P17977 (CATG_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathepsin G
EC=3.4.21.20

Gene names

Name:

Ctsg

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	26 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Specificity similar to chymotrypsin C.
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	defense response to fungus Inferred from electronic annotation. Source: Compara negative regulation of growth of symbiont in host Inferred from electronic annotation. Source: Compara neutrophil mediated killing of gram-positive bacterium Inferred from electronic annotation. Source: Compara positive regulation of immune response Inferred from electronic annotation. Source: Compara proteolysis Inferred from electronic annotation. Source: UniProtKB-KW response to lipopolysaccharide Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular matrix Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara secretory granule Inferred from electronic annotation. Source: Compara
Molecular_function	heparin binding Inferred from electronic annotation. Source: Compara serine-type endopeptidase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›26	›26	Cathepsin G		PRO_0000088661
Regions
	Domain	1 – ›26	›26	Peptidase S1
Experimental info
	Non-terminal residue	26	1

Sequences

	Sequence		Length	Mass (Da)
	P17977 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 11CB1B2E95EC8536	FASTA	26	2,867
	10 20 IIGGREARPN SHPYMAFLLI QSPEGL

References

[1]	"Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G." Bjoerk P., Ohlsson K. Biol. Chem. Hoppe-Seyler 371:595-601(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: Sprague-Dawley and Wistar.
+	Additional computationally mapped references.

Cross-references

Sequence databases
IPI	IPI00767675.
PIR	S10608.
UniGene	Rn.103332.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000056429.
Protein family/group databases
MEROPS	S01.133.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:1307681. rat.
Organism-specific databases
RGD	1307681. Ctsg.
Phylogenomic databases
eggNOG	COG5640.
HOGENOM	HOG000251820.
OrthoDB	EOG4KWJTW.
Gene expression databases
Genevestigator	P17977.
Family and domain databases
PROSITE	PS50240. TRYPSIN_DOM. Partial match. PS00134. TRYPSIN_HIS. Partial match. PS00135. TRYPSIN_SER. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATG_RAT

Accession

Primary (citable) accession number: P17977

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program