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Protein

Sulfotransferase 1A1

Gene

Sult1a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104Proton acceptorBy similarity1
Binding sitei126PAPSBy similarity1
Binding sitei134PAPSBy similarity1
Binding sitei189PAPSBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 49PAPSBy similarity6
Nucleotide bindingi223 – 228PAPSBy similarity6
Nucleotide bindingi251 – 255PAPSBy similarity5

GO - Molecular functioni

  • 3'-phosphoadenosine 5'-phosphosulfate binding Source: RGD
  • aryl sulfotransferase activity Source: RGD
  • protein homodimerization activity Source: RGD
  • sulfotransferase activity Source: RGD

GO - Biological processi

  • 4-nitrophenol metabolic process Source: RGD
  • catecholamine metabolic process Source: RGD
  • drug metabolic process Source: RGD
  • estrogen metabolic process Source: RGD
  • regulation of blood pressure Source: RGD
  • response to activity Source: RGD
  • response to glucocorticoid Source: RGD
  • response to insecticide Source: RGD
  • sulfation Source: RGD
  • xenobiotic metabolic process Source: RGD

Keywordsi

Molecular functionTransferase
Biological processLipid metabolism, Steroid metabolism

Enzyme and pathway databases

BRENDAi2.8.2.1 5301
ReactomeiR-RNO-156584 Cytosolic sulfonation of small molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A1 (EC:2.8.2.1)
Short name:
ST1A1
Alternative name(s):
Aryl sulfotransferase
Aryl sulfotransferase IV
Short name:
ASTIV
Minoxidil sulfotransferase
Short name:
Mx-ST
PST-1
Phenol sulfotransferase
Sulfokinase
Tyrosine-ester sulfotransferase
Gene namesi
Name:Sult1a1
Synonyms:St1a1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3767 Sult1a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4886

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851311 – 291Sulfotransferase 1A1Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei134PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP17988
PRIDEiP17988

PTM databases

iPTMnetiP17988
PhosphoSitePlusiP17988

Expressioni

Tissue specificityi

Liver, kidney, heart and colon.

Inductioni

Induced by androgens and suppressed by estrogens. The expression is under the influence of pituitary growth hormone and thyroid hormone.

Gene expression databases

BgeeiENSRNOG00000019342
GenevisibleiP17988 RN

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026186

Structurei

3D structure databases

ProteinModelPortaliP17988
SMRiP17988
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 104Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00760000118932
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiP17988
KOiK01014
OMAiFAIMSRK
OrthoDBiEOG091G0D5F
PhylomeDBiP17988
TreeFamiTF321745

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P17988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSRPPLVH VKGIPLIKYF AETIGPLQNF TAWPDDLLIS TYPKSGTTWM
60 70 80 90 100
SEILDMIYQG GKLEKCGRAP IYARVPFLEF KCPGVPSGLE TLEETPAPRL
110 120 130 140 150
LKTHLPLSLL PQSLLDQKVK VIYIARNAKD VVVSYYNFYN MAKLHPDPGT
160 170 180 190 200
WDSFLENFMD GEVSYGSWYQ HVKEWWELRH THPVLYLFYE DIKENPKREI
210 220 230 240 250
KKILEFLGRS LPEETVDSIV HHTSFKKMKE NCMTNYTTIP TEIMDHNVSP
260 270 280 290
FMRKGTTGDW KNTFTVAQNE RFDAHYAKTM TDCDFKFRCE L
Length:291
Mass (Da):33,906
Last modified:November 1, 1990 - v1
Checksum:i9EC66C72923DB872
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52883 mRNA Translation: CAA37065.1
L19998 mRNA Translation: AAA41644.1
L16241 Genomic DNA No translation available.
AF394783 mRNA Translation: AAK77559.1
X68640 mRNA Translation: CAA48604.1
PIRiS10329
RefSeqiNP_114022.1, NM_031834.1
UniGeneiRn.1507

Genome annotation databases

EnsembliENSRNOT00000026186; ENSRNOP00000026186; ENSRNOG00000019342
GeneIDi83783
KEGGirno:83783
UCSCiRGD:3767 rat

Similar proteinsi

Entry informationi

Entry nameiST1A1_RAT
AccessioniPrimary (citable) accession number: P17988
Secondary accession number(s): Q548D2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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