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P18080

- HEM0_CHICK

UniProt

P18080 - HEM0_CHICK

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Protein

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Gene

ALAS2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981SubstrateBy similarity
Binding sitei212 – 2121SubstrateBy similarity
Binding sitei231 – 2311SubstrateBy similarity
Binding sitei264 – 2641Pyridoxal phosphateBy similarity
Binding sitei292 – 2921Pyridoxal phosphateBy similarity
Binding sitei320 – 3201Pyridoxal phosphateBy similarity
Active sitei323 – 3231By similarity
Binding sitei352 – 3521Pyridoxal phosphateBy similarity
Binding sitei353 – 3531Pyridoxal phosphateBy similarity
Binding sitei437 – 4371SubstrateBy similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. heme biosynthetic process Source: Reactome
  2. heme metabolic process Source: Reactome
  3. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_115611. Heme synthesis.
UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, erythroid-specific, mitochondrial (EC:2.3.1.37)
Short name:
ALAS-E
Alternative name(s):
5-aminolevulinic acid synthase 2
Delta-ALA synthase 2
Delta-aminolevulinate synthase 2
Gene namesi
Name:ALAS2
Synonyms:ALASE
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. mitochondrial matrix Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1818MitochondrionSequence AnalysisAdd
BLAST
Chaini19 – 5134955-aminolevulinate synthase, erythroid-specific, mitochondrialPRO_0000001226Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei323 – 3231N6-(pyridoxal phosphate)lysineCurated

Expressioni

Tissue specificityi

Erythroid specific.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP18080.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005954.
InParanoidiP18080.
PhylomeDBiP18080.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18080-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAFLRCPLL ARHPPLARAF ATGARCPFMG FAHRAAPELQ EDVERPQIPA
60 70 80 90 100
VEVLEELLRD GGAALNRTVR DCMDEDAFPY EEQFQAQLGA LRRTHTYRVV
110 120 130 140 150
TAVGRRADAP PLGTRGTAPH TSVELWCSSD YLGLSRHPAV LRAARAALDA
160 170 180 190 200
HGLGAGGTRN IGGTSPLHGA LERALALLHR QPRAALFSSC FAANDTALDT
210 220 230 240 250
LARILPGCQV YSDAGNHASM IQGIRRRGVP KFIFRHNDPH HLEQLLGRSP
260 270 280 290 300
PGVPKIVAFE SLHSMDGSIA PLEELCDVAH AYGALTFVDE VHAVGLYGAR
310 320 330 340 350
GAGIAERDGV QHKVDVVSGT LGKALGAVGG YIAGSEALVD AVRSLGPGFI
360 370 380 390 400
FTTALPPQRG GGALAALQVV GSAEGAALRR AHQRHAKHLR VLLRDRGLPA
410 420 430 440 450
LPSHIVPVRW DAEANTRLSR ALLEEHGLYV QAINHPTVPR GQELLLRIAP
460 470 480 490 500
TPHHSPPMLE NLADKLSECW GAVGLPREDP PGPSCSSCHR PLHLSLLSPL
510
ERDQFGVRGA AAG
Length:513
Mass (Da):54,778
Last modified:November 1, 1995 - v2
Checksum:iC319A4DE5294CF74
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24367 mRNA. Translation: AAA20400.1.
PIRiA31452. SYCHLE.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24367 mRNA. Translation: AAA20400.1 .
PIRi A31452. SYCHLE.

3D structure databases

ProteinModelPortali P18080.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005954.
InParanoidi P18080.
PhylomeDBi P18080.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .
Reactomei REACT_115611. Heme synthesis.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes."
    Riddle R.D., Yamamoto M., Engel J.D.
    Proc. Natl. Acad. Sci. U.S.A. 86:792-796(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Erythroid cell.

Entry informationi

Entry nameiHEM0_CHICK
AccessioniPrimary (citable) accession number: P18080
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3