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P17977

- CATG_RAT

UniProt

P17977 - CATG_RAT

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Protein

Cathepsin G

Gene
Ctsg
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Specificity similar to chymotrypsin C.

GO - Molecular functioni

  1. heparin binding Source: Ensembl
  2. serine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. defense response to fungus Source: RefGenome
  2. negative regulation of growth of symbiont in host Source: Ensembl
  3. neutrophil mediated killing of gram-positive bacterium Source: RefGenome
  4. positive regulation of immune response Source: Ensembl
  5. proteolysis Source: RefGenome
  6. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiREACT_198590. Activation of Matrix Metalloproteinases.
REACT_198807. Metabolism of Angiotensinogen to Angiotensins.
REACT_199178. Degradation of the extracellular matrix.

Protein family/group databases

MEROPSiS01.133.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin G (EC:3.4.21.20)
Gene namesi
Name:Ctsg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1307681. Ctsg.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular space Source: Ensembl
  3. plasma membrane Source: Ensembl
  4. secretory granule Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›26›26Cathepsin GPRO_0000088661Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP17977.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056429.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – ›26›26Peptidase S1Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.

Sequencei

Sequence statusi: Fragment.

P17977-1 [UniParc]FASTAAdd to Basket

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IIGGREARPN SHPYMAFLLI QSPEGL                             26
Length:26
Mass (Da):2,867
Last modified:November 1, 1990 - v1
Checksum:i11CB1B2E95EC8536
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei26 – 261

Sequence databases

PIRiS10608.
UniGeneiRn.103332.

Genome annotation databases

UCSCiRGD:1307681. rat.

Cross-referencesi

Sequence databases

PIRi S10608.
UniGenei Rn.103332.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000056429.

Protein family/group databases

MEROPSi S01.133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:1307681. rat.

Organism-specific databases

RGDi 1307681. Ctsg.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.

Enzyme and pathway databases

Reactomei REACT_198590. Activation of Matrix Metalloproteinases.
REACT_198807. Metabolism of Angiotensinogen to Angiotensins.
REACT_199178. Degradation of the extracellular matrix.

Gene expression databases

Genevestigatori P17977.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G."
    Bjoerk P., Ohlsson K.
    Biol. Chem. Hoppe-Seyler 371:595-601(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: Sprague-Dawley and Wistar.

Entry informationi

Entry nameiCATG_RAT
AccessioniPrimary (citable) accession number: P17977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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