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P18080

- HEM0_CHICK

UniProt

P18080 - HEM0_CHICK

Protein

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Gene

ALAS2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei98 – 981SubstrateBy similarity
    Binding sitei212 – 2121SubstrateBy similarity
    Binding sitei231 – 2311SubstrateBy similarity
    Binding sitei264 – 2641Pyridoxal phosphateBy similarity
    Binding sitei292 – 2921Pyridoxal phosphateBy similarity
    Binding sitei320 – 3201Pyridoxal phosphateBy similarity
    Active sitei323 – 3231By similarity
    Binding sitei352 – 3521Pyridoxal phosphateBy similarity
    Binding sitei353 – 3531Pyridoxal phosphateBy similarity
    Binding sitei437 – 4371SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. heme biosynthetic process Source: Reactome
    2. heme metabolic process Source: Reactome
    3. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
    4. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_115611. Heme synthesis.
    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, erythroid-specific, mitochondrial (EC:2.3.1.37)
    Short name:
    ALAS-E
    Alternative name(s):
    5-aminolevulinic acid synthase 2
    Delta-ALA synthase 2
    Delta-aminolevulinate synthase 2
    Gene namesi
    Name:ALAS2
    Synonyms:ALASE
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. mitochondrial matrix Source: Reactome

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1818MitochondrionSequence AnalysisAdd
    BLAST
    Chaini19 – 5134955-aminolevulinate synthase, erythroid-specific, mitochondrialPRO_0000001226Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei323 – 3231N6-(pyridoxal phosphate)lysineCurated

    Expressioni

    Tissue specificityi

    Erythroid specific.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP18080.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG005954.
    PhylomeDBiP18080.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18080-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAFLRCPLL ARHPPLARAF ATGARCPFMG FAHRAAPELQ EDVERPQIPA    50
    VEVLEELLRD GGAALNRTVR DCMDEDAFPY EEQFQAQLGA LRRTHTYRVV 100
    TAVGRRADAP PLGTRGTAPH TSVELWCSSD YLGLSRHPAV LRAARAALDA 150
    HGLGAGGTRN IGGTSPLHGA LERALALLHR QPRAALFSSC FAANDTALDT 200
    LARILPGCQV YSDAGNHASM IQGIRRRGVP KFIFRHNDPH HLEQLLGRSP 250
    PGVPKIVAFE SLHSMDGSIA PLEELCDVAH AYGALTFVDE VHAVGLYGAR 300
    GAGIAERDGV QHKVDVVSGT LGKALGAVGG YIAGSEALVD AVRSLGPGFI 350
    FTTALPPQRG GGALAALQVV GSAEGAALRR AHQRHAKHLR VLLRDRGLPA 400
    LPSHIVPVRW DAEANTRLSR ALLEEHGLYV QAINHPTVPR GQELLLRIAP 450
    TPHHSPPMLE NLADKLSECW GAVGLPREDP PGPSCSSCHR PLHLSLLSPL 500
    ERDQFGVRGA AAG 513
    Length:513
    Mass (Da):54,778
    Last modified:November 1, 1995 - v2
    Checksum:iC319A4DE5294CF74
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24367 mRNA. Translation: AAA20400.1.
    PIRiA31452. SYCHLE.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24367 mRNA. Translation: AAA20400.1 .
    PIRi A31452. SYCHLE.

    3D structure databases

    ProteinModelPortali P18080.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG005954.
    PhylomeDBi P18080.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .
    Reactomei REACT_115611. Heme synthesis.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes."
      Riddle R.D., Yamamoto M., Engel J.D.
      Proc. Natl. Acad. Sci. U.S.A. 86:792-796(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Erythroid cell.

    Entry informationi

    Entry nameiHEM0_CHICK
    AccessioniPrimary (citable) accession number: P18080
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3