Sulfotransferase 1A1 - Rattus norvegicus (Rat)

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P17988 (ST1A1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 108. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sulfotransferase 1A1
Short name=ST1A1
EC=2.8.2.1

Alternative name(s):
Aryl sulfotransferase
Aryl sulfotransferase IV
Short name=ASTIV
Minoxidil sulfotransferase
Short name=Mx-ST
PST-1
Phenol sulfotransferase
Sulfokinase
Tyrosine-ester sulfotransferase

Gene names

Name:	Sult1a1
Synonyms:	St1a1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
Catalytic activity	3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Liver, kidney, heart and colon.
Induction	Induced by androgens and suppressed by estrogens. The expression is under the influence of pituitary growth hormone and thyroid hormone.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Belongs to the sulfotransferase 1 family.

Ontologies

Keywords
Biological process	Lipid metabolism Steroid metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	4-nitrophenol metabolic process Inferred from direct assay PubMed 11181495. Source: RGD catecholamine metabolic process Inferred from direct assay PubMed 6959650. Source: RGD drug metabolic process Inferred from direct assay PubMed 6959650. Source: RGD estrogen metabolic process Inferred from mutant phenotype PubMed 14742143. Source: RGD regulation of blood pressure Inferred from expression pattern PubMed 15942020. Source: RGD response to glucocorticoid stimulus Inferred from mutant phenotype PubMed 14570770. Source: RGD response to stress Inferred from direct assay PubMed 15351727. Source: RGD sulfation Inferred from direct assay PubMed 15849721. Source: RGD xenobiotic metabolic process Inferred from direct assay PubMed 14754874. Source: RGD
Cellular_component	cytosol Inferred from direct assay PubMed 15849721 PubMed 16822482. Source: RGD
Molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding Inferred from direct assay PubMed 16822482. Source: RGD aryl sulfotransferase activity Inferred from direct assay PubMed 15849721. Source: RGD protein homodimerization activity Inferred from direct assay PubMed 15849721. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 291

291

Sulfotransferase 1A1

PRO_0000085131

Regions

Nucleotide binding

44 – 49

PAPS By similarity

Nucleotide binding

223 – 228

PAPS By similarity

Nucleotide binding

251 – 255

PAPS By similarity

Region

102 – 104

Substrate binding By similarity

Sites

Active site

104

Proton acceptor By similarity

Binding site

126

PAPS By similarity

Binding site

134

PAPS By similarity

Binding site

189

PAPS By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P17988 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 9EC66C72923DB872
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FASTA

291

33,906

        10         20         30         40         50         60 
MEFSRPPLVH VKGIPLIKYF AETIGPLQNF TAWPDDLLIS TYPKSGTTWM SEILDMIYQG 

        70         80         90        100        110        120 
GKLEKCGRAP IYARVPFLEF KCPGVPSGLE TLEETPAPRL LKTHLPLSLL PQSLLDQKVK 

       130        140        150        160        170        180 
VIYIARNAKD VVVSYYNFYN MAKLHPDPGT WDSFLENFMD GEVSYGSWYQ HVKEWWELRH 

       190        200        210        220        230        240 
THPVLYLFYE DIKENPKREI KKILEFLGRS LPEETVDSIV HHTSFKKMKE NCMTNYTTIP 

       250        260        270        280        290 
TEIMDHNVSP FMRKGTTGDW KNTFTVAQNE RFDAHYAKTM TDCDFKFRCE L

« Hide

References

[1]	"Nucleotide sequence of a full-length cDNA (PST-1) for aryl sulfotransferase from rat liver." Ozawa S., Nagata K., Gong D., Yamazoe Y., Kato R. Nucleic Acids Res. 18:4001-4001(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Liver.
[2]	"Sequence analysis, in vitro translation and expression of the cDNA for rat liver minoxidil sulfotransferase." Hirshey S.J., Dooley T.P., Reardon I.M., Heinrikson R.L., Falany C.N. Mol. Pharmacol. 42:257-264(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Liver.
[3]	"Genomic structure of rat liver aryl sulfotransferase IV-encoding gene." Khan A.S., Taylor B.R., Chung K., Etheredge J., Gonzales R., Ringer D.P. Gene 137:321-326(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley. Tissue: Liver.
[4]	"Cloning, bacterial expression and characterization of rat brain phenol sulfotransferase SULT1A1: an enzyme involved in neurosteroid and dopamine sulfonation." Mao C., Sanchez R.I., Clairmont K., Coughtrie M.W.H., Kauffman F.C. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[5]	"Characterization of a complementary DNA for rat liver aryl sulfotransferase IV and use in evaluating the hepatic gene transcript levels of rats at various stages of 2-acetylaminofluorene-induced hepatocarcinogenesis." Yerokun T., Etheredge J.L., Norton T.R., Carter H.A., Chung K.H., Birckbichler P.J., Ringer D.P. Cancer Res. 52:4779-4786(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-291.
[6]	"Affinity labeling of aryl sulfotransferase IV. Identification of a peptide sequence at the binding site for 3'-phosphoadenosine-5'-phosphosulfate." Zheng Y., Bergold A., Duffel M.W. J. Biol. Chem. 269:30313-30319(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 63-68, CHARACTERIZATION.
[7]	"cDNA expression studies of rat liver aryl sulphotransferase." Cruickshank D., Sansom L.N., Veronese M.E., Mojarrabi B., McManus M.E., Zhu X. Biochem. Biophys. Res. Commun. 191:295-301(1993) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION. Tissue: Liver.
[8]	"Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds." Yamazoe Y., Ozawa S., Nagata K., Gong D.-W., Kato R. Environ. Health Perspect. 102:99-103(1994) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[9]	"Sulfotransferase gene expression in rat hepatic and extrahepatic tissues." Runge-Morris M.A. Chem. Biol. Interact. 92:67-76(1994) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52883 mRNA. Translation: CAA37065.1. L19998 mRNA. Translation: AAA41644.1. L16241 Genomic DNA. No translation available. AF394783 mRNA. Translation: AAK77559.1. X68640 mRNA. Translation: CAA48604.1.
IPI	IPI00193049.
PIR	S10329.
RefSeq	NP_114022.1. NM_031834.1.
UniGene	Rn.1507.
3D structure databases
ProteinModelPortal	P17988.
SMR	P17988. Positions 4-291.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000026186.
Proteomic databases
PaxDb	P17988.
PRIDE	P17988.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000026186; ENSRNOP00000026186; ENSRNOG00000019342.
GeneID	83783.
KEGG	rno:83783.
UCSC	RGD:3767. rat.
Organism-specific databases
CTD	6817.
RGD	3767. Sult1a1.
Phylogenomic databases
eggNOG	NOG260792.
GeneTree	ENSGT00560000076773.
HOGENOM	HOG000037209.
HOVERGEN	HBG001195.
InParanoid	P17988.
KO	K01014.
OMA	ISAPPKC.
OrthoDB	EOG4255T9.
Enzyme and pathway databases
BRENDA	2.8.2.1. 5301.
Gene expression databases
Genevestigator	P17988.
GermOnline	ENSRNOG00000019342. Rattus norvegicus.
Family and domain databases
InterPro	IPR000863. Sulfotransferase_dom. [Graphical view]
Pfam	PF00685. Sulfotransfer_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL4886.
NextBio	616347.

Entry information

Entry name

ST1A1_RAT

Accession

Primary (citable) accession number: P17988
Secondary accession number(s): Q548D2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	April 3, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents