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Reviewed, UniProtKB/Swiss-Prot P18075 (BMP7_HUMAN)

Last modified June 16, 2009. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Bone morphogenetic protein 7
      Short name=BMP-7
Alternative name(s):
    Osteogenic protein 1
      Short name=OP-1
    INN=Eptotermin alfa
Gene names
Name: BMP7
Synonyms: OP1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Subunit structure

Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed in the kidneys and bladder. Lower levels seen in the brain.

Post-translational modification

Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (Ref.5).

Pharmaceutical use

Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.

Sequence similarities

Belongs to the TGF-beta family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Acvr2aP270381EBI-1035195,EBI-1036102From a different organism.
NOGQ132531EBI-1035195,EBI-1035205

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Propeptide30 – 292263 Ref.5
PRO_0000033876
Chain293 – 431139Bone morphogenetic protein 7
PRO_0000033877

Amino acid modifications

Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation3721N-linked (GlcNAc...) Potential
Disulfide bond330 ↔ 396
Disulfide bond359 ↔ 428
Disulfide bond363 ↔ 430
Disulfide bond395Interchain

Secondary structure

....................... 431
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P18075-1 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 47A05E45C6815F8A

FASTA43149,313
        10         20         30         40         50         60 
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 

        70         80         90        100        110        120 
ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS 

       130        140        150        160        170        180 
LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY 

       190        200        210        220        230        240 
IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR 

       250        260        270        280        290        300 
HNLGLQLSVE TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS 

       310        320        330        340        350        360 
QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE 

       370        380        390        400        410        420 
GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY 

       430 
RNMVVRACGC H 

« Hide

References

« Hide 'large scale' references
[1]"OP-1 cDNA encodes an osteogenic protein in the TGF-beta family."
Oezkaynak E., Rueger D.C., Drier E.A., Corbett C., Ridge R.J., Sampath T.K., Oppermann H.
EMBO J. 9:2085-2093(1990) [PubMed: 2357959] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Placenta.
[2]"Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.
Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed: 2263636] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Expression and characterization of a human BMP-7 variant with improved biochemical properties."
Swencki-Underwood B., Mills J.K., Vennarini J., Boakye K., Luo J., Pomerantz S., Cunningham M.R., Farrell F.X., Naso M.F., Amegadzie B.
Protein Expr. Purif. 57:312-319(2008) [PubMed: 17977014] [Abstract]
Cited for: PROTEIN SEQUENCE OF 293-302.
[6]"USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney."
Yanagita M., Oka M., Watabe T., Iguchi H., Niida A., Takahashi S., Akiyama T., Miyazono K., Yanagisawa M., Sakurai T.
Biochem. Biophys. Res. Commun. 316:490-500(2004) [PubMed: 15020244] [Abstract]
Cited for: INTERACTION WITH SOSTDC1.
[7]"Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily."
Griffith D.L., Keck P.C., Sampath T.K., Rueger D.C., Carlson W.D.
Proc. Natl. Acad. Sci. U.S.A. 93:878-883(1996) [PubMed: 8570652] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 293-431.
+Additional computationally mapped references.

Web resources

Wikipedia

Bone morphogenetic protein 7 entry

Cross-references

Sequence databases

X51801 mRNA. Translation: CAA36100.1.
M60316 mRNA. Translation: AAA36738.1.
AL122058, AL157414 Genomic DNA. Translation: CAB90273.2.
AL157414, AL122058 Genomic DNA. Translation: CAC08434.2.
BC008584 mRNA. Translation: AAH08584.1.
IPIIPI00550949.
PIRBMHU7. C39263.
RefSeqNP_001710.1.
UniGeneHs.473163

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1BMPX-ray2.80A293-431[»]
1LX5X-ray3.30A293-431[»]
1LXIX-ray2.00A293-431[»]
1M4UX-ray2.42L293-431[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:5800N.
IntActP18075. 2 interactions.

Proteomic databases

PRIDEP18075.

Genome annotation databases

EnsemblENSG00000101144. Homo sapiens. [Contig view]
GeneID655.
KEGGhsa:655.

Organism-specific databases

GeneCardsGC20M055178.
H-InvDBHIX0015936.
HGNCHGNC:1074. BMP7.
MIM112267. gene.
PharmGKBPA25384.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP18075.
HOVERGENP18075.
OMAP18075. FTTQGPP.

Enzyme and pathway databases

Pathway_Interaction_DBbmppathway. BMP receptor signaling.

Gene expression databases

ArrayExpressP18075.
BgeeP18075.
CleanExHS_BMP7.
GermOnlineENSG00000101144. Homo sapiens.

Family and domain databases

InterProIPR001839. TGFb.
IPR017948. TGFb_CS.
IPR001111. TGFb_N.
IPR015615. TGFbeta.
[Graphical view]
PANTHERPTHR11848. TGFbeta. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
ProDomPD000357. TGFb. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio2664.
SOURCESearch...

Entry information

Entry nameBMP7_HUMAN
AccessionPrimary (citable) accession number: P18075
Secondary accession number(s): Q9H512, Q9NTQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 16, 2009
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents