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Protein

Cathepsin G

Gene

Ctsg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Specificity similar to chymotrypsin C.

GO - Molecular functioni

  1. heparin binding Source: Ensembl
  2. serine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. defense response to fungus Source: Ensembl
  2. negative regulation of growth of symbiont in host Source: Ensembl
  3. neutrophil mediated killing of gram-positive bacterium Source: Ensembl
  4. positive regulation of immune response Source: Ensembl
  5. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiREACT_277593. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
REACT_278849. Activation of Matrix Metalloproteinases.
REACT_309654. Metabolism of Angiotensinogen to Angiotensins.
REACT_319794. Degradation of the extracellular matrix.

Protein family/group databases

MEROPSiS01.133.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin G (EC:3.4.21.20)
Gene namesi
Name:Ctsg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307681. Ctsg.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular space Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. nucleus Source: Ensembl
  5. plasma membrane Source: Ensembl
  6. secretory granule Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›26›26Cathepsin GPRO_0000088661Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiP17977. baseline and differential.
GenevestigatoriP17977.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056429.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – ›26›26Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
InParanoidiP17977.

Sequencei

Sequence statusi: Fragment.

P17977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
IIGGREARPN SHPYMAFLLI QSPEGL
Length:26
Mass (Da):2,867
Last modified:November 1, 1990 - v1
Checksum:i11CB1B2E95EC8536
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei26 – 261

Sequence databases

PIRiS10608.
UniGeneiRn.103332.

Genome annotation databases

UCSCiRGD:1307681. rat.

Cross-referencesi

Sequence databases

PIRiS10608.
UniGeneiRn.103332.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056429.

Protein family/group databases

MEROPSiS01.133.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1307681. rat.

Organism-specific databases

RGDi1307681. Ctsg.

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
InParanoidiP17977.

Enzyme and pathway databases

ReactomeiREACT_277593. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
REACT_278849. Activation of Matrix Metalloproteinases.
REACT_309654. Metabolism of Angiotensinogen to Angiotensins.
REACT_319794. Degradation of the extracellular matrix.

Gene expression databases

ExpressionAtlasiP17977. baseline and differential.
GenevestigatoriP17977.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G."
    Bjoerk P., Ohlsson K.
    Biol. Chem. Hoppe-Seyler 371:595-601(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: Sprague-Dawley and Wistar.

Entry informationi

Entry nameiCATG_RAT
AccessioniPrimary (citable) accession number: P17977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 1, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.