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P18075 (BMP7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 163. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 7

Short name=BMP-7
Alternative name(s):
Osteogenic protein 1
Short name=OP-1
INN=Eptotermin alfa
Gene names
Name:BMP7
Synonyms:OP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Subunit structure

Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 By similarity. Ref.6

Subcellular location

Secreted.

Tissue specificity

Expressed in the kidney and bladder. Lower levels seen in the brain.

Developmental stage

Expressed in the developing eye, brain and ear during embryogenesis. Ref.7

Post-translational modification

Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (Ref.5).

Pharmaceutical use

Available under the name Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Biological processChondrogenesis
Differentiation
Osteogenesis
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Pharmaceutical
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay PubMed 16049014PubMed 18436533. Source: BHF-UCL

SMAD protein signal transduction

Inferred from direct assay PubMed 17244894. Source: UniProtKB

axon guidance

Inferred from electronic annotation. Source: Ensembl

branching involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

branching morphogenesis of an epithelial tube

Inferred from electronic annotation. Source: Ensembl

cartilage development

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to hypoxia

Inferred from sequence or structural similarity. Source: BHF-UCL

dendrite development

Traceable author statement PubMed 11580864. Source: BHF-UCL

embryonic camera-type eye morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic limb morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic pattern specification

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal joint morphogenesis

Inferred from electronic annotation. Source: Ensembl

epithelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

epithelial to mesenchymal transition

Traceable author statement PubMed 14679171. Source: HGNC

extracellular matrix organization

Traceable author statement. Source: Reactome

growth

Inferred from electronic annotation. Source: InterPro

mesenchymal cell differentiation

Inferred from direct assay PubMed 9693150. Source: UniProtKB

mesenchyme development

Inferred from sequence or structural similarity. Source: UniProtKB

mesoderm formation

Inferred from electronic annotation. Source: Ensembl

mesonephros development

Inferred from expression pattern PubMed 18437684. Source: UniProtKB

metanephric mesenchymal cell proliferation involved in metanephros development

Inferred from electronic annotation. Source: Ensembl

metanephric mesenchyme morphogenesis

Inferred from electronic annotation. Source: Ensembl

metanephros development

Inferred from expression pattern PubMed 18437684. Source: UniProtKB

monocyte aggregation

Inferred from direct assay PubMed 15100360. Source: UniProtKB

negative regulation of MAP kinase activity

Inferred from direct assay PubMed 17244894. Source: UniProtKB

negative regulation of NF-kappaB import into nucleus

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of NF-kappaB transcription factor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of Notch signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell cycle

Inferred from direct assay PubMed 11502704. Source: HGNC

negative regulation of cell death

Inferred from direct assay PubMed 12631064. Source: UniProtKB

negative regulation of glomerular mesangial cell proliferation

Inferred from direct assay PubMed 17244894. Source: UniProtKB

negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of mitosis

Inferred from direct assay PubMed 17244894. Source: UniProtKB

negative regulation of neurogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron differentiation

Inferred from direct assay PubMed 16325379. Source: MGI

negative regulation of phosphorylation

Inferred from direct assay PubMed 17244894. Source: UniProtKB

negative regulation of prostatic bud formation

Inferred from electronic annotation. Source: Ensembl

negative regulation of striated muscle cell apoptotic process

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 15100360PubMed 17244894. Source: UniProtKB

nephrogenic mesenchyme morphogenesis

Inferred from electronic annotation. Source: Ensembl

neuron projection morphogenesis

Inferred from direct assay PubMed 16325379. Source: MGI

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

ossification

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of bone mineralization

Inferred from direct assay PubMed 18436533. Source: BHF-UCL

positive regulation of dendrite development

Inferred from direct assay PubMed 11580864. Source: BHF-UCL

positive regulation of heterotypic cell-cell adhesion

Inferred from direct assay PubMed 15100360. Source: UniProtKB

positive regulation of hyaluranon cable assembly

Inferred from direct assay PubMed 15100360. Source: UniProtKB

positive regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast differentiation

Inferred from direct assay PubMed 18436533. Source: BHF-UCL

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from direct assay PubMed 17244894. Source: UniProtKB

positive regulation of peptidyl-threonine phosphorylation

Inferred from direct assay PubMed 19736306. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 15100360. Source: UniProtKB

protein localization to nucleus

Inferred from direct assay PubMed 17244894. Source: UniProtKB

regulation of branching involved in prostate gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

regulation of pathway-restricted SMAD protein phosphorylation

Inferred from direct assay PubMed 16049014. Source: BHF-UCL

regulation of removal of superoxide radicals

Inferred from sequence or structural similarity. Source: BHF-UCL

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

response to vitamin D

Inferred from electronic annotation. Source: Ensembl

skeletal system development

Traceable author statement Ref.1. Source: ProtInc

steroid hormone mediated signaling pathway

Inferred from mutant phenotype PubMed 17244894. Source: UniProtKB

ureteric bud development

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentextracellular matrix

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay Ref.5. Source: UniProtKB

membrane-bounded vesicle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 18184661. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Propeptide30 – 292263
PRO_0000033876
Chain293 – 431139Bone morphogenetic protein 7
PRO_0000033877

Amino acid modifications

Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation3721N-linked (GlcNAc...) Potential
Disulfide bond330 ↔ 396
Disulfide bond359 ↔ 428
Disulfide bond363 ↔ 430
Disulfide bond395Interchain

Natural variations

Natural variant1981L → P Found in a patient with unilateral microphthalmia, optic disk and chorioretinal coloboma, mild learning difficulties. Ref.7
VAR_064058
Natural variant3211N → S. Ref.7
Corresponds to variant rs61733438 [ dbSNP | Ensembl ].
VAR_064059

Secondary structure

.......................... 431
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P18075 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 47A05E45C6815F8A

FASTA43149,313
        10         20         30         40         50         60 
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 

        70         80         90        100        110        120 
ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS 

       130        140        150        160        170        180 
LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY 

       190        200        210        220        230        240 
IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR 

       250        260        270        280        290        300 
HNLGLQLSVE TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS 

       310        320        330        340        350        360 
QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE 

       370        380        390        400        410        420 
GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY 

       430 
RNMVVRACGC H 

« Hide

References

« Hide 'large scale' references
[1]"OP-1 cDNA encodes an osteogenic protein in the TGF-beta family."
Oezkaynak E., Rueger D.C., Drier E.A., Corbett C., Ridge R.J., Sampath T.K., Oppermann H.
EMBO J. 9:2085-2093(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Placenta.
[2]"Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.
Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Expression and characterization of a human BMP-7 variant with improved biochemical properties."
Swencki-Underwood B., Mills J.K., Vennarini J., Boakye K., Luo J., Pomerantz S., Cunningham M.R., Farrell F.X., Naso M.F., Amegadzie B.
Protein Expr. Purif. 57:312-319(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 293-302.
[6]"USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney."
Yanagita M., Oka M., Watabe T., Iguchi H., Niida A., Takahashi S., Akiyama T., Miyazono K., Yanagisawa M., Sakurai T.
Biochem. Biophys. Res. Commun. 316:490-500(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SOSTDC1.
[7]"Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies."
Wyatt A.W., Osborne R.J., Stewart H., Ragge N.K.
Hum. Mutat. 31:781-787(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE, VARIANTS PRO-198 AND SER-321, ASSOCIATION WITH DEVELOPMENTAL EYE ANOMALIES.
[8]"Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily."
Griffith D.L., Keck P.C., Sampath T.K., Rueger D.C., Carlson W.D.
Proc. Natl. Acad. Sci. U.S.A. 93:878-883(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 293-431.
+Additional computationally mapped references.

Web resources

Wikipedia

Bone morphogenetic protein 7 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X51801 mRNA. Translation: CAA36100.1.
M60316 mRNA. Translation: AAA36738.1.
AL122058, AL157414 Genomic DNA. Translation: CAB90273.2.
AL157414, AL122058 Genomic DNA. Translation: CAC08434.2.
BC008584 mRNA. Translation: AAH08584.1.
CCDSCCDS13455.1.
PIRBMHU7. C39263.
RefSeqNP_001710.1. NM_001719.2.
UniGeneHs.473163.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMPX-ray2.80A293-431[»]
1LX5X-ray3.30A293-431[»]
1LXIX-ray2.00A293-431[»]
1M4UX-ray2.42L293-431[»]
ProteinModelPortalP18075.
SMRP18075. Positions 211-431.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107123. 14 interactions.
DIPDIP-5800N.
IntActP18075. 3 interactions.
MINTMINT-263199.
STRING9606.ENSP00000379204.

PTM databases

PhosphoSiteP18075.

Polymorphism databases

DMDM115078.

Proteomic databases

MaxQBP18075.
PaxDbP18075.
PRIDEP18075.

Protocols and materials databases

DNASU655.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395863; ENSP00000379204; ENSG00000101144.
GeneID655.
KEGGhsa:655.
UCSCuc010gip.1. human.

Organism-specific databases

CTD655.
GeneCardsGC20M055743.
HGNCHGNC:1074. BMP7.
MIM112267. gene.
neXtProtNX_P18075.
PharmGKBPA25384.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272883.
HOGENOMHOG000249476.
HOVERGENHBG004860.
InParanoidP18075.
KOK16621.
OMAVVNPQHN.
OrthoDBEOG7J9VPQ.
PhylomeDBP18075.
TreeFamTF316134.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.
SignaLinkP18075.

Gene expression databases

ArrayExpressP18075.
BgeeP18075.
CleanExHS_BMP7.
GenevestigatorP18075.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBMP7. human.
EvolutionaryTraceP18075.
GeneWikiBone_morphogenetic_protein_7.
GenomeRNAi655.
NextBio2664.
PROP18075.
SOURCESearch...

Entry information

Entry nameBMP7_HUMAN
AccessionPrimary (citable) accession number: P18075
Secondary accession number(s): Q9H512, Q9NTQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 9, 2014
This is version 163 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM