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P18075

- BMP7_HUMAN

UniProt

P18075 - BMP7_HUMAN

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Protein

Bone morphogenetic protein 7

Gene

BMP7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. axon guidance Source: Ensembl
  2. BMP signaling pathway Source: BHF-UCL
  3. branching involved in salivary gland morphogenesis Source: Ensembl
  4. branching morphogenesis of an epithelial tube Source: Ensembl
  5. cartilage development Source: UniProtKB-KW
  6. cellular response to hypoxia Source: BHF-UCL
  7. dendrite development Source: BHF-UCL
  8. embryonic camera-type eye morphogenesis Source: Ensembl
  9. embryonic limb morphogenesis Source: Ensembl
  10. embryonic pattern specification Source: Ensembl
  11. embryonic skeletal joint morphogenesis Source: Ensembl
  12. epithelial cell differentiation Source: Ensembl
  13. epithelial to mesenchymal transition Source: HGNC
  14. extracellular matrix organization Source: Reactome
  15. growth Source: InterPro
  16. mesenchymal cell differentiation Source: UniProtKB
  17. mesenchyme development Source: UniProtKB
  18. mesoderm formation Source: Ensembl
  19. mesonephros development Source: UniProtKB
  20. metanephric mesenchymal cell proliferation involved in metanephros development Source: Ensembl
  21. metanephric mesenchyme morphogenesis Source: Ensembl
  22. metanephros development Source: UniProtKB
  23. monocyte aggregation Source: UniProtKB
  24. negative regulation of cell cycle Source: HGNC
  25. negative regulation of cell death Source: UniProtKB
  26. negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
  27. negative regulation of MAP kinase activity Source: UniProtKB
  28. negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Source: Ensembl
  29. negative regulation of mitosis Source: UniProtKB
  30. negative regulation of neurogenesis Source: Ensembl
  31. negative regulation of neuron differentiation Source: MGI
  32. negative regulation of NF-kappaB import into nucleus Source: BHF-UCL
  33. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  34. negative regulation of Notch signaling pathway Source: Ensembl
  35. negative regulation of phosphorylation Source: UniProtKB
  36. negative regulation of prostatic bud formation Source: Ensembl
  37. negative regulation of striated muscle cell apoptotic process Source: BHF-UCL
  38. negative regulation of transcription, DNA-templated Source: UniProtKB
  39. nephrogenic mesenchyme morphogenesis Source: Ensembl
  40. neuron projection morphogenesis Source: MGI
  41. odontogenesis of dentin-containing tooth Source: Ensembl
  42. ossification Source: UniProtKB-KW
  43. positive regulation of apoptotic process Source: Ensembl
  44. positive regulation of bone mineralization Source: BHF-UCL
  45. positive regulation of dendrite development Source: BHF-UCL
  46. positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
  47. positive regulation of hyaluranon cable assembly Source: UniProtKB
  48. positive regulation of neuron differentiation Source: Ensembl
  49. positive regulation of osteoblast differentiation Source: BHF-UCL
  50. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  51. positive regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
  52. positive regulation of transcription, DNA-templated Source: UniProtKB
  53. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  54. protein localization to nucleus Source: UniProtKB
  55. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  56. regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  57. regulation of removal of superoxide radicals Source: BHF-UCL
  58. response to estradiol Source: Ensembl
  59. response to peptide hormone Source: Ensembl
  60. response to vitamin D Source: Ensembl
  61. skeletal system development Source: ProtInc
  62. SMAD protein signal transduction Source: UniProtKB
  63. steroid hormone mediated signaling pathway Source: UniProtKB
  64. ureteric bud development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

ReactomeiREACT_150331. Molecules associated with elastic fibres.
SignaLinkiP18075.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 7
Short name:
BMP-7
Alternative name(s):
Osteogenic protein 1
Short name:
OP-1
INN: Eptotermin alfa
Gene namesi
Name:BMP7
Synonyms:OP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:1074. BMP7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProtKB
  4. membrane-bounded vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the name Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.

Organism-specific databases

PharmGKBiPA25384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Propeptidei30 – 2922631 PublicationPRO_0000033876Add
BLAST
Chaini293 – 431139Bone morphogenetic protein 7PRO_0000033877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi330 ↔ 396
Disulfide bondi359 ↔ 428
Disulfide bondi363 ↔ 430
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi395 – 395Interchain

Post-translational modificationi

Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP18075.
PaxDbiP18075.
PRIDEiP18075.

PTM databases

PhosphoSiteiP18075.

Expressioni

Tissue specificityi

Expressed in the kidney and bladder. Lower levels seen in the brain.

Developmental stagei

Expressed in the developing eye, brain and ear during embryogenesis.1 Publication

Gene expression databases

BgeeiP18075.
CleanExiHS_BMP7.
ExpressionAtlasiP18075. baseline and differential.
GenevestigatoriP18075.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi107123. 26 interactions.
DIPiDIP-5800N.
IntActiP18075. 3 interactions.
MINTiMINT-263199.
STRINGi9606.ENSP00000379204.

Structurei

Secondary structure

1
431
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi329 – 3335Combined sources
Beta strandi336 – 3383Combined sources
Helixi339 – 3424Combined sources
Turni345 – 3473Combined sources
Beta strandi348 – 3503Combined sources
Beta strandi352 – 3554Combined sources
Beta strandi358 – 3625Combined sources
Beta strandi365 – 3684Combined sources
Helixi369 – 3713Combined sources
Helixi375 – 38612Combined sources
Turni388 – 3903Combined sources
Beta strandi396 – 40914Combined sources
Helixi411 – 4133Combined sources
Beta strandi415 – 43016Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMPX-ray2.80A293-431[»]
1LX5X-ray3.30A293-431[»]
1LXIX-ray2.00A293-431[»]
1M4UX-ray2.42L293-431[»]
ProteinModelPortaliP18075.
SMRiP18075. Positions 211-431.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18075.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG272883.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP18075.
KOiK16621.
OMAiVVNPQHN.
OrthoDBiEOG7J9VPQ.
PhylomeDBiP18075.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18075-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE
60 70 80 90 100
RREMQREILS ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG
110 120 130 140 150
QGFSYPYKAV FSTQGPPLAS LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR
160 170 180 190 200
YHHREFRFDL SKIPEGEAVT AAEFRIYKDY IRERFDNETF RISVYQVLQE
210 220 230 240 250
HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR HNLGLQLSVE
260 270 280 290 300
TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS
310 320 330 340 350
QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA
360 370 380 390 400
PEGYAAYYCE GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ
410 420 430
LNAISVLYFD DSSNVILKKY RNMVVRACGC H
Length:431
Mass (Da):49,313
Last modified:November 1, 1990 - v1
Checksum:i47A05E45C6815F8A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti198 – 1981L → P Found in a patient with unilateral microphthalmia, optic disk and chorioretinal coloboma, mild learning difficulties. 1 Publication
VAR_064058
Natural varianti321 – 3211N → S.1 Publication
Corresponds to variant rs61733438 [ dbSNP | Ensembl ].
VAR_064059

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51801 mRNA. Translation: CAA36100.1.
M60316 mRNA. Translation: AAA36738.1.
AL122058, AL157414 Genomic DNA. Translation: CAB90273.2.
AL157414, AL122058 Genomic DNA. Translation: CAC08434.2.
BC008584 mRNA. Translation: AAH08584.1.
CCDSiCCDS13455.1.
PIRiC39263. BMHU7.
RefSeqiNP_001710.1. NM_001719.2.
UniGeneiHs.473163.

Genome annotation databases

EnsembliENST00000395863; ENSP00000379204; ENSG00000101144.
GeneIDi655.
KEGGihsa:655.
UCSCiuc010gip.1. human.

Polymorphism databases

DMDMi115078.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 7 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51801 mRNA. Translation: CAA36100.1 .
M60316 mRNA. Translation: AAA36738.1 .
AL122058 , AL157414 Genomic DNA. Translation: CAB90273.2 .
AL157414 , AL122058 Genomic DNA. Translation: CAC08434.2 .
BC008584 mRNA. Translation: AAH08584.1 .
CCDSi CCDS13455.1.
PIRi C39263. BMHU7.
RefSeqi NP_001710.1. NM_001719.2.
UniGenei Hs.473163.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BMP X-ray 2.80 A 293-431 [» ]
1LX5 X-ray 3.30 A 293-431 [» ]
1LXI X-ray 2.00 A 293-431 [» ]
1M4U X-ray 2.42 L 293-431 [» ]
ProteinModelPortali P18075.
SMRi P18075. Positions 211-431.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107123. 26 interactions.
DIPi DIP-5800N.
IntActi P18075. 3 interactions.
MINTi MINT-263199.
STRINGi 9606.ENSP00000379204.

PTM databases

PhosphoSitei P18075.

Polymorphism databases

DMDMi 115078.

Proteomic databases

MaxQBi P18075.
PaxDbi P18075.
PRIDEi P18075.

Protocols and materials databases

DNASUi 655.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395863 ; ENSP00000379204 ; ENSG00000101144 .
GeneIDi 655.
KEGGi hsa:655.
UCSCi uc010gip.1. human.

Organism-specific databases

CTDi 655.
GeneCardsi GC20M055743.
HGNCi HGNC:1074. BMP7.
MIMi 112267. gene.
neXtProti NX_P18075.
PharmGKBi PA25384.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272883.
GeneTreei ENSGT00760000118883.
HOGENOMi HOG000249476.
HOVERGENi HBG004860.
InParanoidi P18075.
KOi K16621.
OMAi VVNPQHN.
OrthoDBi EOG7J9VPQ.
PhylomeDBi P18075.
TreeFami TF316134.

Enzyme and pathway databases

Reactomei REACT_150331. Molecules associated with elastic fibres.
SignaLinki P18075.

Miscellaneous databases

ChiTaRSi BMP7. human.
EvolutionaryTracei P18075.
GeneWikii Bone_morphogenetic_protein_7.
GenomeRNAii 655.
NextBioi 2664.
PROi P18075.
SOURCEi Search...

Gene expression databases

Bgeei P18075.
CleanExi HS_BMP7.
ExpressionAtlasi P18075. baseline and differential.
Genevestigatori P18075.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "OP-1 cDNA encodes an osteogenic protein in the TGF-beta family."
    Oezkaynak E., Rueger D.C., Drier E.A., Corbett C., Ridge R.J., Sampath T.K., Oppermann H.
    EMBO J. 9:2085-2093(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Placenta.
  2. "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
    Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.
    Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Expression and characterization of a human BMP-7 variant with improved biochemical properties."
    Swencki-Underwood B., Mills J.K., Vennarini J., Boakye K., Luo J., Pomerantz S., Cunningham M.R., Farrell F.X., Naso M.F., Amegadzie B.
    Protein Expr. Purif. 57:312-319(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 293-302.
  6. Cited for: INTERACTION WITH SOSTDC1.
  7. "Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies."
    Wyatt A.W., Osborne R.J., Stewart H., Ragge N.K.
    Hum. Mutat. 31:781-787(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, VARIANTS PRO-198 AND SER-321, ASSOCIATION WITH DEVELOPMENTAL EYE ANOMALIES.
  8. "Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily."
    Griffith D.L., Keck P.C., Sampath T.K., Rueger D.C., Carlson W.D.
    Proc. Natl. Acad. Sci. U.S.A. 93:878-883(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 293-431.

Entry informationi

Entry nameiBMP7_HUMAN
AccessioniPrimary (citable) accession number: P18075
Secondary accession number(s): Q9H512, Q9NTQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 26, 2014
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3