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P18084

- ITB5_HUMAN

UniProt

P18084 - ITB5_HUMAN

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Protein

Integrin beta-5

Gene

ITGB5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  4. cell-matrix adhesion Source: UniProtKB
  5. endodermal cell differentiation Source: UniProtKB
  6. epithelial cell-cell adhesion Source: UniProtKB
  7. extracellular matrix organization Source: Reactome
  8. integrin-mediated signaling pathway Source: UniProtKB
  9. muscle contraction Source: Reactome
  10. stress fiber assembly Source: UniProtKB
  11. transforming growth factor beta receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_111174. Cross-presentation of particulate exogenous antigens (phagosomes).
REACT_13552. Integrin cell surface interactions.
REACT_150331. Molecules associated with elastic fibres.
REACT_163906. ECM proteoglycans.
REACT_163942. Syndecan interactions.
REACT_20558. Smooth Muscle Contraction.
SignaLinkiP18084.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-5
Gene namesi
Name:ITGB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:6160. ITGB5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 719696ExtracellularSequence AnalysisAdd
BLAST
Transmembranei720 – 74223HelicalSequence AnalysisAdd
BLAST
Topological domaini743 – 79957CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell leading edge Source: Ensembl
  2. cell surface Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProtKB
  4. focal adhesion Source: UniProtKB
  5. integrin alphav-beta5 complex Source: UniProtKB
  6. phagocytic vesicle Source: Reactome
  7. plasma membrane Source: Reactome
  8. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 799776Integrin beta-5PRO_0000016348Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 463By similarity
Disulfide bondi36 ↔ 46By similarity
Disulfide bondi39 ↔ 75By similarity
Disulfide bondi49 ↔ 64By similarity
Disulfide bondi202 ↔ 211By similarity
Disulfide bondi259 ↔ 300By similarity
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi401 ↔ 413By similarity
Disulfide bondi433 ↔ 682By similarity
Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi461 ↔ 465By similarity
Disulfide bondi476 ↔ 487By similarity
Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi484 ↔ 522By similarity
Disulfide bondi489 ↔ 498By similarity
Disulfide bondi500 ↔ 513By similarity
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi528 ↔ 533By similarity
Disulfide bondi530 ↔ 563By similarity
Disulfide bondi535 ↔ 548By similarity
Disulfide bondi550 ↔ 555By similarity
Glycosylationi552 – 5521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi569 ↔ 574By similarity
Disulfide bondi571 ↔ 602By similarity
Disulfide bondi576 ↔ 585By similarity
Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi587 ↔ 594By similarity
Disulfide bondi608 ↔ 613By similarity
Disulfide bondi610 ↔ 657By similarity
Disulfide bondi615 ↔ 625By similarity
Disulfide bondi628 ↔ 631By similarity
Disulfide bondi635 ↔ 644By similarity
Disulfide bondi641 ↔ 714By similarity
Glycosylationi654 – 6541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi661 ↔ 690By similarity
Glycosylationi705 – 7051N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP18084.
PaxDbiP18084.
PRIDEiP18084.

PTM databases

PhosphoSiteiP18084.

Expressioni

Gene expression databases

BgeeiP18084.
CleanExiHS_ITGB5.
ExpressionAtlasiP18084. baseline and differential.
GenevestigatoriP18084.

Organism-specific databases

HPAiCAB022050.
HPA001820.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Interacts with DAB2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ANGPTL4Q9BY763EBI-1223434,EBI-2968146
ITGAVP067562EBI-1223434,EBI-298282
MYO10Q9HD672EBI-1223434,EBI-307061
Myo7aP974798EBI-1223434,EBI-1149557From a different organism.

Protein-protein interaction databases

BioGridi109899. 21 interactions.
IntActiP18084. 18 interactions.
MINTiMINT-258539.
STRINGi9606.ENSP00000296181.

Structurei

3D structure databases

ProteinModelPortaliP18084.
SMRiP18084. Positions 24-714, 741-797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 7650PSIAdd
BLAST
Domaini136 – 378243VWFAAdd
BLAST
Repeati465 – 51248IAdd
BLAST
Repeati513 – 55442IIAdd
BLAST
Repeati555 – 59339IIIAdd
BLAST
Repeati594 – 63037IVAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni465 – 630166Cysteine-rich tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 PSI domain.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287997.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP18084.
KOiK06588.
OMAiKPLCSGR.
OrthoDBiEOG7T7GSB.
PhylomeDBiP18084.
TreeFamiTF105392.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR027067. Integrin_beta-5.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF26. PTHR10082:SF26. 1 hit.
PfamiPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00181. EGF. 1 hit.
SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 2 hits.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18084-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRAPAPLYA CLLGLCALLP RLAGLNICTS GSATSCEECL LIHPKCAWCS
60 70 80 90 100
KEDFGSPRSI TSRCDLRANL VKNGCGGEIE SPASSFHVLR SLPLSSKGSG
110 120 130 140 150
SAGWDVIQMT PQEIAVNLRP GDKTTFQLQV RQVEDYPVDL YYLMDLSLSM
160 170 180 190 200
KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG SFVDKDISPF SYTAPRYQTN
210 220 230 240 250
PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS RNRDAPEGGF
260 270 280 290 300
DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC
310 320 330 340 350
HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA
360 370 380 390 400
LIPGTTVEIL DGDSKNIIQL IINAYNSIRS KVELSVWDQP EDLNLFFTAT
410 420 430 440 450
CQDGVSYPGQ RKCEGLKIGD TASFEVSLEA RSCPSRHTEH VFALRPVGFR
460 470 480 490 500
DSLEVGVTYN CTCGCSVGLE PNSARCNGSG TYVCGLCECS PGYLGTRCEC
510 520 530 540 550
QDGENQSVYQ NLCREAEGKP LCSGRGDCSC NQCSCFESEF GKIYGPFCEC
560 570 580 590 600
DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD ISTCRGRDGQ
610 620 630 640 650
ICSERGHCLC GQCQCTEPGA FGEMCEKCPT CPDACSTKRD CVECLLLHSG
660 670 680 690 700
KPDNQTCHSL CRDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFTYVELP
710 720 730 740 750
SGKSNLTVLR EPECGNTPNA MTILLAVVGS ILLVGLALLA IWKLLVTIHD
760 770 780 790
RREFAKFQSE RSRARYEMAS NPLYRKPIST HTVDFTFNKF NKSYNGTVD
Length:799
Mass (Da):88,054
Last modified:November 1, 1990 - v1
Checksum:iD7E4727CA310512B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti193 – 1931T → A in AAA52707. (PubMed:2371275)Curated
Sequence conflicti645 – 6451L → P in AAA59183. (PubMed:2211615)Curated
Sequence conflicti790 – 7923Missing in AAA52707. (PubMed:2371275)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti428 – 4281L → V.
Corresponds to variant rs2291090 [ dbSNP | Ensembl ].
VAR_024290
Natural varianti431 – 4311R → Q.1 Publication
Corresponds to variant rs2291089 [ dbSNP | Ensembl ].
VAR_049634
Natural varianti477 – 4771N → S.
Corresponds to variant rs2291087 [ dbSNP | Ensembl ].
VAR_049635

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53002 mRNA. Translation: CAA37188.1.
M35011 mRNA. Translation: AAA52707.1.
J05633 mRNA. Translation: AAA59183.1.
AK315429 mRNA. Translation: BAG37817.1.
EU332848 Genomic DNA. Translation: ABY87537.1.
BC006541 mRNA. Translation: AAH06541.1.
CCDSiCCDS3030.1.
PIRiA38308.
RefSeqiNP_002204.2. NM_002213.3.
UniGeneiHs.536663.

Genome annotation databases

EnsembliENST00000296181; ENSP00000296181; ENSG00000082781.
GeneIDi3693.
KEGGihsa:3693.
UCSCiuc003eho.3. human.

Polymorphism databases

DMDMi124970.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53002 mRNA. Translation: CAA37188.1 .
M35011 mRNA. Translation: AAA52707.1 .
J05633 mRNA. Translation: AAA59183.1 .
AK315429 mRNA. Translation: BAG37817.1 .
EU332848 Genomic DNA. Translation: ABY87537.1 .
BC006541 mRNA. Translation: AAH06541.1 .
CCDSi CCDS3030.1.
PIRi A38308.
RefSeqi NP_002204.2. NM_002213.3.
UniGenei Hs.536663.

3D structure databases

ProteinModelPortali P18084.
SMRi P18084. Positions 24-714, 741-797.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109899. 21 interactions.
IntActi P18084. 18 interactions.
MINTi MINT-258539.
STRINGi 9606.ENSP00000296181.

Chemistry

BindingDBi P18084.
ChEMBLi CHEMBL2096675.

PTM databases

PhosphoSitei P18084.

Polymorphism databases

DMDMi 124970.

Proteomic databases

MaxQBi P18084.
PaxDbi P18084.
PRIDEi P18084.

Protocols and materials databases

DNASUi 3693.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296181 ; ENSP00000296181 ; ENSG00000082781 .
GeneIDi 3693.
KEGGi hsa:3693.
UCSCi uc003eho.3. human.

Organism-specific databases

CTDi 3693.
GeneCardsi GC03M124480.
HGNCi HGNC:6160. ITGB5.
HPAi CAB022050.
HPA001820.
MIMi 147561. gene.
neXtProti NX_P18084.
PharmGKBi PA29959.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287997.
GeneTreei ENSGT00760000119064.
HOGENOMi HOG000252936.
HOVERGENi HBG006190.
InParanoidi P18084.
KOi K06588.
OMAi KPLCSGR.
OrthoDBi EOG7T7GSB.
PhylomeDBi P18084.
TreeFami TF105392.

Enzyme and pathway databases

Reactomei REACT_111174. Cross-presentation of particulate exogenous antigens (phagosomes).
REACT_13552. Integrin cell surface interactions.
REACT_150331. Molecules associated with elastic fibres.
REACT_163906. ECM proteoglycans.
REACT_163942. Syndecan interactions.
REACT_20558. Smooth Muscle Contraction.
SignaLinki P18084.

Miscellaneous databases

ChiTaRSi ITGB5. human.
GeneWikii Integrin,_beta_5.
GenomeRNAii 3693.
NextBioi 14473.
PROi P18084.
SOURCEi Search...

Gene expression databases

Bgeei P18084.
CleanExi HS_ITGB5.
ExpressionAtlasi P18084. baseline and differential.
Genevestigatori P18084.

Family and domain databases

Gene3Di 1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR027067. Integrin_beta-5.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF26. PTHR10082:SF26. 1 hit.
Pfami PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF002512. Integrin_B. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00181. EGF. 1 hit.
SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 2 hits.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, primary structure and properties of a novel human integrin beta subunit."
    Ramaswamy H., Hemler M.E.
    EMBO J. 9:1561-1568(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymic epithelium.
  2. "Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit."
    Suzuki S., Huang Z.S., Tanihara H.
    Proc. Natl. Acad. Sci. U.S.A. 87:5354-5358(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "cDNA sequence of the human integrin beta 5 subunit."
    McLean J.W., Vestal D.J., Cheresh D.A., Bodary S.C.
    J. Biol. Chem. 265:17126-17131(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-431.
    Tissue: Brain.
  5. SeattleSNPs variation discovery resource
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  7. "Myosin-X provides a motor-based link between integrins and the cytoskeleton."
    Zhang H., Berg J.S., Li Z., Wang Y., Lang P., Sousa A.D., Bhaskar A., Cheney R.E., Stromblad S.
    Nat. Cell Biol. 6:523-531(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYO10.

Entry informationi

Entry nameiITB5_HUMAN
AccessioniPrimary (citable) accession number: P18084
Secondary accession number(s): B0LPF8, B2RD70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 26, 2014
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3