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P18065

- IBP2_HUMAN

UniProt

P18065 - IBP2_HUMAN

Protein

Insulin-like growth factor-binding protein 2

Gene

IGFBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 2 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.1 Publication

    GO - Molecular functioni

    1. insulin-like growth factor I binding Source: UniProtKB
    2. insulin-like growth factor II binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular protein metabolic process Source: Reactome
    3. cellular response to hormone stimulus Source: Ensembl
    4. female pregnancy Source: Ensembl
    5. positive regulation of activated T cell proliferation Source: BHF-UCL
    6. regulation of cell growth Source: InterPro
    7. regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
    8. response to drug Source: Ensembl
    9. response to estradiol Source: Ensembl
    10. response to glucocorticoid Source: Ensembl
    11. response to lithium ion Source: Ensembl
    12. response to mechanical stimulus Source: Ensembl
    13. response to nutrient Source: Ensembl
    14. response to retinoic acid Source: Ensembl
    15. signal transduction Source: Ensembl

    Keywords - Biological processi

    Growth regulation

    Keywords - Ligandi

    Growth factor binding

    Enzyme and pathway databases

    ReactomeiREACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Protein family/group databases

    MEROPSiI31.953.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 2
    Short name:
    IBP-2
    Short name:
    IGF-binding protein 2
    Short name:
    IGFBP-2
    Gene namesi
    Name:IGFBP2
    Synonyms:BP2, IBP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5471. IGFBP2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cytoplasmic vesicle Source: Ensembl
    3. extracellular region Source: UniProtKB
    4. extracellular space Source: BHF-UCL
    5. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi216 – 2194KKLR → NNLA: Does not disrupt growth-inhibiting activity.
    Mutagenesisi303 – 3031D → E: Does not disrupt growth-inhibiting activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA29704.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Add
    BLAST
    Chaini36 – 325290Insulin-like growth factor-binding protein 2PRO_0000014370Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi227 ↔ 2611 PublicationPROSITE-ProRule annotation
    Disulfide bondi272 ↔ 2831 PublicationPROSITE-ProRule annotation
    Disulfide bondi285 ↔ 3061 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    O-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP18065.
    PRIDEiP18065.

    PTM databases

    PhosphoSiteiP18065.

    Miscellaneous databases

    PMAP-CutDBP18065.

    Expressioni

    Gene expression databases

    ArrayExpressiP18065.
    BgeeiP18065.
    CleanExiHS_IGFBP2.
    GenevestigatoriP18065.

    Interactioni

    Subunit structurei

    Binds IGF2 more than IGF1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    INO80BQ9C0864EBI-2504392,EBI-715611

    Protein-protein interaction databases

    BioGridi109706. 3 interactions.
    IntActiP18065. 3 interactions.
    STRINGi9606.ENSP00000233809.

    Structurei

    Secondary structure

    1
    325
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi226 – 24015
    Beta strandi247 – 2493
    Beta strandi269 – 2768
    Turni277 – 2793
    Beta strandi282 – 2854

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2H7TNMR-A220-325[»]
    ProteinModelPortaliP18065.
    SMRiP18065. Positions 42-138, 220-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP18065.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 13497IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini224 – 30683Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi301 – 3033Cell attachment site

    Domaini

    The C-terminus is required for IGF-binding and growth inhibition.1 Publication

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47500.
    HOGENOMiHOG000253012.
    HOVERGENiHBG002631.
    InParanoidiP18065.
    OMAiGAGTCEK.
    PhylomeDBiP18065.
    TreeFamiTF331211.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR012210. IGFBP-2.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF5. PTHR11551:SF5. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01978. IGFBPFAMILY2.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18065-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPRVGCPAL PLPPPPLLPL LLLLLGASGG GGGARAEVLF RCPPCTPERL    50
    AACGPPPVAP PAAVAAVAGG ARMPCAELVR EPGCGCCSVC ARLEGEACGV 100
    YTPRCGQGLR CYPHPGSELP LQALVMGEGT CEKRRDAEYG ASPEQVADNG 150
    DDHSEGGLVE NHVDSTMNML GGGGSAGRKP LKSGMKELAV FREKVTEQHR 200
    QMGKGGKHHL GLEEPKKLRP PPARTPCQQE LDQVLERIST MRLPDERGPL 250
    EHLYSLHIPN CDKHGLYNLK QCKMSLNGQR GECWCVNPNT GKLIQGAPTI 300
    RGDPECHLFY NEQQEARGVH TQRMQ 325
    Length:325
    Mass (Da):34,814
    Last modified:March 2, 2010 - v2
    Checksum:i9E1436DBCCC6EA2A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151P → PPLL in CAA34373. (PubMed:2479552)Curated
    Sequence conflicti15 – 151P → PPLL in AAA36048. (PubMed:1710112)Curated
    Sequence conflicti15 – 151P → PPLL in AAA03246. (PubMed:1712312)Curated
    Sequence conflicti15 – 151P → PPLL in AAB22308. (PubMed:1376411)Curated
    Sequence conflicti15 – 151P → PPLL in AAQ87876. 1 PublicationCurated
    Sequence conflicti15 – 151P → PPLL in AAH04312. (PubMed:15489334)Curated
    Sequence conflicti15 – 151P → PPLL in AAH09902. (PubMed:15489334)Curated
    Sequence conflicti15 – 151P → PPLL in AAH12769. (PubMed:15489334)Curated
    Sequence conflicti15 – 151P → PPLL in AAH71967. (PubMed:15489334)Curated
    Sequence conflicti57 – 571P → R in AAA36048. (PubMed:1710112)Curated
    Sequence conflicti317 – 3171R → C in CAA34373. (PubMed:2479552)Curated
    Sequence conflicti320 – 3201H → D in AAA36048. (PubMed:1710112)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti137 – 1371A → D.1 Publication
    Corresponds to variant rs9341096 [ dbSNP | Ensembl ].
    VAR_018871

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16302 mRNA. Translation: CAA34373.1.
    M69241
    , M69237, M69239, M69240 Genomic DNA. Translation: AAA36048.1.
    M35410 mRNA. Translation: AAA03246.1.
    S37730
    , S37712, S37722, S37726 Genomic DNA. Translation: AAB22308.1.
    CR610845 mRNA. No translation available.
    AY398667 Genomic DNA. Translation: AAQ87876.1.
    AC073321 Genomic DNA. No translation available.
    AC007563 Genomic DNA. No translation available.
    BC004312 mRNA. Translation: AAH04312.1.
    BC009902 mRNA. Translation: AAH09902.1.
    BC012769 mRNA. Translation: AAH12769.1.
    BC071967 mRNA. Translation: AAH71967.1.
    PIRiA41927.
    RefSeqiNP_000588.2. NM_000597.2.
    UniGeneiHs.438102.

    Genome annotation databases

    EnsembliENST00000233809; ENSP00000233809; ENSG00000115457.
    GeneIDi3485.
    KEGGihsa:3485.
    UCSCiuc010zju.2. human.

    Polymorphism databases

    DMDMi290457647.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16302 mRNA. Translation: CAA34373.1 .
    M69241
    , M69237 , M69239 , M69240 Genomic DNA. Translation: AAA36048.1 .
    M35410 mRNA. Translation: AAA03246.1 .
    S37730
    , S37712 , S37722 , S37726 Genomic DNA. Translation: AAB22308.1 .
    CR610845 mRNA. No translation available.
    AY398667 Genomic DNA. Translation: AAQ87876.1 .
    AC073321 Genomic DNA. No translation available.
    AC007563 Genomic DNA. No translation available.
    BC004312 mRNA. Translation: AAH04312.1 .
    BC009902 mRNA. Translation: AAH09902.1 .
    BC012769 mRNA. Translation: AAH12769.1 .
    BC071967 mRNA. Translation: AAH71967.1 .
    PIRi A41927.
    RefSeqi NP_000588.2. NM_000597.2.
    UniGenei Hs.438102.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2H7T NMR - A 220-325 [» ]
    ProteinModelPortali P18065.
    SMRi P18065. Positions 42-138, 220-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109706. 3 interactions.
    IntActi P18065. 3 interactions.
    STRINGi 9606.ENSP00000233809.

    Chemistry

    ChEMBLi CHEMBL3088.

    Protein family/group databases

    MEROPSi I31.953.

    PTM databases

    PhosphoSitei P18065.

    Polymorphism databases

    DMDMi 290457647.

    Proteomic databases

    PaxDbi P18065.
    PRIDEi P18065.

    Protocols and materials databases

    DNASUi 3485.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233809 ; ENSP00000233809 ; ENSG00000115457 .
    GeneIDi 3485.
    KEGGi hsa:3485.
    UCSCi uc010zju.2. human.

    Organism-specific databases

    CTDi 3485.
    GeneCardsi GC02P217497.
    HGNCi HGNC:5471. IGFBP2.
    MIMi 146731. gene.
    neXtProti NX_P18065.
    PharmGKBi PA29704.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47500.
    HOGENOMi HOG000253012.
    HOVERGENi HBG002631.
    InParanoidi P18065.
    OMAi GAGTCEK.
    PhylomeDBi P18065.
    TreeFami TF331211.

    Enzyme and pathway databases

    Reactomei REACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Miscellaneous databases

    EvolutionaryTracei P18065.
    GeneWikii IGFBP2.
    GenomeRNAii 3485.
    NextBioi 13704.
    PMAP-CutDB P18065.
    PROi P18065.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18065.
    Bgeei P18065.
    CleanExi HS_IGFBP2.
    Genevestigatori P18065.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR012210. IGFBP-2.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF5. PTHR11551:SF5. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01978. IGFBPFAMILY2.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)."
      Binkert C., Landwehr J., Mary J.L., Schwander J., Heinrich G.
      EMBO J. 8:2497-2502(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal liver.
    2. "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia."
      Zapf J., Kiefer M., Merryweather J., Musiarz F., Bauer D., Born W., Fischer J.A., Froesch E.R.
      J. Biol. Chem. 265:14892-14898(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 37-74.
    3. "Structure and localization of the human insulin-like growth factor-binding protein 2 gene."
      Ehrenborg E., Vilhelmsdotter S., Bajalica S., Larsson C., Sterm I., Koch J., Brondum-Nielsen K., Luthman H.
      Biochem. Biophys. Res. Commun. 176:1250-1255(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    4. "Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2)."
      Agarwal N., Hsieh C.L., Sills D., Swaroop M., Desai B., Francke U., Swaroop A.
      Exp. Eye Res. 52:549-561(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Retina.
    5. "Structure of the human insulin-like growth factor binding protein-2 gene."
      Binkert C., Margot J.B., Landwehr J., Heinrich G., Schwander J.
      Mol. Endocrinol. 6:826-836(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    6. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    7. NIEHS SNPs program
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-137.
    8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Ovary and Uterus.
    10. "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species."
      Roghani M., Segovia B., Whitechurch O., Binoux M.
      Growth Regul. 1:125-130(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 40-58, INTERACTION WITH IGF2, GLYCOSYLATION.
      Tissue: Cerebrospinal fluid.
    11. "Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence."
      Zhou J., Li W., Kamei H., Duan C.
      PLoS ONE 3:E3926-E3926(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IGF1-BINDING, DOMAIN, MUTAGENESIS OF 216-LYS--ARG-219 AND ASP-303.
    12. "Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)."
      Kuang Z., Yao S., Keizer D.W., Wang C.C., Bach L.A., Forbes B.E., Wallace J.C., Norton R.S.
      J. Mol. Biol. 364:690-704(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 220-325, DISULFIDE BONDS.

    Entry informationi

    Entry nameiIBP2_HUMAN
    AccessioniPrimary (citable) accession number: P18065
    Secondary accession number(s): Q14619, Q9UCL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 156 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3