq||NP_056843.1. NC_001722.1. |
3D structure databases
Protocols and materials databases
Genome annotation databases
Family and domain databases
|InterPro||IPR000625. REV_protein. |
|Pfam||PF00424. REV. 1 hit. |
|Accession||Primary (citable) accession number: P18093|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|