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Protein

Bone morphogenetic protein 7

Gene

BMP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

ReactomeiR-HSA-2129379 Molecules associated with elastic fibres
SignaLinkiP18075
SIGNORiP18075

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 7
Short name:
BMP-7
Alternative name(s):
Osteogenic protein 1
Short name:
OP-1
INN: Eptotermin alfa
Gene namesi
Name:BMP7
Synonyms:OP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101144.12
HGNCiHGNC:1074 BMP7
MIMi112267 gene
neXtProtiNX_P18075

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the name Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.

Organism-specific databases

DisGeNETi655
OpenTargetsiENSG00000101144
PharmGKBiPA25384

Polymorphism and mutation databases

BioMutaiBMP7
DMDMi115078

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000003387630 – 2921 PublicationAdd BLAST263
ChainiPRO_0000033877293 – 431Bone morphogenetic protein 7Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi330 ↔ 396
Disulfide bondi359 ↔ 428
Disulfide bondi363 ↔ 430
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi395Interchain

Post-translational modificationi

Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP18075
PaxDbiP18075
PeptideAtlasiP18075
PRIDEiP18075

PTM databases

iPTMnetiP18075
PhosphoSitePlusiP18075

Expressioni

Tissue specificityi

Expressed in the kidney and bladder. Lower levels seen in the brain.

Developmental stagei

Expressed in the developing eye, brain and ear during embryogenesis.1 Publication

Gene expression databases

BgeeiENSG00000101144
CleanExiHS_BMP7
ExpressionAtlasiP18075 baseline and differential
GenevisibleiP18075 HS

Organism-specific databases

HPAiHPA057757

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107123, 53 interactors
DIPiDIP-5800N
IntActiP18075, 16 interactors
MINTiP18075
STRINGi9606.ENSP00000379204

Structurei

Secondary structure

1431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi329 – 333Combined sources5
Beta strandi336 – 338Combined sources3
Helixi339 – 342Combined sources4
Turni345 – 347Combined sources3
Beta strandi348 – 350Combined sources3
Beta strandi352 – 355Combined sources4
Beta strandi358 – 362Combined sources5
Beta strandi365 – 368Combined sources4
Helixi369 – 371Combined sources3
Helixi375 – 386Combined sources12
Turni388 – 390Combined sources3
Beta strandi396 – 409Combined sources14
Helixi411 – 413Combined sources3
Beta strandi415 – 430Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMPX-ray2.80A293-431[»]
1LX5X-ray3.30A293-431[»]
1LXIX-ray2.00A293-431[»]
1M4UX-ray2.42L293-431[»]
ProteinModelPortaliP18075
SMRiP18075
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18075

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOGENOMiHOG000249476
HOVERGENiHBG004860
InParanoidiP18075
KOiK16621
OMAiETFQISV
OrthoDBiEOG091G0C2J
PhylomeDBiP18075
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE
60 70 80 90 100
RREMQREILS ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG
110 120 130 140 150
QGFSYPYKAV FSTQGPPLAS LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR
160 170 180 190 200
YHHREFRFDL SKIPEGEAVT AAEFRIYKDY IRERFDNETF RISVYQVLQE
210 220 230 240 250
HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR HNLGLQLSVE
260 270 280 290 300
TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS
310 320 330 340 350
QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA
360 370 380 390 400
PEGYAAYYCE GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ
410 420 430
LNAISVLYFD DSSNVILKKY RNMVVRACGC H
Length:431
Mass (Da):49,313
Last modified:November 1, 1990 - v1
Checksum:i47A05E45C6815F8A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064058198L → P Found in a patient with unilateral microphthalmia, optic disk and chorioretinal coloboma, mild learning difficulties. 1 PublicationCorresponds to variant dbSNP:rs376798352Ensembl.1
Natural variantiVAR_064059321N → S1 PublicationCorresponds to variant dbSNP:rs61733438Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51801 mRNA Translation: CAA36100.1
M60316 mRNA Translation: AAA36738.1
AL122058 Genomic DNA No translation available.
AL157414 Genomic DNA No translation available.
BC008584 mRNA Translation: AAH08584.1
CCDSiCCDS13455.1
PIRiC39263 BMHU7
RefSeqiNP_001710.1, NM_001719.2
UniGeneiHs.473163

Genome annotation databases

EnsembliENST00000395863; ENSP00000379204; ENSG00000101144
GeneIDi655
KEGGihsa:655
UCSCiuc010gip.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBMP7_HUMAN
AccessioniPrimary (citable) accession number: P18075
Secondary accession number(s): Q9H512, Q9NTQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 198 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome
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Main funding by: National Institutes of Health