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Protein

Bone morphogenetic protein 7

Gene

BMP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101144-MONOMER.
ReactomeiR-HSA-2129379. Molecules associated with elastic fibres.
SignaLinkiP18075.
SIGNORiP18075.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 7
Short name:
BMP-7
Alternative name(s):
Osteogenic protein 1
Short name:
OP-1
INN: Eptotermin alfa
Gene namesi
Name:BMP7
Synonyms:OP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:1074. BMP7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the name Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.

Organism-specific databases

DisGeNETi655.
OpenTargetsiENSG00000101144.
PharmGKBiPA25384.

Polymorphism and mutation databases

BioMutaiBMP7.
DMDMi115078.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000003387630 – 2921 PublicationAdd BLAST263
ChainiPRO_0000033877293 – 431Bone morphogenetic protein 7Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi330 ↔ 396
Disulfide bondi359 ↔ 428
Disulfide bondi363 ↔ 430
Glycosylationi372N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi395Interchain

Post-translational modificationi

Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP18075.
MaxQBiP18075.
PaxDbiP18075.
PeptideAtlasiP18075.
PRIDEiP18075.

PTM databases

iPTMnetiP18075.
PhosphoSitePlusiP18075.

Expressioni

Tissue specificityi

Expressed in the kidney and bladder. Lower levels seen in the brain.

Developmental stagei

Expressed in the developing eye, brain and ear during embryogenesis.1 Publication

Gene expression databases

BgeeiENSG00000101144.
CleanExiHS_BMP7.
ExpressionAtlasiP18075. baseline and differential.
GenevisibleiP18075. HS.

Organism-specific databases

HPAiHPA057757.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107123. 43 interactors.
DIPiDIP-5800N.
IntActiP18075. 12 interactors.
MINTiMINT-263199.
STRINGi9606.ENSP00000379204.

Structurei

Secondary structure

1431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi329 – 333Combined sources5
Beta strandi336 – 338Combined sources3
Helixi339 – 342Combined sources4
Turni345 – 347Combined sources3
Beta strandi348 – 350Combined sources3
Beta strandi352 – 355Combined sources4
Beta strandi358 – 362Combined sources5
Beta strandi365 – 368Combined sources4
Helixi369 – 371Combined sources3
Helixi375 – 386Combined sources12
Turni388 – 390Combined sources3
Beta strandi396 – 409Combined sources14
Helixi411 – 413Combined sources3
Beta strandi415 – 430Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMPX-ray2.80A293-431[»]
1LX5X-ray3.30A293-431[»]
1LXIX-ray2.00A293-431[»]
1M4UX-ray2.42L293-431[»]
ProteinModelPortaliP18075.
SMRiP18075.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18075.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP18075.
KOiK16621.
OMAiKVPNDNY.
OrthoDBiEOG091G0C2J.
PhylomeDBiP18075.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE
60 70 80 90 100
RREMQREILS ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG
110 120 130 140 150
QGFSYPYKAV FSTQGPPLAS LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR
160 170 180 190 200
YHHREFRFDL SKIPEGEAVT AAEFRIYKDY IRERFDNETF RISVYQVLQE
210 220 230 240 250
HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR HNLGLQLSVE
260 270 280 290 300
TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS
310 320 330 340 350
QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA
360 370 380 390 400
PEGYAAYYCE GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ
410 420 430
LNAISVLYFD DSSNVILKKY RNMVVRACGC H
Length:431
Mass (Da):49,313
Last modified:November 1, 1990 - v1
Checksum:i47A05E45C6815F8A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064058198L → P Found in a patient with unilateral microphthalmia, optic disk and chorioretinal coloboma, mild learning difficulties. 1 PublicationCorresponds to variant rs376798352dbSNPEnsembl.1
Natural variantiVAR_064059321N → S.1 PublicationCorresponds to variant rs61733438dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51801 mRNA. Translation: CAA36100.1.
M60316 mRNA. Translation: AAA36738.1.
AL122058, AL157414 Genomic DNA. Translation: CAB90273.2.
AL157414, AL122058 Genomic DNA. Translation: CAC08434.2.
BC008584 mRNA. Translation: AAH08584.1.
CCDSiCCDS13455.1.
PIRiC39263. BMHU7.
RefSeqiNP_001710.1. NM_001719.2.
UniGeneiHs.473163.

Genome annotation databases

EnsembliENST00000395863; ENSP00000379204; ENSG00000101144.
GeneIDi655.
KEGGihsa:655.
UCSCiuc010gip.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 7 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51801 mRNA. Translation: CAA36100.1.
M60316 mRNA. Translation: AAA36738.1.
AL122058, AL157414 Genomic DNA. Translation: CAB90273.2.
AL157414, AL122058 Genomic DNA. Translation: CAC08434.2.
BC008584 mRNA. Translation: AAH08584.1.
CCDSiCCDS13455.1.
PIRiC39263. BMHU7.
RefSeqiNP_001710.1. NM_001719.2.
UniGeneiHs.473163.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMPX-ray2.80A293-431[»]
1LX5X-ray3.30A293-431[»]
1LXIX-ray2.00A293-431[»]
1M4UX-ray2.42L293-431[»]
ProteinModelPortaliP18075.
SMRiP18075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107123. 43 interactors.
DIPiDIP-5800N.
IntActiP18075. 12 interactors.
MINTiMINT-263199.
STRINGi9606.ENSP00000379204.

PTM databases

iPTMnetiP18075.
PhosphoSitePlusiP18075.

Polymorphism and mutation databases

BioMutaiBMP7.
DMDMi115078.

Proteomic databases

EPDiP18075.
MaxQBiP18075.
PaxDbiP18075.
PeptideAtlasiP18075.
PRIDEiP18075.

Protocols and materials databases

DNASUi655.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395863; ENSP00000379204; ENSG00000101144.
GeneIDi655.
KEGGihsa:655.
UCSCiuc010gip.2. human.

Organism-specific databases

CTDi655.
DisGeNETi655.
GeneCardsiBMP7.
HGNCiHGNC:1074. BMP7.
HPAiHPA057757.
MIMi112267. gene.
neXtProtiNX_P18075.
OpenTargetsiENSG00000101144.
PharmGKBiPA25384.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP18075.
KOiK16621.
OMAiKVPNDNY.
OrthoDBiEOG091G0C2J.
PhylomeDBiP18075.
TreeFamiTF316134.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101144-MONOMER.
ReactomeiR-HSA-2129379. Molecules associated with elastic fibres.
SignaLinkiP18075.
SIGNORiP18075.

Miscellaneous databases

ChiTaRSiBMP7. human.
EvolutionaryTraceiP18075.
GeneWikiiBone_morphogenetic_protein_7.
GenomeRNAii655.
PROiP18075.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101144.
CleanExiHS_BMP7.
ExpressionAtlasiP18075. baseline and differential.
GenevisibleiP18075. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMP7_HUMAN
AccessioniPrimary (citable) accession number: P18075
Secondary accession number(s): Q9H512, Q9NTQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 30, 2016
This is version 187 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.