P17972 (KCNAW_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel protein Shaw

Alternative name(s):
Shaw2

Gene names

Name:	Shaw
Synonyms:	SHAW2
ORF Names:	CG2822

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subunit structure	Heterotetramer of potassium channel proteins By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Miscellaneous	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. This channel protein belongs to the delayed rectifier class.
Sequence similarities	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro sleep Inferred from mutant phenotype PubMed 19038223. Source: FlyBase
Cellular_component	voltage-gated potassium channel complex Traceable author statement PubMed 10798390. Source: FlyBase
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	Potassium voltage-gated channel protein Shaw		PRO_0000053967
Regions
	Transmembrane	175 – 193	19	Helical; Name=Segment S1; Potential
	Transmembrane	230 – 252	23	Helical; Name=Segment S2; Potential
	Transmembrane	263 – 284	22	Helical; Name=Segment S3; Potential
	Transmembrane	292 – 313	22	Helical; Voltage-sensor; Name=Segment S4; Potential
	Transmembrane	329 – 350	22	Helical; Name=Segment S5; Potential
	Transmembrane	392 – 413	22	Helical; Name=Segment S6; Potential
	Motif	377 – 382	6	Selectivity filter By similarity
Amino acid modifications
	Glycosylation	206	1	N-linked (GlcNAc...) Potential
	Glycosylation	213	1	N-linked (GlcNAc...) Potential
	Glycosylation	481	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P17972 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 977E3B7F22F098E2	FASTA	498	56,509
	10 20 30 40 50 60 MNLINMDSEN RVVLNVGGIR HETYKATLKK IPATRLSRLT EALANYDPIL NEYFFDRHPG 70 80 90 100 110 120 VFAQVLNYYR TGKLHYPTDV CGPLFEEELE FWGLDSNQVE PCCWMTYTQH RDTQETLAVL 130 140 150 160 170 180 DRLDLDTEKP SEEELARKFG FEEDYYKGTI SWWQEMKPRI WSLFDEPYSS NAAKTIGVVS 190 200 210 220 230 240 VFFICISILS FCLKTHPDMR VPIVRNITVK TANGSNGWFL DKTQTNAHIA FFYIECVCNA 250 260 270 280 290 300 WFTFEILVRF ISSPNKWEFI KSSVNIIDYI ATLSFYIDLV LQRFASHLEN ADILEFFSII 310 320 330 340 350 360 RIMRLFKLTR HSSGLKILIQ TFRASAKELT LLVFFLVLGI VIFASLVYYA ERIQPNPHND 370 380 390 400 410 420 FNSIPLGLWW ALVTMTTVGY GDMAPKTYIG MFVGALCALA GVLTIALPVP VIVSNFAMYY 430 440 450 460 470 480 SHTQARAKLP KKRRRVLPVE QPRQPRLPGA PGGVSGCGTP GSGPHSGPMG SGGTGPRRMN 490 NKTKDLVSPK SDMAFSFD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse." Wei A.G., Covarrubias M., Butler A., Baker K., Pak M., Salkoff L. Science 248:599-603(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Shal, Shab, and Shaw: three genes encoding potassium channels in Drosophila." Butler A., Wei A., Baker K., Salkoff L. Nucleic Acids Res. 18:2173-2174(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M32661 mRNA. Translation: AAA28897.1. AE014134 Genomic DNA. Translation: AAF51069.1.
PIR	A41359.
RefSeq	NP_476721.1. NM_057373.3.
UniGene	Dm.4566.
3D structure databases
ProteinModelPortal	P17972.
SMR	P17972. Positions 9-420.
ModBase	Search...
Protein family/group databases
TCDB	1.A.1.2.2. voltage-gated ion channel (VIC) superfamily.
Proteomic databases
PRIDE	P17972.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0089274; FBpp0088331; FBgn0003386.
GeneID	33599.
KEGG	dme:Dmel_CG2822.
Organism-specific databases
CTD	33599.
FlyBase	FBgn0003386. Shaw.
Phylogenomic databases
eggNOG	COG1226.
GeneTree	ENSGT00630000089518.
HOGENOM	HOG000238082.
InParanoid	P17972.
KO	K05320.
OrthoDB	EOG4H18B1.
Gene expression databases
Bgee	P17972.
GermOnline	CG2822. Drosophila melanogaster.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003974. K_chnl_volt-dep_Kv3. IPR015572. K_chnl_volt-dep_Kv3_inv. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit. PTHR11537:SF31. PTHR11537:SF31. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01491. KVCHANNEL. PR01498. SHAWCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	33599.
NextBio	784375.

Entry information

Entry name

KCNAW_DROME

Accession

Primary (citable) accession number: P17972
Secondary accession number(s): Q9VQU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project