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P18084 (ITB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 153. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin beta-5
Gene names
Name:ITGB5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length799 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

Subunit structure

Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Interacts with DAB2. Ref.7

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the integrin beta chain family.

Contains 1 PSI domain.

Contains 1 VWFA domain.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionIntegrin
Receptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

extracellular matrix organization

Traceable author statement. Source: Reactome

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: InterPro

muscle contraction

Traceable author statement. Source: Reactome

   Cellular_componentcell leading edge

Inferred from electronic annotation. Source: Ensembl

focal adhesion

Inferred from electronic annotation. Source: Ensembl

integrin complex

Inferred from electronic annotation. Source: InterPro

phagocytic vesicle

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

receptor complex

Inferred from direct assay PubMed 23382219. Source: MGI

   Molecular_functionreceptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 799776Integrin beta-5
PRO_0000016348

Regions

Topological domain24 – 719696Extracellular Potential
Transmembrane720 – 74223Helical; Potential
Topological domain743 – 79957Cytoplasmic Potential
Domain27 – 7650PSI
Domain136 – 378243VWFA
Repeat465 – 51248I
Repeat513 – 55442II
Repeat555 – 59339III
Repeat594 – 63037IV
Region465 – 630166Cysteine-rich tandem repeats

Amino acid modifications

Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation4601N-linked (GlcNAc...) Potential
Glycosylation4771N-linked (GlcNAc...) Potential
Glycosylation5051N-linked (GlcNAc...) Potential
Glycosylation5521N-linked (GlcNAc...) Potential
Glycosylation5861N-linked (GlcNAc...) Potential
Glycosylation6541N-linked (GlcNAc...) Potential
Glycosylation7051N-linked (GlcNAc...) Potential
Disulfide bond28 ↔ 463 By similarity
Disulfide bond36 ↔ 46 By similarity
Disulfide bond39 ↔ 75 By similarity
Disulfide bond49 ↔ 64 By similarity
Disulfide bond202 ↔ 211 By similarity
Disulfide bond259 ↔ 300 By similarity
Disulfide bond401 ↔ 413 By similarity
Disulfide bond433 ↔ 682 By similarity
Disulfide bond461 ↔ 465 By similarity
Disulfide bond476 ↔ 487 By similarity
Disulfide bond484 ↔ 522 By similarity
Disulfide bond489 ↔ 498 By similarity
Disulfide bond500 ↔ 513 By similarity
Disulfide bond528 ↔ 533 By similarity
Disulfide bond530 ↔ 563 By similarity
Disulfide bond535 ↔ 548 By similarity
Disulfide bond550 ↔ 555 By similarity
Disulfide bond569 ↔ 574 By similarity
Disulfide bond571 ↔ 602 By similarity
Disulfide bond576 ↔ 585 By similarity
Disulfide bond587 ↔ 594 By similarity
Disulfide bond608 ↔ 613 By similarity
Disulfide bond610 ↔ 657 By similarity
Disulfide bond615 ↔ 625 By similarity
Disulfide bond628 ↔ 631 By similarity
Disulfide bond635 ↔ 644 By similarity
Disulfide bond641 ↔ 714 By similarity
Disulfide bond661 ↔ 690 By similarity

Natural variations

Natural variant4281L → V.
Corresponds to variant rs2291090 [ dbSNP | Ensembl ].
VAR_024290
Natural variant4311R → Q. Ref.4
Corresponds to variant rs2291089 [ dbSNP | Ensembl ].
VAR_049634
Natural variant4771N → S.
Corresponds to variant rs2291087 [ dbSNP | Ensembl ].
VAR_049635

Experimental info

Sequence conflict1931T → A in AAA52707. Ref.2
Sequence conflict6451L → P in AAA59183. Ref.3
Sequence conflict790 – 7923Missing in AAA52707. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P18084 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: D7E4727CA310512B

FASTA79988,054
        10         20         30         40         50         60 
MPRAPAPLYA CLLGLCALLP RLAGLNICTS GSATSCEECL LIHPKCAWCS KEDFGSPRSI 

        70         80         90        100        110        120 
TSRCDLRANL VKNGCGGEIE SPASSFHVLR SLPLSSKGSG SAGWDVIQMT PQEIAVNLRP 

       130        140        150        160        170        180 
GDKTTFQLQV RQVEDYPVDL YYLMDLSLSM KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG 

       190        200        210        220        230        240 
SFVDKDISPF SYTAPRYQTN PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS 

       250        260        270        280        290        300 
RNRDAPEGGF DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC 

       310        320        330        340        350        360 
HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA LIPGTTVEIL 

       370        380        390        400        410        420 
DGDSKNIIQL IINAYNSIRS KVELSVWDQP EDLNLFFTAT CQDGVSYPGQ RKCEGLKIGD 

       430        440        450        460        470        480 
TASFEVSLEA RSCPSRHTEH VFALRPVGFR DSLEVGVTYN CTCGCSVGLE PNSARCNGSG 

       490        500        510        520        530        540 
TYVCGLCECS PGYLGTRCEC QDGENQSVYQ NLCREAEGKP LCSGRGDCSC NQCSCFESEF 

       550        560        570        580        590        600 
GKIYGPFCEC DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD ISTCRGRDGQ 

       610        620        630        640        650        660 
ICSERGHCLC GQCQCTEPGA FGEMCEKCPT CPDACSTKRD CVECLLLHSG KPDNQTCHSL 

       670        680        690        700        710        720 
CRDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFTYVELP SGKSNLTVLR EPECGNTPNA 

       730        740        750        760        770        780 
MTILLAVVGS ILLVGLALLA IWKLLVTIHD RREFAKFQSE RSRARYEMAS NPLYRKPIST 

       790 
HTVDFTFNKF NKSYNGTVD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, primary structure and properties of a novel human integrin beta subunit."
Ramaswamy H., Hemler M.E.
EMBO J. 9:1561-1568(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thymic epithelium.
[2]"Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit."
Suzuki S., Huang Z.S., Tanihara H.
Proc. Natl. Acad. Sci. U.S.A. 87:5354-5358(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"cDNA sequence of the human integrin beta 5 subunit."
McLean J.W., Vestal D.J., Cheresh D.A., Bodary S.C.
J. Biol. Chem. 265:17126-17131(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-431.
Tissue: Brain.
[5]SeattleSNPs variation discovery resource
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[7]"Myosin-X provides a motor-based link between integrins and the cytoskeleton."
Zhang H., Berg J.S., Li Z., Wang Y., Lang P., Sousa A.D., Bhaskar A., Cheney R.E., Stromblad S.
Nat. Cell Biol. 6:523-531(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MYO10.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53002 mRNA. Translation: CAA37188.1.
M35011 mRNA. Translation: AAA52707.1.
J05633 mRNA. Translation: AAA59183.1.
AK315429 mRNA. Translation: BAG37817.1.
EU332848 Genomic DNA. Translation: ABY87537.1.
BC006541 mRNA. Translation: AAH06541.1.
PIRA38308.
RefSeqNP_002204.2. NM_002213.3.
UniGeneHs.536663.

3D structure databases

ProteinModelPortalP18084.
SMRP18084. Positions 24-797.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109899. 16 interactions.
IntActP18084. 18 interactions.
MINTMINT-258539.
STRING9606.ENSP00000296181.

Chemistry

BindingDBP18084.
ChEMBLCHEMBL2096675.

PTM databases

PhosphoSiteP18084.

Polymorphism databases

DMDM124970.

Proteomic databases

PaxDbP18084.
PRIDEP18084.

Protocols and materials databases

DNASU3693.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296181; ENSP00000296181; ENSG00000082781.
GeneID3693.
KEGGhsa:3693.
UCSCuc003eho.3. human.

Organism-specific databases

CTD3693.
GeneCardsGC03M124498.
HGNCHGNC:6160. ITGB5.
HPACAB022050.
HPA001820.
MIM147561. gene.
neXtProtNX_P18084.
PharmGKBPA29959.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG287997.
HOGENOMHOG000252936.
HOVERGENHBG006190.
InParanoidP18084.
KOK06588.
OMALRPVGFR.
OrthoDBEOG7T7GSB.
PhylomeDBP18084.
TreeFamTF105392.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.
REACT_17044. Muscle contraction.
REACT_6900. Immune System.
SignaLinkP18084.

Gene expression databases

ArrayExpressP18084.
BgeeP18084.
CleanExHS_ITGB5.
GenevestigatorP18084.

Family and domain databases

Gene3D1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProIPR000742. EG-like_dom.
IPR027067. Integrin_beta-5.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF26. PTHR10082:SF26. 1 hit.
PfamPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFPIRSF002512. Integrin_B. 1 hit.
PRINTSPR01186. INTEGRINB.
SMARTSM00181. EGF. 1 hit.
SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 2 hits.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSITGB5. human.
GeneWikiIntegrin,_beta_5.
GenomeRNAi3693.
NextBio14473.
PROP18084.
SOURCESearch...

Entry information

Entry nameITB5_HUMAN
AccessionPrimary (citable) accession number: P18084
Secondary accession number(s): B0LPF8, B2RD70
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM