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P17988

- ST1A1_RAT

UniProt

P17988 - ST1A1_RAT

Protein

Sulfotransferase 1A1

Gene

Sult1a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

    Catalytic activityi

    3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei104 – 1041Proton acceptorBy similarity
    Binding sitei126 – 1261PAPSBy similarity
    Binding sitei134 – 1341PAPSBy similarity
    Binding sitei189 – 1891PAPSBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 496PAPSBy similarity
    Nucleotide bindingi223 – 2286PAPSBy similarity
    Nucleotide bindingi251 – 2555PAPSBy similarity

    GO - Molecular functioni

    1. 3'-phosphoadenosine 5'-phosphosulfate binding Source: RGD
    2. aryl sulfotransferase activity Source: RGD
    3. protein homodimerization activity Source: RGD
    4. sulfotransferase activity Source: RGD

    GO - Biological processi

    1. 4-nitrophenol metabolic process Source: RGD
    2. catecholamine metabolic process Source: RGD
    3. drug metabolic process Source: RGD
    4. estrogen metabolic process Source: RGD
    5. regulation of blood pressure Source: RGD
    6. response to activity Source: RGD
    7. response to glucocorticoid Source: RGD
    8. response to insecticide Source: RGD
    9. sulfation Source: RGD
    10. xenobiotic metabolic process Source: RGD

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipid metabolism, Steroid metabolism

    Enzyme and pathway databases

    BRENDAi2.8.2.1. 5301.
    ReactomeiREACT_93415. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfotransferase 1A1 (EC:2.8.2.1)
    Short name:
    ST1A1
    Alternative name(s):
    Aryl sulfotransferase
    Aryl sulfotransferase IV
    Short name:
    ASTIV
    Minoxidil sulfotransferase
    Short name:
    Mx-ST
    PST-1
    Phenol sulfotransferase
    Sulfokinase
    Tyrosine-ester sulfotransferase
    Gene namesi
    Name:Sult1a1
    Synonyms:St1a1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi3767. Sult1a1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Sulfotransferase 1A1PRO_0000085131Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.

    Proteomic databases

    PaxDbiP17988.
    PRIDEiP17988.

    Expressioni

    Tissue specificityi

    Liver, kidney, heart and colon.

    Inductioni

    Induced by androgens and suppressed by estrogens. The expression is under the influence of pituitary growth hormone and thyroid hormone.

    Gene expression databases

    GenevestigatoriP17988.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    MINTiMINT-4563534.
    STRINGi10116.ENSRNOP00000026186.

    Structurei

    3D structure databases

    ProteinModelPortaliP17988.
    SMRiP17988. Positions 4-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni102 – 1043Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the sulfotransferase 1 family.Curated

    Phylogenomic databases

    eggNOGiNOG260792.
    GeneTreeiENSGT00740000115442.
    HOGENOMiHOG000037209.
    HOVERGENiHBG001195.
    InParanoidiP17988.
    KOiK01014.
    OMAiIMDHNVS.
    OrthoDBiEOG7V49ZK.
    PhylomeDBiP17988.
    TreeFamiTF321745.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view]
    PfamiPF00685. Sulfotransfer_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P17988-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFSRPPLVH VKGIPLIKYF AETIGPLQNF TAWPDDLLIS TYPKSGTTWM    50
    SEILDMIYQG GKLEKCGRAP IYARVPFLEF KCPGVPSGLE TLEETPAPRL 100
    LKTHLPLSLL PQSLLDQKVK VIYIARNAKD VVVSYYNFYN MAKLHPDPGT 150
    WDSFLENFMD GEVSYGSWYQ HVKEWWELRH THPVLYLFYE DIKENPKREI 200
    KKILEFLGRS LPEETVDSIV HHTSFKKMKE NCMTNYTTIP TEIMDHNVSP 250
    FMRKGTTGDW KNTFTVAQNE RFDAHYAKTM TDCDFKFRCE L 291
    Length:291
    Mass (Da):33,906
    Last modified:November 1, 1990 - v1
    Checksum:i9EC66C72923DB872
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52883 mRNA. Translation: CAA37065.1.
    L19998 mRNA. Translation: AAA41644.1.
    L16241 Genomic DNA. No translation available.
    AF394783 mRNA. Translation: AAK77559.1.
    X68640 mRNA. Translation: CAA48604.1.
    PIRiS10329.
    RefSeqiNP_114022.1. NM_031834.1.
    UniGeneiRn.1507.

    Genome annotation databases

    EnsembliENSRNOT00000026186; ENSRNOP00000026186; ENSRNOG00000019342.
    GeneIDi83783.
    KEGGirno:83783.
    UCSCiRGD:3767. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52883 mRNA. Translation: CAA37065.1 .
    L19998 mRNA. Translation: AAA41644.1 .
    L16241 Genomic DNA. No translation available.
    AF394783 mRNA. Translation: AAK77559.1 .
    X68640 mRNA. Translation: CAA48604.1 .
    PIRi S10329.
    RefSeqi NP_114022.1. NM_031834.1.
    UniGenei Rn.1507.

    3D structure databases

    ProteinModelPortali P17988.
    SMRi P17988. Positions 4-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4563534.
    STRINGi 10116.ENSRNOP00000026186.

    Chemistry

    ChEMBLi CHEMBL4886.

    Proteomic databases

    PaxDbi P17988.
    PRIDEi P17988.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026186 ; ENSRNOP00000026186 ; ENSRNOG00000019342 .
    GeneIDi 83783.
    KEGGi rno:83783.
    UCSCi RGD:3767. rat.

    Organism-specific databases

    CTDi 6817.
    RGDi 3767. Sult1a1.

    Phylogenomic databases

    eggNOGi NOG260792.
    GeneTreei ENSGT00740000115442.
    HOGENOMi HOG000037209.
    HOVERGENi HBG001195.
    InParanoidi P17988.
    KOi K01014.
    OMAi IMDHNVS.
    OrthoDBi EOG7V49ZK.
    PhylomeDBi P17988.
    TreeFami TF321745.

    Enzyme and pathway databases

    BRENDAi 2.8.2.1. 5301.
    Reactomei REACT_93415. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    NextBioi 616347.
    PROi P17988.

    Gene expression databases

    Genevestigatori P17988.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view ]
    Pfami PF00685. Sulfotransfer_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a full-length cDNA (PST-1) for aryl sulfotransferase from rat liver."
      Ozawa S., Nagata K., Gong D., Yamazoe Y., Kato R.
      Nucleic Acids Res. 18:4001-4001(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "Sequence analysis, in vitro translation and expression of the cDNA for rat liver minoxidil sulfotransferase."
      Hirshey S.J., Dooley T.P., Reardon I.M., Heinrikson R.L., Falany C.N.
      Mol. Pharmacol. 42:257-264(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    3. "Genomic structure of rat liver aryl sulfotransferase IV-encoding gene."
      Khan A.S., Taylor B.R., Chung K., Etheredge J., Gonzales R., Ringer D.P.
      Gene 137:321-326(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    4. "Cloning, bacterial expression and characterization of rat brain phenol sulfotransferase SULT1A1: an enzyme involved in neurosteroid and dopamine sulfonation."
      Mao C., Sanchez R.I., Clairmont K., Coughtrie M.W.H., Kauffman F.C.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    5. "Characterization of a complementary DNA for rat liver aryl sulfotransferase IV and use in evaluating the hepatic gene transcript levels of rats at various stages of 2-acetylaminofluorene-induced hepatocarcinogenesis."
      Yerokun T., Etheredge J.L., Norton T.R., Carter H.A., Chung K.H., Birckbichler P.J., Ringer D.P.
      Cancer Res. 52:4779-4786(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-291.
    6. "Affinity labeling of aryl sulfotransferase IV. Identification of a peptide sequence at the binding site for 3'-phosphoadenosine-5'-phosphosulfate."
      Zheng Y., Bergold A., Duffel M.W.
      J. Biol. Chem. 269:30313-30319(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 63-68, CHARACTERIZATION.
    7. Cited for: CHARACTERIZATION.
      Tissue: Liver.
    8. "Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds."
      Yamazoe Y., Ozawa S., Nagata K., Gong D.-W., Kato R.
      Environ. Health Perspect. 102:99-103(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    9. "Sulfotransferase gene expression in rat hepatic and extrahepatic tissues."
      Runge-Morris M.A.
      Chem. Biol. Interact. 92:67-76(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiST1A1_RAT
    AccessioniPrimary (citable) accession number: P17988
    Secondary accession number(s): Q548D2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3