Reviewed,
UniProtKB/Swiss-Prot P17980 (PRS6A_HUMAN)
Last modified
November 25, 2008.
Version 95.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 26S protease regulatory subunit 6A Alternative name(s): Proteasome 26S subunit ATPase 3 TAT-binding protein 1 Short name=TBP-1 Proteasome subunit P50 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 439 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex By similarity. In case of HIV-1 infection, suppresses Tat-mediated transactivation. |
| Subunit structure | May form a heterodimer with a related family member. Interacts with PAAF1. Interacts with HIV-1 Tat. |
| Subcellular location | |
| Sequence similarities | Belongs to the AAA ATPase family. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| HTR1E | P28566 | 1 | EBI-359720,EBI-1043151 | |
| NDRG1 | Q92597 | 1 | EBI-359720,EBI-716486 | |
| PAAF1 | Q9BRP4 | 1 | EBI-359720,EBI-1056358 | |
| PSMC4 | P43686 | 1 | EBI-359720,EBI-743997 | |
| PSMD10 | O75832 | 1 | EBI-359720,EBI-752185 | |
| PSMD6 | Q15008 | 1 | EBI-359720,EBI-359701 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 439 | 439 | 26S protease regulatory subunit 6A | PRO_0000084698 | |||||
Regions | |||||||||
| Nucleotide binding | 227 – 234 | 8 | ATP Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine | ||||||
| Modified residue | 9 | 1 | Phosphoserine | ||||||
Experimental info | |||||||||
| Mutagenesis | 233 | 1 | K → H: Loss of function | ||||||
| Mutagenesis | 289 | 1 | D → A: Loss of function | ||||||
| Sequence conflict | 356 | 1 | M → T in BAD96205. Ref.3 | ||||||
| Sequence conflict | 409 | 1 | R → A in AAA36666. Ref.1 | ||||||
| Sequence conflict | 409 | 1 | R → A Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes." Ohana B., Moore P.A., Ruben S.M., Southgate C.D., Green M.R., Rosen C.A. Proc. Natl. Acad. Sci. U.S.A. 90:138-142(1993) [PubMed: 8419915] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney, Lung and Peripheral nerve. |
| [3] | Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-439. Tissue: Adipose tissue. |
| [4] | "A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator." Nelbock P., Dillion P.J., Perkins A., Rosen C.A. Science 248:1650-1653(1990) [PubMed: 2194290] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-439, INTERACTION WITH HIV-1 TAT. |
| [5] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-439. |
| [6] | Lubec G., Afjehi-Sadat L. Submitted (MAR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 156-171, MASS SPECTROMETRY. Tissue: Brain and Cajal-Retzius cell. |
| [7] | "Identification, purification, and characterization of a PA700-dependent activator of the proteasome." Demartino G.N., Proske R.J., Moomaw C.R., Strong A.A., Song X., Hisamatsu H., Tanaka K., Slaughter C.A. J. Biol. Chem. 271:3112-3118(1996) [PubMed: 8621709] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. |
| [8] | "Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases." Park Y., Hwang Y.-P., Lee J.-S., Seo S.-H., Yoon S.K., Yoon J.-B. Mol. Cell. Biol. 25:3842-3853(2005) [PubMed: 15831487] [Abstract] Cited for: INTERACTION WITH PAAF1. |
| [9] | "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex." Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L. Biochemistry 46:3553-3565(2007) [PubMed: 17323924] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, ACETYLATION AT MET-1, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M34079 mRNA. Translation: AAA36666.1. BC008713 mRNA. Translation: AAH08713.4. BC073165 mRNA. Translation: AAH73165.3. BC106920 mRNA. Translation: AAI06921.1. BC107804 mRNA. Translation: AAI07805.1. Different initiation. AK222485 mRNA. Translation: BAD96205.1. CR456731 mRNA. Translation: CAG33012.1. | |
| PIR | A34832. |
| RefSeq | NP_002795.2. |
| UniGene | Hs.250758 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IY0 based on UniProtKB Q9LCZ4. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:27555N. |
| IntAct | P17980. |
PTM databases | |
| PhosphoSite | P17980. |
2-D gel databases | |
| REPRODUCTION-2DPAGE | IPI00018398. |
Proteomic databases | |
| PeptideAtlas | P17980. |
Genome annotation databases | |
| Ensembl | ENSG00000165916. Homo sapiens. [Contig view] |
| GeneID | 5702. |
| KEGG | hsa:5702. |
| NMPDR | fig|9606.3.peg.5546. |
Organism-specific databases | |
| H-InvDB | HIX0035958. |
| HGNC | HGNC:9549. PSMC3. |
| HPA | HPA006065. |
| MIM | 186852. gene. |
| PharmGKB | PA33894. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | P17980. |
Enzyme and pathway databases | |
| Reactome | REACT_11045. Signaling by Wnt. REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_383. DNA Replication. REACT_6185. HIV Infection. REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. REACT_9035. APC/C:Cdh1-mediated degradation of Skp2. |
Gene expression databases | |
| ArrayExpress | P17980. |
| CleanEx | HS_PSMC3. |
| GermOnline | ENSG00000165916. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR005937. 26S_Psome_P45. IPR003593. AAA+_ATPase_core. IPR003959. AAA_ATPase_core. IPR003960. AAA_ATPase_CS. [Graphical view] |
| Pfam | PF00004. AAA. 1 hit. [Graphical view] |
| SMART | SM00382. AAA. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01242. 26Sp45. 1 hit. |
| PROSITE | PS00674. AAA. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 22154. |
| SOURCE | Search... |
Entry information
| Entry name | PRS6A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P17980 Secondary accession number(s): Q3B757 Q96HD3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


