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Protein

Integrin beta-5

Gene

ITGB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.1 Publication

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  • cell-matrix adhesion Source: UniProtKB
  • endodermal cell differentiation Source: UniProtKB
  • epithelial cell-cell adhesion Source: UniProtKB
  • extracellular matrix organization Source: Reactome
  • integrin-mediated signaling pathway Source: UniProtKB
  • muscle contraction Source: Reactome
  • stress fiber assembly Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB

Keywordsi

Molecular functionHost cell receptor for virus entry, Integrin, Receptor
Biological processCell adhesion, Host-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-2129379 Molecules associated with elastic fibres
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-445355 Smooth Muscle Contraction
SignaLinkiP18084
SIGNORiP18084

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-5
Gene namesi
Name:ITGB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000082781.11
HGNCiHGNC:6160 ITGB5
MIMi147561 gene
neXtProtiNX_P18084

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 719ExtracellularSequence analysisAdd BLAST696
Transmembranei720 – 742HelicalSequence analysisAdd BLAST23
Topological domaini743 – 799CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3693
OpenTargetsiENSG00000082781
PharmGKBiPA29959

Chemistry databases

ChEMBLiCHEMBL2096675

Polymorphism and mutation databases

BioMutaiITGB5
DMDMi124970

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001634824 – 799Integrin beta-5Add BLAST776

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 463By similarity
Disulfide bondi36 ↔ 46By similarity
Disulfide bondi39 ↔ 75By similarity
Disulfide bondi49 ↔ 64By similarity
Disulfide bondi202 ↔ 211By similarity
Disulfide bondi259 ↔ 300By similarity
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi401 ↔ 413By similarity
Disulfide bondi433 ↔ 682By similarity
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi461 ↔ 465By similarity
Disulfide bondi476 ↔ 487By similarity
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi484 ↔ 522By similarity
Disulfide bondi489 ↔ 498By similarity
Disulfide bondi500 ↔ 513By similarity
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi528 ↔ 533By similarity
Disulfide bondi530 ↔ 563By similarity
Disulfide bondi535 ↔ 548By similarity
Disulfide bondi550 ↔ 555By similarity
Glycosylationi552N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi569 ↔ 574By similarity
Disulfide bondi571 ↔ 602By similarity
Disulfide bondi576 ↔ 585By similarity
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi587 ↔ 594By similarity
Disulfide bondi608 ↔ 613By similarity
Disulfide bondi610 ↔ 657By similarity
Disulfide bondi615 ↔ 625By similarity
Disulfide bondi628 ↔ 631By similarity
Disulfide bondi635 ↔ 644By similarity
Disulfide bondi641 ↔ 714By similarity
Glycosylationi654N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi661 ↔ 690By similarity
Glycosylationi705N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei770PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP18084
MaxQBiP18084
PaxDbiP18084
PeptideAtlasiP18084
PRIDEiP18084

PTM databases

iPTMnetiP18084
PhosphoSitePlusiP18084

Expressioni

Gene expression databases

BgeeiENSG00000082781
CleanExiHS_ITGB5
ExpressionAtlasiP18084 baseline and differential
GenevisibleiP18084 HS

Organism-specific databases

HPAiCAB022050
HPA001820

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-5 (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10 (PubMed:15156152). Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5 (via N-terminus) (By similarity). ITGAV:ITGB5 interacts with NOV (PubMed:15611078).By similarity2 Publications
(Microbial infection) Integrin ITGAV:ITGB5 interacts with adenovirus type C penton protein.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109899, 40 interactors
CORUMiP18084
ELMiP18084
IntActiP18084, 44 interactors
MINTiP18084
STRINGi9606.ENSP00000296181

Chemistry databases

BindingDBiP18084

Structurei

3D structure databases

ProteinModelPortaliP18084
SMRiP18084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 76PSIAdd BLAST50
Domaini136 – 378VWFAAdd BLAST243
Repeati465 – 512IAdd BLAST48
Repeati513 – 554IIAdd BLAST42
Repeati555 – 593IIIAdd BLAST39
Repeati594 – 630IVAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni465 – 630Cysteine-rich tandem repeatsAdd BLAST166

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064
HOGENOMiHOG000252936
HOVERGENiHBG006190
InParanoidiP18084
KOiK06588
OMAiPDACSTK
OrthoDBiEOG091G029W
PhylomeDBiP18084
TreeFamiTF105392

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR027067 Integrin_beta-5
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF26 PTHR10082:SF26, 1 hit
PfamiView protein in Pfam
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS00243 INTEGRIN_BETA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRAPAPLYA CLLGLCALLP RLAGLNICTS GSATSCEECL LIHPKCAWCS
60 70 80 90 100
KEDFGSPRSI TSRCDLRANL VKNGCGGEIE SPASSFHVLR SLPLSSKGSG
110 120 130 140 150
SAGWDVIQMT PQEIAVNLRP GDKTTFQLQV RQVEDYPVDL YYLMDLSLSM
160 170 180 190 200
KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG SFVDKDISPF SYTAPRYQTN
210 220 230 240 250
PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS RNRDAPEGGF
260 270 280 290 300
DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC
310 320 330 340 350
HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA
360 370 380 390 400
LIPGTTVEIL DGDSKNIIQL IINAYNSIRS KVELSVWDQP EDLNLFFTAT
410 420 430 440 450
CQDGVSYPGQ RKCEGLKIGD TASFEVSLEA RSCPSRHTEH VFALRPVGFR
460 470 480 490 500
DSLEVGVTYN CTCGCSVGLE PNSARCNGSG TYVCGLCECS PGYLGTRCEC
510 520 530 540 550
QDGENQSVYQ NLCREAEGKP LCSGRGDCSC NQCSCFESEF GKIYGPFCEC
560 570 580 590 600
DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD ISTCRGRDGQ
610 620 630 640 650
ICSERGHCLC GQCQCTEPGA FGEMCEKCPT CPDACSTKRD CVECLLLHSG
660 670 680 690 700
KPDNQTCHSL CRDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFTYVELP
710 720 730 740 750
SGKSNLTVLR EPECGNTPNA MTILLAVVGS ILLVGLALLA IWKLLVTIHD
760 770 780 790
RREFAKFQSE RSRARYEMAS NPLYRKPIST HTVDFTFNKF NKSYNGTVD
Length:799
Mass (Da):88,054
Last modified:November 1, 1990 - v1
Checksum:iD7E4727CA310512B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193T → A in AAA52707 (PubMed:2371275).Curated1
Sequence conflicti645L → P in AAA59183 (PubMed:2211615).Curated1
Sequence conflicti790 – 792Missing in AAA52707 (PubMed:2371275).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024290428L → V. Corresponds to variant dbSNP:rs2291090Ensembl.1
Natural variantiVAR_049634431R → Q1 PublicationCorresponds to variant dbSNP:rs2291089Ensembl.1
Natural variantiVAR_049635477N → S. Corresponds to variant dbSNP:rs2291087Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53002 mRNA Translation: CAA37188.1
M35011 mRNA Translation: AAA52707.1
J05633 mRNA Translation: AAA59183.1
AK315429 mRNA Translation: BAG37817.1
EU332848 Genomic DNA Translation: ABY87537.1
BC006541 mRNA Translation: AAH06541.1
CCDSiCCDS3030.1
PIRiA38308
RefSeqiNP_002204.2, NM_002213.4
UniGeneiHs.13155
Hs.536663

Genome annotation databases

EnsembliENST00000296181; ENSP00000296181; ENSG00000082781
GeneIDi3693
KEGGihsa:3693
UCSCiuc003eho.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiITB5_HUMAN
AccessioniPrimary (citable) accession number: P18084
Secondary accession number(s): B0LPF8, B2RD70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 192 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health