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Protein

Bone morphogenetic protein 7

Gene

BMP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

ReactomeiREACT_150331. Molecules associated with elastic fibres.
SignaLinkiP18075.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 7
Short name:
BMP-7
Alternative name(s):
Osteogenic protein 1
Short name:
OP-1
INN: Eptotermin alfa
Gene namesi
Name:BMP7
Synonyms:OP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:1074. BMP7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the name Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.

Organism-specific databases

PharmGKBiPA25384.

Polymorphism and mutation databases

BioMutaiBMP7.
DMDMi115078.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Propeptidei30 – 2922631 PublicationPRO_0000033876Add
BLAST
Chaini293 – 431139Bone morphogenetic protein 7PRO_0000033877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi330 ↔ 396
Disulfide bondi359 ↔ 428
Disulfide bondi363 ↔ 430
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi395 – 395Interchain

Post-translational modificationi

Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP18075.
PaxDbiP18075.
PRIDEiP18075.

PTM databases

PhosphoSiteiP18075.

Expressioni

Tissue specificityi

Expressed in the kidney and bladder. Lower levels seen in the brain.

Developmental stagei

Expressed in the developing eye, brain and ear during embryogenesis.1 Publication

Gene expression databases

BgeeiP18075.
CleanExiHS_BMP7.
ExpressionAtlasiP18075. baseline and differential.
GenevestigatoriP18075.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi107123. 37 interactions.
DIPiDIP-5800N.
IntActiP18075. 3 interactions.
MINTiMINT-263199.
STRINGi9606.ENSP00000379204.

Structurei

Secondary structure

1
431
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi329 – 3335Combined sources
Beta strandi336 – 3383Combined sources
Helixi339 – 3424Combined sources
Turni345 – 3473Combined sources
Beta strandi348 – 3503Combined sources
Beta strandi352 – 3554Combined sources
Beta strandi358 – 3625Combined sources
Beta strandi365 – 3684Combined sources
Helixi369 – 3713Combined sources
Helixi375 – 38612Combined sources
Turni388 – 3903Combined sources
Beta strandi396 – 40914Combined sources
Helixi411 – 4133Combined sources
Beta strandi415 – 43016Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMPX-ray2.80A293-431[»]
1LX5X-ray3.30A293-431[»]
1LXIX-ray2.00A293-431[»]
1M4UX-ray2.42L293-431[»]
ProteinModelPortaliP18075.
SMRiP18075. Positions 211-431.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18075.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG272883.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP18075.
KOiK16621.
OMAiHKEFRFD.
OrthoDBiEOG7J9VPQ.
PhylomeDBiP18075.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE
60 70 80 90 100
RREMQREILS ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG
110 120 130 140 150
QGFSYPYKAV FSTQGPPLAS LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR
160 170 180 190 200
YHHREFRFDL SKIPEGEAVT AAEFRIYKDY IRERFDNETF RISVYQVLQE
210 220 230 240 250
HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR HNLGLQLSVE
260 270 280 290 300
TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS
310 320 330 340 350
QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA
360 370 380 390 400
PEGYAAYYCE GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ
410 420 430
LNAISVLYFD DSSNVILKKY RNMVVRACGC H
Length:431
Mass (Da):49,313
Last modified:November 1, 1990 - v1
Checksum:i47A05E45C6815F8A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti198 – 1981L → P Found in a patient with unilateral microphthalmia, optic disk and chorioretinal coloboma, mild learning difficulties. 1 Publication
VAR_064058
Natural varianti321 – 3211N → S.1 Publication
Corresponds to variant rs61733438 [ dbSNP | Ensembl ].
VAR_064059

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51801 mRNA. Translation: CAA36100.1.
M60316 mRNA. Translation: AAA36738.1.
AL122058, AL157414 Genomic DNA. Translation: CAB90273.2.
AL157414, AL122058 Genomic DNA. Translation: CAC08434.2.
BC008584 mRNA. Translation: AAH08584.1.
CCDSiCCDS13455.1.
PIRiC39263. BMHU7.
RefSeqiNP_001710.1. NM_001719.2.
UniGeneiHs.473163.

Genome annotation databases

EnsembliENST00000395863; ENSP00000379204; ENSG00000101144.
GeneIDi655.
KEGGihsa:655.
UCSCiuc010gip.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 7 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51801 mRNA. Translation: CAA36100.1.
M60316 mRNA. Translation: AAA36738.1.
AL122058, AL157414 Genomic DNA. Translation: CAB90273.2.
AL157414, AL122058 Genomic DNA. Translation: CAC08434.2.
BC008584 mRNA. Translation: AAH08584.1.
CCDSiCCDS13455.1.
PIRiC39263. BMHU7.
RefSeqiNP_001710.1. NM_001719.2.
UniGeneiHs.473163.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMPX-ray2.80A293-431[»]
1LX5X-ray3.30A293-431[»]
1LXIX-ray2.00A293-431[»]
1M4UX-ray2.42L293-431[»]
ProteinModelPortaliP18075.
SMRiP18075. Positions 211-431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107123. 37 interactions.
DIPiDIP-5800N.
IntActiP18075. 3 interactions.
MINTiMINT-263199.
STRINGi9606.ENSP00000379204.

PTM databases

PhosphoSiteiP18075.

Polymorphism and mutation databases

BioMutaiBMP7.
DMDMi115078.

Proteomic databases

MaxQBiP18075.
PaxDbiP18075.
PRIDEiP18075.

Protocols and materials databases

DNASUi655.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395863; ENSP00000379204; ENSG00000101144.
GeneIDi655.
KEGGihsa:655.
UCSCiuc010gip.1. human.

Organism-specific databases

CTDi655.
GeneCardsiGC20M055743.
HGNCiHGNC:1074. BMP7.
MIMi112267. gene.
neXtProtiNX_P18075.
PharmGKBiPA25384.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG272883.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP18075.
KOiK16621.
OMAiHKEFRFD.
OrthoDBiEOG7J9VPQ.
PhylomeDBiP18075.
TreeFamiTF316134.

Enzyme and pathway databases

ReactomeiREACT_150331. Molecules associated with elastic fibres.
SignaLinkiP18075.

Miscellaneous databases

ChiTaRSiBMP7. human.
EvolutionaryTraceiP18075.
GeneWikiiBone_morphogenetic_protein_7.
GenomeRNAii655.
NextBioi2664.
PROiP18075.
SOURCEiSearch...

Gene expression databases

BgeeiP18075.
CleanExiHS_BMP7.
ExpressionAtlasiP18075. baseline and differential.
GenevestigatoriP18075.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "OP-1 cDNA encodes an osteogenic protein in the TGF-beta family."
    Oezkaynak E., Rueger D.C., Drier E.A., Corbett C., Ridge R.J., Sampath T.K., Oppermann H.
    EMBO J. 9:2085-2093(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Placenta.
  2. "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
    Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.
    Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Expression and characterization of a human BMP-7 variant with improved biochemical properties."
    Swencki-Underwood B., Mills J.K., Vennarini J., Boakye K., Luo J., Pomerantz S., Cunningham M.R., Farrell F.X., Naso M.F., Amegadzie B.
    Protein Expr. Purif. 57:312-319(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 293-302.
  6. Cited for: INTERACTION WITH SOSTDC1.
  7. "Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies."
    Wyatt A.W., Osborne R.J., Stewart H., Ragge N.K.
    Hum. Mutat. 31:781-787(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, VARIANTS PRO-198 AND SER-321, ASSOCIATION WITH DEVELOPMENTAL EYE ANOMALIES.
  8. "Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily."
    Griffith D.L., Keck P.C., Sampath T.K., Rueger D.C., Carlson W.D.
    Proc. Natl. Acad. Sci. U.S.A. 93:878-883(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 293-431.

Entry informationi

Entry nameiBMP7_HUMAN
AccessioniPrimary (citable) accession number: P18075
Secondary accession number(s): Q9H512, Q9NTQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 27, 2015
This is version 172 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.