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P17989

- GUB_FIBSS

UniProt

P17989 - GUB_FIBSS

Protein

Beta-glucanase

Gene

Fisuc_2961

Organism
Fibrobacter succinogenes (strain ATCC 19169 / S85)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3)- and (1->4)-bonds.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei79 – 791NucleophilePROSITE-ProRule annotation
    Active sitei83 – 831Proton donorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. licheninase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH16. Glycoside Hydrolase Family 16.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-glucanase (EC:3.2.1.73)
    Alternative name(s):
    1,3-1,4-beta-D-glucan 4-glucanohydrolase
    Endo-beta-1,3-1,4 glucanase
    Lichenase
    Mixed linkage beta-glucanase
    Gene namesi
    Ordered Locus Names:Fisuc_2961, FSU_0226
    OrganismiFibrobacter succinogenes (strain ATCC 19169 / S85)
    Taxonomic identifieri59374 [NCBI]
    Taxonomic lineageiBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter
    ProteomesiUP000000517: Chromosome, UP000001497: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 27271 PublicationAdd
    BLAST
    Chaini28 – 349322Beta-glucanasePRO_0000011793Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59374.Fisuc_2961.

    Structurei

    Secondary structure

    1
    349
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 3911
    Beta strandi41 – 5111
    Beta strandi58 – 658
    Turni67 – 704
    Beta strandi72 – 743
    Beta strandi79 – 857
    Beta strandi91 – 10010
    Beta strandi103 – 1053
    Beta strandi109 – 1124
    Turni117 – 1193
    Beta strandi122 – 1287
    Beta strandi133 – 1375
    Beta strandi140 – 1456
    Helixi148 – 1514
    Beta strandi157 – 16711
    Helixi169 – 1724
    Helixi177 – 1793
    Beta strandi182 – 19413
    Turni196 – 1983
    Helixi200 – 2023
    Beta strandi204 – 2118
    Turni218 – 2203
    Beta strandi221 – 2233
    Beta strandi233 – 2353
    Helixi237 – 2393
    Beta strandi240 – 2434
    Beta strandi246 – 2538

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MVEX-ray1.70A25-266[»]
    1ZM1X-ray2.30A/B27-267[»]
    2R49X-ray2.20A26-266[»]
    3AXDX-ray1.53A/B25-271[»]
    3AXEX-ray1.53A25-271[»]
    3H0OX-ray1.40A27-266[»]
    3HR9X-ray1.70A26-266[»]
    ProteinModelPortaliP17989.
    SMRiP17989. Positions 25-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17989.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati271 – 27771
    Repeati278 – 28472
    Repeati285 – 29173
    Repeati292 – 29874
    Repeati301 – 30775

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni271 – 307375 X 7 AA tandem repeats of P-X-S-S-S-S-XAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 16 family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2273.
    OMAiVEYRRIN.
    OrthoDBiEOG6JB18P.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008264. Beta_glucanase.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000757. Glyco_hydro_16.
    IPR008263. Glycoside_hydrolase_16_AS.
    [Graphical view]
    PfamiPF00722. Glyco_hydro_16. 1 hit.
    [Graphical view]
    PRINTSiPR00737. GLHYDRLASE16.
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS01034. GLYCOSYL_HYDROL_F16. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17989-1 [UniParc]FASTAAdd to Basket

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    MNIKKTAVKS ALAVAAAAAA LTTNVSAKDF SGAELYTLEE VQYGKFEARM    50
    KMAAASGTVS SMFLYQNGSE IADGRPWVEV DIEVLGKNPG SFQSNIITGK 100
    AGAQKTSEKH HAVSPAADQA FHTYGLEWTP NYVRWTVDGQ EVRKTEGGQV 150
    SNLTGTQGLR FNLWSSESAA WVGQFDESKL PLFQFINWVK VYKYTPGQGE 200
    GGSDFTLDWT DNFDTFDGSR WGKGDWTFDG NRVDLTDKNI YSRDGMLILA 250
    LTRKGQESFN GQVPRDDEPA PQSSSSAPAS SSSVPASSSS VPASSSSAFV 300
    PPSSSSATNA IHGMRTTPAV AKEHRNLVNA KGAKVNPNGH KRYRVNFEH 349
    Length:349
    Mass (Da):37,738
    Last modified:November 1, 1990 - v1
    Checksum:i16DC4F5BDEFC578A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33676 Genomic DNA. Translation: AAA24896.1.
    CP001792 Genomic DNA. Translation: ACX76541.1.
    CP002158 Genomic DNA. Translation: ADL24776.1.
    PIRiA44507.
    RefSeqiWP_014545066.1. NC_017448.1.
    YP_003251023.1. NC_013410.1.
    YP_005820380.1. NC_017448.1.

    Genome annotation databases

    EnsemblBacteriaiACX76541; ACX76541; Fisuc_2961.
    ADL24776; ADL24776; FSU_0226.
    GeneIDi12431871.
    8523608.
    KEGGifsc:FSU_0226.
    fsu:Fisuc_2961.
    PATRICi32145677. VBIFibSuc28982_2886.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33676 Genomic DNA. Translation: AAA24896.1 .
    CP001792 Genomic DNA. Translation: ACX76541.1 .
    CP002158 Genomic DNA. Translation: ADL24776.1 .
    PIRi A44507.
    RefSeqi WP_014545066.1. NC_017448.1.
    YP_003251023.1. NC_013410.1.
    YP_005820380.1. NC_017448.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MVE X-ray 1.70 A 25-266 [» ]
    1ZM1 X-ray 2.30 A/B 27-267 [» ]
    2R49 X-ray 2.20 A 26-266 [» ]
    3AXD X-ray 1.53 A/B 25-271 [» ]
    3AXE X-ray 1.53 A 25-271 [» ]
    3H0O X-ray 1.40 A 27-266 [» ]
    3HR9 X-ray 1.70 A 26-266 [» ]
    ProteinModelPortali P17989.
    SMRi P17989. Positions 25-266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59374.Fisuc_2961.

    Protein family/group databases

    CAZyi GH16. Glycoside Hydrolase Family 16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACX76541 ; ACX76541 ; Fisuc_2961 .
    ADL24776 ; ADL24776 ; FSU_0226 .
    GeneIDi 12431871.
    8523608.
    KEGGi fsc:FSU_0226.
    fsu:Fisuc_2961.
    PATRICi 32145677. VBIFibSuc28982_2886.

    Phylogenomic databases

    eggNOGi COG2273.
    OMAi VEYRRIN.
    OrthoDBi EOG6JB18P.

    Miscellaneous databases

    EvolutionaryTracei P17989.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008264. Beta_glucanase.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000757. Glyco_hydro_16.
    IPR008263. Glycoside_hydrolase_16_AS.
    [Graphical view ]
    Pfami PF00722. Glyco_hydro_16. 1 hit.
    [Graphical view ]
    PRINTSi PR00737. GLHYDRLASE16.
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS01034. GLYCOSYL_HYDROL_F16. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of a Fibrobacter succinogenes mixed-linkage beta-glucanase (1,3-1,4-beta-D-glucan 4-glucanohydrolase) gene."
      Teather R.M., Erfle J.D.
      J. Bacteriol. 172:3837-3841(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 28-57.
    2. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Weimer P.J.
      , Stevenson D.M., Boyum J., Brumm P.I., Mead D.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19169 / S85.
    3. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
      Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B., Russell J.B., Cann I.K.O., Mackie R.I., White B.A.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19169 / S85.

    Entry informationi

    Entry nameiGUB_FIBSS
    AccessioniPrimary (citable) accession number: P17989
    Secondary accession number(s): C9RPK9, D9S550
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3