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P17980

- PRS6A_HUMAN

UniProt

P17980 - PRS6A_HUMAN

Protein

26S protease regulatory subunit 6A

Gene

PSMC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 160 (01 Oct 2014)
      Sequence version 3 (10 May 2002)
      Previous versions | rss
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    Functioni

    The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex By similarity. In case of HIV-1 infection, suppresses Tat-mediated transactivation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi227 – 2348ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. transcription coactivator activity Source: ProtInc
    5. transcription corepressor activity Source: ProtInc

    GO - Biological processi

    1. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. apoptotic process Source: Reactome
    6. ATP catabolic process Source: GOC
    7. blastocyst development Source: Ensembl
    8. cellular nitrogen compound metabolic process Source: Reactome
    9. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
    10. G1/S transition of mitotic cell cycle Source: Reactome
    11. gene expression Source: Reactome
    12. mitotic cell cycle Source: Reactome
    13. mRNA metabolic process Source: Reactome
    14. negative regulation of apoptotic process Source: Reactome
    15. negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    16. positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    17. protein polyubiquitination Source: Reactome
    18. regulation of apoptotic process Source: Reactome
    19. regulation of cellular amino acid metabolic process Source: Reactome
    20. regulation of RNA biosynthetic process Source: GOC
    21. regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    22. RNA metabolic process Source: Reactome
    23. small molecule metabolic process Source: Reactome
    24. viral process Source: Reactome

    Keywords - Biological processi

    Host-virus interaction

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_111178. ER-Phagosome pathway.
    REACT_1156. Orc1 removal from chromatin.
    REACT_118656. Activation of NF-kappaB in B cells.
    REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
    REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_13565. Regulation of ornithine decarboxylase (ODC).
    REACT_150471. Separation of Sister Chromatids.
    REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_200766. degradation of AXIN.
    REACT_200841. degradation of DVL.
    REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
    REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_9031. Vpu mediated degradation of CD4.
    REACT_9453. Vif-mediated degradation of APOBEC3G.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    26S protease regulatory subunit 6A
    Alternative name(s):
    26S proteasome AAA-ATPase subunit RPT5
    Proteasome 26S subunit ATPase 3
    Proteasome subunit P50
    Tat-binding protein 1
    Short name:
    TBP-1
    Gene namesi
    Name:PSMC3
    Synonyms:TBP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:9549. PSMC3.

    Subcellular locationi

    Cytoplasm Curated. Nucleus Curated. CytoplasmP-body By similarity
    Note: Colocalizes with TRIM5 in the cytoplasmic bodies.By similarity

    GO - Cellular componenti

    1. cytoplasmic mRNA processing body Source: UniProtKB
    2. cytosol Source: Reactome
    3. membrane Source: UniProtKB
    4. nucleoplasm Source: Reactome
    5. nucleus Source: UniProt
    6. perinuclear region of cytoplasm Source: Ensembl
    7. proteasome accessory complex Source: UniProtKB
    8. proteasome complex Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi233 – 2331K → H: Loss of function.
    Mutagenesisi289 – 2891D → A: Loss of function.

    Organism-specific databases

    PharmGKBiPA33894.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 43943926S protease regulatory subunit 6APRO_0000084698Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine4 Publications
    Modified residuei9 – 91Phosphoserine3 Publications

    Post-translational modificationi

    Sumoylated by UBE2I in response to MEKK1-mediated stimuli.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP17980.
    PaxDbiP17980.
    PeptideAtlasiP17980.
    PRIDEiP17980.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00018398.

    PTM databases

    PhosphoSiteiP17980.

    Miscellaneous databases

    PMAP-CutDBP17980.

    Expressioni

    Gene expression databases

    ArrayExpressiP17980.
    BgeeiP17980.
    CleanExiHS_PSMC3.
    GenevestigatoriP17980.

    Organism-specific databases

    HPAiHPA006065.

    Interactioni

    Subunit structurei

    May form a heterodimer with a related family member. Interacts with PAAF1. Interacts with HIV-1 Tat.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P03255-12EBI-359720,EBI-6692439From a different organism.
    PSMC6P623335EBI-359720,EBI-357669
    PSMD9O002334EBI-359720,EBI-750973

    Protein-protein interaction databases

    BioGridi111675. 92 interactions.
    DIPiDIP-27555N.
    IntActiP17980. 26 interactions.
    MINTiMINT-1149785.
    STRINGi9606.ENSP00000298852.

    Structurei

    3D structure databases

    ProteinModelPortaliP17980.
    SMRiP17980. Positions 52-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated

    Phylogenomic databases

    eggNOGiCOG1222.
    HOVERGENiHBG000109.
    InParanoidiP17980.
    KOiK03065.
    OMAiATELNHE.
    OrthoDBiEOG7TMZRN.
    PhylomeDBiP17980.
    TreeFamiTF105648.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR005937. 26S_Psome_P45.
    IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17980-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLLPNIESP VTRQEKMATV WDEAEQDGIG EEVLKMSTEE IIQRTRLLDS    50
    EIKIMKSEVL RVTHELQAMK DKIKENSEKI KVNKTLPYLV SNVIELLDVD 100
    PNDQEEDGAN IDLDSQRKGK CAVIKTSTRQ TYFLPVIGLV DAEKLKPGDL 150
    VGVNKDSYLI LETLPTEYDS RVKAMEVDER PTEQYSDIGG LDKQIQELVE 200
    AIVLPMNHKE KFENLGIQPP KGVLMYGPPG TGKTLLARAC AAQTKATFLK 250
    LAGPQLVQMF IGDGAKLVRD AFALAKEKAP SIIFIDELDA IGTKRFDSEK 300
    AGDREVQRTM LELLNQLDGF QPNTQVKVIA ATNRVDILDP ALLRSGRLDR 350
    KIEFPMPNEE ARARIMQIHS RKMNVSPDVN YEELARCTDD FNGAQCKAVC 400
    VEAGMIALRR GATELTHEDY MEGILEVQAK KKANLQYYA 439
    Length:439
    Mass (Da):49,204
    Last modified:May 10, 2002 - v3
    Checksum:i0E443465DDDEBB0B
    GO

    Sequence cautioni

    The sequence AAI07805.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti356 – 3561M → T in BAD96205. 1 PublicationCurated
    Sequence conflicti409 – 4091R → A in AAA36666. (PubMed:2194290)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK313518 mRNA. Translation: BAG36298.1.
    CH471064 Genomic DNA. Translation: EAW67916.1.
    BC008713 mRNA. Translation: AAH08713.4.
    BC073165 mRNA. Translation: AAH73165.3.
    BC106920 mRNA. Translation: AAI06921.1.
    BC107804 mRNA. Translation: AAI07805.1. Different initiation.
    AK222485 mRNA. Translation: BAD96205.1.
    M34079 mRNA. Translation: AAA36666.1.
    CR456731 mRNA. Translation: CAG33012.1.
    CCDSiCCDS7935.1.
    PIRiA34832.
    RefSeqiNP_002795.2. NM_002804.4.
    UniGeneiHs.250758.

    Genome annotation databases

    EnsembliENST00000298852; ENSP00000298852; ENSG00000165916.
    GeneIDi5702.
    KEGGihsa:5702.
    UCSCiuc001nfh.2. human.

    Polymorphism databases

    DMDMi20532406.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK313518 mRNA. Translation: BAG36298.1 .
    CH471064 Genomic DNA. Translation: EAW67916.1 .
    BC008713 mRNA. Translation: AAH08713.4 .
    BC073165 mRNA. Translation: AAH73165.3 .
    BC106920 mRNA. Translation: AAI06921.1 .
    BC107804 mRNA. Translation: AAI07805.1 . Different initiation.
    AK222485 mRNA. Translation: BAD96205.1 .
    M34079 mRNA. Translation: AAA36666.1 .
    CR456731 mRNA. Translation: CAG33012.1 .
    CCDSi CCDS7935.1.
    PIRi A34832.
    RefSeqi NP_002795.2. NM_002804.4.
    UniGenei Hs.250758.

    3D structure databases

    ProteinModelPortali P17980.
    SMRi P17980. Positions 52-439.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111675. 92 interactions.
    DIPi DIP-27555N.
    IntActi P17980. 26 interactions.
    MINTi MINT-1149785.
    STRINGi 9606.ENSP00000298852.

    PTM databases

    PhosphoSitei P17980.

    Polymorphism databases

    DMDMi 20532406.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00018398.

    Proteomic databases

    MaxQBi P17980.
    PaxDbi P17980.
    PeptideAtlasi P17980.
    PRIDEi P17980.

    Protocols and materials databases

    DNASUi 5702.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298852 ; ENSP00000298852 ; ENSG00000165916 .
    GeneIDi 5702.
    KEGGi hsa:5702.
    UCSCi uc001nfh.2. human.

    Organism-specific databases

    CTDi 5702.
    GeneCardsi GC11M047440.
    HGNCi HGNC:9549. PSMC3.
    HPAi HPA006065.
    MIMi 186852. gene.
    neXtProti NX_P17980.
    PharmGKBi PA33894.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1222.
    HOVERGENi HBG000109.
    InParanoidi P17980.
    KOi K03065.
    OMAi ATELNHE.
    OrthoDBi EOG7TMZRN.
    PhylomeDBi P17980.
    TreeFami TF105648.

    Enzyme and pathway databases

    Reactomei REACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_111178. ER-Phagosome pathway.
    REACT_1156. Orc1 removal from chromatin.
    REACT_118656. Activation of NF-kappaB in B cells.
    REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
    REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_13565. Regulation of ornithine decarboxylase (ODC).
    REACT_150471. Separation of Sister Chromatids.
    REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_200766. degradation of AXIN.
    REACT_200841. degradation of DVL.
    REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
    REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_9031. Vpu mediated degradation of CD4.
    REACT_9453. Vif-mediated degradation of APOBEC3G.

    Miscellaneous databases

    ChiTaRSi PSMC3. human.
    GeneWikii PSMC3.
    GenomeRNAii 5702.
    NextBioi 22154.
    PMAP-CutDB P17980.
    PROi P17980.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17980.
    Bgeei P17980.
    CleanExi HS_PSMC3.
    Genevestigatori P17980.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR005937. 26S_Psome_P45.
    IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01242. 26Sp45. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes."
      Ohana B., Moore P.A., Ruben S.M., Southgate C.D., Green M.R., Rosen C.A.
      Proc. Natl. Acad. Sci. U.S.A. 90:138-142(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney, Lung and Peripheral nerve.
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-439.
      Tissue: Adipose tissue.
    6. "A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator."
      Nelbock P., Dillion P.J., Perkins A., Rosen C.A.
      Science 248:1650-1653(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-439, INTERACTION WITH HIV-1 TAT.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-439.
    8. Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 130-144; 156-171; 174-233; 251-266; 277-294; 309-327; 335-344; 351-362; 372-386 AND 398-409, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
    9. "Identification, purification, and characterization of a PA700-dependent activator of the proteasome."
      Demartino G.N., Proske R.J., Moomaw C.R., Strong A.A., Song X., Hisamatsu H., Tanaka K., Slaughter C.A.
      J. Biol. Chem. 271:3112-3118(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
    10. "Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases."
      Park Y., Hwang Y.-P., Lee J.-S., Seo S.-H., Yoon S.K., Yoon J.-B.
      Mol. Cell. Biol. 25:3842-3853(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PAAF1.
    11. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."
      Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.
      Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    12. "Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation."
      Jakobs A., Himstedt F., Funk M., Korn B., Gaestel M., Niedenthal R.
      Nucleic Acids Res. 35:E109-E109(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUMOYLATION.
    13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPRS6A_HUMAN
    AccessioniPrimary (citable) accession number: P17980
    Secondary accession number(s): B2R8V1
    , Q3B757, Q3B865, Q53HU5, Q6GPG8, Q6IBS1, Q96HD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: May 10, 2002
    Last modified: October 1, 2014
    This is version 160 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3