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Protein

Deoxycytidylate 5-hydroxymethyltransferase

Gene

42

Organism
Enterobacteria phage T6 (Bacteriophage T6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate = tetrahydrofolate + 5-hydroxymethyldeoxycytidylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei148Sequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate 5-hydroxymethyltransferase (EC:2.1.2.8)
Short name:
Deoxycytidylate hydroxymethylase
Alternative name(s):
dCMP hydroxymethylase
Short name:
dCMP HMase
Gene namesi
Name:42
OrganismiEnterobacteria phage T6 (Bacteriophage T6)
Taxonomic identifieri10666 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001410691 – 246Deoxycytidylate 5-hydroxymethyltransferaseAdd BLAST246

Structurei

3D structure databases

ProteinModelPortaliP18030.
SMRiP18030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family.Curated

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
InterProiView protein in InterPro
IPR014619. Deoxycytidylate_hydroxyMease.
IPR023451. Thymidate_synth/dCMP_Mease.
IPR036926. Thymidate_synth/dCMP_Mease_sf.
PfamiView protein in Pfam
PF00303. Thymidylat_synt. 1 hit.
PIRSFiPIRSF036750. dCMP_HMase. 1 hit.
SUPFAMiSSF55831. SSF55831. 1 hit.

Sequencei

Sequence statusi: Complete.

P18030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISDSMTVEE IRLHLGLALK EKDFVVDKTG VKTIEIIGAS FVADEPFIFG
60 70 80 90 100
ALNDEYIQRE LEWYKSKSLF VKDIPGETPK IWQQVASSKG EINSNYGWAI
110 120 130 140 150
WSEDNYAQYD MCLAELGQNP DSRRGIMIYT RPSMQFDYNK DGMSDFMCTN
160 170 180 190 200
TVQYLIRDKK INAVVNMRSN DVVFGFRNDY AWQKYVLDKL VSDLNAGDPT
210 220 230 240
RQYKAGSIIW NVGSLHVYSR HFYLVDHWWK TGETHIVKKD YKGEWK
Length:246
Mass (Da):28,621
Last modified:November 1, 1990 - v1
Checksum:iA370095E32451E8D
GO

Sequence databases

PIRiB34273. SZBPT6.

Similar proteinsi

Entry informationi

Entry nameiDCHM_BPT6
AccessioniPrimary (citable) accession number: P18030
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 25, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families