##gff-version 3
P18089	UniProtKB	Chain	1	450	.	.	.	ID=PRO_0000069094;Note=Alpha-2B adrenergic receptor	
P18089	UniProtKB	Topological domain	1	12	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Transmembrane	13	38	.	.	.	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Topological domain	39	48	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Transmembrane	49	69	.	.	.	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Topological domain	70	86	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Transmembrane	87	107	.	.	.	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Topological domain	108	128	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Transmembrane	129	149	.	.	.	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Topological domain	150	172	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Transmembrane	173	193	.	.	.	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Topological domain	194	368	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Transmembrane	369	389	.	.	.	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Topological domain	390	405	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Transmembrane	406	426	.	.	.	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Topological domain	427	450	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Region	204	229	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P18089	UniProtKB	Region	241	329	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P18089	UniProtKB	Compositional bias	249	264	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P18089	UniProtKB	Compositional bias	293	312	.	.	.	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P18089	UniProtKB	Site	92	92	.	.	.	Note=Implicated in ligand binding;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Site	176	176	.	.	.	Note=Implicated in catechol agonist binding;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Site	180	180	.	.	.	Note=Implicated in catechol agonist binding;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P18089	UniProtKB	Lipidation	442	442	.	.	.	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P18089	UniProtKB	Disulfide bond	85	164	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00521	
P18089	UniProtKB	Natural variant	211	211	.	.	.	ID=VAR_025099;Note=G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs9333568	
P18089	UniProtKB	Natural variant	225	229	.	.	.	ID=VAR_073953;Note=In FAME2%3B gain of function%3B decreases interaction with PPP1R9B upon activation by neurotransmitter. HGGAL->QFGR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24114805;Dbxref=PMID:24114805	
P18089	UniProtKB	Natural variant	301	303	.	.	.	ID=VAR_070775;Note=Found with a frequency of 0.31 in Caucasians and 0.12 in African-Americans%3B exhibits impaired phosphorylation and desensitization by G protein-coupled receptor kinases%3B does not affect ligand-binding. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11056163,ECO:0000269|PubMed:15815621;Dbxref=PMID:11056163,PMID:15815621	
P18089	UniProtKB	Natural variant	376	376	.	.	.	ID=VAR_033462;Note=V->I;Dbxref=dbSNP:rs1431850417	
P18089	UniProtKB	Natural variant	379	379	.	.	.	ID=VAR_025100;Note=V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs527655811	
P18089	UniProtKB	Natural variant	379	379	.	.	.	ID=VAR_033463;Note=V->I;Dbxref=dbSNP:rs29000569	
P18089	UniProtKB	Sequence conflict	362	363	.	.	.	Note=QL->HV;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P18089	UniProtKB	Helix	12	38	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41	
P18089	UniProtKB	Turn	46	48	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41	
P18089	UniProtKB	Helix	49	73	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41	
P18089	UniProtKB	Helix	86	115	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41	
P18089	UniProtKB	Helix	117	121	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41	
P18089	UniProtKB	Helix	126	144	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41	
P18089	UniProtKB	Turn	146	148	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41	
P18089	UniProtKB	Helix	171	180	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41	
P18089	UniProtKB	Helix	182	202	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41	
P18089	UniProtKB	Helix	363	392	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41	
P18089	UniProtKB	Helix	407	427	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41	
P18089	UniProtKB	Helix	431	441	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6K41