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P17989

- GUB_FIBSS

UniProt

P17989 - GUB_FIBSS

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Protein
Beta-glucanase
Gene
Fisuc_2961, FSU_0226
Organism
Fibrobacter succinogenes (strain ATCC 19169 / S85)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3)- and (1->4)-bonds.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791Nucleophile By similarity
Active sitei83 – 831Proton donor By similarity

GO - Molecular functioni

  1. licheninase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH16. Glycoside Hydrolase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucanase (EC:3.2.1.73)
Alternative name(s):
1,3-1,4-beta-D-glucan 4-glucanohydrolase
Endo-beta-1,3-1,4 glucanase
Lichenase
Mixed linkage beta-glucanase
Gene namesi
Ordered Locus Names:Fisuc_2961, FSU_0226
OrganismiFibrobacter succinogenes (strain ATCC 19169 / S85)
Taxonomic identifieri59374 [NCBI]
Taxonomic lineageiBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter
ProteomesiUP000000517: Chromosome, UP000001497: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 Publication
Add
BLAST
Chaini28 – 349322Beta-glucanase
PRO_0000011793Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59374.Fisuc_2961.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 3911
Beta strandi41 – 5111
Beta strandi58 – 658
Turni67 – 704
Beta strandi72 – 743
Beta strandi79 – 857
Beta strandi91 – 10010
Beta strandi103 – 1053
Beta strandi109 – 1124
Turni117 – 1193
Beta strandi122 – 1287
Beta strandi133 – 1375
Beta strandi140 – 1456
Helixi148 – 1514
Beta strandi157 – 16711
Helixi169 – 1724
Helixi177 – 1793
Beta strandi182 – 19413
Turni196 – 1983
Helixi200 – 2023
Beta strandi204 – 2118
Turni218 – 2203
Beta strandi221 – 2233
Beta strandi233 – 2353
Helixi237 – 2393
Beta strandi240 – 2434
Beta strandi246 – 2538

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MVEX-ray1.70A25-266[»]
1ZM1X-ray2.30A/B27-267[»]
2R49X-ray2.20A26-266[»]
3AXDX-ray1.53A/B25-271[»]
3AXEX-ray1.53A25-271[»]
3H0OX-ray1.40A27-266[»]
3HR9X-ray1.70A26-266[»]
ProteinModelPortaliP17989.
SMRiP17989. Positions 25-266.

Miscellaneous databases

EvolutionaryTraceiP17989.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati271 – 27771
Repeati278 – 28472
Repeati285 – 29173
Repeati292 – 29874
Repeati301 – 30775

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni271 – 307375 X 7 AA tandem repeats of P-X-S-S-S-S-X
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2273.
OMAiVEYRRIN.
OrthoDBiEOG6JB18P.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008264. Beta_glucanase.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000757. Glyco_hydro_16.
IPR008263. Glycoside_hydrolase_16_AS.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
PRINTSiPR00737. GLHYDRLASE16.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS01034. GLYCOSYL_HYDROL_F16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17989-1 [UniParc]FASTAAdd to Basket

« Hide

MNIKKTAVKS ALAVAAAAAA LTTNVSAKDF SGAELYTLEE VQYGKFEARM    50
KMAAASGTVS SMFLYQNGSE IADGRPWVEV DIEVLGKNPG SFQSNIITGK 100
AGAQKTSEKH HAVSPAADQA FHTYGLEWTP NYVRWTVDGQ EVRKTEGGQV 150
SNLTGTQGLR FNLWSSESAA WVGQFDESKL PLFQFINWVK VYKYTPGQGE 200
GGSDFTLDWT DNFDTFDGSR WGKGDWTFDG NRVDLTDKNI YSRDGMLILA 250
LTRKGQESFN GQVPRDDEPA PQSSSSAPAS SSSVPASSSS VPASSSSAFV 300
PPSSSSATNA IHGMRTTPAV AKEHRNLVNA KGAKVNPNGH KRYRVNFEH 349
Length:349
Mass (Da):37,738
Last modified:November 1, 1990 - v1
Checksum:i16DC4F5BDEFC578A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33676 Genomic DNA. Translation: AAA24896.1.
CP001792 Genomic DNA. Translation: ACX76541.1.
CP002158 Genomic DNA. Translation: ADL24776.1.
PIRiA44507.
RefSeqiWP_014545066.1. NC_017448.1.
YP_003251023.1. NC_013410.1.
YP_005820380.1. NC_017448.1.

Genome annotation databases

EnsemblBacteriaiACX76541; ACX76541; Fisuc_2961.
ADL24776; ADL24776; FSU_0226.
GeneIDi12431871.
8523608.
KEGGifsc:FSU_0226.
fsu:Fisuc_2961.
PATRICi32145677. VBIFibSuc28982_2886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33676 Genomic DNA. Translation: AAA24896.1 .
CP001792 Genomic DNA. Translation: ACX76541.1 .
CP002158 Genomic DNA. Translation: ADL24776.1 .
PIRi A44507.
RefSeqi WP_014545066.1. NC_017448.1.
YP_003251023.1. NC_013410.1.
YP_005820380.1. NC_017448.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MVE X-ray 1.70 A 25-266 [» ]
1ZM1 X-ray 2.30 A/B 27-267 [» ]
2R49 X-ray 2.20 A 26-266 [» ]
3AXD X-ray 1.53 A/B 25-271 [» ]
3AXE X-ray 1.53 A 25-271 [» ]
3H0O X-ray 1.40 A 27-266 [» ]
3HR9 X-ray 1.70 A 26-266 [» ]
ProteinModelPortali P17989.
SMRi P17989. Positions 25-266.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59374.Fisuc_2961.

Protein family/group databases

CAZyi GH16. Glycoside Hydrolase Family 16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACX76541 ; ACX76541 ; Fisuc_2961 .
ADL24776 ; ADL24776 ; FSU_0226 .
GeneIDi 12431871.
8523608.
KEGGi fsc:FSU_0226.
fsu:Fisuc_2961.
PATRICi 32145677. VBIFibSuc28982_2886.

Phylogenomic databases

eggNOGi COG2273.
OMAi VEYRRIN.
OrthoDBi EOG6JB18P.

Miscellaneous databases

EvolutionaryTracei P17989.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008264. Beta_glucanase.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000757. Glyco_hydro_16.
IPR008263. Glycoside_hydrolase_16_AS.
[Graphical view ]
Pfami PF00722. Glyco_hydro_16. 1 hit.
[Graphical view ]
PRINTSi PR00737. GLHYDRLASE16.
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS01034. GLYCOSYL_HYDROL_F16. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of a Fibrobacter succinogenes mixed-linkage beta-glucanase (1,3-1,4-beta-D-glucan 4-glucanohydrolase) gene."
    Teather R.M., Erfle J.D.
    J. Bacteriol. 172:3837-3841(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 28-57.
  2. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Weimer P.J.
    , Stevenson D.M., Boyum J., Brumm P.I., Mead D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19169 / S85.
  3. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
    Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B., Russell J.B., Cann I.K.O., Mackie R.I., White B.A.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19169 / S85.

Entry informationi

Entry nameiGUB_FIBSS
AccessioniPrimary (citable) accession number: P17989
Secondary accession number(s): C9RPK9, D9S550
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3