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Protein

Glutamate decarboxylase 1

Gene

Gad1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the production of GABA.

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei566SubstrateBy similarity1

GO - Molecular functioni

  • glutamate binding Source: RGD
  • glutamate decarboxylase activity Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein N-terminus binding Source: RGD
  • pyridoxal phosphate binding Source: RGD

GO - Biological processi

  • gamma-aminobutyric acid biosynthetic process Source: RGD
  • locomotory exploration behavior Source: Ensembl
  • response to drug Source: RGD
  • social behavior Source: Ensembl

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processNeurotransmitter biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-RNO-888568 GABA synthesis
R-RNO-888590 GABA synthesis, release, reuptake and degradation
SABIO-RKiP18088

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase 1 (EC:4.1.1.15)
Alternative name(s):
67 kDa glutamic acid decarboxylase
Short name:
GAD-67
Glutamate decarboxylase 67 kDa isoform
Gene namesi
Name:Gad1
Synonyms:Gad67
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2652 Gad1

Subcellular locationi

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3758

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469671 – 593Glutamate decarboxylase 1Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineBy similarity1
Modified residuei404N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP18088
PRIDEiP18088

PTM databases

iPTMnetiP18088
PhosphoSitePlusiP18088

Expressioni

Gene expression databases

BgeeiENSRNOG00000000007
ExpressionAtlasiP18088 baseline and differential
GenevisibleiP18088 RN

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein N-terminus binding Source: RGD

Protein-protein interaction databases

BioGridi246550, 1 interactor
ComplexPortaliCPX-3063 Glutamate decarboxylase 1/2 complex
CPX-3066 Glutamate decarboxylase 1 complex
IntActiP18088, 2 interactors
STRINGi10116.ENSRNOP00000000008

Structurei

3D structure databases

ProteinModelPortaliP18088
SMRiP18088
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 191Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0629 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
HOGENOMiHOG000005382
HOVERGENiHBG004980
InParanoidiP18088
KOiK01580
OMAiFHKHFFQ
PhylomeDBiP18088
TreeFamiTF314688

Family and domain databases

Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

Sequencei

Sequence statusi: Complete.

P18088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTPSPAT SSNAGADPNT TNLRPTTYDT WCGVAHGCTR KLGLKICGFL
60 70 80 90 100
QRTNSLEEKS RLVSAFRERQ ASKNLLSCEN SDPGARFRRT ETDFSNLFAQ
110 120 130 140 150
DLLPAKNGEE QTVQFLLEVV DILLNYVRKT FDRSTKVLDF HHPHQLLEGM
160 170 180 190 200
EGFNLELSDH PESLEQILVD CRDTLKYGVR TGHPRFFNQL STGLDIIGLA
210 220 230 240 250
GEWLTSTANT NMFTYEIAPV FVLMEQITLK KMREIIGWSN KDGDGIFSPG
260 270 280 290 300
GAISNMYSIM AARYKYFPEV KTKGMAAVPK LVLFTSEHSH YSIKKAGAAL
310 320 330 340 350
GFGTDNVILI KCNERGKIIP ADLEAKILDA KQKGFVPLYV NATAGTTVYG
360 370 380 390 400
AFDPIQEIAD ICEKYNLWLH VDAAWGGGLL MSRKHRHKLS GIERANSVTW
410 420 430 440 450
NPHKMMGVLL QCSAILVKEK GILQGCNQMC AGYLFQPDKQ YDVSYDTGDK
460 470 480 490 500
AIQCGRHVDI FKFWLMWKAK GTVGFENQIN KCLELAEYLY AKIKNREEFE
510 520 530 540 550
MVFNGEPEHT NVCFWYIPQS LRGVPDSPER REKLHRVAPK IKALMMESGT
560 570 580 590
TMVGYQPQGD KANFFRMVIS NPAATQSDID FLIEEIERLG QDL
Length:593
Mass (Da):66,640
Last modified:November 1, 1990 - v1
Checksum:iEF83239C30301F69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103L → V in CAA40800 (PubMed:2299361).Curated1
Sequence conflicti284F → S in CAA40800 (PubMed:2299361).Curated1
Sequence conflicti287 – 288EH → AD in CAA40800 (PubMed:2299361).Curated2
Sequence conflicti344 – 345AG → EA in CAA40800 (PubMed:2299361).Curated2
Sequence conflicti347T → I in CAA40800 (PubMed:2299361).Curated1
Sequence conflicti352 – 353FD → LE in CAA40800 (PubMed:2299361).Curated2
Sequence conflicti380L → R in CAA40800 (PubMed:2299361).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34445 mRNA Translation: AAC42037.1
X57572 mRNA Translation: CAA40800.1
X57573 mRNA Translation: CAA40801.1
M76177 mRNA Translation: AAA41184.1
PIRiA41367
RefSeqiNP_058703.1, NM_017007.1
XP_017446943.1, XM_017591454.1
XP_017446944.1, XM_017591455.1
UniGeneiRn.91245

Genome annotation databases

EnsembliENSRNOT00000000008; ENSRNOP00000000008; ENSRNOG00000000007
ENSRNOT00000087712; ENSRNOP00000072778; ENSRNOG00000000007
GeneIDi24379
KEGGirno:24379
UCSCiRGD:2652 rat

Similar proteinsi

Entry informationi

Entry nameiDCE1_RAT
AccessioniPrimary (citable) accession number: P18088
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 20, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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