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P18075

- BMP7_HUMAN

UniProt

P18075 - BMP7_HUMAN

Protein

Bone morphogenetic protein 7

Gene

BMP7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 165 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

    GO - Molecular functioni

    1. heparin binding Source: Ensembl
    2. protein binding Source: BHF-UCL

    GO - Biological processi

    1. axon guidance Source: Ensembl
    2. BMP signaling pathway Source: BHF-UCL
    3. branching involved in salivary gland morphogenesis Source: Ensembl
    4. branching morphogenesis of an epithelial tube Source: Ensembl
    5. cartilage development Source: UniProtKB-KW
    6. cellular response to hypoxia Source: BHF-UCL
    7. dendrite development Source: BHF-UCL
    8. embryonic camera-type eye morphogenesis Source: Ensembl
    9. embryonic limb morphogenesis Source: Ensembl
    10. embryonic pattern specification Source: Ensembl
    11. embryonic skeletal joint morphogenesis Source: Ensembl
    12. epithelial cell differentiation Source: Ensembl
    13. epithelial to mesenchymal transition Source: HGNC
    14. extracellular matrix organization Source: Reactome
    15. growth Source: InterPro
    16. mesenchymal cell differentiation Source: UniProtKB
    17. mesenchyme development Source: UniProtKB
    18. mesoderm formation Source: Ensembl
    19. mesonephros development Source: UniProtKB
    20. metanephric mesenchymal cell proliferation involved in metanephros development Source: Ensembl
    21. metanephric mesenchyme morphogenesis Source: Ensembl
    22. metanephros development Source: UniProtKB
    23. monocyte aggregation Source: UniProtKB
    24. negative regulation of cell cycle Source: HGNC
    25. negative regulation of cell death Source: UniProtKB
    26. negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
    27. negative regulation of MAP kinase activity Source: UniProtKB
    28. negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Source: Ensembl
    29. negative regulation of mitosis Source: UniProtKB
    30. negative regulation of neurogenesis Source: Ensembl
    31. negative regulation of neuron differentiation Source: MGI
    32. negative regulation of NF-kappaB import into nucleus Source: BHF-UCL
    33. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    34. negative regulation of Notch signaling pathway Source: Ensembl
    35. negative regulation of phosphorylation Source: UniProtKB
    36. negative regulation of prostatic bud formation Source: Ensembl
    37. negative regulation of striated muscle cell apoptotic process Source: BHF-UCL
    38. negative regulation of transcription, DNA-templated Source: UniProtKB
    39. nephrogenic mesenchyme morphogenesis Source: Ensembl
    40. neuron projection morphogenesis Source: MGI
    41. odontogenesis of dentin-containing tooth Source: Ensembl
    42. ossification Source: UniProtKB-KW
    43. positive regulation of apoptotic process Source: Ensembl
    44. positive regulation of bone mineralization Source: BHF-UCL
    45. positive regulation of dendrite development Source: BHF-UCL
    46. positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
    47. positive regulation of hyaluranon cable assembly Source: UniProtKB
    48. positive regulation of neuron differentiation Source: Ensembl
    49. positive regulation of osteoblast differentiation Source: BHF-UCL
    50. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    51. positive regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
    52. positive regulation of transcription, DNA-templated Source: UniProtKB
    53. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    54. protein localization to nucleus Source: UniProtKB
    55. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
    56. regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    57. regulation of removal of superoxide radicals Source: BHF-UCL
    58. response to estradiol Source: Ensembl
    59. response to peptide hormone Source: Ensembl
    60. response to vitamin D Source: Ensembl
    61. skeletal system development Source: ProtInc
    62. SMAD protein signal transduction Source: UniProtKB
    63. steroid hormone mediated signaling pathway Source: UniProtKB
    64. ureteric bud development Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Enzyme and pathway databases

    ReactomeiREACT_150331. Molecules associated with elastic fibres.
    SignaLinkiP18075.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 7
    Short name:
    BMP-7
    Alternative name(s):
    Osteogenic protein 1
    Short name:
    OP-1
    INN: Eptotermin alfa
    Gene namesi
    Name:BMP7
    Synonyms:OP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:1074. BMP7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular region Source: Reactome
    3. extracellular space Source: UniProtKB
    4. membrane-bounded vesicle Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Pharmaceutical usei

    Available under the name Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.

    Organism-specific databases

    PharmGKBiPA25384.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Propeptidei30 – 2922631 PublicationPRO_0000033876Add
    BLAST
    Chaini293 – 431139Bone morphogenetic protein 7PRO_0000033877Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi330 ↔ 396
    Disulfide bondi359 ↔ 428
    Disulfide bondi363 ↔ 430
    Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi395 – 395Interchain

    Post-translational modificationi

    Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP18075.
    PaxDbiP18075.
    PRIDEiP18075.

    PTM databases

    PhosphoSiteiP18075.

    Expressioni

    Tissue specificityi

    Expressed in the kidney and bladder. Lower levels seen in the brain.

    Developmental stagei

    Expressed in the developing eye, brain and ear during embryogenesis.1 Publication

    Gene expression databases

    ArrayExpressiP18075.
    BgeeiP18075.
    CleanExiHS_BMP7.
    GenevestigatoriP18075.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi107123. 14 interactions.
    DIPiDIP-5800N.
    IntActiP18075. 3 interactions.
    MINTiMINT-263199.
    STRINGi9606.ENSP00000379204.

    Structurei

    Secondary structure

    1
    431
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi329 – 3335
    Beta strandi336 – 3383
    Helixi339 – 3424
    Turni345 – 3473
    Beta strandi348 – 3503
    Beta strandi352 – 3554
    Beta strandi358 – 3625
    Beta strandi365 – 3684
    Helixi369 – 3713
    Helixi375 – 38612
    Turni388 – 3903
    Beta strandi396 – 40914
    Helixi411 – 4133
    Beta strandi415 – 43016

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BMPX-ray2.80A293-431[»]
    1LX5X-ray3.30A293-431[»]
    1LXIX-ray2.00A293-431[»]
    1M4UX-ray2.42L293-431[»]
    ProteinModelPortaliP18075.
    SMRiP18075. Positions 211-431.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP18075.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG272883.
    HOGENOMiHOG000249476.
    HOVERGENiHBG004860.
    InParanoidiP18075.
    KOiK16621.
    OMAiVVNPQHN.
    OrthoDBiEOG7J9VPQ.
    PhylomeDBiP18075.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18075-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE    50
    RREMQREILS ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG 100
    QGFSYPYKAV FSTQGPPLAS LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR 150
    YHHREFRFDL SKIPEGEAVT AAEFRIYKDY IRERFDNETF RISVYQVLQE 200
    HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR HNLGLQLSVE 250
    TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS 300
    QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA 350
    PEGYAAYYCE GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ 400
    LNAISVLYFD DSSNVILKKY RNMVVRACGC H 431
    Length:431
    Mass (Da):49,313
    Last modified:November 1, 1990 - v1
    Checksum:i47A05E45C6815F8A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti198 – 1981L → P Found in a patient with unilateral microphthalmia, optic disk and chorioretinal coloboma, mild learning difficulties. 1 Publication
    VAR_064058
    Natural varianti321 – 3211N → S.1 Publication
    Corresponds to variant rs61733438 [ dbSNP | Ensembl ].
    VAR_064059

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51801 mRNA. Translation: CAA36100.1.
    M60316 mRNA. Translation: AAA36738.1.
    AL122058, AL157414 Genomic DNA. Translation: CAB90273.2.
    AL157414, AL122058 Genomic DNA. Translation: CAC08434.2.
    BC008584 mRNA. Translation: AAH08584.1.
    CCDSiCCDS13455.1.
    PIRiC39263. BMHU7.
    RefSeqiNP_001710.1. NM_001719.2.
    UniGeneiHs.473163.

    Genome annotation databases

    EnsembliENST00000395863; ENSP00000379204; ENSG00000101144.
    GeneIDi655.
    KEGGihsa:655.
    UCSCiuc010gip.1. human.

    Polymorphism databases

    DMDMi115078.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Bone morphogenetic protein 7 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51801 mRNA. Translation: CAA36100.1 .
    M60316 mRNA. Translation: AAA36738.1 .
    AL122058 , AL157414 Genomic DNA. Translation: CAB90273.2 .
    AL157414 , AL122058 Genomic DNA. Translation: CAC08434.2 .
    BC008584 mRNA. Translation: AAH08584.1 .
    CCDSi CCDS13455.1.
    PIRi C39263. BMHU7.
    RefSeqi NP_001710.1. NM_001719.2.
    UniGenei Hs.473163.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BMP X-ray 2.80 A 293-431 [» ]
    1LX5 X-ray 3.30 A 293-431 [» ]
    1LXI X-ray 2.00 A 293-431 [» ]
    1M4U X-ray 2.42 L 293-431 [» ]
    ProteinModelPortali P18075.
    SMRi P18075. Positions 211-431.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107123. 14 interactions.
    DIPi DIP-5800N.
    IntActi P18075. 3 interactions.
    MINTi MINT-263199.
    STRINGi 9606.ENSP00000379204.

    PTM databases

    PhosphoSitei P18075.

    Polymorphism databases

    DMDMi 115078.

    Proteomic databases

    MaxQBi P18075.
    PaxDbi P18075.
    PRIDEi P18075.

    Protocols and materials databases

    DNASUi 655.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395863 ; ENSP00000379204 ; ENSG00000101144 .
    GeneIDi 655.
    KEGGi hsa:655.
    UCSCi uc010gip.1. human.

    Organism-specific databases

    CTDi 655.
    GeneCardsi GC20M055743.
    HGNCi HGNC:1074. BMP7.
    MIMi 112267. gene.
    neXtProti NX_P18075.
    PharmGKBi PA25384.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272883.
    HOGENOMi HOG000249476.
    HOVERGENi HBG004860.
    InParanoidi P18075.
    KOi K16621.
    OMAi VVNPQHN.
    OrthoDBi EOG7J9VPQ.
    PhylomeDBi P18075.
    TreeFami TF316134.

    Enzyme and pathway databases

    Reactomei REACT_150331. Molecules associated with elastic fibres.
    SignaLinki P18075.

    Miscellaneous databases

    ChiTaRSi BMP7. human.
    EvolutionaryTracei P18075.
    GeneWikii Bone_morphogenetic_protein_7.
    GenomeRNAii 655.
    NextBioi 2664.
    PROi P18075.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18075.
    Bgeei P18075.
    CleanExi HS_BMP7.
    Genevestigatori P18075.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "OP-1 cDNA encodes an osteogenic protein in the TGF-beta family."
      Oezkaynak E., Rueger D.C., Drier E.A., Corbett C., Ridge R.J., Sampath T.K., Oppermann H.
      EMBO J. 9:2085-2093(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Placenta.
    2. "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
      Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.
      Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Expression and characterization of a human BMP-7 variant with improved biochemical properties."
      Swencki-Underwood B., Mills J.K., Vennarini J., Boakye K., Luo J., Pomerantz S., Cunningham M.R., Farrell F.X., Naso M.F., Amegadzie B.
      Protein Expr. Purif. 57:312-319(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 293-302.
    6. Cited for: INTERACTION WITH SOSTDC1.
    7. "Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies."
      Wyatt A.W., Osborne R.J., Stewart H., Ragge N.K.
      Hum. Mutat. 31:781-787(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, VARIANTS PRO-198 AND SER-321, ASSOCIATION WITH DEVELOPMENTAL EYE ANOMALIES.
    8. "Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily."
      Griffith D.L., Keck P.C., Sampath T.K., Rueger D.C., Carlson W.D.
      Proc. Natl. Acad. Sci. U.S.A. 93:878-883(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 293-431.

    Entry informationi

    Entry nameiBMP7_HUMAN
    AccessioniPrimary (citable) accession number: P18075
    Secondary accession number(s): Q9H512, Q9NTQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 165 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3