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P17957 (CHS2_SOYBN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 2

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 2
Gene names
Name:CHS2
OrganismGlycine max (Soybean) (Glycine hispida) [Reference proteome]
Taxonomic identifier3847 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Chalcone synthase 2
PRO_0000216063

Sites

Active site1641 By similarity

Experimental info

Sequence conflict91K → Q in CAA46590. Ref.2
Sequence conflict1001M → V in CAA46590. Ref.2
Sequence conflict2991R → W in CAA46590. Ref.2
Sequence conflict3871T → S in CAA46590. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P17957 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 634D3F1CEDC5F973

FASTA38842,504
        10         20         30         40         50         60 
MVSVEEIRKA QRAEGPATVM AIGTATPPNC VDQSTYPDYY FRITNSEHMT ELKEKFKRMC 

        70         80         90        100        110        120 
DKSMIKKRYM YLNEEILKEN PSVCAYMAPS LDARQDMVVM EVPKLGKEAA TKAIKEWGQP 

       130        140        150        160        170        180 
KSKITHLIFC TTSGVDMPGA DYQLTKLLGL RPSVKRYMMY QQGCFAGGTV LRLAKDLAEN 

       190        200        210        220        230        240 
NKGARVLVVC SEITAVTFRG PTDTHLDSLV GQALFGDGAA AVIVGSDPLP VEKPLFQLVW 

       250        260        270        280        290        300 
TAQTILPDSE GAIDGHLREV GLTFHLLKDV PGLISKNIEK ALVEAFQPLG ISDYNSIFRI 

       310        320        330        340        350        360 
AHPGGPAILD QVEAKLGLKP EKMEATRHVL SEYGNMSSAC VLFILDQMRK KSIENGLGTT 

       370        380 
GEGLDWGVLF GFGPGLTVET VVLRSVTV 

« Hide

References

[1]"Nucleotide sequence of one member of soybean chalcone synthase multi-gene family."
Akada S., Kung S.D., Dube S.K.
Nucleic Acids Res. 18:3398-3398(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Williams.
[2]"Nucleotide sequence and putative regulatory elements of gene 2 of the soybean (Glycine max) chalcone synthase multigene family."
Akada S., Kung S.D., Dube S.K.
Plant Physiol. 102:317-319(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Williams.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52097 Genomic DNA. Translation: CAA36317.1.
X65636 Genomic DNA. Translation: CAA46590.1.
PIRJQ2249.
SYSYCN. S16338.
RefSeqXP_003524935.1. XM_003524887.2.

3D structure databases

ProteinModelPortalP17957.
SMRP17957. Positions 3-388.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsGLYMA05G28610.1; GLYMA05G28610.1; GLYMA05G28610.
GLYMA05G28610.2; GLYMA05G28610.2; GLYMA05G28610.
GeneID100775307.
KEGGgmx:100775307.

Enzyme and pathway databases

UniPathwayUPA00154.

Gene expression databases

GenevestigatorP17957.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS2_SOYBN
AccessionPrimary (citable) accession number: P17957
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways