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Protein

Receptor-type tyrosine-protein phosphatase alpha

Gene

Ptpra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei437SubstrateBy similarity1
Active sitei469Phosphocysteine intermediateBy similarity1
Binding sitei513SubstrateBy similarity1
Active sitei759Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • insulin receptor signaling pathway Source: MGI
  • protein phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase alpha (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase alpha
Short name:
R-PTP-alpha
Alternative name(s):
LCA-related phosphatase
PTPTY-28
Gene namesi
Name:Ptpra
Synonyms:Lrp, Ptpa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97808. Ptpra.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 142ExtracellularSequence analysisAdd BLAST123
Transmembranei143 – 166HelicalSequence analysisAdd BLAST24
Topological domaini167 – 829CytoplasmicSequence analysisAdd BLAST663

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19CuratedAdd BLAST19
ChainiPRO_000002543420 – 829Receptor-type tyrosine-protein phosphatase alphaAdd BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi124N-linked (GlcNAc...)Sequence analysis1
Modified residuei202PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei825PhosphotyrosineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP18052.
PaxDbiP18052.
PeptideAtlasiP18052.
PRIDEiP18052.

PTM databases

iPTMnetiP18052.
PhosphoSitePlusiP18052.

Expressioni

Tissue specificityi

Widely expressed. Highest expression in brain and kidney.3 Publications

Gene expression databases

BgeeiENSMUSG00000027303.
CleanExiMM_PTPRA.
ExpressionAtlasiP18052. baseline and differential.
GenevisibleiP18052. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Chl1P702324EBI-6597520,EBI-7703109
Grb2Q606314EBI-6597520,EBI-1688
PrkcbP684033EBI-6597520,EBI-397072From a different organism.
PtprnQ606733EBI-6597520,EBI-8328895
SRCP005232EBI-6597520,EBI-848039From a different organism.
SRCP129313EBI-6597520,EBI-621482From a different organism.
SrcP054802EBI-6597520,EBI-298680

Protein-protein interaction databases

BioGridi202491. 2 interactors.
IntActiP18052. 12 interactors.
MINTiMINT-129698.
STRINGi10090.ENSMUSP00000076533.

Structurei

Secondary structure

1829
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi214 – 238Combined sources25
Helixi249 – 252Combined sources4
Helixi254 – 259Combined sources6
Turni305 – 307Combined sources3
Turni318 – 321Combined sources4
Beta strandi324 – 330Combined sources7
Beta strandi333 – 340Combined sources8
Helixi345 – 347Combined sources3
Helixi348 – 357Combined sources10
Beta strandi362 – 365Combined sources4
Beta strandi369 – 371Combined sources3
Beta strandi383 – 389Combined sources7
Beta strandi392 – 401Combined sources10
Beta strandi403 – 413Combined sources11
Beta strandi425 – 432Combined sources8
Beta strandi437 – 439Combined sources3
Helixi445 – 457Combined sources13
Beta strandi465 – 468Combined sources4
Beta strandi470 – 473Combined sources4
Helixi474 – 491Combined sources18
Beta strandi492 – 495Combined sources4
Helixi497 – 504Combined sources8
Turni505 – 507Combined sources3
Helixi515 – 530Combined sources16
Helixi579 – 581Combined sources3
Turni583 – 585Combined sources3
Beta strandi608 – 612Combined sources5
Beta strandi617 – 621Combined sources5
Beta strandi630 – 633Combined sources4
Beta strandi638 – 640Combined sources3
Helixi641 – 650Combined sources10
Beta strandi655 – 658Combined sources4
Beta strandi664 – 667Combined sources4
Beta strandi676 – 678Combined sources3
Beta strandi696 – 706Combined sources11
Beta strandi712 – 721Combined sources10
Beta strandi726 – 728Combined sources3
Beta strandi731 – 733Combined sources3
Helixi736 – 746Combined sources11
Turni747 – 751Combined sources5
Beta strandi755 – 763Combined sources9
Helixi764 – 782Combined sources19
Helixi789 – 795Combined sources7
Turni805 – 808Combined sources4
Helixi809 – 817Combined sources9
Turni818 – 820Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P15X-ray2.00A/B577-829[»]
1YFOX-ray2.25A/B202-539[»]
ProteinModelPortaliP18052.
SMRiP18052.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18052.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 528Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST297
Domaini560 – 818Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni469 – 475Substrate bindingBy similarity7

Sequence similaritiesi

Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
InParanoidiP18052.
KOiK18032.
OMAiFNRVIIP.
OrthoDBiEOG091G02ID.
TreeFamiTF351829.

Family and domain databases

Gene3Di3.90.190.10. 3 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 3 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P18052-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSWFILVLF GSGLIHVSAN NATTVSPSLG TTRLIKTSTT ELAKEENKTS
60 70 80 90 100
NSTSSVISLS VAPTFSPNLT LEPTYVTTVN SSHSDNGTRR AASTESGGTT
110 120 130 140 150
ISPNGSWLIE NQFTDAITEP WEGNSSTAAT TPETFPPADE TPIIAVMVAL
160 170 180 190 200
SSLLVIVFII IVLYMLRFKK YKQAGSHSNS FRLSNGRTED VEPQSVPLLA
210 220 230 240 250
RSPSTNRKYP PLPVDKLEEE INRRMADDNK LFREEFNALP ACPIQATCEA
260 270 280 290 300
ASKEENKEKN RYVNILPFLS LAVSKDAVKA LNKTTPLLER RFIGKSNSRG
310 320 330 340 350
CLSDDHSRVH LTPVEGVPDS DYINASFING YQEKNKFIAA QGPKEETVND
360 370 380 390 400
FWRMIWEQNT ATIVMVTNLK ERKECKCAQY WPDQGCWTYG NVRVSVEDVT
410 420 430 440 450
VLVDYTVRKF CIQQVGDVTN RKPQRLITQF HFTSWPDFGV PFTPIGMLKF
460 470 480 490 500
LKKVKACNPQ YAGAIVVHCS AGVGRTGTFV VIDAMLDMMH SERKVDVYGF
510 520 530 540 550
VSRIRAQRCQ MVQTDMQYVF IYQALLEHYL YGDTELEVTS LETHLQKIYN
560 570 580 590 600
KIPGTSNNGL EEEFKKLTSI KIQNDKMRTG NLPANMKKNR VLQIIPYEFN
610 620 630 640 650
RVIIPVKRGE ENTDYVNASF IDGYRQKDSY IASQGPLLHT IEDFWRMIWE
660 670 680 690 700
WKSCSIVMLT ELEERGQEKC AQYWPSDGLV SYGDITVELK KEEECESYTV
710 720 730 740 750
RDLLVTNTRE NKSRQIRQFH FHGWPEVGIP SDGKGMINII AAVQKQQQQS
760 770 780 790 800
GNHPITVHCS AGAGRTGTFC ALSTVLERVK AEGILDVFQT VKSLRLQRPH
810 820
MVQTLEQYEF CYKVVQEYID AFSDYANFK
Length:829
Mass (Da):93,698
Last modified:July 27, 2011 - v3
Checksum:i4724A0F477D304B5
GO
Isoform 2 (identifier: P18052-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     268-268: F → Y
     269-303: Missing.

Show »
Length:794
Mass (Da):89,957
Checksum:i5A282BF9347D18A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231L → I in AAA39448 (PubMed:2162042).Curated1
Sequence conflicti326S → G (PubMed:1590786).Curated1
Sequence conflicti411C → S (PubMed:2166945).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011880268F → Y in isoform 2. 2 Publications1
Alternative sequenceiVSP_005146269 – 303Missing in isoform 2. 2 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36033 mRNA. Translation: AAA39448.1.
M36034 Genomic DNA. Translation: AAA39449.2.
L13607 Genomic DNA. No translation available.
AL731707 Genomic DNA. Translation: CAM13265.1.
CH466519 Genomic DNA. Translation: EDL28272.1.
Z23054 mRNA. Translation: CAA80589.1.
Z23055 mRNA. Translation: CAA80590.1.
CCDSiCCDS16743.1. [P18052-1]
PIRiA47373.
RefSeqiNP_033006.2. NM_008980.2. [P18052-1]
UniGeneiMm.224246.

Genome annotation databases

EnsembliENSMUST00000077303; ENSMUSP00000076533; ENSMUSG00000027303. [P18052-1]
GeneIDi19262.
KEGGimmu:19262.
UCSCiuc008mjc.2. mouse. [P18052-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36033 mRNA. Translation: AAA39448.1.
M36034 Genomic DNA. Translation: AAA39449.2.
L13607 Genomic DNA. No translation available.
AL731707 Genomic DNA. Translation: CAM13265.1.
CH466519 Genomic DNA. Translation: EDL28272.1.
Z23054 mRNA. Translation: CAA80589.1.
Z23055 mRNA. Translation: CAA80590.1.
CCDSiCCDS16743.1. [P18052-1]
PIRiA47373.
RefSeqiNP_033006.2. NM_008980.2. [P18052-1]
UniGeneiMm.224246.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P15X-ray2.00A/B577-829[»]
1YFOX-ray2.25A/B202-539[»]
ProteinModelPortaliP18052.
SMRiP18052.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202491. 2 interactors.
IntActiP18052. 12 interactors.
MINTiMINT-129698.
STRINGi10090.ENSMUSP00000076533.

PTM databases

iPTMnetiP18052.
PhosphoSitePlusiP18052.

Proteomic databases

MaxQBiP18052.
PaxDbiP18052.
PeptideAtlasiP18052.
PRIDEiP18052.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077303; ENSMUSP00000076533; ENSMUSG00000027303. [P18052-1]
GeneIDi19262.
KEGGimmu:19262.
UCSCiuc008mjc.2. mouse. [P18052-1]

Organism-specific databases

CTDi5786.
MGIiMGI:97808. Ptpra.

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
InParanoidiP18052.
KOiK18032.
OMAiFNRVIIP.
OrthoDBiEOG091G02ID.
TreeFamiTF351829.

Enzyme and pathway databases

ReactomeiR-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

EvolutionaryTraceiP18052.
PROiP18052.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027303.
CleanExiMM_PTPRA.
ExpressionAtlasiP18052. baseline and differential.
GenevisibleiP18052. MM.

Family and domain databases

Gene3Di3.90.190.10. 3 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 3 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRA_MOUSE
AccessioniPrimary (citable) accession number: P18052
Secondary accession number(s): A2AHF2, Q61808
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 164 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.