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Protein

Beta-glucanase

Gene

Fisuc_2961

Organism
Fibrobacter succinogenes (strain ATCC 19169 / S85)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3)- and (1->4)-bonds.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79NucleophilePROSITE-ProRule annotation1
Active sitei83Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.73. 771.

Protein family/group databases

CAZyiGH16. Glycoside Hydrolase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucanase (EC:3.2.1.73)
Alternative name(s):
1,3-1,4-beta-D-glucan 4-glucanohydrolase
Endo-beta-1,3-1,4 glucanase
Lichenase
Mixed linkage beta-glucanase
Gene namesi
Ordered Locus Names:Fisuc_2961, FSU_0226
OrganismiFibrobacter succinogenes (strain ATCC 19169 / S85)
Taxonomic identifieri59374 [NCBI]
Taxonomic lineageiBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter
Proteomesi
  • UP000000517 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000001179328 – 349Beta-glucanaseAdd BLAST322

Interactioni

Protein-protein interaction databases

STRINGi59374.Fisuc_2961.

Structurei

Secondary structure

1349
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 39Combined sources11
Beta strandi41 – 51Combined sources11
Beta strandi58 – 65Combined sources8
Turni67 – 70Combined sources4
Beta strandi72 – 74Combined sources3
Beta strandi79 – 85Combined sources7
Beta strandi91 – 100Combined sources10
Beta strandi103 – 105Combined sources3
Beta strandi109 – 112Combined sources4
Turni117 – 119Combined sources3
Beta strandi122 – 128Combined sources7
Beta strandi133 – 137Combined sources5
Beta strandi140 – 145Combined sources6
Helixi148 – 151Combined sources4
Beta strandi157 – 167Combined sources11
Helixi169 – 172Combined sources4
Helixi177 – 179Combined sources3
Beta strandi182 – 194Combined sources13
Turni196 – 198Combined sources3
Helixi200 – 202Combined sources3
Beta strandi204 – 211Combined sources8
Turni218 – 220Combined sources3
Beta strandi221 – 223Combined sources3
Beta strandi233 – 235Combined sources3
Helixi237 – 239Combined sources3
Beta strandi240 – 243Combined sources4
Beta strandi246 – 253Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MVEX-ray1.70A25-266[»]
1ZM1X-ray2.30A/B27-267[»]
2R49X-ray2.20A26-266[»]
3AXDX-ray1.53A/B25-271[»]
3AXEX-ray1.53A25-271[»]
3H0OX-ray1.40A27-266[»]
3HR9X-ray1.70A26-266[»]
ProteinModelPortaliP17989.
SMRiP17989.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17989.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 197GH16PROSITE-ProRule annotationAdd BLAST170
Repeati271 – 27717
Repeati278 – 28427
Repeati285 – 29137
Repeati292 – 29847
Repeati301 – 30757

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni271 – 3075 X 7 AA tandem repeats of P-X-S-S-S-S-XAdd BLAST37

Sequence similaritiesi

Belongs to the glycosyl hydrolase 16 family.Curated
Contains 1 GH16 (glycosyl hydrolase family 16) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4108RZ2. Bacteria.
COG2273. LUCA.
OMAiSWQSNII.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008264. Beta_glucanase.
IPR013320. ConA-like_dom.
IPR000757. GH16.
IPR008263. GH16_AS.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
PRINTSiPR00737. GLHYDRLASE16.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS01034. GH16_1. 1 hit.
PS51762. GH16_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIKKTAVKS ALAVAAAAAA LTTNVSAKDF SGAELYTLEE VQYGKFEARM
60 70 80 90 100
KMAAASGTVS SMFLYQNGSE IADGRPWVEV DIEVLGKNPG SFQSNIITGK
110 120 130 140 150
AGAQKTSEKH HAVSPAADQA FHTYGLEWTP NYVRWTVDGQ EVRKTEGGQV
160 170 180 190 200
SNLTGTQGLR FNLWSSESAA WVGQFDESKL PLFQFINWVK VYKYTPGQGE
210 220 230 240 250
GGSDFTLDWT DNFDTFDGSR WGKGDWTFDG NRVDLTDKNI YSRDGMLILA
260 270 280 290 300
LTRKGQESFN GQVPRDDEPA PQSSSSAPAS SSSVPASSSS VPASSSSAFV
310 320 330 340
PPSSSSATNA IHGMRTTPAV AKEHRNLVNA KGAKVNPNGH KRYRVNFEH
Length:349
Mass (Da):37,738
Last modified:November 1, 1990 - v1
Checksum:i16DC4F5BDEFC578A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33676 Genomic DNA. Translation: AAA24896.1.
CP001792 Genomic DNA. Translation: ACX76541.1.
CP002158 Genomic DNA. Translation: ADL24776.1.
PIRiA44507.
RefSeqiWP_014545066.1. NC_017448.1.

Genome annotation databases

EnsemblBacteriaiACX76541; ACX76541; Fisuc_2961.
ADL24776; ADL24776; FSU_0226.
KEGGifsc:FSU_0226.
fsu:Fisuc_2961.
PATRICi32145677. VBIFibSuc28982_2886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33676 Genomic DNA. Translation: AAA24896.1.
CP001792 Genomic DNA. Translation: ACX76541.1.
CP002158 Genomic DNA. Translation: ADL24776.1.
PIRiA44507.
RefSeqiWP_014545066.1. NC_017448.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MVEX-ray1.70A25-266[»]
1ZM1X-ray2.30A/B27-267[»]
2R49X-ray2.20A26-266[»]
3AXDX-ray1.53A/B25-271[»]
3AXEX-ray1.53A25-271[»]
3H0OX-ray1.40A27-266[»]
3HR9X-ray1.70A26-266[»]
ProteinModelPortaliP17989.
SMRiP17989.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59374.Fisuc_2961.

Protein family/group databases

CAZyiGH16. Glycoside Hydrolase Family 16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX76541; ACX76541; Fisuc_2961.
ADL24776; ADL24776; FSU_0226.
KEGGifsc:FSU_0226.
fsu:Fisuc_2961.
PATRICi32145677. VBIFibSuc28982_2886.

Phylogenomic databases

eggNOGiENOG4108RZ2. Bacteria.
COG2273. LUCA.
OMAiSWQSNII.

Enzyme and pathway databases

BRENDAi3.2.1.73. 771.

Miscellaneous databases

EvolutionaryTraceiP17989.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008264. Beta_glucanase.
IPR013320. ConA-like_dom.
IPR000757. GH16.
IPR008263. GH16_AS.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
PRINTSiPR00737. GLHYDRLASE16.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS01034. GH16_1. 1 hit.
PS51762. GH16_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUB_FIBSS
AccessioniPrimary (citable) accession number: P17989
Secondary accession number(s): C9RPK9, D9S550
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.