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Protein

Insulin-like growth factor-binding protein 2

Gene

IGFBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.1 Publication

GO - Molecular functioni

  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: UniProtKB
  • receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115457-MONOMER.
ReactomeiR-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
Gene namesi
Name:IGFBP2
Synonyms:BP2, IBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5471. IGFBP2.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • cytoplasmic vesicle Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi216 – 219KKLR → NNLA: Does not disrupt growth-inhibiting activity. 1 Publication4
Mutagenesisi303D → E: Does not disrupt growth-inhibiting activity. 1 Publication1

Organism-specific databases

DisGeNETi3485.
OpenTargetsiENSG00000115457.
PharmGKBiPA29704.

Chemistry databases

ChEMBLiCHEMBL3088.

Polymorphism and mutation databases

BioMutaiIGFBP2.
DMDMi290457647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Add BLAST35
ChainiPRO_000001437036 – 325Insulin-like growth factor-binding protein 2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi227 ↔ 261PROSITE-ProRule annotation1 Publication
Disulfide bondi272 ↔ 283PROSITE-ProRule annotation1 Publication
Disulfide bondi285 ↔ 306PROSITE-ProRule annotation1 Publication

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP18065.
PaxDbiP18065.
PeptideAtlasiP18065.
PRIDEiP18065.

PTM databases

iPTMnetiP18065.
PhosphoSitePlusiP18065.

Miscellaneous databases

PMAP-CutDBP18065.

Expressioni

Gene expression databases

BgeeiENSG00000115457.
CleanExiHS_IGFBP2.
ExpressionAtlasiP18065. baseline and differential.
GenevisibleiP18065. HS.

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.

Binary interactionsi

WithEntry#Exp.IntActNotes
INO80BQ9C0864EBI-2504392,EBI-715611

GO - Molecular functioni

  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: UniProtKB
  • receptor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi109706. 4 interactors.
IntActiP18065. 3 interactors.
STRINGi9606.ENSP00000233809.

Chemistry databases

BindingDBiP18065.

Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi226 – 240Combined sources15
Beta strandi247 – 249Combined sources3
Beta strandi269 – 276Combined sources8
Turni277 – 279Combined sources3
Beta strandi282 – 285Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H7TNMR-A220-325[»]
ProteinModelPortaliP18065.
SMRiP18065.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18065.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 134IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST97
Domaini224 – 306Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi301 – 303Cell attachment site3

Domaini

The C-terminus is required for IGF-binding and growth inhibition.1 Publication

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUR. Eukaryota.
ENOG4111GWQ. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP18065.
OMAiGAGTCEK.
OrthoDBiEOG091G0EIN.
PhylomeDBiP18065.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 2 hits.
PTHR11551:SF5. PTHR11551:SF5. 2 hits.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRVGCPAL PLPPPPLLPL LLLLLGASGG GGGARAEVLF RCPPCTPERL
60 70 80 90 100
AACGPPPVAP PAAVAAVAGG ARMPCAELVR EPGCGCCSVC ARLEGEACGV
110 120 130 140 150
YTPRCGQGLR CYPHPGSELP LQALVMGEGT CEKRRDAEYG ASPEQVADNG
160 170 180 190 200
DDHSEGGLVE NHVDSTMNML GGGGSAGRKP LKSGMKELAV FREKVTEQHR
210 220 230 240 250
QMGKGGKHHL GLEEPKKLRP PPARTPCQQE LDQVLERIST MRLPDERGPL
260 270 280 290 300
EHLYSLHIPN CDKHGLYNLK QCKMSLNGQR GECWCVNPNT GKLIQGAPTI
310 320
RGDPECHLFY NEQQEARGVH TQRMQ
Length:325
Mass (Da):34,814
Last modified:March 2, 2010 - v2
Checksum:i9E1436DBCCC6EA2A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15P → PPLL in CAA34373 (PubMed:2479552).Curated1
Sequence conflicti15P → PPLL in AAA36048 (PubMed:1710112).Curated1
Sequence conflicti15P → PPLL in AAA03246 (PubMed:1712312).Curated1
Sequence conflicti15P → PPLL in AAB22308 (PubMed:1376411).Curated1
Sequence conflicti15P → PPLL in AAQ87876 (Ref. 7) Curated1
Sequence conflicti15P → PPLL in AAH04312 (PubMed:15489334).Curated1
Sequence conflicti15P → PPLL in AAH09902 (PubMed:15489334).Curated1
Sequence conflicti15P → PPLL in AAH12769 (PubMed:15489334).Curated1
Sequence conflicti15P → PPLL in AAH71967 (PubMed:15489334).Curated1
Sequence conflicti57P → R in AAA36048 (PubMed:1710112).Curated1
Sequence conflicti317R → C in CAA34373 (PubMed:2479552).Curated1
Sequence conflicti320H → D in AAA36048 (PubMed:1710112).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018871137A → D.1 PublicationCorresponds to variant rs9341096dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16302 mRNA. Translation: CAA34373.1.
M69241
, M69237, M69239, M69240 Genomic DNA. Translation: AAA36048.1.
M35410 mRNA. Translation: AAA03246.1.
S37730
, S37712, S37722, S37726 Genomic DNA. Translation: AAB22308.1.
CR610845 mRNA. No translation available.
AY398667 Genomic DNA. Translation: AAQ87876.1.
AC073321 Genomic DNA. No translation available.
AC007563 Genomic DNA. No translation available.
BC004312 mRNA. Translation: AAH04312.1.
BC009902 mRNA. Translation: AAH09902.1.
BC012769 mRNA. Translation: AAH12769.1.
BC071967 mRNA. Translation: AAH71967.1.
PIRiA41927.
RefSeqiNP_000588.2. NM_000597.2.
NP_001300919.1. NM_001313990.1.
NP_001300921.1. NM_001313992.1.
NP_001300922.1. NM_001313993.1.
UniGeneiHs.438102.

Genome annotation databases

EnsembliENST00000233809; ENSP00000233809; ENSG00000115457.
GeneIDi3485.
KEGGihsa:3485.
UCSCiuc061sgd.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16302 mRNA. Translation: CAA34373.1.
M69241
, M69237, M69239, M69240 Genomic DNA. Translation: AAA36048.1.
M35410 mRNA. Translation: AAA03246.1.
S37730
, S37712, S37722, S37726 Genomic DNA. Translation: AAB22308.1.
CR610845 mRNA. No translation available.
AY398667 Genomic DNA. Translation: AAQ87876.1.
AC073321 Genomic DNA. No translation available.
AC007563 Genomic DNA. No translation available.
BC004312 mRNA. Translation: AAH04312.1.
BC009902 mRNA. Translation: AAH09902.1.
BC012769 mRNA. Translation: AAH12769.1.
BC071967 mRNA. Translation: AAH71967.1.
PIRiA41927.
RefSeqiNP_000588.2. NM_000597.2.
NP_001300919.1. NM_001313990.1.
NP_001300921.1. NM_001313992.1.
NP_001300922.1. NM_001313993.1.
UniGeneiHs.438102.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H7TNMR-A220-325[»]
ProteinModelPortaliP18065.
SMRiP18065.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109706. 4 interactors.
IntActiP18065. 3 interactors.
STRINGi9606.ENSP00000233809.

Chemistry databases

BindingDBiP18065.
ChEMBLiCHEMBL3088.

Protein family/group databases

MEROPSiI31.953.

PTM databases

iPTMnetiP18065.
PhosphoSitePlusiP18065.

Polymorphism and mutation databases

BioMutaiIGFBP2.
DMDMi290457647.

Proteomic databases

EPDiP18065.
PaxDbiP18065.
PeptideAtlasiP18065.
PRIDEiP18065.

Protocols and materials databases

DNASUi3485.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233809; ENSP00000233809; ENSG00000115457.
GeneIDi3485.
KEGGihsa:3485.
UCSCiuc061sgd.1. human.

Organism-specific databases

CTDi3485.
DisGeNETi3485.
GeneCardsiIGFBP2.
HGNCiHGNC:5471. IGFBP2.
MIMi146731. gene.
neXtProtiNX_P18065.
OpenTargetsiENSG00000115457.
PharmGKBiPA29704.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHUR. Eukaryota.
ENOG4111GWQ. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP18065.
OMAiGAGTCEK.
OrthoDBiEOG091G0EIN.
PhylomeDBiP18065.
TreeFamiTF331211.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115457-MONOMER.
ReactomeiR-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

ChiTaRSiIGFBP2. human.
EvolutionaryTraceiP18065.
GeneWikiiIGFBP2.
GenomeRNAii3485.
PMAP-CutDBP18065.
PROiP18065.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115457.
CleanExiHS_IGFBP2.
ExpressionAtlasiP18065. baseline and differential.
GenevisibleiP18065. HS.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 2 hits.
PTHR11551:SF5. PTHR11551:SF5. 2 hits.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBP2_HUMAN
AccessioniPrimary (citable) accession number: P18065
Secondary accession number(s): Q14619, Q9UCL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 2, 2010
Last modified: November 2, 2016
This is version 174 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.