Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P17977

- CATG_RAT

UniProt

P17977 - CATG_RAT

Protein

Cathepsin G

Gene

Ctsg

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    Specificity similar to chymotrypsin C.

    GO - Molecular functioni

    1. heparin binding Source: Ensembl
    2. serine-type endopeptidase activity Source: Ensembl

    GO - Biological processi

    1. defense response to fungus Source: Ensembl
    2. negative regulation of growth of symbiont in host Source: Ensembl
    3. neutrophil mediated killing of gram-positive bacterium Source: Ensembl
    4. positive regulation of immune response Source: Ensembl
    5. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    ReactomeiREACT_198590. Activation of Matrix Metalloproteinases.
    REACT_198807. Metabolism of Angiotensinogen to Angiotensins.
    REACT_199178. Degradation of the extracellular matrix.

    Protein family/group databases

    MEROPSiS01.133.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin G (EC:3.4.21.20)
    Gene namesi
    Name:Ctsg
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1307681. Ctsg.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular space Source: Ensembl
    3. plasma membrane Source: Ensembl
    4. secretory granule Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›26›26Cathepsin GPRO_0000088661Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP17977.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000056429.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – ›26›26Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.

    Sequencei

    Sequence statusi: Fragment.

    P17977-1 [UniParc]FASTAAdd to Basket

    « Hide

    IIGGREARPN SHPYMAFLLI QSPEGL                             26
    Length:26
    Mass (Da):2,867
    Last modified:November 1, 1990 - v1
    Checksum:i11CB1B2E95EC8536
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei26 – 261

    Sequence databases

    PIRiS10608.
    UniGeneiRn.103332.

    Genome annotation databases

    UCSCiRGD:1307681. rat.

    Cross-referencesi

    Sequence databases

    PIRi S10608.
    UniGenei Rn.103332.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000056429.

    Protein family/group databases

    MEROPSi S01.133.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:1307681. rat.

    Organism-specific databases

    RGDi 1307681. Ctsg.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.

    Enzyme and pathway databases

    Reactomei REACT_198590. Activation of Matrix Metalloproteinases.
    REACT_198807. Metabolism of Angiotensinogen to Angiotensins.
    REACT_199178. Degradation of the extracellular matrix.

    Gene expression databases

    Genevestigatori P17977.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G."
      Bjoerk P., Ohlsson K.
      Biol. Chem. Hoppe-Seyler 371:595-601(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Strain: Sprague-Dawley and Wistar.

    Entry informationi

    Entry nameiCATG_RAT
    AccessioniPrimary (citable) accession number: P17977
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3