ID GUB_FIBSS Reviewed; 349 AA. AC P17989; C9RPK9; D9S550; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1990, sequence version 1. DT 27-MAR-2024, entry version 143. DE RecName: Full=Beta-glucanase; DE EC=3.2.1.73; DE AltName: Full=1,3-1,4-beta-D-glucan 4-glucanohydrolase; DE AltName: Full=Endo-beta-1,3-1,4 glucanase; DE AltName: Full=Lichenase; DE AltName: Full=Mixed linkage beta-glucanase; DE Flags: Precursor; GN OrderedLocusNames=Fisuc_2961, FSU_0226; OS Fibrobacter succinogenes (strain ATCC 19169 / S85). OC Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae; OC Fibrobacter. OX NCBI_TaxID=59374; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 28-57. RX PubMed=2193918; DOI=10.1128/jb.172.7.3837-3841.1990; RA Teather R.M., Erfle J.D.; RT "DNA sequence of a Fibrobacter succinogenes mixed-linkage beta-glucanase RT (1,3-1,4-beta-D-glucan 4-glucanohydrolase) gene."; RL J. Bacteriol. 172:3837-3841(1990). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 19169 / S85; RG US DOE Joint Genome Institute; RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., RA Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Weimer P.J., RA Stevenson D.M., Boyum J., Brumm P.I., Mead D.; RT "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."; RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 19169 / S85; RA Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B., RA Russell J.B., Cann I.K.O., Mackie R.I., White B.A.; RT "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."; RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=Hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D- CC glucans containing (1->3)- and (1->4)-bonds.; EC=3.2.1.73; CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 16 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M33676; AAA24896.1; -; Genomic_DNA. DR EMBL; CP001792; ACX76541.1; -; Genomic_DNA. DR EMBL; CP002158; ADL24776.1; -; Genomic_DNA. DR PIR; A44507; A44507. DR RefSeq; WP_014545066.1; NC_017448.1. DR PDB; 1MVE; X-ray; 1.70 A; A=25-266. DR PDB; 1ZM1; X-ray; 2.30 A; A/B=27-267. DR PDB; 2R49; X-ray; 2.20 A; A=26-266. DR PDB; 3AXD; X-ray; 1.53 A; A/B=25-271. DR PDB; 3AXE; X-ray; 1.53 A; A=25-271. DR PDB; 3H0O; X-ray; 1.40 A; A=27-266. DR PDB; 3HR9; X-ray; 1.70 A; A=26-266. DR PDBsum; 1MVE; -. DR PDBsum; 1ZM1; -. DR PDBsum; 2R49; -. DR PDBsum; 3AXD; -. DR PDBsum; 3AXE; -. DR PDBsum; 3H0O; -. DR PDBsum; 3HR9; -. DR AlphaFoldDB; P17989; -. DR SMR; P17989; -. DR STRING; 59374.FSU_0226; -. DR CAZy; GH16; Glycoside Hydrolase Family 16. DR GeneID; 34754199; -. DR KEGG; fsc:FSU_0226; -. DR KEGG; fsu:Fisuc_2961; -. DR eggNOG; COG2273; Bacteria. DR HOGENOM; CLU_063230_0_0_0; -. DR OrthoDB; 9809583at2; -. DR BRENDA; 3.2.1.73; 771. DR EvolutionaryTrace; P17989; -. DR Proteomes; UP000000517; Chromosome. DR GO; GO:0042972; F:licheninase activity; IEA:UniProtKB-EC. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR Gene3D; 2.60.120.200; -; 1. DR InterPro; IPR008264; Beta_glucanase. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR000757; GH16. DR InterPro; IPR008263; GH16_AS. DR PANTHER; PTHR10963:SF22; GLYCOSIDASE CRH2-RELATED; 1. DR PANTHER; PTHR10963; GLYCOSYL HYDROLASE-RELATED; 1. DR Pfam; PF00722; Glyco_hydro_16; 1. DR PRINTS; PR00737; GLHYDRLASE16. DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1. DR PROSITE; PS01034; GH16_1; 1. DR PROSITE; PS51762; GH16_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Direct protein sequencing; Glycosidase; Hydrolase; Repeat; KW Signal. FT SIGNAL 1..27 FT /evidence="ECO:0000269|PubMed:2193918" FT CHAIN 28..349 FT /note="Beta-glucanase" FT /id="PRO_0000011793" FT DOMAIN 28..197 FT /note="GH16" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01098" FT REPEAT 271..277 FT /note="1" FT REPEAT 278..284 FT /note="2" FT REPEAT 285..291 FT /note="3" FT REPEAT 292..298 FT /note="4" FT REPEAT 301..307 FT /note="5" FT REGION 258..311 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 271..307 FT /note="5 X 7 AA tandem repeats of P-X-S-S-S-S-X" FT COMPBIAS 267..311 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 79 FT /note="Nucleophile" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10064" FT ACT_SITE 83 FT /note="Proton donor" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10064" FT STRAND 29..39 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 41..51 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 58..65 FT /evidence="ECO:0007829|PDB:3H0O" FT TURN 67..70 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 72..74 FT /evidence="ECO:0007829|PDB:2R49" FT STRAND 79..85 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 91..100 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 103..105 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 109..112 FT /evidence="ECO:0007829|PDB:3H0O" FT TURN 117..119 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 122..128 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 133..137 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 140..145 FT /evidence="ECO:0007829|PDB:3H0O" FT HELIX 148..151 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 157..167 FT /evidence="ECO:0007829|PDB:3H0O" FT HELIX 169..172 FT /evidence="ECO:0007829|PDB:3H0O" FT HELIX 177..179 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 182..194 FT /evidence="ECO:0007829|PDB:3H0O" FT TURN 196..198 FT /evidence="ECO:0007829|PDB:3H0O" FT HELIX 200..202 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 204..211 FT /evidence="ECO:0007829|PDB:3H0O" FT TURN 218..220 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 221..223 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 233..235 FT /evidence="ECO:0007829|PDB:3H0O" FT HELIX 237..239 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 240..243 FT /evidence="ECO:0007829|PDB:3H0O" FT STRAND 246..253 FT /evidence="ECO:0007829|PDB:3H0O" SQ SEQUENCE 349 AA; 37738 MW; 16DC4F5BDEFC578A CRC64; MNIKKTAVKS ALAVAAAAAA LTTNVSAKDF SGAELYTLEE VQYGKFEARM KMAAASGTVS SMFLYQNGSE IADGRPWVEV DIEVLGKNPG SFQSNIITGK AGAQKTSEKH HAVSPAADQA FHTYGLEWTP NYVRWTVDGQ EVRKTEGGQV SNLTGTQGLR FNLWSSESAA WVGQFDESKL PLFQFINWVK VYKYTPGQGE GGSDFTLDWT DNFDTFDGSR WGKGDWTFDG NRVDLTDKNI YSRDGMLILA LTRKGQESFN GQVPRDDEPA PQSSSSAPAS SSSVPASSSS VPASSSSAFV PPSSSSATNA IHGMRTTPAV AKEHRNLVNA KGAKVNPNGH KRYRVNFEH //