Reviewed, UniProtKB/Swiss-Prot P18091 (ACTN_DROME)

Names and origin

Protein names

Recommended name:
    Alpha-actinin, sarcomeric
Alternative name(s):
    F-actin cross-linking protein

Gene names

Name:	Actn
Synonyms:	fliA, l(1)2Cb
ORF Names:	CG4376

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	924 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Subunit structure	Homodimer; antiparallel.
Tissue specificity	Larval muscle isoform is expressed in the larval body wall, adult muscles of the head and abdomen and supercontractile muscles of the larva and adult. Adult muscle isoform accumulates within adult fibrillar and tubular muscles.
Developmental stage	Larval muscle isoform is found in the larvae and adults, the adult muscle isoform in adults only.
Sequence similarities	Belongs to the alpha-actinin family. Contains 1 actin-binding domain. Contains 2 CH (calponin-homology) domains. Contains 2 EF-hand domains. Contains 4 spectrin repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	Actin-binding Calcium
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	actin cytoskeleton reorganization Inferred from mutant phenotype. Source: FlyBase flight behavior Inferred from mutant phenotype. Source: FlyBase
Molecular function	actin binding Inferred from physical interaction. Source: UniProtKB calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform Long (identifier: P18091-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Non-muscle (identifier: P18091-2)

The sequence of this isoform differs from the canonical sequence as follows:
     229-260: Missing.
     261-261: N → Q

Isoform Larval muscle (identifier: P18091-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     261-286: NTALPDERAVMTYVSSYYHCFSGAQK → VTHVPEPTRQYTYVPNNYN

Isoform Adult muscle (identifier: P18091-4)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     258-286: Missing.

Isoform A (identifier: P18091-5)

The sequence of this isoform differs from the canonical sequence as follows:
     231-260: INTPKPDERAIMTYVSCYYHAFQGAQQVGN → Q

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 924	924	Alpha-actinin, sarcomeric		PRO_0000073447
Regions
	Domain	1 – 250	250	Actin-binding
	Domain	34 – 138	105	CH 1
	Domain	147 – 250	104	CH 2
	Repeat	251 – 395	145	Spectrin 1
	Repeat	396 – 510	115	Spectrin 2
	Repeat	511 – 631	121	Spectrin 3
	Repeat	632 – 744	113	Spectrin 4
	Domain	778 – 813	36	EF-hand 1
	Domain	819 – 854	36	EF-hand 2
	Calcium binding	791 – 802	12	1 By similarity
	Calcium binding	832 – 843	12	2 By similarity
Natural variations
	Alternative sequence	229 – 260	32	Missing in isoform Non-muscle.		VSP_000712
	Alternative sequence	231 – 260	30	INTPK…QQVGN → Q in isoform A.		VSP_000713
	Alternative sequence	258 – 286	29	Missing in isoform Adult muscle.		VSP_000715
	Alternative sequence	261 – 286	26	NTALP…SGAQK → VTHVPEPTRQYTYVPNNYN in isoform Larval muscle.		VSP_000716
	Alternative sequence	261	1	N → Q in isoform Non-muscle.		VSP_000714
Experimental info
	Sequence conflict	409	1	A → G in CAA36042. Ref.1
	Sequence conflict	457	1	C → Y in CAA36042. Ref.1
	Sequence conflict	474	1	S → C in CAA36042. Ref.1
	Sequence conflict	503	1	S → C in CAA36042. Ref.1
	Sequence conflict	574	1	E → V in CAA36042. Ref.1
	Sequence conflict	654	1	L → R in CAA36042. Ref.1
	Sequence conflict	684 – 691	8	AVTAIGMG → VVTPLVWD in CAA36042. Ref.1
	Sequence conflict	711	1	Y → H in CAA36042. Ref.1
	Sequence conflict	817	1	D → E in CAA36042. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long [UniParc]. Last modified February 21, 2001. Version 2. Checksum: 08F8961520328ACE	FASTA	924	107,019
	10 20 30 40 50 60 MMMENGLSME YGDGYMEQEE EWEREGLLDP AWEKQQKKTF TAWCNSHLRK AGTAIDNIEE 70 80 90 100 110 120 DFRNGLKLML LLEVISGETL PKPDRGKMRF HKIANVNKAL DFIASKGVHL VSIGAEEIVD 130 140 150 160 170 180 GNLKMTLGMI WTIILRFAIQ DISVEEMTAK EGLLLWCQRK TAPYKNVNVQ NFHLSFKDGL 190 200 210 220 230 240 AFCALIHRHR PDLIDYAKLS KDNPLENLNT AFDVAEKYLD IPRMLDPDDL INTPKPDERA 250 260 270 280 290 300 IMTYVSCYYH AFQGAQQVGN NTALPDERAV MTYVSSYYHC FSGAQKAETA ANRICKVLKV 310 320 330 340 350 360 NQENERLMEE YERLASDLLE WIRRTMPWLN SRQADNSLAG VQKKLEEYRT YRRKHKPPRV 370 380 390 400 410 420 EQKAKLETNF NTLQTKLRLS NRPAYLPTEG KTVSDISNSW KGLELAEKAF EEWLLAETMR 430 440 450 460 470 480 LERLEHLAQK FKHKADAHED WTRGKEEMLQ SQDFRQCKLN ELKALKKKHE AFESDLAAHQ 490 500 510 520 530 540 DRVEQIAAIA QELNTLEYHD CVSVNARCQR ICDQWDRLGA LTQRRRTALD EAERILEKID 550 560 570 580 590 600 ILHLEFAKRA APFNNWLDGT REDLVDMFIV HTMEEIQGLI QAHDQFKATL GEADKEFNLI 610 620 630 640 650 660 VNLVREVESI VKQHQIPGGL ENPYTTLTAN DMTRKWSDVR QLVPQRDQTL ANELRKQQNN 670 680 690 700 710 720 EMLRRQFAEK ANIVGPWIER QMDAVTAIGM GLQGSLEDQL HRLKEYEQAV YAYKPNIEEL 730 740 750 760 770 780 EKIHQAVQES MIFENRYTNY TMETLRVGWE QLLTSINRNI NEVENQILTR DSKGISQEQL 790 800 810 820 830 840 NEFRSSFNHF DKNRTGRLSP EEFKSCLVSL GYSIGKDRQG DLDFQRILAV VDPNNTGYVH 850 860 870 880 890 900 FDAFLDFMTR ESTDTDTAEQ VIDSFRILAA DKPYILPDEL RRELPPDQAE YCIQRMPPYK 910 920 GPNGVPGALD YMSFSTALYG ETDL
	Isoform Non-muscle. Checksum: CDE214DD3B7E5A72	FASTA	892	103,420
	10 20 30 40 50 60 MMMENGLSME YGDGYMEQEE EWEREGLLDP AWEKQQKKTF TAWCNSHLRK AGTAIDNIEE 70 80 90 100 110 120 DFRNGLKLML LLEVISGETL PKPDRGKMRF HKIANVNKAL DFIASKGVHL VSIGAEEIVD 130 140 150 160 170 180 GNLKMTLGMI WTIILRFAIQ DISVEEMTAK EGLLLWCQRK TAPYKNVNVQ NFHLSFKDGL 190 200 210 220 230 240 AFCALIHRHR PDLIDYAKLS KDNPLENLNT AFDVAEKYLD IPRMLDPDQT ALPDERAVMT 250 260 270 280 290 300 YVSSYYHCFS GAQKAETAAN RICKVLKVNQ ENERLMEEYE RLASDLLEWI RRTMPWLNSR 310 320 330 340 350 360 QADNSLAGVQ KKLEEYRTYR RKHKPPRVEQ KAKLETNFNT LQTKLRLSNR PAYLPTEGKT 370 380 390 400 410 420 VSDISNSWKG LELAEKAFEE WLLAETMRLE RLEHLAQKFK HKADAHEDWT RGKEEMLQSQ 430 440 450 460 470 480 DFRQCKLNEL KALKKKHEAF ESDLAAHQDR VEQIAAIAQE LNTLEYHDCV SVNARCQRIC 490 500 510 520 530 540 DQWDRLGALT QRRRTALDEA ERILEKIDIL HLEFAKRAAP FNNWLDGTRE DLVDMFIVHT 550 560 570 580 590 600 MEEIQGLIQA HDQFKATLGE ADKEFNLIVN LVREVESIVK QHQIPGGLEN PYTTLTANDM 610 620 630 640 650 660 TRKWSDVRQL VPQRDQTLAN ELRKQQNNEM LRRQFAEKAN IVGPWIERQM DAVTAIGMGL 670 680 690 700 710 720 QGSLEDQLHR LKEYEQAVYA YKPNIEELEK IHQAVQESMI FENRYTNYTM ETLRVGWEQL 730 740 750 760 770 780 LTSINRNINE VENQILTRDS KGISQEQLNE FRSSFNHFDK NRTGRLSPEE FKSCLVSLGY 790 800 810 820 830 840 SIGKDRQGDL DFQRILAVVD PNNTGYVHFD AFLDFMTRES TDTDTAEQVI DSFRILAADK 850 860 870 880 890 PYILPDELRR ELPPDQAEYC IQRMPPYKGP NGVPGALDYM SFSTALYGET DL
	Isoform Larval muscle (C). Checksum: 31573181B7230DAA	FASTA	917	106,373
	10 20 30 40 50 60 MMMENGLSME YGDGYMEQEE EWEREGLLDP AWEKQQKKTF TAWCNSHLRK AGTAIDNIEE 70 80 90 100 110 120 DFRNGLKLML LLEVISGETL PKPDRGKMRF HKIANVNKAL DFIASKGVHL VSIGAEEIVD 130 140 150 160 170 180 GNLKMTLGMI WTIILRFAIQ DISVEEMTAK EGLLLWCQRK TAPYKNVNVQ NFHLSFKDGL 190 200 210 220 230 240 AFCALIHRHR PDLIDYAKLS KDNPLENLNT AFDVAEKYLD IPRMLDPDDL INTPKPDERA 250 260 270 280 290 300 IMTYVSCYYH AFQGAQQVGN VTHVPEPTRQ YTYVPNNYNA ETAANRICKV LKVNQENERL 310 320 330 340 350 360 MEEYERLASD LLEWIRRTMP WLNSRQADNS LAGVQKKLEE YRTYRRKHKP PRVEQKAKLE 370 380 390 400 410 420 TNFNTLQTKL RLSNRPAYLP TEGKTVSDIS NSWKGLELAE KAFEEWLLAE TMRLERLEHL 430 440 450 460 470 480 AQKFKHKADA HEDWTRGKEE MLQSQDFRQC KLNELKALKK KHEAFESDLA AHQDRVEQIA 490 500 510 520 530 540 AIAQELNTLE YHDCVSVNAR CQRICDQWDR LGALTQRRRT ALDEAERILE KIDILHLEFA 550 560 570 580 590 600 KRAAPFNNWL DGTREDLVDM FIVHTMEEIQ GLIQAHDQFK ATLGEADKEF NLIVNLVREV 610 620 630 640 650 660 ESIVKQHQIP GGLENPYTTL TANDMTRKWS DVRQLVPQRD QTLANELRKQ QNNEMLRRQF 670 680 690 700 710 720 AEKANIVGPW IERQMDAVTA IGMGLQGSLE DQLHRLKEYE QAVYAYKPNI EELEKIHQAV 730 740 750 760 770 780 QESMIFENRY TNYTMETLRV GWEQLLTSIN RNINEVENQI LTRDSKGISQ EQLNEFRSSF 790 800 810 820 830 840 NHFDKNRTGR LSPEEFKSCL VSLGYSIGKD RQGDLDFQRI LAVVDPNNTG YVHFDAFLDF 850 860 870 880 890 900 MTRESTDTDT AEQVIDSFRI LAADKPYILP DELRRELPPD QAEYCIQRMP PYKGPNGVPG 910 ALDYMSFSTA LYGETDL
	Isoform Adult muscle (B). Checksum: 196879A84FB0E259	FASTA	895	103,828
	10 20 30 40 50 60 MMMENGLSME YGDGYMEQEE EWEREGLLDP AWEKQQKKTF TAWCNSHLRK AGTAIDNIEE 70 80 90 100 110 120 DFRNGLKLML LLEVISGETL PKPDRGKMRF HKIANVNKAL DFIASKGVHL VSIGAEEIVD 130 140 150 160 170 180 GNLKMTLGMI WTIILRFAIQ DISVEEMTAK EGLLLWCQRK TAPYKNVNVQ NFHLSFKDGL 190 200 210 220 230 240 AFCALIHRHR PDLIDYAKLS KDNPLENLNT AFDVAEKYLD IPRMLDPDDL INTPKPDERA 250 260 270 280 290 300 IMTYVSCYYH AFQGAQQAET AANRICKVLK VNQENERLME EYERLASDLL EWIRRTMPWL 310 320 330 340 350 360 NSRQADNSLA GVQKKLEEYR TYRRKHKPPR VEQKAKLETN FNTLQTKLRL SNRPAYLPTE 370 380 390 400 410 420 GKTVSDISNS WKGLELAEKA FEEWLLAETM RLERLEHLAQ KFKHKADAHE DWTRGKEEML 430 440 450 460 470 480 QSQDFRQCKL NELKALKKKH EAFESDLAAH QDRVEQIAAI AQELNTLEYH DCVSVNARCQ 490 500 510 520 530 540 RICDQWDRLG ALTQRRRTAL DEAERILEKI DILHLEFAKR AAPFNNWLDG TREDLVDMFI 550 560 570 580 590 600 VHTMEEIQGL IQAHDQFKAT LGEADKEFNL IVNLVREVES IVKQHQIPGG LENPYTTLTA 610 620 630 640 650 660 NDMTRKWSDV RQLVPQRDQT LANELRKQQN NEMLRRQFAE KANIVGPWIE RQMDAVTAIG 670 680 690 700 710 720 MGLQGSLEDQ LHRLKEYEQA VYAYKPNIEE LEKIHQAVQE SMIFENRYTN YTMETLRVGW 730 740 750 760 770 780 EQLLTSINRN INEVENQILT RDSKGISQEQ LNEFRSSFNH FDKNRTGRLS PEEFKSCLVS 790 800 810 820 830 840 LGYSIGKDRQ GDLDFQRILA VVDPNNTGYV HFDAFLDFMT RESTDTDTAE QVIDSFRILA 850 860 870 880 890 ADKPYILPDE LRRELPPDQA EYCIQRMPPY KGPNGVPGAL DYMSFSTALY GETDL
	Isoform A. Checksum: FB2D59D86C6B9619	FASTA	895	103,763
	10 20 30 40 50 60 MMMENGLSME YGDGYMEQEE EWEREGLLDP AWEKQQKKTF TAWCNSHLRK AGTAIDNIEE 70 80 90 100 110 120 DFRNGLKLML LLEVISGETL PKPDRGKMRF HKIANVNKAL DFIASKGVHL VSIGAEEIVD 130 140 150 160 170 180 GNLKMTLGMI WTIILRFAIQ DISVEEMTAK EGLLLWCQRK TAPYKNVNVQ NFHLSFKDGL 190 200 210 220 230 240 AFCALIHRHR PDLIDYAKLS KDNPLENLNT AFDVAEKYLD IPRMLDPDDL QNTALPDERA 250 260 270 280 290 300 VMTYVSSYYH CFSGAQKAET AANRICKVLK VNQENERLME EYERLASDLL EWIRRTMPWL 310 320 330 340 350 360 NSRQADNSLA GVQKKLEEYR TYRRKHKPPR VEQKAKLETN FNTLQTKLRL SNRPAYLPTE 370 380 390 400 410 420 GKTVSDISNS WKGLELAEKA FEEWLLAETM RLERLEHLAQ KFKHKADAHE DWTRGKEEML 430 440 450 460 470 480 QSQDFRQCKL NELKALKKKH EAFESDLAAH QDRVEQIAAI AQELNTLEYH DCVSVNARCQ 490 500 510 520 530 540 RICDQWDRLG ALTQRRRTAL DEAERILEKI DILHLEFAKR AAPFNNWLDG TREDLVDMFI 550 560 570 580 590 600 VHTMEEIQGL IQAHDQFKAT LGEADKEFNL IVNLVREVES IVKQHQIPGG LENPYTTLTA 610 620 630 640 650 660 NDMTRKWSDV RQLVPQRDQT LANELRKQQN NEMLRRQFAE KANIVGPWIE RQMDAVTAIG 670 680 690 700 710 720 MGLQGSLEDQ LHRLKEYEQA VYAYKPNIEE LEKIHQAVQE SMIFENRYTN YTMETLRVGW 730 740 750 760 770 780 EQLLTSINRN INEVENQILT RDSKGISQEQ LNEFRSSFNH FDKNRTGRLS PEEFKSCLVS 790 800 810 820 830 840 LGYSIGKDRQ GDLDFQRILA VVDPNNTGYV HFDAFLDFMT RESTDTDTAE QVIDSFRILA 850 860 870 880 890 ADKPYILPDE LRRELPPDQA EYCIQRMPPY KGPNGVPGAL DYMSFSTALY GETDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular genetics of Drosophila alpha-actinin: mutant alleles disrupt Z disc integrity and muscle insertions." Fyrberg E.A., Kelly M., Ball E., Fyrberg C., Reedy M.C. J. Cell Biol. 110:1999-2011(1990) [PubMed: 2112549] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ADULT MUSCLE). Strain: Canton-S.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
[4]	"From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M. Science 287:2220-2222(2000) [PubMed: 10731137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS LONG AND ADULT MUSCLE). Strain: Oregon-R.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Strain: Berkeley. Tissue: Embryo.
[6]	"Perturbations of Drosophila alpha-actinin cause muscle paralysis, weakness, and atrophy but do not confer obvious nonmuscle phenotypes." Roulier E.M., Fyrberg C., Fyrberg E. J. Cell Biol. 116:911-922(1992) [PubMed: 1734023] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 229-286 (ISOFORM NON-MUSCLE), ALTERNATIVE SPLICING. Strain: Oregon-R. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X51753 mRNA. Translation: CAA36042.1. AE014298 Genomic DNA. Translation: AAF45705.2. AE014298 Genomic DNA. Translation: AAF45706.2. AE014298 Genomic DNA. Translation: AAN09068.1. AL009192, AL031765 Genomic DNA. Translation: CAA15688.1. AL009192, AL031765 Genomic DNA. Translation: CAA15689.1. AL031765, AL009192 Genomic DNA. Translation: CAA21120.1. AL031765, AL009192 Genomic DNA. Translation: CAA21121.1. AY069615 mRNA. Translation: AAL39760.1. X64419 mRNA. Translation: CAA45764.1.
PIR	FAFFAA. A35598. T13413. T13414.
RefSeq	NP_477484.2. NP_477485.1. NP_726784.1.
UniGene	Dm.33411
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-22313N.
IntAct	P18091. 10 interactions.
STRING	P18091.
Genome annotation databases
Ensembl	FBtr0070343; FBpp0070329; FBgn0000667; Drosophila melanogaster. [Genome view] FBtr0070344; FBpp0070330; FBgn0000667; Drosophila melanogaster. [Genome view] FBtr0070345; FBpp0070331; FBgn0000667; Drosophila melanogaster. [Genome view]
GeneID	31166.
KEGG	dme:Dmel_CG4376.
Organism-specific databases
CTD	31166.
FlyBase	FBgn0000667. Actn.
Phylogenomic databases
InParanoid	P18091.
OMA	INNAWGG.
OrthoDB	EOG92JNZZ.
Gene expression databases
ArrayExpress	P18091.
Bgee	P18091.
GermOnline	CG4376. Drosophila melanogaster.
Family and domain databases
InterPro	IPR001589. Actinin_actin-bd_CS. IPR016146. Calponin-homology. IPR001715. Calponin_act_bd. IPR014837. EF-hand_Ca_insen. IPR011992. EF-Hand_type. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca_bd. IPR018248. EF_Hand_dom. IPR018159. Spectrin/alpha-actinin. IPR002017. Spectrin_repeat. [Graphical view]
Gene3D	G3DSA:1.10.418.10. Calponin-homology. 2 hits. G3DSA:1.10.238.10. EF-Hand_type. 2 hits.
Pfam	PF00307. CH. 2 hits. PF00036. efhand. 1 hit. PF08726. efhand_Ca_insen. 1 hit. PF00435. Spectrin. 4 hits. [Graphical view]
SMART	SM00033. CH. 2 hits. SM00054. EFh. 2 hits. SM00150. SPEC. 4 hits. [Graphical view]
PROSITE	PS00019. ACTININ_1. 1 hit. PS00020. ACTININ_2. 1 hit. PS50021. CH. 2 hits. PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	772252.

Entry information

Entry name

ACTN_DROME

Accession

Primary (citable) accession number: P18091
Secondary accession number(s): O46044 , O46045, Q24370, Q8T024, Q9W536, Q9W537

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	February 21, 2001
Last modified:	December 15, 2009
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project