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P18067

- RAB7A_CANFA

UniProt

P18067 - RAB7A_CANFA

Protein

Ras-related protein Rab-7a

Gene

RAB7A

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria. Plays a role in the fusion of phagosomes with lysosomes By similarity. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.By similarity3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228GTPBy similarity
    Nucleotide bindingi34 – 407GTPBy similarity
    Nucleotide bindingi63 – 675GTPBy similarity
    Nucleotide bindingi125 – 1284GTPBy similarity
    Nucleotide bindingi156 – 1572GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: Ensembl
    2. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. early endosome to late endosome transport Source: UniProtKB
    2. endosome to lysosome transport Source: Ensembl
    3. epidermal growth factor catabolic process Source: UniProtKB
    4. phagosome acidification Source: UniProtKB
    5. phagosome-lysosome fusion Source: UniProtKB
    6. protein targeting to lysosome Source: Ensembl
    7. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_221251. MHC class II antigen presentation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-7a
    Gene namesi
    Name:RAB7A
    Synonyms:RAB7
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 20

    Subcellular locationi

    Late endosome. Lysosome By similarity. Cytoplasmic vesiclephagosome By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Melanosome By similarity
    Note: Colocalizes with OSBPL1A at the late endosome. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. late endosome Source: UniProtKB
    3. lysosome Source: UniProtKB-SubCell
    4. melanosome Source: UniProtKB-SubCell
    5. phagocytic vesicle Source: UniProtKB
    6. phagocytic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endosome, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Ras-related protein Rab-7aPRO_0000121120Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei72 – 721PhosphoserineBy similarity
    Lipidationi205 – 2051S-geranylgeranyl cysteineBy similarity
    Modified residuei207 – 2071Cysteine methyl esterBy similarity
    Lipidationi207 – 2071S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    PaxDbiP18067.
    PRIDEiP18067.

    Interactioni

    Subunit structurei

    Interacts with NTRK1/TRKA, RILP, PSMA7, RNF115 and FYCO1. Interacts with the PIK3C3/VPS34-PIK3R4 complex. The GTP-bound form interacts with OSBPL1A and RAC1 By similarity. Interacts with CLN3. Interacts with CHM, the substrate-binding subunit of the Rab geranylgeranyltransferase complex By similarity. Interacts with C9orf72 By similarity.By similarity

    Protein-protein interaction databases

    IntActiP18067. 2 interactions.
    MINTiMINT-8387239.
    STRINGi9615.ENSCAFP00000034211.

    Structurei

    3D structure databases

    ProteinModelPortaliP18067.
    SMRiP18067. Positions 7-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi37 – 459Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00700000104345.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP18067.
    KOiK07897.
    OMAiDYPDPIK.
    OrthoDBiEOG7G4QG8.
    TreeFamiTF105605.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18067-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV    50
    MVDDRLVTMQ IWDTAGQERF QSLGVAFYRG ADCCVLVFDV TAPNTFKTLD 100
    SWRDEFLIQA SPRDPENFPF VVLGNKIDLE NRQVATKRAQ AWCYSKNNIP 150
    YFETSAKEAI NVEQAFQTIA RNALKQETEV ELYNEFPEPI KLDKNDRAKT 200
    SAESCSC 207
    Length:207
    Mass (Da):23,520
    Last modified:November 1, 1990 - v1
    Checksum:iE3AF33B16A67296D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35522 mRNA. Translation: AAA30890.1.
    PIRiB30413.
    RefSeqiNP_001003316.1. NM_001003316.1.
    XP_005632072.1. XM_005632015.1.
    UniGeneiCfa.29293.

    Genome annotation databases

    EnsembliENSCAFT00000038482; ENSCAFP00000034211; ENSCAFG00000004157.
    GeneIDi404007.
    KEGGicfa:404007.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35522 mRNA. Translation: AAA30890.1 .
    PIRi B30413.
    RefSeqi NP_001003316.1. NM_001003316.1.
    XP_005632072.1. XM_005632015.1.
    UniGenei Cfa.29293.

    3D structure databases

    ProteinModelPortali P18067.
    SMRi P18067. Positions 7-190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P18067. 2 interactions.
    MINTi MINT-8387239.
    STRINGi 9615.ENSCAFP00000034211.

    Chemistry

    BindingDBi P18067.

    Proteomic databases

    PaxDbi P18067.
    PRIDEi P18067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000038482 ; ENSCAFP00000034211 ; ENSCAFG00000004157 .
    GeneIDi 404007.
    KEGGi cfa:404007.

    Organism-specific databases

    CTDi 7879.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00700000104345.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P18067.
    KOi K07897.
    OMAi DYPDPIK.
    OrthoDBi EOG7G4QG8.
    TreeFami TF105605.

    Enzyme and pathway databases

    Reactomei REACT_221251. MHC class II antigen presentation.

    Miscellaneous databases

    NextBioi 20817494.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments."
      Chavrier P., Parton R.G., Hauri H.P., Simons K., Zerial M.
      Cell 62:317-329(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line."
      Chavrier P., Vingron M., Sander C., Simons K., Zerial M.
      Mol. Cell. Biol. 10:6578-6585(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Cocker spaniel.
      Tissue: Kidney.
    3. "Rab 7: an important regulator of late endocytic membrane traffic."
      Feng Y., Press B., Wandinger-Ness A.
      J. Cell Biol. 131:1435-1452(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartment."
      Press B., Feng Y., Hoflack B., Wandinger-Ness A.
      J. Cell Biol. 140:1075-1089(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome."
      Ceresa B.P., Bahr S.J.
      J. Biol. Chem. 281:1099-1106(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiRAB7A_CANFA
    AccessioniPrimary (citable) accession number: P18067
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3