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Protein

Immediate early response gene 2 protein

Gene

Ier2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-binding protein that seems to act as a transcription factor (By similarity). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immediate early response gene 2 protein
Alternative name(s):
CHX1
Cycloheximide-induced gene protein
Growth factor-inducible immediate early protein
Proline-rich-induced protein 92
Short name:
Pip92
T-lymphocyte-activated protein
Gene namesi
Name:Ier2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:104815. Ier2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Cytoplasmic during quiescence, translocates to the nucleus upon stimulation.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904361 – 221Immediate early response gene 2 proteinAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP17950.
PRIDEiP17950.

PTM databases

iPTMnetiP17950.
PhosphoSitePlusiP17950.

Expressioni

Inductioni

By growth factors and cycloheximide.2 Publications

Gene expression databases

BgeeiENSMUSG00000053560.
CleanExiMM_IER2.
GenevisibleiP17950. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060275.

Structurei

3D structure databases

ProteinModelPortaliP17950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IER family.Curated

Phylogenomic databases

eggNOGiENOG410IXGG. Eukaryota.
ENOG410Z3CN. LUCA.
GeneTreeiENSGT00730000111404.
HOGENOMiHOG000112998.
HOVERGENiHBG068883.
InParanoidiP17950.
OMAiCEAKPAC.
OrthoDBiEOG091G0HLK.
TreeFamiTF331376.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiPF05760. IER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSAREVYLSA
60 70 80 90 100
KVEAHQPEFP PSRRALDPRL HPPREAEVAV EVASPEAVQP PEPMDTQEEV
110 120 130 140 150
LRVQETPALC DPPPARVSRK RRSSSDLSDG SDAGLVPSKK ARLEEVEGEA
160 170 180 190 200
TSEVPDRLQL PPAQSEGAFP NLARVLQRRF SSLLNCGPAV PPPTPPTCEA
210 220
KPACRPADNM LNVLVRAVVA F
Length:221
Mass (Da):24,459
Last modified:October 3, 2012 - v3
Checksum:i661D2E167EC5D081
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27G → D in AAA40059 (PubMed:2308934).Curated1
Sequence conflicti46V → L in AAA40059 (PubMed:2308934).Curated1
Sequence conflicti46V → L in AAA39931 (PubMed:2247083).Curated1
Sequence conflicti46V → L in AAB00120 (PubMed:8083220).Curated1
Sequence conflicti59F → S in AAA40059 (PubMed:2308934).Curated1
Sequence conflicti76A → D in BAC27990 (PubMed:16141072).Curated1
Sequence conflicti92E → G in BAC27990 (PubMed:16141072).Curated1
Sequence conflicti130G → S in AAA40059 (PubMed:2308934).Curated1
Sequence conflicti130G → S in AAA39931 (PubMed:2247083).Curated1
Sequence conflicti130G → S in AAB00120 (PubMed:8083220).Curated1
Sequence conflicti183L → F in BAC27990 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31042 mRNA. Translation: AAA40059.1.
M59821 mRNA. Translation: AAA39931.1.
L26490 Genomic DNA. Translation: AAB00120.1.
AK032692 mRNA. Translation: BAC27990.1.
AK144601 mRNA. Translation: BAE25960.1.
AK170433 mRNA. Translation: BAE41793.1.
AC145556 Genomic DNA. No translation available.
BC002067 mRNA. Translation: AAH02067.1.
CCDSiCCDS22474.1.
PIRiA54722. A36370.
RefSeqiNP_034629.3. NM_010499.4.
UniGeneiMm.399.

Genome annotation databases

EnsembliENSMUST00000060427; ENSMUSP00000060275; ENSMUSG00000053560.
GeneIDi15936.
KEGGimmu:15936.
UCSCiuc009mmr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31042 mRNA. Translation: AAA40059.1.
M59821 mRNA. Translation: AAA39931.1.
L26490 Genomic DNA. Translation: AAB00120.1.
AK032692 mRNA. Translation: BAC27990.1.
AK144601 mRNA. Translation: BAE25960.1.
AK170433 mRNA. Translation: BAE41793.1.
AC145556 Genomic DNA. No translation available.
BC002067 mRNA. Translation: AAH02067.1.
CCDSiCCDS22474.1.
PIRiA54722. A36370.
RefSeqiNP_034629.3. NM_010499.4.
UniGeneiMm.399.

3D structure databases

ProteinModelPortaliP17950.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060275.

PTM databases

iPTMnetiP17950.
PhosphoSitePlusiP17950.

Proteomic databases

PaxDbiP17950.
PRIDEiP17950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060427; ENSMUSP00000060275; ENSMUSG00000053560.
GeneIDi15936.
KEGGimmu:15936.
UCSCiuc009mmr.2. mouse.

Organism-specific databases

CTDi9592.
MGIiMGI:104815. Ier2.

Phylogenomic databases

eggNOGiENOG410IXGG. Eukaryota.
ENOG410Z3CN. LUCA.
GeneTreeiENSGT00730000111404.
HOGENOMiHOG000112998.
HOVERGENiHBG068883.
InParanoidiP17950.
OMAiCEAKPAC.
OrthoDBiEOG091G0HLK.
TreeFamiTF331376.

Miscellaneous databases

ChiTaRSiIer2. mouse.
PROiP17950.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053560.
CleanExiMM_IER2.
GenevisibleiP17950. MM.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiPF05760. IER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIER2_MOUSE
AccessioniPrimary (citable) accession number: P17950
Secondary accession number(s): Q3TD12
, Q64251, Q8BME8, Q99M25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.